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Artificial cavernosa-like tissue based on multibubble Matrigel and a human corpus cavernous fibroblast scaffold

Asian Journal of Andrology 2024年第3期26卷 260-267页

作者： yu-zhuo chen Yi-Hong Zhou Min-Bo Yan Ming Xiao Biao Liu Ying-Hao Yin Xiao-Li Tan Yong-Quan Huang yu-Hong Lin Ting Xie Jia-Li Tian Qi Wang Jian-Ying Li Zi-Zhou Meng Zheng Li Emily Xing yu-Xin Tang Ya-Wei Li Zhong-Zhen Su Liang-yu Zhao Department of Ultrasound The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Interventional Medicine Guangdong Provincial Key Laboratory of Biomedical ImagingThe Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Urology The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Andrology the Center for Men’s HealthUrologic Medical CenterShanghai Key Laboratory of ReproductiveMedicineShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Cedars-Sinai Medical Center Los AngelesCA 90024USA

Ex vivo tissue culture of the human corpus cavernosum(cc)can be used to explore the tissue structural changes and complex signaling *** present,artificial Cc-like tissues based on acellular or three-dimensional(3D)-printed scaffolds are used to solve the scarcity of primary penis tissue ***,inconvenience and high costs limit the wide application of such ***,we describe a simple,fast,and economical method of constructing artificial CC-like *** Cc fibroblasts(FBs),endothelial cells(ECs),and smooth muscle cells(SMCs)were expanded in vitro and mixed with Matrigel in specific proportions.A large number of bubbles were formed in the mixture by vortexing combined with pipette blowing,creating a porous,spongy,and spatial *** Cc FBs produced a variety of signaling factors,showed multidirectional differentiation potential,and grew in a 3D grid in Matrigel,which is necessary for CC-like tissue to maintain a porous structure as a cell *** the C-like tissue,ECs covered the surface of the lumen,and SMCs were located inside the trabeculae,similar to the structure of the primary *** cell components remained stable for 3 days in vitro,but the EC content decreased on the 7th ***/integrated(WNT)signaling activation led to lumen atrophy and increased tissue fibrosis in CC-like tissue,inducing the same changes in characteristics as in the primary *** study describes a preparation method for human artificial cC-like tissue that may provide an improved experimental platform for exploring the function and structure of the cC and conducting drug screening for erectile dysfunction therapy.

关键词： artificial tissue corpus cavernosum ex vivo fibroblasts

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Low XIST expression in Sertoli cells of Klinefelter syndrome patients causes high susceptibility of these cells to an extra X chromosome

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Asian Journal of Andrology 2023年第6期25卷 662-673页

作者： Liang-yu Zhao Peng Li chen-cheng Yao Ru-Hui Tian yu-Xin Tang yu-zhuo chen Zhi Zhou Zheng Li Department of Andrology The Center for Men’s HealthUrologic Medical CenterShanghai Key Laboratory of Reproductive MedicineShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of Urology The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000China Department of Interventional Medicine Guangdong Provincial Key Laboratory of Biomedical ImagingThe Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000China School of Life Science and Technology ShanghaiTech UniversityShanghai 200120China

Klinefelter syndrome(KS)is the most common genetic cause of human male ***,the effect of the extra X chromosome on different testicular cell types remains poorly ***,we profiled testicular single-cell transcriptomes from three KS patients and normal karyotype control *** the different somatic cells,Sertoli cells showed the greatest transcriptome changes in KS *** analysis showed that X-inactive-specific transcript(XIST),a key factor that inactivates one X chromosome in female mammals,was widely expressed in each testicular somatic cell type but not in Sertoli *** loss of XIST in Sertoli cells leads to an increased level of X chromosome genes,and further disrupts their transcription pattern and cellular *** phenomenon was not detected in other somatic cells such as Leydig cells and vascular endothelial *** results proposed a new mechanism to explain why testicular atrophy in KS patients is heterogeneous with loss of seminiferous tubules but interstitial *** study provides a theoretical basis for subsequent research and related treatment of KS by identifying Sertoli cell-specific X chromosome inactivation failure.

关键词： Klinefelter syndrome nonobstructive azoospermia Sertoli cell spermatogenesis X chromosome inactivation

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壳聚糖和营养小肽对大口黑鲈幼鱼生长性能、抗氧化能力及免疫基因表达的影响

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饲料研究 2024年第13期47卷 58-64页

作者：张坤张蕉南胡兵张电光卓玉琛张晶晶陈斌樊海平福建天马科技集团股份有限公司福建福州350308 福建省特种水产配合饲料重点实验室福建福州350308 福建农林大学海洋学院福建福州350002 福建省海洋生物技术重点实验室福建福州350002 福建省淡水水产研究所福建福州350002

试验旨在研究饲料中添加壳聚糖和营养小肽对大口黑鲈生长性能、抗氧化能力和免疫基因表达的影响。选取规格一致的3000尾大口黑鲈幼鱼,随机分为两组,对照组投喂基础饲料,试验组在基础饲料中添加2 g/kg壳聚糖及20 g/kg营养小肽,每组3个重... 详细信息

试验旨在研究饲料中添加壳聚糖和营养小肽对大口黑鲈生长性能、抗氧化能力和免疫基因表达的影响。选取规格一致的3000尾大口黑鲈幼鱼,随机分为两组,对照组投喂基础饲料,试验组在基础饲料中添加2 g/kg壳聚糖及20 g/kg营养小肽,每组3个重复,每个重复500尾幼鱼。试验期60 d。结果表明:第30 d,试验组大口黑鲈的增重率和特定生长率极显著高于对照组(P<0.01);肠道淀粉酶、脂肪酶、过氧化氢酶(CAT)、总抗氧化能力(T-AOC)、血清免疫球蛋白M(IgM)、溶菌酶(LZM)、碱性磷酸酶(AKP)水平显著高于对照组(P<0.05);中肠的组织结构明显优于对照组;肠道中封闭蛋白-4(Claudin-4)的表达量显著高于对照组(P<0.05),白细胞介素-34(IL-34)和肿瘤坏死因子(TNF-α)的表达量显著低于对照组(P<0.05)。试验第60 d,试验组大口黑鲈肝脏丙二醛(MDA)含量显著低于对照组(P<0.05),AKP水平极显著高于对照组(P<0.01),肠道形态优于对照组,闭合小环蛋白-1(ZO-1)、封闭蛋白-1(Claudin-1)、Claudin-4、闭合蛋白(Claudin)、白细胞介素-10(IL-10)的表达量极显著高于对照组(P<0.05),肿瘤坏死因子-α(TNF-α)的表达量极显著低于对照组(P<0.01)。研究表明,饲料中添加2 g/kg壳聚糖和20 g/kg营养小肽能够提高大口黑鲈的生长性能、消化酶活性、抗氧化能力及免疫基因表达。

关键词：大口黑鲈壳聚糖营养小肽生长性能抗氧化能力基因表达

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Pyridinic-N doping carbon layers coupled with tensile strain of FeNi alloy for activating water and urea oxidation

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Green Energy & Environment 2024年第4期9卷 684-694页

作者： Guangfu Qian Wei chen Jinli chen Li Yong Gan Tianqi yu Miaojing Pan Xiaoyan zhuo Shibin Yin Guangxi Key Laboratory of Electrochemical Energy Materials College of Chemistry and Chemical EngineeringState Key Laboratory of Processing for Non-Ferrous Metal and Featured MaterialsGuangxi University100 Daxue RoadNanning530004China Institute for Structure and Function and Department of Physics Chongqing UniversityChongqing400030China

Exploitation of oxygen evolution reaction(OER)and urea oxidation reaction(UOR)catalysts with high activity and stability at large current density is a major challenge for energy-saving H_(2) production in water ***,we use the pyridinic-N doping carbon layers coupled with tensile strain of FeNi alloy activated by NiFe_(2)O_(4)(FeNi/NiFe_(2)O_(4)@NC)for efficiently increasing the performance of water and urea *** to the tensile strain effect on FeNi/NiFe_(2)O_(4)@NC,it provides a favorable modulation on the electronic properties of the active center,thus enabling amazing OER(η_(100)=196 mV)and UOR(E_(10)=1.32 V)intrinsic ***,the carbon-coated layers can be used as armor to prevent FeNi alloy from being corroded by the electrolyte for enhancing the OER/UOR stability at large current density,showing high industrial *** work thus provides a simple way to prepare high-efficiency catalyst for activating water and urea oxidation.

关键词： Carbon-encapsulated Tensile strain Catalyst Oxygen evolution reaction Urea oxidation reaction

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The impact of the Rural Minimum Living Standard Guarantee(Rural Dibao)Program on child nutrition outcomes

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Journal of Integrative Agriculture 2024年第2期23卷 444-456页

作者： Dian chen Xiangming Fang yu chen Xiaodong Zheng zhuo chen Rodney B.W.Smith Academy of Global Food Economics and Policy China Agricultural UniversityBeijing 100083China School of Public Health Georgia State UniversityAtlanta 30303USA School of Economics Zhejiang Gongshang UniversityHangzhou 310018China College of Public Health University of GeorgiaAthens 30602USA Department of Applied Economics University of MinnesotaSaint Paul 55108USA

The Rural Minimum Living Standard Guarantee(Rural Dibao)is an important unconditional cash transfer program to alleviate poverty in rural *** the importance of children’s nutrition in breaking poverty cycles,little is known about the impact of Rural Dibao on child nutrition *** China Family Panel Studies(CFPS),this paper examines the effects of Rural Dibao on child nutrition outcomes and investigates potential pathways and heterogeneous *** exploit propensity score matching and difference-in-differences techniques to evaluate the effects of the Rural Dibao program on child nutrition *** results suggest that Rural Dibao significantly impacts the nutrition outcomes of children up to 15 years of ***,our results suggest that Rural Dibao improves child height-to-age z-scores by 1.05 standard deviations and lowers the probability of stunting by 11.9 percentage *** analyses suggest that increased protein intake is the main pathway through which Rural Dibao participation contributes to better nutrition *** also find that the effect of the program is more pronounced among girls,children who are non-left-behind or live with highly educated mothers,and those from low-income families and poor *** findings suggest that Rural Dibao participation helps improve child nutrition outcomes through improving diet quality.

关键词： Rural Minimum Living Standard Guarantee nutrition height-to-age z-scores stunting rural China

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Precise control of page cache for containers

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Frontiers of Computer Science 2024年第2期18卷 17-30页

作者： Kun WANG Song WU Shengbang LI zhuo HUANG Hao FAN chen yu Hai JIN National Engineering Research Center for Big Data Technology and System Services Computing Technology and System LabCluster and Grid Computing Lab School of Computer Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China

Container-based virtualization isbecoming increasingly popular in cloud computing due to its efficiency and *** isolation is a fundamental property of *** works have indicated weak resource isolation could cause significant performance degradation for containerized applications and enhanced resource ***,current studies have almost not discussed the isolation problems of page cache which is a key resource for *** leverage memory cgroup to control page cache ***,existing policy introduces two major problems in a container-based ***,containers can utilize more memory than limited by their cgroup,effectively breaking memory ***,the Os kernel has to evict page cache to make space for newly-arrived memory requests,slowing down containerized *** paper performs an empirical study of these problems and demonstrates the performance impacts on containerized *** we propose pCache(precise control of page cache)to address the problems by dividing page cache into private and shared and controlling both kinds of page cache separately and *** do so,pCache leverages two new technologies:fair account(f-account)and evict on demand(EoD).F-account splits the shared page cache charging based on per-container share to prevent containers from using memory for free,enhancing memory *** EoD reduces unnecessary page cache evictions to avoid the performance *** evaluation results demonstrate that our system can effectively enhance memory isolation for containers and achieve substantial performance improvement over the original page cache management policy.

关键词： page cache memory cgroup container isolation cloud computing

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Relative Broken Family Sensitivity

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2297-2306页

作者： zhuo Wei LIU Tao yu Department of Mathematics Shantou UniversityShantou 515063P.R.China

Letπ:(X,T)→(Y,S)be a factor map between two topological dynamical systems,and F_(a) Furstenberg family of *** introduce the notion of relative broken *** Fs(***,Finf)be the families consisting of all syndetic subsets(*** upper Banach density subsets,infinite subsets).We show that for a factor mapπ:(X,T)→(Y,S)between transitive systems,πis relatively broken F-sensitive for F=Fs or Fpubd if and only if there exists a relative sensitive pair which is an F-recurrent point of(R_(π),T^((2)));is relatively broken Finf-sensitive if and only if there exists a relative sensitive pair which is not *** a factor mapπ:(X,T)→(Y,S)between minimal systems,we get the structure of relative broken F-sensitivity by the factor map to its maximal equicontinuous factor.

关键词： Relative sensitivity recurrent points Furstenberg family relative sensitive pairs maximal equicontinuous factor

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NbN quantum dots anchored hollow carbon nanorods as efficient polysulfide immobilizer and lithium stabilizer for Li-S full batteries

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Journal of Energy Chemistry 2024年第1期88卷 260-271,I0007页

作者： Fei Ma zhuo chen Katam Srinivas Ziheng Zhang yu Wu Dawei Liu Hesheng yu yue Wang Xinsheng Li Ming-qiang Zhu Qi Wu yuanfu chen School of Integrated Circuit Science and Engineering and State Key Laboratory of Electronic Thin Films and Integrated DevicesUniversity of Electronic Science and TechnologyChengdu 610054SichuanChina College of Science and Institute of Oxygen Supply Center of Tibetan Studies(Everest Research Institute)Tibet UniversityLhasa 850000TibetChina College of Mechanical and Electronic Engineering Northwest A&F UniversityXianyang 712100ShaanxiChina

The shuttle effect of lithium polysulfides(LiPSs)and uncontrollable lithium dendrite growth seriously hinder the practical application of lithium-sulfur(Li-S)*** simultaneously address such issues,monodispersed Nb N quantum dots anchored on nitrogen-doped hollow carbon nanorods(NbN@NHCR)are elaborately developed as efficient Li PSs immobilizer and Li stabilizer for high-performance Li-S full *** functional theory(DFT)calculations and experimental characterizations demonstrate that the sulfiphilic and lithiophilic NbN@NHCR hybrid can not only efficiently immobilize the soluble Li PSs and facilitate diffusion-conversion kinetics for alleviating the shuttling effect,but also homogenize the distribution of Li+ions and regulate uniform Li deposition for suppressing Li-dendrite *** a result,the assembled Li-S full batteries(NbN@NHCR-S||Nb N@NHCR-Li)deliver excellent long-term cycling stability with a low decay rate of 0.031%per cycle over 1000 cycles at high rate of 2 *** at a high S loading of 5.8 mg cm^(-2)and a low electrolyte/sulfur ratio of 5.2μL mg^(-1),a large areal capacity of 6.2 mA h cm^(-2)can be achieved in Li-S pouch cell at 0.1 *** study provides a new perspective via designing a dual-functional sulfiphilic and lithiophilic hybrid to address serious issues of the shuttle effect of S cathode and dendrite growth of Li anode.

关键词： Dual-functional host NbN quantum dots Shuttle effect Dendrite-free Li anode Li-S full batteries

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Embracing the age of artificial intelligence:paradigm shifts,opportunities,and challenges in the treatment of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

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Science China(Life Sciences) 2024年第6期67卷 1302-1304页

作者： zhuo-yu An Xiao-Hui Zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Collaborative Innovation Center of Hematology Peking UniversityBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China

Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is an important medical development in treating hematological ***,the risk of acute graft-versus-host disease(a GVHD)severely limits its use.a GVHD is a sev... 详细信息

关键词： hematopoietic graft artificial

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Dual-salt poly(tetrahydrofuran) electrolyte enables quasi-solid-state lithium metal batteries to operate at -30 ℃

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Journal of Energy Chemistry 2024年第9期96卷 456-463页

作者： Zhiyong Li zhuo Li Rui yu Xin Guo School of Materials Science and Engineering State Key Laboratory of Material Processing and Die&Mould TechnologyHuazhong University of Science and TechnologyWuhan 430074HubeiChina The State Key Laboratory of Refractories and Metallurgy and Institute of Advanced Materials and Nanotechnology Wuhan University of Science and TechnologyWuhan 430081HubeiChina

The stable operation of solid-state lithium metal batteries at low temperatures is plagued by severe restrictions from inferior electrolyte-electrode interface compatibility and increased energy barrier for Li^(+)***,we prepare a dual-salt poly(tetrahydrofuran)-based electrolyte consisting of lithium hexafluorophosphate and lithium difluoro(oxalato)borate(LiDFOB).The Li-salt anions(DFOB−)not only accelerate the ring-opening polymerization of tetrahydrofuran,but also promote the formation of highly ion-conductive and sustainable interphases on Li metal anodes without sacrificing the Li^(+)conductivity of electrolytes,which is favorable for Li^(+)transport kinetics at low *** of this polymer electrolyte in Li||LiFePO_(4)cells show 82.3%capacity retention over 1000 cycles at 30℃and endow stable discharge capacity at−30℃.Remarkably,the Li||LiFePO4 cells retain 52%of their room-temperature capacity at−20℃and 0.1 *** rational design of dual-salt polymer-based electrolytes may provide a new perspective for the stable operation of quasi-solid-state batteries at low temperatures.

关键词： Poly(tetrahydrofuran) Dual-salt electrolyte Solidel ectrolyte interphase Low-temperature operation Quasi-solid-state battery

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