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Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia:randomized trials and multiomics analysis

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Military Medical Research 2024年第1期11卷 19-33页

作者： Liang-Kun Guo Yi Su yu-Ya-Nan Zhang Hao yu zhe Lu Wen-Qiang Li Yong-Feng Yang Xiao Xiao Hao Yan Tian-Lan Lu Jun Li yun-Dan Liao zhe-Wei Kang Li-Fang Wang yue Li Ming Li Bing Liu Hai-Liang Huang Lu-Xian Lv Yin Yao yun-Long Tan Gerome Breen Ian Everall Hong-Xing Wang Zhuo Huang Dai Zhang Wei-Hua yue Institute of Mental Health Peking University Sixth HospitalBeijing 100191China National Clinical Research Center for Mental Disorders Peking University Sixth HospitalBeijing 100191China NHC Key Laboratory of Mental Health and Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder(2018RU006) Chinese Academy of Medical SciencesBeijing 100191China Peking University Huilongguan Clinical Medical School Beijing Huilongguan HospitalBeijing 100096China Department of Psychiatry Jining Medical UniversityJining 272067ShandongChina Henan Key Lab of Biological Psychiatry the Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 435001HenanChina Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Institute of Psychiatry Psychology and NeuroscienceKing’s College LondonLondon WC2R 2LSUK State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Analytic and Translational Genetics Unit Massachusetts General HospitalBostonMA 02114USA Stanley Center for Psychiatric Research the Broad Institute of MIT and HarvardCambridgeMA 02141USA Department of Medicine Harvard Medical SchoolBostonMA 02115USA Department of Biostatistics and Computational Biology School of Life SciencesFudan UniversityShanghai 200438China Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Natural and Biomimetic Drugs Key Laboratory for Neuroscience for Ministry of EducationSchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China

Background:Choosing the appropriate antipsychotic drug(APD)treatment for patients with schizophrenia(SCZ)can be challenging,as the treatment response to APD is highly variable and difficult to predict due to the lack of effective *** studies have indicated the association between treatment response and genetic and epigenetic factors,but no effective biomarkers have been ***,further research is imperative to enhance precision medicine in SCZ ***:Participants with SCZ were recruited from two randomized *** discovery cohort was recruited from the CAPOC trial(n=2307)involved 6 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,Quetiapine,Aripiprazole,Ziprasidone,and Haloperidol/Perphenazine(subsequently equally assigned to one or the other)*** external validation cohort was recruited from the CAPEC trial(n=1379),which involved 8 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,and Aripiprazole ***,healthy controls(n=275)from the local community were utilized as a genetic/epigenetic *** genetic and epigenetic(DNA methylation)risks of SCZ were assessed using the polygenic risk score(PRS)and polymethylation score,*** study also examined the genetic-epigenetic interactions with treatment response through differential methylation analysis,methylation quantitative trait loci,colocalization,and promoteranchored chromatin *** learning was used to develop a prediction model for treatment response,which was evaluated for accuracy and clinical benefit using the area under curve(AUC)for classification,R^(2) for regression,and decision curve ***:Six risk genes for SCZ(LINC01795,DDHD2,SBNO1,KCNG2,SEMA7A,and RUFY1)involved in cortical morphology were identified as having a genetic-epigenetic interaction associated with treatment *** developed and externally validated predictio

关键词： Schizophrenia Antipsychotic drug Treatment response Prediction model Genetics Epigenetics

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基于印度主流媒体的中印边界争端批判地缘政治解读

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地理学报 2024年第4期79卷 991-1006页

作者：余珍鑫胡志丁张喆华东师范大学地理科学学院上海200241 华东师范大学世界地理与地缘战略研究中心上海200062 华东师范大学全球创新与发展研究院上海200062

边界问题是困扰中印关系发展的重要议题之一。学界往往从殖民、历史、安全、第三方介入等因素解释中印边界争端的原因,忽视边界可作为资源被国内外多方行为体复杂权力斗争所利用,进而制造边界争端的事实。本文援引批判地缘政治的理念与... 详细信息

边界问题是困扰中印关系发展的重要议题之一。学界往往从殖民、历史、安全、第三方介入等因素解释中印边界争端的原因,忽视边界可作为资源被国内外多方行为体复杂权力斗争所利用,进而制造边界争端的事实。本文援引批判地缘政治的理念与分析方法,从多方行为体协同作用的角度对其进行话语分析并划分地缘政治想象类型,进而提出理解边界争端的新分析框架,以解读2020年5月—2021年2月的中印边界争端。研究表明:①边界争端可以看作不同行为体利用的工具或资源,即多方行为体协同对边界争端进行话语与地缘政治想象的建构,以达成其目的或利益。②基于2020年4月—2021年3月印度主流媒体报道,印度国内的印人党、国大党、军队、外交部、企业社会精英等将中印边界争端作为谋取政治、军事、外交和经济利益的工具,通过话语建构偏执风格式、亲密隐喻式或道德抵制式的地缘政治想象,制造或加剧边界争端形势。③边界争端可被认为是印方行为体制造利用而持续发生的过程,即当其目的还未达成时,班公湖对峙等争端事件再次发生或持续,而当其目的基本达成后才趋于缓和或平息。对此,中国须理性认识近年来中印边界争端呈现的阶段性和持续性特征,并适时发挥积极性探究的方式建设两国间经贸互补的合作性结构,以有效缓和或化解边界问题。

关键词：批判地缘政治中印边界争端话语地缘政治想象印度

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Temperature inversion enables superior stability for low-temperature Zn-ion batteries

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Journal of Energy Chemistry 2024年第4期91卷 245-253页

作者： Fu-Da yu zhe-Jian Yi Rui-Yang Li Wei-Hao Lin Jie Chen Xiao-yue Chen Yi-Ming Xie Ji-Huai Wu Zhang Lan Lan-Fang Que Bao-Sheng Liu Hao Luo zhen-Bo Wang Engineering Research Center of Environment-Friendly Functional Materials Ministry of EducationInstitute of Materials Physical ChemistryHuaqiao UniversityXiamen 361021FujianChina b2 School of Electronic Engineering Guangxi University of Science and TechnologyLiuzhou 545006GuangxiChina School of Materials Science and Engineering Xiamen University of TechnologyXiamen 361024FujianChina School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001HenanChina MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Laboratory of Space Power-SourcesSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001HeilongjiangChina College of Materials Science and Engineering Shenzhen UniversityShenzhen 518071GuangdongChina

It is challenging for aqueous Zn-ion batteries(ZIBs)to achieve comparable low-temperature(low-T)performance due to the easy-frozen electrolyte and severe Zn ***,an aqueous electrolyte with a low freezing point and high ionic conductivity is *** with molecular dynamics simulation and multi-scale interface analysis(time of flight secondary ion mass spectrometry threedimensional mapping and in-situ electrochemical impedance spectroscopy method),the temperature independence of the V_(2)O_(5)cathode and Zn anode is observed to be ***,dominated by the solvent structure of the designed electrolyte at low temperatures,vanadium dissolution/shuttle is significantly inhibited,and the zinc dendrites caused by this electrochemical crosstalk are greatly relieved,thus showing an abnormal temperature inversion *** the disclosure and improvement of the above phenomena,the designed Zn||V_(2)O_(5)full cell delivers superior low-T performance,maintaining almost 99%capacity retention after 9500 cycles(working more than 2500 h)at-20°*** work proposes a kind of electrolyte suitable for low-T ZIBs and reveals the inverse temperature dependence of the Zn anode,which might offer a novel perspective for the investigation of low-T aqueous battery systems.

关键词： Aqueous Zn-ion batteries Low-temperature performance Opposite temperature dependence Zndendrite growth Vanadium dissolution

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Inhibitory effect of saffron on head and neck squamous cell carcinoma via targeting of ESR1 and CCND1 by its active compound crocetin

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Traditional Medicine Research 2024年第7期9卷 25-34页

作者： Xiao-Jie Wang Ming-Jun Zhang Li-Mei Cui zhe-Ying Song Ya-Qi Wang yu-Teng Yang Xiang-Kun Zhao Ya-Kui Mou yu-Mei Li Xi-Cheng Song School of Clinical Medicine Weifang Medical UniversityWeifang 261042China. Department of Otorhinolaryngology Head and Neck SurgeryYantai Yuhuangding HospitalQingdao UniversityYantai 264000China. Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases Yantai 264000China. Yantai Key Laboratory of Otorhinolaryngologic Diseases Yantai Yuhuangding HospitalYantai 264000China. The 2nd Medical College of Binzhou Medical University Yantai 264000China.

Background:Traditional Chinese medicine is promising for managing challenging and complex disorders,including cancer,and in particular,saffron is applied in treating various cancer ***,its potential therapeutic efficacy and active components in managing squamous cell carcinoma of the head and neck(HNSCC)remain unclear ***:Using network pharmacology approaches,active ingredients of saffron,their target genes,and HNSCC-related genes were *** analyses were conducted for determining molecular functions and pathways enriched by genes that overlapped between the saffron target gene set and the HNSCC gene *** the four known active ingredients of saffron,crocetin was found to have the strongest inhibitory impact on HNSCC,based on the findings of cell viability and migration ***,the potential target genes of crocetin in HNSCC cells were examined using molecular docking experiments and were confirmed by *** s:Four active ingredients of saffron and 184 of their target genes were ***,a total of 34 overlapping saffron-/HNSCC-associated targets related to the four active ingredients were screened,and crocetin was chosen for further investigation because it had the strongest inhibitory effect on HNSCC *** docking experiments indicated that ESR1 and CCND1 were the target genes of *** results were confirmed through qPCR analysis,in which crocetin was found to lower the expression of the ESR1 and CCND1 genes in AMC-HN-8 and FaDu ***:According to our results,crocetin is a primary active anti-cancer component of saffron that may have potential in the development of novel HNSCC-treating ***,more thorough molecular research is necessary for confirming these results and elucidating the anti-cancer mechanism underlying saffron.

关键词： saffron hub genes crocetin network pharmacology analysis HNSCC ESR1 CCND1

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Hotspots and research trends of Piwi-interacting RNAs from 2006 to 2023 based on bibliometric analysis

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Medical Data Mining 2024年第3期7卷 33-45页

作者： Lu Shen zhe-Zhong Zhang Shi-Liang Chen Ting-yu Weng Department of Clinical Laboratory The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou 310006China Department of Pathology The First People’s Hospital of Fuyang DistrictHangzhou 311499China

Background:Piwi-interacting RNAs(piRNAs)are a type of non-coding RNAs,initially identified in germ cells in 2006,known to bind to the Piwi family *** studies indicate their importance in genome stability,epigenetics regulation,germ cell differentiation,and tumor *** growing interest in piRNA research,there is a lack of comprehensive bibliometric studies on the *** study aims to analyze piRNA research trends from 2006 to ***:The literature regarding piRNA was sourced from the Web of Science on April 25,***,CiteSpace and a bibliometric online website(https://***/app)were employed to perform bibliometric *** maps were constructed to evaluate the collaborations among countries,institutions,authors,journals,references,keywords,and research hot ***:In this study,2549 literature were published across 464 countries and 6921 institutions,comprising 2010 articles and 539 *** United States led in publication output(n=1011,39.66%),followed by China(635,24.91%).The University of Tokyo had the most publications among all institutions(n=100,3.92%),followed by the Chinese Academy of Sciences(n=86,3.37%).Among 631 published journals,Nucleic Acids Research was the most published journal(n=83,3.26%).Siomi Mikiko C published the most articles(n=58),with Aravin Alexei A as the most co-cited *** of term co-occurrence unveiled three highly interconnected clusters,including“piRNA biogenesis and function”,“cancer and regulation”,as well as“protein and species”.The research focus has transferred from male reproductive development to tumor ***:This bibliometric analysis offered a thorough overview of the current state of piRNA research,deepening understanding of the progress in this field over the last 17 years and providing a valuable reference for scholars engaged in piRNA studies.

关键词： piRNA research trends bibliometric analysis VOSviewer CiteSpace

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磁等离子体发动机中磁喷管分离过程的流体模拟

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物理学报 2024年第10期73卷 246-255页

作者：杨振宇张元哲范威杨广杰韩先伟西安航天动力研究所陕西省等离子体物理与应用技术重点实验室西安710100

磁等离子体发动机在深空探测、载人航天等领域具备广阔的应用前景.发动机的磁喷管单元将离子能量转化为轴向动能,对磁喷管中等离子体与磁场分离的物理过程开展研究对提升发动机推进效率具有重要意义.本文建立了针对磁等离子体发动机中... 详细信息

磁等离子体发动机在深空探测、载人航天等领域具备广阔的应用前景.发动机的磁喷管单元将离子能量转化为轴向动能,对磁喷管中等离子体与磁场分离的物理过程开展研究对提升发动机推进效率具有重要意义.本文建立了针对磁等离子体发动机中磁喷管的流体数值模型,并在不同入口离子温度、背景磁场条件下开展了数值模拟.计算结果表明:等离子体向下游运动的过程中轴向速度增大,并与磁力线逐渐分离,绝热性损失分离机制在分离过程中起主导作用;入口离子温度升高,离子轴向速度增大,离子与磁场分离位置更靠上游,但不会对阻性分离过程产生影响;背景磁场增强,下游离子速度减小,流线与对称轴的夹角减小,各种分离机制中绝热性损失分离机制仍起主要作用.

关键词：磁等离子体发动机磁喷管等离子体分离流体模拟

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中国工业产业链现代化指数:区域差异及动态演进

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统计与决策 2024年第4期40卷 96-101页

作者：余姗张哲西安财经大学经济学院西安710100 西安财经大学西部能源经济与区域发展协同创新研究中心西安710100

文章基于工业产业链流通、盈利、数字化、创新、协同以及绿色化六个维度构建指标体系,采用熵值法测算2011—2022年中国31个省份工业产业链现代化指数,并运用Dagum基尼系数、Moran指数、核密度估计及马尔可夫链的方法分析区域差异及动态... 详细信息

文章基于工业产业链流通、盈利、数字化、创新、协同以及绿色化六个维度构建指标体系,采用熵值法测算2011—2022年中国31个省份工业产业链现代化指数,并运用Dagum基尼系数、Moran指数、核密度估计及马尔可夫链的方法分析区域差异及动态演进规律。结果表明:中国工业产业链现代化指数整体呈稳定上升趋势,且东部地区和中部地区相对较高,而区域差异则主要表现在各区域之间,但是长期来看高水平地区将会辐射和带动其他地区的发展,进而促进工业产业链现代化整体水平提升。

关键词：工业产业链现代化区域差异动态演进 Dagum基尼系数核密度估计马尔可夫链

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Taming heat with tiny pressure

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The Innovation 2024年第2期5卷 70-78页

作者： Kun Zhang zhe Zhang Hailong Pan Haoyu Wang Xueting Zhao Ji Qi Zhao Zhang Ruiqi Song Chenyang yu Biaohong Huang Xujing Li Huaican Chen Wen Yin Changlong Tan Weijin Hu Michael Wüubbenhorst Jiangshui Luo Dehong yu Zhidong Zhang Bing Li Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Laboratory for Soft Matter and Biophysics Department of Physics and AstronomyKU Leuven3001 LeuvenBelgium Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China College of Materials Science and Engineering Sichuan UniversityChengdu 610064China School of Materials Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150080China Australian Nuclear Science and Technology Organisation Lucas HeightsNSW 2234Australia

Heat is almost *** electricity,which can be easily manipulated,the current ability to control heat is still highly limited owing to spontaneous thermal dissipation imposed by the second law of *** illumination and pressure have been used to switch endothermic/exothermic responses of materials via phase transitions;however,these strategies are less cost-effective and ***,we spectroscopically demonstrate the glassy crystal state of 2-amino-2-methyl-1,3-propanediol(AMP)to realize an affordable,easily manageable approach for thermal energy *** supercooled state of AMP is so sensitive to pressure that even several megapascals can induce crystallization to the ordered crystal,resulting in a substantial temperature increase of 48 K within 20 ***,we demonstrate a proof-of-concept device capable of programable heating with an extremely high work-to-heat conversion effi-ciency of*** delicate and efficient tuning of heat may remarkably facilitate rational utilization of waste heat.

关键词： illumination thermal rational

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基于PLUS-InVEST模型吐哈盆地陆地生态系统碳储量时空变化及多情景模拟

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干旱区地理 2024年第2期47卷 260-269页

作者：韩楚翘郑江华王哲于雯婕新疆大学地理与遥感科学学院新疆乌鲁木齐830017 新疆绿洲生态重点实验室新疆乌鲁木齐830017

土地覆盖变化能够改变区域碳储存能力,从而引起全球气候变化。研究土地覆盖变化对碳储量的影响,预测未来不同土地覆盖情景下的碳储量,对实现区域“碳中和”战略目标具有重要意义,然而目前针对中国西部生态脆弱区的研究仍有待探究。以新... 详细信息

土地覆盖变化能够改变区域碳储存能力,从而引起全球气候变化。研究土地覆盖变化对碳储量的影响,预测未来不同土地覆盖情景下的碳储量,对实现区域“碳中和”战略目标具有重要意义,然而目前针对中国西部生态脆弱区的研究仍有待探究。以新疆吐哈盆地为研究区,基于土地覆盖产品数据,结合PLUS模型和InVEST模型,探讨了土地覆盖变化与区域碳储量的时空变化关系,预测和评估了2025、2030年可持续发展情景,维持现状发展情景,经济优先发展情景下土地覆盖和碳储量的时空动态特征。结果表明:(1)近20 a来,吐哈盆地耕地和裸土地面积增加最大,其次是建设用地,而草地表现出最大的减少趋势,草地转为耕地和建设用地是最主要的转移类型。(2)2000、2010年和2020年吐哈盆地平均碳储量分别为26.01 t·hm~(-2)、25.68 t·hm~(-2)、25.73 t·hm~(-2),呈现出先降低后增加的趋势,平均碳储量累计减少了0.28 t·hm~(-2),其中土壤有机质碳储量占比最高,约占总碳储量的94%,裸土地、草地贡献了最多的碳储量。(3)2030年3种情景下,森林、灌木林、湿地几乎无明显变化,裸土地呈现出减少的趋势,而建设用地呈现增加的趋势。(4)到2030年可持续发展情景下吐哈盆地总碳储量较2020年增加了0.18×10~6t,维持现状发展情景和经济优先发展情景下分别减少了0.30×10~6t、1.01×10~6t,经济优先发展情景下碳储量损失最大。研究结果可为吐哈盆地土地利用优化以及制定生态系统可持续发展措施提供依据。

关键词：土地覆盖变化情景模拟碳储量吐哈盆地

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不确定切除对非小细胞肺癌预后的影响

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中华外科杂志 2024年第8期62卷 764-770页

作者：张难张少为韩晶王哲容宇刘俊峰河北医科大学第四医院胸外科石家庄050011 河北医科大学第四医院肿瘤内科石家庄050011 河北北方学院附属第一医院胸外科张家口075061

目的探讨非小细胞肺癌不确定切除[R(un)]对术后生存的影响。方法本研究为回顾性队列研究。回顾性分析2012年12月至2013年12月在河北医科大学第四医院胸外科接受手术治疗的477例非小细胞肺癌患者的资料。男性302例,女性175例,年龄(59±8)... 详细信息

目的探讨非小细胞肺癌不确定切除[R(un)]对术后生存的影响。方法本研究为回顾性队列研究。回顾性分析2012年12月至2013年12月在河北医科大学第四医院胸外科接受手术治疗的477例非小细胞肺癌患者的资料。男性302例,女性175例,年龄(59±8)岁(范围:27~79岁)。依据国际肺癌协会颁布的手术切除标准将患者分为完整性切除(R0)组(286例)和R(un)组(191例)。采用χ2检验比较两组间的临床资料,以性别、年龄、吸烟史、辅助治疗、TNM分期、病理学类型及肿瘤部位为协变量进行倾向性评分匹配,采用最近邻法1∶3匹配,卡钳值为0.02。通过Kaplan-Meier法绘制生存曲线,Log-rank检验进行单因素生存分析,Cox比例风险模型分析总体生存的预后因素,对TNM分期、纵隔淋巴结转移状态进行亚组分层分析。结果R(un)组中最高组淋巴结阳性68例,纵隔淋巴结未达到清扫范围129例。倾向性评分匹配后,R0组227例,R(un)组142例。匹配后R0组和R(un)组5年总体生存率分别为64.3%和52.1%(P=0.021),Ⅰ、Ⅱ、Ⅲ期患者的5年总体生存率分别为85.2%、65.9%、34.8%(P<0.01),TNM分期(χ^(2)=46.913,P<0.01)、病理学分型为腺鳞癌(HR=5.970,95%CI:3.117~11.431,P<0.01)及R(un)(HR=1.512,95%CI:1.065~2.147,P=0.021)是总体生存的预后因素。亚组分析结果显示,Ⅲ期患者中,R0组和R(un)组5年总体生存率分别为45.8%和9.5%(P=0.002);纵隔淋巴结转移患者中,R0组和R(un)组5年总体生存率分别为50.6%和7.1%(P<0.01)。结论TNM分期、病理学类型及是否为R(un)是非小细胞肺癌术后总体生存的预后因素。在Ⅰ~Ⅱ期非小细胞肺癌患者中,R(un)不影响术后总体生存;在Ⅲ期及有纵隔淋巴结转移的患者中,R(un)患者的总体生存较R0患者更差。

关键词：癌,非小细胞肺淋巴结切除术预后不确定性切除病理学分型

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