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IDH1 mutation inhibits differentiation of astrocytes and glioma cells with low oxoglutarate dehydrogenase expression by disturbingα-ketoglutarate-related metabolism and epigenetic modification

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Life Metabolism 2024年第2期3卷 24-37页

作者： yuanlin zhao Ying Yang Risheng Yang Chao Sun Xing Gao Xiwen Gu yuan yuan Yating Nie Shenhui Xu Ruili Han Lijun zhang Jing Li Peiz.en Hu Yingmei Wang Huangtao Chen Xiangmei cao Jing Wu z.e Wang yu Gu Jing Ye State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Department of PathologyXijing Hospital and School of Basic MedicineFourth Military Medical UniversityXi’anShaanxi 710032China Department of Pathology Air Force Hospital of Southern Theater CommandGuangzhouGuangdong 510000China Department of Neurology Tangdu HospitalFourth Military Medical UniversityXi’anShaanxi 710038China Department of Clinical Diagnosis Tangdu HospitalFourth Military Medical UniversityXi’anShaanxi 710038China Department of Neurosurgery the Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710004China Department of Pathology School of Basic Medical SciencesNingxia Medical UniversityYinchuanNingxia 750004China Institute of Analytical Chemistry and Instrument for Life Science The Key Laboratory of Biomedical Information Engineering of Ministry of EducationSchool of Life Science and TechnologyXi’an Jiaotong UniversityXi’anShaanxi 710049China

Isocitrate dehydrogenase(IDH)mutations frequently occur in lower-grade gliomas and secondary *** IDHs exhibit a gain-of-function activity,leading to the production of D-2-hydroxyglutarate(D-2HG)by reducingα-ketoglutarate(α-KG),a central player in metabolism and epigenetic ***,the role ofα-KG homeostasis in IDH-mutated gliomagenesis remains *** this study,we found that low expression of oxoglutarate dehydrogenase(OGDH)was a common feature in IDH-mutated gliomas,***α-***,IDH1 mutation significantly reducedα-KG levels and increased glutaminolysis and DNA/histone methylation in *** metabolic and epigenetic alterations inhibited astrocyte maturation and led to cortical dysplasia in ***,our results also indicated that reduced OGDH expression can promote the differentiation of glioma cells,while IDH1 mutations impeded the differentiation of glioma cells with low OGDH by reducing the accumulation ofα-KG and increasing ***,we found that l-glutamine increasedα-KG levels and augmented the differentiation-promoting effects of AGI5198,an IDH1-mutant inhibitor,in IDH1-mutant glioma ***,this study reveals that low OGDH expression is a crucial metabolic characteristic of IDH-mutant gliomas,providing a potential strategy for the treatment of IDH-mutant gliomas by targetingα-KG homeostasis.

关键词： α-ketoglutarate IDH1 mutation OGDH l-glutamine gliomas

Roadmap for rechargeable batteries:present and beyond

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Science China Chemistry 2024年第1期67卷 13-42页

作者： Sen Xin Xu zhang Lin Wang Haijun yu Xin Chang yu-Ming zhao Qinghai Meng Pan Xu Chen-zi zhao Jiahang Chen Huichao Lu Xirui Kong Jiulin Wang Kai Chen Gang Huang Xinbo zhang yu Su Yao Xiao Shu-Lei Chou Shilin zhang zaiping Guo Aobing Du Guanglei Cui Gaojing Yang Qing zhao Liubing Dong Dong zhou Feiyu Kang Hu Hong Chunyi zhi zhizhang yuan Xianfeng Li Yifei Mo Yizhou zhu Dongfang yu Xincheng Lei Jianxiong zhao Jiayi Wang Dong Su yu-Guo Guo Qiang zhang Jun Chen Li-Jun Wan CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China University of Chinese Academy of Sciences.Beijing 100049 China Institute of Advanced Battery Materials and Devices Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China Key Laboratory of Advanced Functional Materials Ministry of EducationBeijing University of TechnologyBeijing 100124China Beijing Key Laboratory of Green Chemical Reaction engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China State Key Laboratory of Chemistry and Utilization of Carbon-Based energy Resources College of ChemistryXinjiang UniversityUrumqi 830046China Department of Chemical engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Rare earth Resource Utilization Changchun Institute of Applied ChemistryChangchun 130022China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China School of Chemical engineering and Advanced Materials The University of AdelaideAdelaide 5000Australia Qingdao Industrial energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Frontiers Science Center for New Organic Matter Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education)College of ChemistryNankai UniversityTianjin 300071China College of Chemistry and Materials Science Jinan UniversityGuangzhou 511443China Tsinghua Shenz.en International Graduate School Tsinghua UniversityShenzhen 518055China Department of Materials Science and engineering City University of Hong KongHong Kong 999077China Division of energy Storage Dalian National Laboratory for Clean Energy(DNL)Dalian Institute of Chem

Rechargeable batteries currently hold the largest share of the electrochemical energy storage market,and they play a major role in the sustainable energy transition and industrial decarbonization to respond to global climate *** to the increased popularity of consumer electronics and electric vehicles,lithium-ion batteries have quickly become the most successful rechargeable batteries in the past three decades,yet growing demands in diversified application scenarios call for new types of rechargeable *** efforts are made to developing the next-generation post-Li-ion rechargeable batteries,which include,but are not limited to solid-state batteries,lithium–sulfur batteries,sodium-/potassium-ion batteries,organic batteries,magnesium-/zinc-ion batteries,aqueous batteries and flow *** the great achievements,challenges persist in precise understandings about the electrochemical reaction and charge transfer process,and optimal design of key materials and interfaces in a *** roadmap tends to provide an overview about the current research progress,key challenges and future prospects of various types of rechargeable *** computational methods for materials development,and characterization techniques will also be discussed as they play an important role in battery research.

关键词： energy storage rechargeable batteries battery materials electrochemistry

NO_(x) reduction against alkali poisoning over Ce(SO_(4))_(2)-V_(2)O_(5)/TiO_(2) catalysts by constructing the Ce^(4+)-SO_(4)^(2−)pair sites

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Chinese Chemical Letters 2024年第5期35卷 355-360页

作者： Shuangxi Li Huijun yu Tianwei Lan Liyi Shi Danhong Cheng Lupeng Han Dengsong zhang State Key Laboratory of Advanced Special Steel School of Materials Science and EngineeringInternational Joint Laboratory of Catalytic ChemistryCollege of SciencesShanghai UniversityShanghai 200444China

Commercial V_(2)O_(5)-based catalysts have been successfully applied in NH_(3) selective catalytic reduction(NH_(3)-SCR)of NO_(x) from power stations,but their poor alkali-resistance restrains the wider application in nonelectrical *** this study,NO_(x) reduction against alkali poisoning over V_(2)O_(5)/TiO_(2) is greatly improved via Ce(SO_(4))_(2) *** has been originally demonstrated that Ce^(4+)-SO_(4)^(2−)pair sites play crucial roles in improving NO_(x) reduction against alkali poisoning over V_(2)O_(5)/TiO_(2) *** strong interaction between V species and Ce sites of Ce^(4+)-SO_(4)^(2−)pairs triggers the reaction between NH_(4)^(+) species and gaseous NO via eley-Rideal(e-R)reaction *** K-poisoning,the SO_(4)^(2−)sites of Ce^(4+)-SO_(4)^(2−)pairs as protective sites strongly bond with K and thus maintain the high reaction efficiency via the e-R reaction *** work demonstrates an effective strategy to enhance NO_(x) reduction against alkali poisoning over catalysts via constructing Ce^(4+)-SO_(4)^(2−)pair sites,contributing to developing alkali-resistant SCR catalysts for practical application in nonelectrical industries.

关键词： Air pollution control Selective catalytic reduction NOx reduction Alkali poisoning Ce(SO_(4))_(2)

Physiological,transcriptome and gene functional analysis provide novel sights into cadmium accumulation and tolerance mechanisms in kenaf

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Journal of environmental Sciences 2024年第3期137卷 500-514页

作者： Shan cao Meng Wang Jiao Pan Dengjie Luo Samavia Mubeen Caijin Wang Jiao yue Xia Wu Qijing Wu Hui zhang Canni Chen Muzammal Rehman Sichen Xie Ru Li Peng Chen Guangxi Key Laboratory of Agro-environment and Agric-products safety Key Laboratory of Plant Genetics and BreedingCollege of AgricultureGuangxi UniversityNanning 530004China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanning 530004China

Kenaf is considered to have great potential for remediation of heavy metals in ***,studies on molecular mechanisms of root Cd accumulation and tolerance are still *** this study,two differently tolerant kenaf cultivars were selected as materials and the physiological and transcriptomic effects were evaluated under Cd *** study showed that 200μmol/L CdCl_(2) treatment triggered the reactive oxygen species(ROS)explosion and membrane lipid *** with the Cd-sensitive cultivar‘z',the Cd-tolerant cultivar‘F'was able to resist oxidative stress in cells by producing higher antioxidant enzyme activities and increasing the contents of ascorbic acid(AsA)and glutathione(GSH).The root cell wall of‘F'exhibited higher polysaccharide contents under Cd treatment,providing more Cd-binding *** were 3,439 differentially expressed genes(DeGs)that were co-regulated by Cd treatment in two *** biosynthesis and plant hormone signal transduction pathways were significantly enriched by functional annotation *** associated with pectin,cellulose,and hemi-cellulose metabolism were involved in Cd chelation of root cell wall;V-ATPases,ABCC3 and Narmp3 could participated in vacuolar compartmentalization of Cd;PDR1 was responsible for Cd effux;the organic acid transporters contributed to the absorption of Cd in *** genes might have played key roles in kenaf Cd tolerance and Cd ***,HczIP2 was identified to be involved in Cd uptake and transport in *** findings provide a deeper understanding of the molecular pathways underlying Cd accumulation and detoxification mechanisms in kenaf.

关键词： Kenaf Cd stress Physiological Transcriptome HczIP2

电针联合针刺十三鬼穴治疗卒中相关异态睡眠疗效观察

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山西中医 2024年第3期40卷 31-33页

作者：曹玉锦浙江省湖州市安吉县中医医院湖州313300

目的:观察电针联合针刺十三鬼穴治疗卒中相关异态睡眠的疗效。方法:将60例有异态睡眠的卒中患者随机分为两组各30例。治疗组采用电针联合针刺十三鬼穴治疗,对照组采用常规电针治疗,每周治疗5次,4周为1个疗程。于治疗前后采用匹兹堡睡眠... 详细信息

目的:观察电针联合针刺十三鬼穴治疗卒中相关异态睡眠的疗效。方法:将60例有异态睡眠的卒中患者随机分为两组各30例。治疗组采用电针联合针刺十三鬼穴治疗,对照组采用常规电针治疗,每周治疗5次,4周为1个疗程。于治疗前后采用匹兹堡睡眠质量指数量表(PSQI)和快速眼动睡眠期行为障碍量表(RBDSQ)进行评分。结果:治疗后两组PSQI、RBDSQ评分均较前改善(P<0.05),且治疗组明显优于对照组(P<0.05)。结论:电针联合针刺十三鬼穴治疗能改善卒中患者的异态睡眠症状,疗效较好。

关键词：卒中异态睡眠十三鬼穴电针针灸疗法

蛋白质翻译后修饰在肝癌免疫治疗中的作用机制

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生物化学与生物物理进展 2024年第9期51卷 2061-2072页

作者：唐怡王国泰蒋雨涵曹忠强陕西中医药大学第一临床医学院咸阳712099 陕西中医药大学附属医院肝胆胰外科咸阳712099

蛋白质翻译后修饰(PTM)是蛋白质活性调节、定位、表达以及与其他细胞分子相互作用的调节机制,能引起蛋白质性质和功能的变化,其传统形式包括磷酸化、糖基化、甲基化、泛素化等。越来越多的研究表明,PTMs不仅调节肝癌的发生和发展,而且... 详细信息

蛋白质翻译后修饰(PTM)是蛋白质活性调节、定位、表达以及与其他细胞分子相互作用的调节机制,能引起蛋白质性质和功能的变化,其传统形式包括磷酸化、糖基化、甲基化、泛素化等。越来越多的研究表明,PTMs不仅调节肝癌的发生和发展,而且在抗癌免疫反应中起着至关重要的作用。本文综述了目前几种传统类型的PTMs在肝癌免疫治疗中的作用机制,为肝癌治疗提供新的见解和未来研究方向。

关键词：蛋白质翻译后修饰肝癌免疫治疗

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基于TeROS的自然闪电X射线暴观测研究

地球物理学报 2024年第1期67卷 21-33页

作者：张雄张阳李小强郑毅曹保锋王宇吕伟涛李鹏国民核生化灾害防护国家重点实验室北京102205 中国气象科学研究院灾害天气国家重点实验室北京100081 国网电力科学研究院武汉南瑞有限责任公司武汉430074

本文报道了国内首个自然闪电高能辐射(Lightning energetic Radiation,LeR)多点观测结果.基于自主研发的雷暴高能辐射观测系统(Thunderstorm energetic Radiation Observation System,TeROS),在2021年夏季观测期成功捕获3次自然LeR事件,结合闪电定位、低频快电场变化、回击峰值电流等其他资料,对3次事件的高能辐射特征进行研究.分析发现:3次LeR事件均于负地闪下行先导的最后阶段被探测到,是典型的X射线暴,且均具有MeV能量的单光子,最大能量超过2.2 MeV;伴随梯级先导出现的X射线暴持续时间为数百μs,伴随不规则直窜先导的X射线暴持续时间为数十μs,主要与先导发展速度有关;相应回击峰值电流最大的1次事件具有最高的单光子能量、最大的单位面积沉积总能量和最多的爆发过程数量,随着接近回击时刻,该事件还表现出与电场变化一致的增强趋势,表明先导头部电场是影响高能辐射产生的重要因素;随到达强度降低,高能辐射信号逐渐由束流模式向单光子模式转变,呈现出与地球伽马射线闪类似的现象学特征,更多乃至所有的爆发过程无法被探测到,高能辐射可能是闪电发展过程中的普遍现象.

关键词：闪电高能辐射自然闪电 X射线暴地球伽马射线闪闪电先导

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The secondary periodic element β-1 and its applications

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Science China Mathematics 2024年

作者： Jianguo Hong Xiangjun Wang yu zhang Science College Shijiazhuang University School of Mathematical Sciences Nankai University Center for Applied Mathematics Tianjin University

Let p≥7 be a *** prove that βp2/p2-1survives to e∞in the Adams-Novikov spectral ***,using the Thom map Φ:extBP*BP*,*（BP*,BP*）→extA*,*（z/p,z/p）,we can see that h0h3also survives to e∞in the classical Adams sp...

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Searching for the light leptophilic gauge boson zx via four-lepton final states at the CePC

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Chinese Physics C 2024年第4期48卷 59-67页

作者：岳崇兴李妍钰王美舒羽张欣蒙 Department of Physics Liaoning Normal UniversityDalian 116029China Center for Theoretical and experimental High energy Physics Liaoning Normal UniversityDalian 116029China

We investigate the possibility of detecting the leptophilic gauge boson z_(x) predicted by the U(1)Le−Lμmodel via the processes e+e−→ℓ^(+)ℓ^(−)z_(x)(z_(x)→ℓ^(+)ℓ^(−))and e+e−→ℓ^(+)ℓ^(−)z_(x)(z_(x)→νℓ¯νℓ)at the Circular electron Positron Collider(CePC)with a center of mass energy√s=240 GeV and luminosity L=5.6ab^(−1).We provide the expected sensitivities of the CePC to the parameter space at the 1σ,2σ,3σ,and 5σlevels.

关键词： light gauge boson z_(x) U(1)L_(e)-L_(μ)model Circular electron Positron Collider