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Chinese Physics B 2018年第8期27卷 7-12页

作者： Meng-Li Liu yu-yi ouyang Huan-Ran Hou Ming Lei Wen-Jun Liu Zhi-yi Wei State Key Laboratory of Information Photonics and Optical Communications School of ScienceBeijing University of Posts and TelecommunicationsBeijing 100876China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

Due to the remarkable carrier mobility and nonlinear characteristic, MoS2 is considered to be a powerful competitor as an effective optical modulated material in fiber lasers. In this paper, the MoS2 films are prepared by the chemical vapor deposition method to guarantee the high quality of the crystal lattice and uniform thickness. The transfer of the films to microfiber and the operation of gold plated films ensure there is no heat-resistant damage and anti-oxidation. The modulation depth of the prepared integrated microfiber-MoS2 saturable absorber is 11.07%. When the microfiber-MoS2 saturable absorber is used as a light modulator in the Q-switching fiber laser, the stable pulse train with a pulse duration of 888 ns at 1530.9 nm is obtained. The ultimate output power and pulse energy of output pulses are 18.8 mW and 88 nJ, respectively. The signal-to-noise ratio up to 60 dB indicates the good stability of the laser. This work demonstrates that the MoS2 saturable absorber prepared by the chemical vapor deposition method can serve as an effective nonlinear control device for the Q-switching fiber laser.

关键词： nonlinear optical materials fiber laser Q-switching

Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-yu Zhao Juan-Han yu yi-Hua Wang yi-Xin Liu Lu Xu Lin Fu Ning yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

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Traditional Medicine Research 2025年第2期10卷 55-64页

作者： Jin-Fang Wu yi-Sheng Chen yu-Chun Xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(YE).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while YE had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity

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World Journal of Clinical Cases 2025年第6期13卷 24-29页

作者： Wen-Jin yuan yi-Juan Zheng Bing-Rong Zhang yi-Jie Lin You Li Yan-Yan Qiu Xue-Ping yu Department of Infection Disease Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian provinceFujian Medical University Affiliated First Quanzhou HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Hydroxyurea,an antimetabolite,is frequently prescribed for various hemato-logical disorders,and its common side effects include gastrointestinal problems,cutaneous or mucosal lesions and pyrexia/*** SUMMARY This study reports the case of a 67-year-old woman who developed recurrent abdominal pain after 10 years of continuous hydroxyurea therapy for primary *** revealed an ileocecal *** discontinuing hydroxyurea therapy for 6 months,follow-up colonoscopy showed a significant reduction in the *** We consider cecal ulcers as a rare complication of hydroxyurea therapy which typically resolves upon stopping the drug.

关键词： Hydroxyurea Ulcer Abdominal pain Thrombocythemia Colonoscopy Case report

The Gross conjecture over rational function fields

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Science China Mathematics 2005年第12期48卷 1609-1617页

作者： ouyang yi Department of Mathematical Sciences Tsinghua UniversityBeijing 100084China

We study the Gross conjecture for the cyclotomic function field extension k(∧f)/k where k = Fq(t) is the rational function field and f is a monic polynomial in Fq[t].We prove the conjecture in the Fermat curve case(i.e., when f = t(t - 1)) by a direct calculation. We also prove the case when f is irreducible, which is analogous to the Weil reciprocity law. In the general case, we manage to show the weak version of the Gross conjecture here.

关键词： Gross conjecture,L-function,Theta-function,Weil reciprocity.

The Universal Kolyvagin Recursion Implies the Kolyvagin Recursion

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Acta Mathematica Sinica,English Series 2007年第7期23卷 1163-1172页

作者： yi ouyang Department of Mathematical Sciences Tsinghua University

Let Hz. be the universal norm distribution and M a fixed power of prime p. By using the double complex method employed by Anderson, we study the universal Kolyvagin recursion occurring in the canonical basis in the cohomology group H^0（Gz,Hz/MHz）. We furthermore show that the universal Kolyvagin recursion implies the Kolyvagin recursion in the theory of Euler systems. One certainly hopes this could lead to a new way to find new Euler systems.

关键词： Euler system universal distribution Kolyvagin recursion

Metabolic reprogramming: a new option for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie Chen Jinyang Chen Chao yu Kaishun Xia Biao Yang Ronghao Wang yi Li Kesi Shi yuang Zhang Haibin Xu Xuesong Zhang Jingkai Wang Qixin Chen Chengzhen Liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

A Simple Proof of Dieudonn-Manin Classification Theorem

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Acta Mathematica Sinica,English Series 2012年第8期28卷 1553-1574页

作者： yi Wen DING yi ouyang Wu Wen-Tsun Key Laboratory of Mathematics University of Science and Techonology of ChinaChinese Academy of SciencesHefei 230026P.R.China School of Mathematics University of Science and Technology of ChinaHefei 230026P.R.China

The Dieudonne Manin classification theorem on φ-modules （φ-isocrystals） over a perfect field plays a very important role in p-adic Hodge theory. In this note, in a more general setting we give a new proof of this result, and in the course of the proof, we also give an explicit construction of the Harder Narasimhan filtration of a φ-module.

关键词： φ-Module strict ring Dieudonne Manin theorem Harder-Narasimhan filtration

Energy corrugation in atomic-scale friction on graphite revisited by molecular dynamics simulations

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Acta Mechanica Sinica 2016年第4期32卷 604-610页

作者： Xiao-yu Sun yi-Zhou Qi Wengen ouyang Xi-Qiao Feng Qunyang Li AML and CNMM Department of Engineering MechanicsTsinghua University Department of Engineering Mechanics School of Civil Engineering Wuhan University State Key Laboratory of Tribology Tsinghua University

Although atomic stick–slip friction has been extensively studied since its first demonstration on graphite,the physical understanding of this dissipation-dominated phenomenon is still very limited. In this work, we perform molecular dynamics（MD） simulations to study the frictional behavior of a diamond tip sliding over a graphite surface. In contrast to the common wisdom, our MD results suggest that the energy barrier associated lateral sliding（known as energy corrugation） comes not only from interaction between the tip and the top layer of graphite but also from interactions among the deformed atomic layers of graphite. Due to the competition of these two subentries, friction on graphite can be tuned by controlling the relative adhesion of different *** relatively low tip-graphite adhesion, friction behaves normally and increases with increasing normal load. However,for relatively high tip-graphite adhesion, friction increases unusually with decreasing normal load leading to an effectively negative coefficient of friction, which is consistent with the recent experimental observations on chemically modified graphite. Our results provide a new insight into the physical origins of energy corrugation in atomic scale friction.

关键词： graphite friction diamond sliding tuned stick dissipation decreasing chemically oscillatory

Efficient Pairing Computation on Twisted Weierstrass Curves

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Chinese Journal of Electronics 2018年第4期27卷 739-745页

作者： WANG Bei ouyang yi HU Honggang School of Mathematical Sciences University of Science and Technology of China School of Information Science and Technology University of Science and Technology of China

In this paper, we construct the twists of twisted Edwards curves in Weierstrass form. Then we define a new twisted Ate pairing on twisted Weierstrass curves named the Tx-Ate pairing. Following Miller’s algorithm, we give a computation of the Tx-Ate pairing on high degree twisted Weierstrass curves, where the point operations are over Edwards form, and the computation of Miller function is over Weierstrass form. Although, in one doubling loop, our method to compute the Tx-Ate pairing is a litter slower than the previously fastest *** twists, the Tx-Ate pairing can be calculated on more twisted Weierstrass curves with short loop length. The TxAte pairing is even competitive with optimal Ate pairing when they have the same short loop length.

关键词： Weierstrass curves Twisted Ate pairing Twisted Edwards curves Miller function