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Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian yang Jiang Wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale liu Lei Bai Xiang Li Zhengquan yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

Preparation of Co/S co-doped carbon catalysts for excellent methylene blue degradation

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 169-181页

作者： Haixu Li Haobo He Tiannan Jiang yunfei Du Zhichen Wu Liang Xu Xinjie Wang Xiaoguang liu Wanhua yu Wendong Xue School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Beijing Jinyu Tongda Refractory Technologies Co. Ltd.Beijing 100085China

S and Co co-doped carbon catalysts were prepared via pyrolysis of MOF-71 and thiourea mixtures at 800℃at a mass ratio of MOF-71 to thiourea of 1:0.1 to effectively activate peroxymonosulfate(PMS)for methylene blue(MB)*** effects of two different mixing routes were identified on the MB degradation ***,the catalyst obtained by the alcohol solvent evaporation(MOF-AEP)mixing route could degrade 95.60%MB(50 mg/L)within 4 min(degradation rate:K=0.78 min^(-1)),which was faster than that derived from the direct grinding method(MOF-DGP,80.97%,K=0.39 min^(-1)).X-ray photoelectron spectroscopy revealed that the Co-S content of MOF-AEP(43.39at%)was less than that of MOF-DGP(54.73at%),and the proportion of C-S-C in MOF-AEP(13.56at%)was higher than that of MOF-DGP(10.67at%).Density functional theory calculations revealed that the adsorption energy of Co for PMS was -2.94 eV when sulfur was doped as C-S-C on the carbon skeleton,which was higher than that when sulfur was doped next to cobalt in the form of Co-S bond(-2.86 eV).Thus,the C-S-C sites might provide more contributions to activate PMS compared with ***,the degradation parameters,including pH and MOF-AEP dosage,were ***,radical quenching experiments and electron paramagnetic resonance(EPR)measurements revealed that ^(1)O_(2)might be the primary catalytic species,whereas·O~(2-)might be the secondary one in degrading MB.

关键词： advanced oxidation process alcohol solvent evaporation hydrogen bond S and Co co-doped carbon catalysts wastewater remediation

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酶法提取玉米胚芽蛋白的工艺优化

食品科技 2011年第7期36卷 157-160页

作者：皮钰珍刘彦妮岳喜庆尹伊沈阳农业大学食品学院沈阳110866

玉米胚芽蛋白是一种优质植物蛋白,其必需氨基酸种类齐全,营养价值高,同时具有多种生理功能,在食品加工中可作为一种理想的植物蛋白质添加物,研究了使用酶法提取玉米胚芽蛋白的工艺参数,通过单因素实验和响应曲面法确定了提取玉米胚芽蛋... 详细信息

玉米胚芽蛋白是一种优质植物蛋白,其必需氨基酸种类齐全,营养价值高,同时具有多种生理功能,在食品加工中可作为一种理想的植物蛋白质添加物,研究了使用酶法提取玉米胚芽蛋白的工艺参数,通过单因素实验和响应曲面法确定了提取玉米胚芽蛋白的最佳工艺条件:料液比1:6.8g/mL,加酶量3000u/g料,酶解温度60℃,酶解时间180min,pH7.0,此条件玉米胚芽蛋白的提取率可达到31.06%。

关键词：玉米胚芽蛋白酶法提取响应面分析法

Actively tunable electromagnetically induced transparency in hybrid Dirac-VO2 metamaterials

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Optoelectronics Letters 2025年第1期21卷 13-20页

作者： DI Ke XIE Meng XIA Huarong CHENG Anyu liu yu DU Jiajia Department of Optoelectronic Engineering Chongqing University of Post and Telecommunications Chongqing Key Laboratory of Autonomous Navigation and Microsystem Chongqing University of Posts and Telecommunications Department of Automation Chongqing University of Post and Telecommunications

In this paper, we present a metamaterial structure of Dirac and vanadium dioxide（VO2） and investigate its optical properties using the finite-difference time-domain（FDTD） technique. Using the phase transition feature of VO2, the design can realize active tuning of the plasmon induced transparency（PIT） effect at terahertz frequency, thereby converting from a single PIT to a double-PIT. When VO2is in the insulating state, the structure is symmetric to obtain a single-band PIT effect. When VO2is in the metallic state, the structure turns asymmetric to realize a dual-band PIT effect. This design provides a reference direction for the design of actively tunable metamaterials. Additionally, it is discovered that the transparent window's resonant frequency and the Fermi level in this structure have a somewhat linear relationship. In addition, the structure achieves superior refractive index sensitivity in the terahertz band, surpassing 1 THz/RIU. Consequently, the design exhibits encouraging potential for application in refractive index sensors and optical switches.

关键词： Transparency

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春季解冻期降雨对黑土坡面侵蚀影响研究

水土保持学报 2009年第4期23卷 64-67页

作者：刘佳范昊明周丽丽武敏柴宇刘艳华沈阳农业大学水利学院沈阳110161

为开展我国东北地区关于冻融作用对春季降雨与未完全解冻土壤侵蚀关系的定量研究,对东北黑土室外冻结,室内表层融化下部冻结,在此冻融条件下对其进行室内模拟降雨试验,研究了春季解冻期黑土在不同含水率、不同解冻深度及降雨量条件下的... 详细信息

为开展我国东北地区关于冻融作用对春季降雨与未完全解冻土壤侵蚀关系的定量研究,对东北黑土室外冻结,室内表层融化下部冻结,在此冻融条件下对其进行室内模拟降雨试验,研究了春季解冻期黑土在不同含水率、不同解冻深度及降雨量条件下的侵蚀特征。结果表明:在春季解冻期,由于冻融作用,黑土坡面土壤解冻不完全、渗透能力差,此时降雨的侵蚀能力较强,导致这一时期坡面土壤侵蚀严重,土壤坡面侵蚀量受到含水率、降雨强度和解冻深度等因子的综合影响,并随三者变化呈现不同的侵蚀规律。

关键词：冻融侵蚀人工降雨雨强解冻深度春季解冻期

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甲肝病毒及其疫苗研究现状

中国生物制品学杂志 2018年第3期31卷 315-318页

作者：王艺博孙小雨徐艳玲刘令九长春生物制品研究所有限责任公司吉林长春130012

甲型病毒性肝炎(hepatitis A,简称甲肝)是由甲型肝炎病毒(hepatitis A virus,HAV)引起的以肝脏损伤为主的急性肠道传染性疾病。对于HAV的研究很早就已展开,但其大部分致病机理并未确认。本文阐述了近期研究发现的有关HAV的结构、病毒感... 详细信息

甲型病毒性肝炎(hepatitis A,简称甲肝)是由甲型肝炎病毒(hepatitis A virus,HAV)引起的以肝脏损伤为主的急性肠道传染性疾病。对于HAV的研究很早就已展开,但其大部分致病机理并未确认。本文阐述了近期研究发现的有关HAV的结构、病毒感染与免疫及其逃逸机制,并对甲肝疫苗及治疗药物的发展现状进行概述。

关键词：甲型肝炎病毒甲肝疫苗病毒逃逸

替米沙坦对4%高盐饮食诱导肾脏纤维化的保护作用

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中国老年学杂志 2018年第6期38卷 1430-1433页

作者：赵宇刘燕商黔惠王晓春刘婵刘娟遵义医学院附属医院内分泌科北京市垂杨柳医院遵义医学院附属医院心内科遵义医学院附属医院临床医学研究所心血管病研究所高血压研究室贵州遵义563003

目的探讨替米沙坦对4%高盐饮食诱导肾脏纤维化的保护作用。方法雄性Wistar大鼠36只,随机分为普食组(0.5%正常盐);高盐组(4%高盐);高盐+替米沙坦组(4%高盐+替米沙坦40 mg·kg ^(-1)·d ^(-1)),每组12只。每4 w用鼠尾无创测压仪测量鼠尾... 详细信息

目的探讨替米沙坦对4%高盐饮食诱导肾脏纤维化的保护作用。方法雄性Wistar大鼠36只,随机分为普食组(0.5%正常盐);高盐组(4%高盐);高盐+替米沙坦组(4%高盐+替米沙坦40 mg·kg ^(-1)·d ^(-1)),每组12只。每4 w用鼠尾无创测压仪测量鼠尾动脉压;24 w末用代谢笼收集尿液,测定24 h尿微量白蛋白(MAU)、血尿肌酐(Cr)含量,苏木素-伊红(HE)染色观察肾皮质形态,Masson染色观察肾小球纤维化;Western印迹法检测皮质区α-平滑肌肌动蛋白(SMA)、转化生长因子(TGF)-β1、磷酸化Smad2/3(p-Smad2/3)、Smad7蛋白的表达。结果与普食组相比,高盐组及高盐+替米沙坦组大鼠尾动脉收缩压显著升高(P<0.05),双肾重/体重、24 h尿MAU显著增高(均P<0.05),内生肌酐清除率(Ccr)显著降低(P<0.05);肾小球的纤维化指数明显增高(P<0.05);肾脏皮质区的TGF-β1、p-Smad2/3、Smad7蛋白表达显著增高(P<0.05)。与高盐组比较,高盐+替米沙坦组大鼠尾动脉收缩压明显降低(P<0.05),24 h尿MAU显著下降(P<0.05),肾小球的纤维化指数明显降低(P<0.05),上述各蛋白表达也显著降低(均P<0.05)。结论长期4%高盐摄入可诱导Wistar大鼠TGF-β1/Smads信号通路表达增高导致肾脏纤维化;替米沙坦可能通过抑制TGF-β1/Smads信号通路减轻肾脏损伤。

关键词：高盐 TGF-β1/Smads 肾脏纤维化替米沙坦

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一种感应电动机速度检测方法

微电机 2000年第1期33卷 37-38,48页

作者：谷爱昱刘彦彬广东工业大学广东广州510090 哈尔滨工业大学黑龙江哈尔滨150001

针对生产现场的要求 ,提出一种速度检测方法。设计了永磁脉冲转速传感器 ,并利用 80 98单片机的高速输入 HSI1 ,通过变 M-

关键词：感应电动机速度检测电机

Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-yu Zhao Juan-Han yu Yi-Hua Wang Yi-Xin liu Lu Xu Lin Fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report