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Identification,expression,and artificial selection of silkworm epigenetic modification enzymes

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Identification,expression,and artificial selection of silkwo...

白大衣性和隐蔽性高血压的诊断率:用一日或三日诊室血压诊断的差异

中国蚕学会2021年学术年会

作者： Rui Gao Chun-Lin Li Xiao-Ling Tong Min-Jin Han Kun-Peng Lu Shu-Bo Liang Hai Hu yue Luan Bi-Li Zhang yan-yu liu Fang-Yin Dai State Key Laboratory of Silkworm Genome Biology Key Laboratory of Sericultural Biology and Genetic BreedingMinistry of Agriculture and Rural AffairsCollege of BiotechnologySouthwest University

＜正＞Background:Understanding the genetic basis of phenotype variations during domestication and breeding is of great *** and epigenetic modification enzymes（EMEs） may play a role in phenotypic variations;however,no comprehensive study has been performed to *** silkworm（Bombyx mori） may be utilized as a model in determining how EMEs influence domestication traits.

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中华高血压杂志 2020年第4期28卷 325-329页

作者：丁芳俞蔚胡世云宣诚俞柳燕陈奇峰范敏华刘庆敏杨丽徐小玲严静浙江医院浙江省心脑血管病防治研究中心浙江杭州310013 诸暨第二人民医院公共卫生科诸暨市疾病预防控制中心慢病科绍兴市疾控中心杭州市江干区闸弄口社区卫生服务中心杭州市疾病预防控制中心慢病科

目的以家庭血压测量(HBPM)为基准,探讨一日诊室血压和非同日三次诊室血压对社区人群白大衣性高血压(WCH)和隐蔽性高血压(MH)诊断率的影响。方法于2015-2018年在浙江省4个社区纳入既往无高血压病史,首日诊室血压为正常高值或1级高血压水... 详细信息

目的以家庭血压测量(HBPM)为基准,探讨一日诊室血压和非同日三次诊室血压对社区人群白大衣性高血压(WCH)和隐蔽性高血压(MH)诊断率的影响。方法于2015-2018年在浙江省4个社区纳入既往无高血压病史,首日诊室血压为正常高值或1级高血压水平的常住居民,于4周内完成2日诊室血压复查和连续7 dHBPM。诊室一日法的高血压诊断标准为首日诊室收缩压≥140和(或)舒张压≥90 mm Hg;诊室三日法的高血压诊断标准为3日诊室血压均达到收缩压≥140和(或)舒张压≥90 mm Hg。HBPM的高血压诊断标准为后6日平均血压值达到收缩压≥135和(或)舒张压≥85 mm Hg。诊室血压为高血压但HBPM诊断为非高血压者定义为WCH;诊室血压为非高血压但HBPM诊断为高血压者定义为MH。160例调查对象具有完整的血压监测数据。结果依据首日诊室血压、三日诊室血压、家庭血压分别诊断高血压75(46.9%)、23(14.4%)和78例(48.8%)。基于首日诊室血压和家庭血压检出WCH 39例(24.4%),MH 42例(26.3%);基于三日诊室血压和家庭血压检出WCH 11例(6.9%),MH 66例(41.3%),诊室一日法和三日法对于高血压、WCH、MH的诊断率差异有统计学意义(均P<0.05)。诊室血压存在日间差异,首日血压较高,而心率无日间差异。结论以连续7 d家庭血压为基准,在同一人群中,与诊室一日法相比,诊室三日法明显降低WCH的诊断率,而增加MH的诊断率。

关键词：白大衣性高血压隐蔽性高血压家庭血压一日诊室血压三日诊室血压诊断率

Rational modulation of fluorophosphate cathode by anionic groups to reduce the polarization behavior for fast-charging sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 509-521页

作者： Xinyuan Wang Fan Zhang Xingyu Zhou Qian Wang Changyu liu yangyang liu Hui Wang Xiaojie liu Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry & Materials Science Northwest University

Na3V2（PO4）2O2F （VP） is recognized as a promising cathode material for sodium-ion batteries due to its stable structural framework and high specific *** functional theory （DFT） and finite element simulations show that incorporating SO42-into VP decreases its band gap,lowers the migration energy barrier,and ensures a uniform Na+concentration gradient and stress distribution during charge and discharge ***,the average Na+diffusion coefficient of Na3V2（PO4）1.95（SO4）0.05O2F（VPS-1） is roughly double that of VP,leading to enhanced rate capability (80 C,75.5 mAh g-1) and cycling stability (111.0 mAh g-1capacity after 1000 cycles at 10 C current density) for ***-1 exhibits outstanding fast-charging capabilities,achieving an 80%state of charge in just 8.1 *** assembled VPS-1//SbSn/NPC full cell demonstrated stable cycling over 200 cycles at a high 5 C current,maintaining an average coulombic efficiency of 95.35%.

关键词： Anionic group modulation Polarization behavior Fast-charging Sodium-ion battery Fluorophosphate Cathode

Fabrication of carbon-supported Al2O3 nanoparticles via spontaneous cross-linking to enhance selective hydrogenation of furfural

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Journal of Energy Chemistry 2025年第1期100卷 612-620页

作者： Weiwei yu Xinbao Zhang Hongyu Chen yanan Wang Shaoguo Li Fucun Chen Zhenni liu Xiujie Li Xiangxue Zhu State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences

Selective hydrogenation of furfural to furfuryl alcohol is a great challenge in the hydrogenation field due to thermodynamic preference for hydrogenation of C=C over C=***,a novel Al2O3/C-u hybrid catalyst,composed of N-modified dendritic carbon networks supporting Al2O3nanoparticles,was successfully prepared via carbonizing the freeze-dried gel from spontaneous cross-linking of alginate,Al3+and *** obtained carbon-supported Al2O3hybrid catalyst has a high ratio （31%） of Al species in pentahedral-coordinated *** introduction of urea enhances the surface N content,the ratio of pyrrolic N,and specific surface area of catalyst,leading to improved adsorption capacity of C=O and the accessibility of active *** the furfural hydrogenation reaction with isopropyl alcohol as hydrogen donor,Al2O3/C-u catalyst achieved a 90%conversion of furfural with 98.0% selectivity to furfuryl alcohol,outperforming that of commercial γ-***,Al2O3/C-u demonstrates excellent catalytic stability in the recycling tests attributed to the synergistic effect of abundant weak Lewis acid sites and the anchoring effect of the carbon network on *** work provides an innovative and facile strategy for fabrication of carbon-supported Al2O3hybrid catalysts with rich AlVspecies,serving as a high selective hydrogenation catalyst through MPV reaction route.

关键词： Selective hydrogenation Furfural Furfuryl alcohol Cross-linking MPV route

T cell interactions with microglia in immune-inflammatory processes of ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1277-1292页

作者： yuxiao Zheng Zilin Ren Ying liu Juntang yan Congai Chen yanhui He yuyu Shi Fafeng Cheng Qingguo Wang Changxiang Li Xueqian Wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Library Beijing University of Chinese MedicineBeijingChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue *** the first immune cells to be activated after an ischemic stroke,microglia play an important immunomodulatory role in the progression of the *** an ischemic stroke,peripheral blood immune cells(mainly T cells)are recruited to the central nervous system by chemokines secreted by immune cells in the brain,where they interact with central nervous system cells(mainly microglia)to trigger a secondary neuroimmune *** review summarizes the interactions between T cells and microglia in the immune-inflammatory processes of ischemic *** found that,during ischemic stroke,T cells and microglia demonstrate a more pronounced synergistic ***1,Th17,and M1 microglia can co-secrete proinflammatory factors,such as interferon-γ,tumor necrosis factor-α,and interleukin-1β,to promote neuroinflammation and exacerbate brain ***2,Treg,and M2 microglia jointly secrete anti-inflammatory factors,such as interleukin-4,interleukin-10,and transforming growth factor-β,to inhibit the progression of neuroinflammation,as well as growth factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain *** interactions between microglia and T cells influence the direction of the subsequent neuroinflammation,which in turn determines the prognosis of ischemic stroke *** trials have been conducted on the ways to modulate the interactions between T cells and microglia toward anti-inflammatory communication using the immunosuppressant fingolimod or overdosing with Treg cells to promote neural tissue repair and reduce the damage caused by ischemic ***,such studies have been relatively infrequent,and clinical experience is still *** summary,in ischemic stroke,T cell subsets and activated micro

关键词： brain immune inflammation interaction ischemic stroke mechanism microglia neuron secondary injury T cells

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin Zhang Tong Yin yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang yan liu Jie Gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

不同禽源及基因型新城疫病毒对番鸭致病性分析

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中国预防兽医学报 2016年第11期38卷 849-854页

作者：赵晨辰石跃王新蒋艳玉刘培欣孔宪刚刘怀然中国农业科学院哈尔滨兽医研究所禽病毒性呼吸道病创新团队黑龙江哈尔滨150001 东北农业大学动物医学院黑龙江哈尔滨150030

鸭是新城疫病毒(NDV)重要的自然宿主,在NDV的传播和进化中起着重要作用。为研究鸭对不同NDV株易感性及在NDV传播中的作用,本研究选取5株不同禽源及基因型NDV,以不同剂量经滴鼻点眼途径接种15日龄番鸭,鉴定对鸭的致病性、排毒情况、血清... 详细信息

鸭是新城疫病毒(NDV)重要的自然宿主,在NDV的传播和进化中起着重要作用。为研究鸭对不同NDV株易感性及在NDV传播中的作用,本研究选取5株不同禽源及基因型NDV,以不同剂量经滴鼻点眼途径接种15日龄番鸭,鉴定对鸭的致病性、排毒情况、血清抗体变化以及病毒的组织脏器分布;并设立同居鸭、鸡测定NDV水平传播能力。结果显示,疫苗病毒株La Sota和WB383(基因Ⅰ型)株能够在番鸭体内有限复制;La Sota仅诱导产生低水平抗体,而WB383诱导的抗体水平较高,未检测到这2株病毒的水平传播;F48E9对番鸭致病性强,具有较强水平传播能力;同为基因Ⅶ型病毒,鸭源MD株呈现出对番鸭高致病性,野鸭源WB363株则对番鸭致病性较低,但其水平传播能力高于MD株。实验结果显示,5株NDV对番鸭致病性差异较大,La Sota和WB383株对番鸭无致病性,排毒和水平传播能力弱;F48E9对番鸭具有高致病性;同属于基因Ⅶ型的强毒株对番鸭致病性差异较大,这种差异原因尚需进一步研究。本研究结果表明番鸭感染NDV的F48E9、WB363、MD株后水平传播能力较强,应重视其在NDV传播和进化过程中的作用研究。

关键词：新城疫病毒宿主基因型番鸭致病性

原卟啉Ⅸ-声动力学方法对H-22肿瘤细胞损伤机制的研究

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陕西师范大学学报（自然科学版） 2009年第6期37卷 77-81页

作者：王玉仝万艳刘全宏陕西师范大学生命科学学院陕西西安710062

研究了频率为1.43 MHz、强度为1 W/cm2的聚焦超声结合原卟啉Ⅸ对H-22肿瘤细胞的损伤作用,并探讨其生物学机制.应用台盼蓝拒染法检测不同处理后肿瘤细胞的存活率,环境扫描电镜和透射电镜观察细胞表面和内部的超微结构变化,荧光标记技术... 详细信息

研究了频率为1.43 MHz、强度为1 W/cm2的聚焦超声结合原卟啉Ⅸ对H-22肿瘤细胞的损伤作用,并探讨其生物学机制.应用台盼蓝拒染法检测不同处理后肿瘤细胞的存活率,环境扫描电镜和透射电镜观察细胞表面和内部的超微结构变化,荧光标记技术检测肿瘤细胞内活性氧的产生,硫代巴比妥酸(TBA)法检测肿瘤细胞脂质过氧化水平的变化.发现原卟啉Ⅸ-声动力学方法对H-22细胞产生的损伤效应表现为:细胞存活率明显下降,细胞表面和内部的超微结构改变,胞内活性氧和脂质过氧化水平增高.结果表明:原卟啉Ⅸ-声动力学方法能够使肿瘤细胞产生活性氧自由基,造成膜脂质过氧化,直接或间接地破坏细胞的膜系统,从而杀伤肿瘤细胞.

关键词：超声原卟啉Ⅸ H-22肿瘤细胞声动力学疗法

A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan Cheng Jingai Zhang Boxin liu yu Shi Haoxue Wang Lijie Huang Su Zhang Ruixin Zhang Song Wang Guangxu Lu Peifu Tang Zhongyang liu Kai Wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance