检索结果-南通市图书馆

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

引用

Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： yujia liu Xue Han yan Su Yiming Zhou Minhui Xu Jiyan Xu Zhengliang Ma Xiaoping Gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

引用

Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan Sun Shuai Wang yanbo Liang Chao Wang yunhong Zhang Hong liu yu Zhang Lin Han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

引用

Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao yuan Li Xi liu Wenping Liang yu Li Liyong Wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

新型无机高分子复合絮凝剂聚合硅酸铝铁混凝效果研究

引用

山东大学学报（理学版） 2003年第5期38卷 111-115页

作者：王炳建高宝玉岳钦艳刘玉真山东大学环境科学与工程学院山东济南250100

以AlCl3·6H2 O ,FeCl3·6H2 O ,硅酸钠和盐酸为原料 ,以无水碳酸钠为碱化聚合剂 ,制备出了一系列聚合硅酸铝铁 (PAFSC)复合无机高分子絮凝剂 ;通过烧杯实验 ,比较了PAFSC和PAC对各种水样的混凝效果 .结果表明 :PAFSC较PAC具有更好的混... 详细信息

以AlCl3·6H2 O ,FeCl3·6H2 O ,硅酸钠和盐酸为原料 ,以无水碳酸钠为碱化聚合剂 ,制备出了一系列聚合硅酸铝铁 (PAFSC)复合无机高分子絮凝剂 ;通过烧杯实验 ,比较了PAFSC和PAC对各种水样的混凝效果 .结果表明 :PAFSC较PAC具有更好的混凝效果 ;其制备工艺、Al Fe Si摩尔比对PAFSC的混凝效果有一定的影响 ,在Al Fe Si摩尔比一定的情况下 ,共聚法制备的PAFSC(共 )的混凝效果优于复合法制备的PAFSC(复 )的混凝效果 ;在制备工艺一定的情况下 ,随着Al Fe Si摩尔比中Fe和Si摩尔数增加 ,PAFSC絮凝剂的混凝效果变好 .此外 ,pH值对PAFSC的混凝效果也有一定的影响 .

关键词：聚合硅酸铝铁(PAFsC) 絮凝剂制备混凝效果

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

清心饮对柯萨奇B_3病毒感染心脏微血管内皮细胞的保护作用

引用

中国现代应用药学 2017年第1期34卷 20-24页

作者：俞燕刘强杨吕洪浙江中医药大学附属第一医院杭州310006 桐庐县中医院桐庐311500

目的研究清心饮对柯萨奇B_3病毒(Coxsackievirus B_3,CVB_3)感染心脏微血管内皮细胞(cardiac microvascular endothelial cells,CMVECs)的保护作用。方法采用RT-PCR检测CVB_3 RNA,应用倒置显微镜观察CMVECs形态,CCK8检测细胞活性,选择清心饮最佳干预时间点和稀释浓度。在最佳条件下通过免疫荧光法、Western blot法检测内皮细胞标志物CD31,间充质细胞标志物a-SMA的表达。结果 CVB_3能在CMVECs中持续性复制,清心饮最佳干预时间点和浓度分别是72 h和20%含药血清。与空白组比较,CVB_3组CMVECs形态固缩、变异,CD31表达减弱,a-SMA表达增强;与空白血清组比较,清心饮血清组CMVECs形态趋于正常,CD31表达增强,a-SMA表达减弱。结论清心饮可抑制CVB_3感染CMVECs发生内皮细胞转分化,对CMVECs具有保护作用。

关键词：清心饮柯萨奇B3病毒心脏微血管内皮细胞内皮细胞转分化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

裂孔源性视网膜脱离术后黄斑区视网膜下液及其对预后视力影响

引用

国际眼科杂志 2007年第6期7卷 1655-1657页

作者：韩泉洪刘玉燕中国天津医科大学眼科临床学院天津市眼科研究所天津眼科医院网脱科 300020

裂孔源性视网膜脱离复位手术成功后,在通过常规检查不能发现显著病变的情况下,部分患者的视力恢复不佳。通过光学断层扫描技术(OCT)的应用,可以发现检眼镜和荧光造影不能发现的黄斑区视网膜下液的存在。本文对视网膜脱离术后黄斑区结构... 详细信息

裂孔源性视网膜脱离复位手术成功后,在通过常规检查不能发现显著病变的情况下,部分患者的视力恢复不佳。通过光学断层扫描技术(OCT)的应用,可以发现检眼镜和荧光造影不能发现的黄斑区视网膜下液的存在。本文对视网膜脱离术后黄斑区结构变化与视力预后的结果进行文献回顾,并对这一现象可能发生的原因和对视力的影响进行讨论。

关键词：裂孔源性视网膜脱离视网膜下积液视力

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

分子印迹固相萃取/高效液相色谱法分离和富集枳实中4种黄烷酮

引用

分析测试学报 2017年第3期36卷 325-330页

作者：贺美艳叶玉凤刘炎李珍柱焦必宁曾绍梅苏学素西南大学化学化工学院重庆400715 中国农业科学院柑桔研究所重庆400712

采用沉淀聚合法以橙皮素为模板分子,2-乙烯基吡啶为功能单体,二甲基丙烯酸乙二醇酯为交联剂,合成了橙皮素分子印迹聚合物。利用紫外光谱法确定了最佳功能单体与配比,优化了合成条件。采用傅立叶变换红外光谱、扫描电子显微镜、静态吸附... 详细信息

采用沉淀聚合法以橙皮素为模板分子,2-乙烯基吡啶为功能单体,二甲基丙烯酸乙二醇酯为交联剂,合成了橙皮素分子印迹聚合物。利用紫外光谱法确定了最佳功能单体与配比,优化了合成条件。采用傅立叶变换红外光谱、扫描电子显微镜、静态吸附对聚合物进行表征。实验结果表明,分子印迹聚合物的吸附性能明显优于空白印迹聚合物,且此聚合物对柚皮苷、橙皮苷、柚皮素和橙皮素的相对选择系数分别为1.40,1.39,1.59和2.89,表明该分子印迹聚合物对4种黄烷酮有较好的选择性。将印迹聚合物作为固相萃取填料,对枳实提取液进行分离和富集,结果表明上述4种黄烷酮的提取率分别为72.6%,61.1%,95.4%和93.5%,分离富集效果良好,大大提高了枳实中4种黄烷酮的提取效率。

关键词：分子印迹聚合物(MIP) 高效液相色谱黄烷酮橙皮素枳实

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Laser direct writing of flexible multifunctional airflow sensors on the Kevlar fabric

引用

Nano Research 2025年第1期18卷 443-454页

作者： Wei Wang Zi-Qing Chen Yong-Qi Li yu-Long Wang Mei-Chen liu yun-Bo Ruan yang Zhang Shu-Juan liu Qiang Zhao College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China State Key Laboratory of Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and TelecommunicationsNanjing 210023China Zhe Jiang Topsun Logistic Control CO. LTD.Yuhuan 317600China Department of Rehabilitation Medicine School of Acupuncture-Moxibustion and Tuina and School of Health Preservation and RehabilitationNanjing University of Chinese MedicineNanjing 210023China

The growing interest in flexible devices has emerged as a global trend due to their advantages in flexibility,lightweight structure,and wearability,addressing the limitations of traditional *** wearable airflow sensors have been previously reported,the development of flexible fabric-based airflow sensors capable of functioning in environments with open flames—critical for fire rescue operations—has yet to be explored,largely due to the poor fire resistance of conventional *** this work,we first present a flexible,wearable,and multifunctional airflow sensor with excellent fire-resistant properties,fabricated through a simple direct laser writing *** sensor maintains airflow detection capabilities even in the presence of open ***,the fabrication of fabric-based sensors involves complex procedures such as carbon materials doping or vapor-phase deposition,leading to lengthy preparation cycles and high ***,fabric-based devices are inherently prone to *** address these challenges,we introduce twice-vertical laser-induced graphene(TVLIG)as a sensitive and reliable component for fire-resistant airflow *** resulting TVLIG/Kevlar fabric can be integrated into various garments,particularly protective suits,to form sensitive and fire-resistant airflow sensors capable of detecting airflow velocity and direction in both two-dimensional(2D)and three-dimensional(3D)spaces during fire ***,the TVLIG patterns can be expanded to multifunctional platforms,such as glucose detection for injured individuals,offering further applications in rescue *** functional expansion reduces the burden on rescue personnel and streamlines device *** its outstanding sensing capabilities,fire resistance,and expandability,the developed flexible airflow sensor shows great potential for various real-world rescue scenarios,promising advancements in wearable sensing technology for rescue enginee

关键词： flexible airflow sensor direct laser writing twice-vertical laser-induced graphene fire accident rescue Kevlar fabric

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

螺旋CT双期扫描对小肝癌的诊断价值

引用

实用放射学杂志 2001年第6期17卷 440-442页

作者：李玉梅罗祖炎吴颖卢建芳毕玉艳刘子江浙江省人民医院放射科!浙江杭州310014

目的　评价螺旋CT扫描的动脉期、静脉期以及双期联合应用对小肝癌的诊断价值。方法　对 2 7例小肝癌行螺旋CT双期增强扫描 ,增强动脉期于造影剂注射后 2 5～ 30s开始扫描 ,静脉期于 6 5～ 70s开始扫描 ,造影剂注射速率为 2 .5～ 3.0ml/s... 详细信息

目的　评价螺旋CT扫描的动脉期、静脉期以及双期联合应用对小肝癌的诊断价值。方法　对 2 7例小肝癌行螺旋CT双期增强扫描 ,增强动脉期于造影剂注射后 2 5～ 30s开始扫描 ,静脉期于 6 5～ 70s开始扫描 ,造影剂注射速率为 2 .5～ 3.0ml/s,用量 70～ 85ml。结果　 2 7例小肝癌共发现 34个结节病灶。平扫、动脉期、静脉期、动静脉双期的检出率分别为 70 %、91%、79%、94% ,经统计学分析 ,动脉期和动静脉双期的检出率较平扫和静脉期高 (Ρ 0 .0 5 )。 6 5 % (2 2 / 34 )的小肝癌动脉期呈均匀高密度 ,与同期肝组织比较 ,CT值平均增加 2 5 .9± 14.4HU ;2 3%(8/ 34 )呈不均匀高密度。 79%静脉期呈低密度 ,与同期肝组织比较 ,CT值平均减少 18.7± 8.9HU ;2 1% (7/ 34 )为等密度。双期扫描的定性准确率为 97% (31/ 32 )。结论　螺旋CT动、静脉双期扫描对小肝癌诊断有很高的敏感性和特异性。

关键词：肝脏肝癌体层摄影,X线计算机

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

引用

Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige Jiang Dexiang liu Tingting Li Chengcheng Gai Danqing Xin Yijing Zhao yan Song Yahong Cheng Tong Li Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：