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Surgery at early versus late for intermittent exotropia:a Meta-analysis and systematic review

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International Journal of Ophthalmology(English edition) 2021年第4期14卷 582-588页

作者： Yi Dong Li Nan yu—yan liu Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual ScienceTianjin Eye InstituteClinical College of Ophthalmology Tianjin Medical UniversityTianjin 300020China

AIM:To compare the outcomes between early surgery and late surgery for intermittent exotropia(IXT)with a ***:Scientific databases including PubMed,Embase,Web of Science,Cochrane and China National Knowledge Infrastructure were searched prior to December 16,*** this broad database search,we performed some Meta-analysis including eleven independent studies,to further evaluate the outcome(s)when comparing early versus late surgery for *** boundaries between early and late surgery and the surgery methods were not inconsistent,so subgroup analyses were conducted by different boundaries of age at surgery and different surgical *** pooled odds ratios(ORs)and the 95%confidence interval(CI)were estimated according to the random-effects model for high heterogeneity between ***:Eleven retrospective studies were included in this *** significant difference between early and late surgery was observed for IXT patients(OR_(First follow-up)=0.88,95%CI 0.53-1.44,P=0.61;OR_(Final follow-up)=1.48,95%CI 0.94-2.31,P=0.09).However,sensitivity analysis performed by sequentially omitting individual studies showed that the final follow-up result was not *** analyses revealed that an earlier surgical procedure could lead to a better outcome in the 4-year boundary subgroup as well as the bilateral lateral rectus recession(BLR)subgroup for the final follow-up(OR_(4y)=2.64,95%CI 1.57-4.44,P=0.00;OR_(BLR)=2.25,95%CI 1.36-3.74,P=0.00).CONCLUSION:Early surgery for IXT provides a better long term follow-up outcome when patients are younger than 4 years old or choose the BLR surgical method.

关键词： Meta-analysis intermittent exotropia surgery timing

Sensitivity analysis of spacecraft in micrometeoroids and orbital debris environment based on panel method

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Defence Technology（防务技术） 2023年第1期19卷 126-142页

作者： Di-qi Hu Run-qiang Chi yu-yan liu Bao-jun Pang Hypervelocity Impact Research Center Harbin Institute of Technology150080HarbinChina

To reduce the risk of mission failure caused by the MM/OD impact of the spacecraft,it is necessary to optimize the design of the *** survivability assessment is the key technology in the optimal design of *** survivability assessment includes spacecraft impact sensitivity analysis and spacecraft component vulnerability analysis under MM/OD *** impact sensitivity refers to the probability of a spacecraft encountering an MM/OD impact while in *** refers to the probability that each component of a spacecraft may fail or malfunction when impacted by space *** this paper mainly analyzes the impact sensitivity and proposes a spacecraft sensitivity assessment method under the MM/OD environment based on a panel *** this panel method,a spacecraft geometric model is discretized into small panels,and whether they are impacted by MM/OD or not is determined through the analysis of the shielding or shadowing relationships between *** number of impacts on each panel is obtained through calculation,and accordingly the probability of each spacecraft component encountering MM/OD impact can be acquired,thus generating the impact *** paper extracts data from the NASA’s ORDEM2000,the ESA’s MASTER8 as well as the SDEEM2015(Space Debris Environmental Engineering Model developed by HIT),and uses the PCHIP(Piecewise Cubic Hermite Interpolating Polynomial)method to interpolate and fit the size-flux relationship of space *** with linear interpolation and cubic spline interpolation,the fitting results through the method are relatively more *** feasibility of this method is also demonstrated through two actual examples shown in this paper,whose results are close to those from ESABASE,although there are some minor errors mainly due to different debris data *** the cross-check by three risk assessment software-BUMPER,MDPANTO and MODAOST-under standard operating condit

关键词： Shielding algorithm Panel method Spacecraft Sensitivity

Effects of logjams on river hydrodynamics under inundation conditions

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Journal of Hydrodynamics 2024年第4期36卷 757-771页

作者： Huai-jian Bao Ping Wang Wei-jie Wang yu-yan liu Tian-jiao Feng School of Soil and Water Conservation Beijing Forestry UniversityBeijing100091China State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin China Institute of Water Resources and Hydropower ResearchBeijing100048China

Large wood in rivers can lead to accumulations in the river channel, affecting local flow structures, aquatic habitats, and the river’s topography. This plays a crucial role in the ecological restoration of the river. This paper presents flow field measurements downstream of six types of logjams at different flow velocities using acoustic Doppler velocimetry (ADV) for artificially designed engineered logjams. The results indicate that the presence of logjams reduces the flow velocity and increases the turbulent kinetic energy in the wake region, and as the distance downstream increases, the flow velocity and turbulence intensity in the wake region gradually return to the upstream level. The minimum values of normalized flow velocity under different conditions are located in the region of the bottommost logs. The differences in normalized flow velocity at various flow rates are not significant. Jets are less likely to be generated in logjams with larger and more concentrated projection areas, but the strength of the jet is influenced by the physical structure of the logjam (projection area, gap ratio). The flow distribution behind the logjam is primarily influenced by the proportion of the projected area in different regions. Changes in the vertical physical structure of the logjam have minimal effect on the lateral flow distribution. Flow velocity in the gap area (b0) at the bottom of different logjams is influenced by their physical structure. The larger the overall blockage area of the logjams, the larger the flow velocity in the bottom gap area will be. The flow velocity in the bottom gap area of a densely placed logjam is mainly influenced by the gap ratio. The velocity of flow in the gap area can impact the initiation and deposition of sediment near the logjam. However, the internal structure complexity of the logjam does not significantly affect river energy dissipation and flow attenuation. This study broadens the applicability of certain theoretical models a

关键词： Open channel flow engineered logjams nonuniform logs flow structure river ecological restoration

Investigation of sex determination in starry flounder(Platichthys stellatus)reveals sex chromosome evolution in Pleuronectiformes and identifies a sex-specific marker

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Zoological Research 2024年第6期45卷 1347-1356页

作者： Wei-Jing Li yu-Man Zhang Shuo Li yu-yan liu Chen Li Sheng-Lei Han Kai-Qiang liu Lucas Benites Doretto Bing-Hua liu Hai-Jun Huang Zhi-Long Sun Qian Wang Hong-yan Wang Chang-Wei Shao State Key Laboratory of Mariculture Biobreeding and Sustainable Goods Yellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesQingdaoShandong 266071China School of Graduate Chinese Academy of Agricultural SciencesBeijing 100081China Laboratory for Marine Fisheries Science and Food Production Processes Qingdao Marine Science and Technology CenterQingdaoShandong 266237China

The identification of sex chromosomes is fundamental for exploring the mechanism and evolution of sex *** stellatus,a species exhibiting clear sexual dimorphism and homomorphic chromosome pairs,has received limited research concerning its sex determination *** the sex chromosome of *** will enhance our understanding of sex chromosome evolution in *** study employed whole-genome resequencing to investigate the sex chromosome and sex determination system in ***,Chr23 was identified as the sex chromosome in ***,with the sex-determining region(SDR)occupying 48.1%of the chromosome and featuring an XX/XY *** chromosome turnover was observed within Pleuronectiformes,with ***,Verasper variegatus,and Hippoglossus hippoglossus sharing a common ancestral *** inversions were detected within the SDR of ***,although chromosomal rearrangements between sex chromosomes and autosomes were ***,a sex-specific marker for *** was ascertained,enabling genetic sex identification,with significant implications for improving breeding programs and aquaculture practices.

关键词： Sex chromosome Platichthys stellatus Sex determination system Ancestral karyotype of Pleuronectiformes Sex-specific marker

Rescue and Preliminary Application of a Recombinant Newcastle Disease Virus Expressing Green Fluorescent Protein Gene

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中国病毒学 2007年第1期22卷 34-40页

作者： Shun-lin HU Qin SUN Qu-zhi WANG yu-liang liu yan-tao WU Xiu-fan liu Key Laboratory for Animal Infectious Diseases of Ministry of Agriculture Yangzhou University Yang zhou 225009 China

把 ZJI 紧张基于纽卡斯尔疾病病毒(NDV ) 的完全的染色体顺序，七份教材被设计为构造 plasmid pNDV/ZJI 放大 cDNA 碎片，它包含了 NDV ZJI 紧张的全身的 cDNA。与三助手 plasmids， pCIneoNP， pCIneoP 和 pCIneoL， pNDV/ZJI 当时是... 详细信息

把 ZJI 紧张基于纽卡斯尔疾病病毒(NDV ) 的完全的染色体顺序，七份教材被设计为构造 plasmid pNDV/ZJI 放大 cDNA 碎片，它包含了 NDV ZJI 紧张的全身的 cDNA。与三助手 plasmids， pCIneoNP， pCIneoP 和 pCIneoL， pNDV/ZJI 当时是进表示 T7 RNA 聚合酶的 BSR-T7/5 房间的 cotransfected。在进受胎的鸡肉的 transfected 房间文化上层清液的接种以后，从 specific-pathogen-free (SPF ) 的鸡蛋结队，传染 NDV ZJI 紧张成功地被救。格林荧光灯蛋白质(GFP ) 基因被放大并且插入了到 NDV 全身的 cDNA 产生标注 GFP 的 recombinant plasmid pNDV/ZJIGFP。在进 BSR-T7/5 房间的结果的 plasmid 和三支持 plasmids 的 cotransfection 以后， recombinant NDV， NDV/ZJIGFP，被救。特定的绿荧光在 BSR-T7/5 和鸡胚胎成纤维细胞(CEF ) 房间 48h 被观察感染以后，显示 GFP 基因被表示在一相对高级。NDV/ZJIGFP 被 oculonasal 线路接种进 10-day-old SPF 鸡。四天感染以后的、强壮的绿荧光能在肾和 tracheae 被检测，显示标注 GFP 的 NDV 能是的 recombinant 为 NDV 传播和致病的分析的一个很有用的工具。关键词纽卡斯尔疾病病毒(NDV )- 格林荧光灯蛋白质(GFP )- 营救 - 表示 CLC 数字 S831.7 基础条款：给中国(No.30630048 )

关键词： Newcastle disease virus (NDV) Green fluorescent protein (GFP) Rescue Expression

A New Catalogue of Fine Structures Superimposed on Solar Microwave Bursts

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Chinese Journal of Astronomy and Astrophysics 2004年第2期4卷 176-188页

作者： Qi-Jun Fu, Yi-Hua yan, yu-Ying liu, Min Wang and Shu-Juan WangNational Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012 fuqijun2002@*** National Astronomical Observatories Chinese Academy of Sciences Beijing 100012

The 2.6-3.8 GHz, 4.5-7.5 GHz, 5.2-7.6 GHz and 0.7-1.5 GHz componentspectrometers of Solar Broadband Radio Spectrometer (SBRS) started routine observations,respectively, in late August 1996, August 1999, August 1999, and June 2000. They just managed tocatch the coming 23rd solar active maximum. Consequently, a large amount of microwave burst datawith high temporal and high spectral resolution and high sensitivity were obtained. A variety offine structures (FS) superimposed on microwave bursts have been found. Some of them are known, suchas microwave type Ⅲ bursts, microwave spike emission, but these were observed with more detail;some are new. Reported for the first time here are microwave type U bursts with similar spectralmorphology to those in decimetric and metric wavelengths, and with outstanding characteristics suchas very short durations (tens to hundreds ms), narrow bandwidths, higher frequency drift rates andhigher degrees of polarization. Type N and type M bursts were also observed. Detailed zebra patternand fiber bursts at the high frequency were found. Drifting pulsation structure (DPS) phenomenaclosely associated with CME are considered to manifest the initial phase of the CME, andquasi-periodic pulsation with periods of tens ms have been recorded. Microwave 'patches', unlikethose reported previously, were observed with very short durations (about 300 ms), very high fluxdensities (up to 1000 sfu), very high polarization (about 100% RCP), extremely narrow bandwidths(about 5%), and very high spectral indexes. These cannot be interpreted with the gyrosynchrotronprocess. A superfine structure in the form of microwave FS (ZPS, type U), consisting of microwavemillisecond spike emission (MMS), was also found.

关键词： sun: flares sun: radio radiation instrumentation: spectro-graphs

Mesenchymal stem cell-derived exosomes regulate microglia phenotypes:a promising treatment for acute central nervous system injury

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Neural Regeneration Research 2023年第8期18卷 1657-1665页

作者： yu-yan liu yun Li Lu Wang yan Zhao Rui yuan Meng-Meng yang Ying Chen Hao Zhang Fei-Hu Zhou Zhi-Rong Qian Hong-Jun Kang Medical School of Chinese PLA BeijingChina Department of Critical Care Medicine the First Medical CenterChinese PLA General HospitalBeijingChina Beidou Precision Medicine Insititute GuangzhouGuangdong ProvinceChina

There is growing evidence that long-term central nervous system(CNS)inflammation exacerbates secondary deterioration of brain structures and functions and is one of the major determinants of disease outcome and *** acute CNS injury,brain microglia are among the first cells to respond and play a critical role in neural repair and ***,microglial activation can also impede CNS repair and amplify tissue damage,and phenotypic transformation may be responsible for this dual *** stem cell(MSC)-derived exosomes(Exos)are promising therapeutic agents for the treatment of acute CNS injuries due to their immunomodulatory and regenerative ***-Exos are nanoscale membrane vesicles that are actively released by cells and are used clinically as circulating biomarkers for disease diagnosis and ***-Exos can be neuroprotective in several acute CNS models,including for stroke and traumatic brain injury,showing great clinical *** review summarized the classification of acute CNS injury disorders and discussed the prominent role of microglial activation in acute CNS inflammation and the specific role of MSC-Exos in regulating pro-inflammatory microglia in neuroinflammatory repair following acute CNS ***,this review explored the potential mechanisms and factors associated with MSCExos in modulating the phenotypic balance of microglia,focusing on the interplay between CNS inflammation,the brain,and injury aspects,with an emphasis on potential strategies and therapeutic interventions for improving functional recovery from early CNS inflammation caused by acute CNS injury.

关键词： acute CNS injury central nervous system inflammation exosome immune regulation mesenchymal stem cell mesenchymal stem cell-derived exosomes(MSC-Exos) microglia activation microglia phenotypic transformation molecular mechanism neuroinflammation

Shock Waves Increase T-cell Proliferation or IL-2 Expression by Activating p38 MAP Kinase

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Acta Biochimica et Biophysica Sinica 2004年第11期36卷 741-748页

作者： Tie-Cheng yu, Yi liu, yan TAN, yanfang JIANG, Xueqing ZHENG, and Xinxiang XUDepartment of Orthopedics, Central Laboratory, and Lithotriptic Center, the First Teaching Hospital of Jilin University, Changchun 130021, China Department of Orthopedics Central Laboratory the First Teaching Hospital of Jilin UniversityChangchun 130021 China Department of Orthopedics Lithotriptic Center the First Teaching Hospital of Jilin UniversityChangchun 130021 China

Shock waves were elicited by transient pressure disturbances, which could be used to treat musculoskeletal disorders. In present studies, we investigated whether the low-density shock waves (LDSWs), which are able to ... 详细信息

关键词： shock waves p38 MAP kinase IL-2 T-cell proliferation

Computer Assisted Assignments of Rotationally Resolved Molecular Spectra

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Chinese Journal of Chemical Physics 2006年第1期19卷 39-42页

作者： Ling Wu Li-juan Zheng Xiao-hua yang yu-yan liu yang-qin Chena Key Laboratory of Optical and MaEnetic Resonance Spectroscopy Ministry of Education and De-partment of Physics East China Normal University ShanEhai 200062 China School of Science Hangzhou Dianzi University Hangzhou 310018 China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and Mathematics Chinese Academy of Science Wuhan 430071 China

A graphically oriented interactive program for assignments of rotationally resolved molecular spectra has been devised. The program functions by grouping spectral lines in term of the second difference principle. and graphing spectral intensity versus frequency in a bar graph of the selected groups, distinguished by color and/or line-type. This allows for easy detection of regular patterns buried in the observed spectrum. Furthermore, it includes a Loomis-Wood view for assisting in spectral assignments. As an example, the program was applied in assigning the molecular spectrum of the production in the discharge of PCl3 buffered by helium gas, which may belong to several species. The results suggest that the program is highly efficient and quite useful in the assignment and the analysis of molecular spectra, especially those of symmetric top, slightly asymmetric top and linear molecules. The accuracy and efficiency of this program will likely ensure its wide application in the processing of molecular spectra.

关键词： Assignment Rotationally resolved Molecular spectra Computer assisted