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Apoptotic B16-F1 Cells Coated with Recombinant Calreticulin Mediated Anti-tumor Immune Response in Mice

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Chinese Journal of Cancer Research 2010年第4期22卷 253-259页

作者： Chun-yu Cao yu Han yu-shan ren yan-lin Wang Three Gorges University Medical College Three Gorges University Institute of Molecular Biology Yichang 443002 China

Objective： To investigate the recombinant calreticulin （rCRT） mediated antitumor immune response. Methods： Cell proliferation was determined by MTT method, apoptosis was evaluated by DNA fragmentation and CRT expression and cell localization were assayed by western blotting, QT-RT-PCR and immunofluorescence assays. The mouse melanoma cell line B16-F1 was treated with polyamine analogue BENS to induce apoptosis and incubated with rCRT to get rCRT coated on the membrane, and then the cells were used to immune BALB/c mice as a cell-antigen. Immunized animals were rechallenged by live B16-F1 cells and then tumor generation ratio and the lactate dehydrogenase release assay were used to evaluate antitumor effects of rCRT-mediated immunity. Results： BENS induced apoptosis of B16-F1 cells without the redistribution of CRT within the cells. When B16-F1 cells coated with rCRT were used as cell-antigen to inoculate the animals, the mice obtained the ability in inhibiting proliferation of homologous tumor cells in vivo. Comparing with the positive control group, the splenocytes from those inoculated mice have an obvious enhancement on their cytolytic effects specifically against B16-F1 cells. Conclusion： rCRT coated on the cell surface can enhance immunogenicity of apoptotic tumor cells and mediated effective anti-tumor immunoresponse in mice.

关键词： Calreticulin Tumor immunity Melanoma Mouse

Effect of Ti on microstructure and properties of electromagnetic stirred Al-18wt.%Mg_(2)Si alloy

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China Foundry 2023年第1期20卷 78-82页

作者： yu-yan ren Sheng-yuan Chen Tong-yu Liu Song Zhang Ying-min Li Faculty of Electromechanical Information Weifang University of Science and TechnologyShouguang 262700ShandongChina Weifang Key Laboratory of High-temperature Materials and Single Crystal Components Fabrication Technology for Advanced Engine System Weifang 262700ShandongChina School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China

By adding different amounts of Ti into the electromagnetic stirred Al-18wt.%Mg_(2)Si alloy,the effect of Ti element on the microstructure and mechanical properties of the alloy was *** experimental results show that the microstructure is refined after modification with Ti,which is related to the heterogeneous nucleation of TiAl_(3) particles on theα-Al *** the increase of Ti content and holding time after stirring,the primary Mg_(2)Si phase is refined firstly and then coarsened,and correspondingly,the mechanical properties of the alloy show a trend of increasing at first and then *** the addition of Ti is 0.5wt.%and the holding time is about 20 min,the refinement effect of primary Mg_(2)Si phase is the most significant and the mechanical properties of the alloy are optimal.

关键词： Al-18wt.%Mg_(2)Si alloy Ti modification electromagnetic stirring mechanical property

Online upgrading of organic vapors from the fast pyrolysis of biomass

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燃料化学学报 2008年第6期36卷 666-671页

作者： LI Hong-yu yan Yong-jie ren Zheng-wei Research Center for Biomass Energy State Key Laboratory of Bioreactor Engineering East China University of Scince and Technology Shanghai 200237

The online upgrading process that combined the fast pyrolysis of biomass and catalytic cracking of bio-oil was developed to produce a high quality liquid product from the *** installation consisted of a fluidized bed reactor for pyrolysis and a packed bed reactor for *** proper pyrolysis processing conditions with a temperature of 500℃ and a flow rate of 4m3·h-1 were determined in *** such conditions,the effects of temperature and weight hourly space velocity(WHSV) on both the liquid yields and the oil qualities of the online catalytic cracking process were *** results showed that such a combined process had the superiority of increasing the liquid yield and improving the product quality over the separate ***,when the temperature was 500℃,with a WHSV of 3h-1,the liquid yield reached the maximum and the oxygenic compounds also decreased obviously.

关键词：有机水蒸气高温分解反应生物量化学分析

Pion transverse-momentum spectrum, elliptic flow, and Hanbury-Brown-Twiss interferometry in a viscous granular source model

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Chinese Physics C 2017年第8期41卷 78-92页

作者： Jing yang Wei-Ning Zhang yan-yu ren School of Physics and Optoelectronic Technology Dalian University of Technology Dalian Liaoning 116024 China Department of Physics Harbin Institute of Technology Harbin Heilongjiang 150006 China

We examine the evolution of quark-gluon plasma（QGP） droplets with viscous hydrodynamics and analyze the pion transverse-momentum spectrum, elliptic flow, and Hanbury-Brown-Twiss（HBT） interferometry in a granular source model consisting of viscous QGP droplets. The shear viscosity of the QGP droplet speeds up and slows down the droplet evolution in the central and peripheral regions of the droplet, respectively. The effect of the bulk viscosity on the evolution is negligible. Although there are viscous effects on the droplet evolution, the pion momentum spectrum and elliptic flow change little for granular sources with and without viscosity. On the other hand,the influence of viscosity on HBT radius Rout is considerable. It makes Rout decrease in the granular source *** determine the model parameters of granular sources using the experimental data of pion transverse-momentum spectrum, elliptic flow, and HBT radii together, and investigate the effects of viscosity on the model parameters. The results indicate that the granular source model may reproduce the experimental data of pion transverse-momentum spectrum, elliptic flow, and HBT radii in heavy-ion collisions of Au-Au at√s（NN）=200 GeV and Pb-Pb at√s（NN） =2.76 Te V in different centrality intervals. The viscosity of the droplet leads to an increase in the initial droplet radius and a decrease of the source shell parameter in the granular source model.

关键词： high-energy heavy-ion collisions pion interferometry elliptic flow granular source viscous hydrodynamics

Preparation of a new animal glue binder for foundry use

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China Foundry 2016年第4期13卷 238-242页

作者： Wei-hua Liu Tian-shu Wang Ying-min Li yu-yan ren Wen-hui Huo School of Materials Science and Engineering Shenyang University of Technology

A new casting binder was prepared based on an animal bone glue. In order to overcome the disadvantages of the animal glue agglomeration at room temperature, an alkaline decomposition process was used, with acrylic acid, ammonium persulfate, and glucose as modifiers of the animal glue to obtain a high strength of binding. In the process of alkaline decomposition, Na OH was used as the catalyst with the addition of 3, 4, 5, 6, 7, 8wt.%, respectively, into 100 g of animal glue and the alkaline decomposition temperature was set for 30, 40, 50, 60, and 70 °C, with an identical decomposition time of 30 min, in order to reduce viscosity of the animal glue and maintain a liquid state at room temperature. The added acrylic acid, ammonium persulfate and glucose were determined through an orthogonal experiment. The experimental results are as fol ows: the optimal amount of NaOH addition is 5wt.%; alkaline decomposition temperature is 50 °C; the optimal weight ratio of three kinds of modifiers to animal glue is acrylic acid : ammonium persulfate : glucose : animal glue = 30:3:15:100; the modification reaction should be performed at 75 °C with a reaction time of 90 min. With the addition of 3% binder to sand, a final tensile strength of about 3.36 MPa and surface tension value of about 25.387 m N·m^(-1) are achieved; the gas evolution at 850 °C is 19 ml·g^(-1) and the residual strength after high temperature(700 ■× 10 min) is 0 MPa. Finally, the new binder was characterized and analyzed by means of element analysis and an IR infrared spectrum.

关键词： animal glue alkaline decomposition modification graft copolymerization etherification cross-linking

Research progress on refractory composition and deformability of shell molds for TiAl alloy castings

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China Foundry 2018年第1期15卷 1-10页

作者： Chun-ling Bao Shuang-qi Zhang yu-yan ren You-wei Zhang Hua-sheng Xie Jun Zhao Titanium Alloy Division Shenyang Research Institute of Foundry School of Materials Science and Engineering Shenyang University of Technology

At present, most TiAl components are produced by an investment casting process. Environmental and economic pressures have, however, resulted in a need for the industry to improve the current casting quality, reduce manufacturing costs and explore new markets for the process. Currently, the main problems for investment casting of TiAl alloys are cracks, porosities, and surface defects. To solve these problems, many studies have been conducted around the world, and it is found that casting defects can be reduced by improving composition and properties of the shell molds. It is important to make a summary for the related research progress for quality improvement of TiAl castings. So, the development on refractory composition of shell molds for TiAl alloy investment castings was reviewed, and research progress on deformability of shell mold for TiAl alloy castings both at home and abroad in recent years was introduced. The existing methods for deformability characterization and methods for improving the deformability of shell molds were summarized and discussed. The updated advancement in numerical simulation of TiAl alloy investment casting was presented, showing the necessity for considering the deformability of shell mold during simulation. Finally, possible research points for future studies on deformability of shell mold for TiAl alloy investment casting were proposed.

关键词： TiAl based alloys investment casting shell mold deformability

Gradient‑Layered MXene/Hollow Lignin Nanospheres Architecture Design for Flexible and Stretchable Supercapacitors

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Nano-Micro Letters 2025年第2期17卷 447-462页

作者： Haonan Zhang Cheng Hao Tongtong Fu Dian yu Jane Howe Kaiwen Chen Ning yan Hao ren Huamin Zhai Jiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass Materials NanJing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering and Applied Chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada Department of Materials Science and Engineering University of Toronto184 College StreetTorontoON M5S 3E4Canada College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China

With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has *** this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable *** depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene ***,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of *** these strategies effectively enhanced the capacitive performance of the *** addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the *** electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),***,their capacitances were well preserved after 1000 times of 600%stretch-release *** study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.

关键词： Hollow lignin nanospheres MXene Gradient-layered architecture Wrinkled electrodes Stretchable supercapacitors

基于分段信号相关累加的变速度多站联合直接定位方法

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物理学报 2017年第2期66卷 66-75页

作者：逯志宇任衍青巴斌王大鸣张杰解放军信息工程大学解放军66159部队

在低信噪比条件下,基于时延和多普勒频移的直接定位算法在解决宽带信号源定位时精度较差.针对此问题,提出了一种基于分段信号相关累加的变速度多站联合直接定位算法,并给出了其克拉美罗下界.该算法利用多个变速度的观测站对信号进行接收... 详细信息

在低信噪比条件下,基于时延和多普勒频移的直接定位算法在解决宽带信号源定位时精度较差.针对此问题,提出了一种基于分段信号相关累加的变速度多站联合直接定位算法,并给出了其克拉美罗下界.该算法利用多个变速度的观测站对信号进行接收,然后将同一观测站接收的目标信号分割成多段不重叠的短时信号,采用最大似然估计器,联合各段信号的时延、多普勒频移信息对目标进行直接定位.算法充分利用了观测信号包含的定位信息,并利用观测站速度的变化增加了目标位置信息,解决了分段信号联合估计带来的定位模糊问题,使定位精度进一步提高,增加了算法的实用性.仿真实验表明,较之传统直接定位算法,本文算法定位精度更高,尤其在低信噪比条件下更能逼近克拉美罗界.

关键词：直接定位多普勒频移最大似然克拉美罗界

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试论我国中小企业社会责任的界定与实现

特区经济 2009年第4期243卷 257-258页

作者：颜毓洁任佳保陕西科技大学陕西西安710021

在我国,中小企业在经济发展过程中占有举足轻重的作用,其社会责任的履行也逐渐引起全社会的关注。文章主要对我国中小企业应承担的社会责任的范围进行了界定,并提出了对于我国中小企业社会责任实现的几点建议和措施。

关键词：中小企业社会责任界定实现