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Vectorized Discrete Gaussian Sampling with SIMD Support

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Vectorized Discrete Gaussian Sampling with SIMD Support

Plasma metabolomic and lipidomic alterations associated with COVID-19

作者： Jia-jia LU yu-song DU School of Data and Computer Science Sun Yat-sen University

Discrete Gaussian sampling is a fundamental building block of lattice-based *** from a Gaussian distribution ■ over the integers ■ is an important sub-problem of discrete Gaussian sampling,where parameter σ＞ 0 and center ■.In this paper,we show that two common sampling algorithms for discrete Gaussian distribution over the integers can be implemented more efficiently by using vectorization with SIMD（Single Instruction Multiple Data） ***,we use the VCL（C++vector class library） by Agner Fog,which offers optimized vector operations for integers and floating-point numbers with the support of *** VCL is also a simple tool for constant-time implementations,which helps prevent the information leakage caused by the timing attacks on sampling operations.

关键词： Lattice-based cryptosystem Discrete Gaussian sampling SIMD

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National Science Review 2020年第7期7卷 1157-1168页

作者： Di Wu Ting Shu Xiaobo Yang Jian-Xin song Mingliang Zhang Chengye Yao Wen Liu Muhan Huang yuan yu Qingyu Yang Tingju Zhu Jiqian Xu Jingfang Mu Yaxin Wang Hong Wang Tang Tang yujie Ren Yongran Wu Shu-Hai Lin Yang Qiu Ding-yu Zhang You Shang Xi Zhou Joint Laboratory of Infectious Diseases and Health Wuhan Institute of Virology & Wuhan Jinyintan Hospital Wuhan Institute of Virology Center for Biosafety Mega-ScienceChinese Academy of Sciences (CAS) State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-Science CAS Center for Translational Medicine Jinyintan Hospital Joint Laboratory of Infectious Diseases and Health Wuhan Institute of Virology & Wuhan Jinyintan Hospital Wuhan Jinyintan Hospital Department of Critical Care Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Department of Infectious Diseases Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

The pandemic of the coronavirus disease 2019(COVID-19) has become a global public health crisis. The symptoms of COVID-19 range from mild to severe, but the physiological changes associated with COVID-19 are barely understood. In this study, we performed targeted metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 who had experienced different symptoms. We found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients, indicating that the development of COVID-19 affected their whole-body metabolism. In particular, malic acid of the TCA cycle and carbamoyl phosphate of the urea cycle result in altered energy metabolism and hepatic dysfunction, respectively. It should be noted that carbamoyl phosphate is profoundly down-regulated in patients who died compared with patients with mild symptoms. And, more importantly, guanosine monophosphate(GMP), which is mediated not only by GMP synthase but also by CD39 and CD73, is significantly changed between healthy subjects and patients with COVID-19, as well as between the mild and fatal cases. In addition, dyslipidemia was observed in patients with ***, the disturbed metabolic patterns have been found to align with the progress and severity of COVID-19. This work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets, as well as an important resource for further studies of the pathogenesis of COVID-19.

关键词： SARS-Co V-2 COVID-19 metabolome lipidome

Realization of skyrmion shift register

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Science Bulletin 2024年第15期69卷 2370-2378页

作者： Le Zhao Chensong Hua Chengkun song Weichao yu Wanjun Jiang State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing 100084China Frontier Science Center for Quantum Information Tsinghua UniversityBeijing 100084China State Key Laboratory of Surface Physics and Institute for Nanoelectronic Devices and Quantum Computing Fudan UniversityShanghai 200433China Zhangjiang Fudan International Innovation Center Fudan UniversityShanghai 201210China

The big data explosion demands novel data storage technology. Among many different approaches, solitonic racetrack memory devices hold great promise for accommodating nonvolatile and low-power functionalities. As representative topological solitons, magnetic skyrmions are envisioned as potential information carriers for efficient information processing. While their advantages as memory and logic elements have been vastly exploited from theoretical perspectives, the corresponding experimental efforts are rather limited. These challenges, which are key to versatile skyrmionic devices, will be studied in this work. Through patterning concaved surface topography with designed arrays of indentations on standard Si/SiO_(2) substrates, we demonstrate that the resultant non-flat energy landscape could lead to the formation of hexagonal and square skyrmion lattices in Ta/CoFeB/MgO multilayers. Based on these films, one-dimensional racetrack devices are subsequently fabricated, in which a long-distance deterministic shifting of skyrmions between neighboring indentations is achieved at room temperature. Through separating the word line and the bit line, a prototype shift register device, which can sequentially generate and precisely shift complex skyrmionic data strings, is presented. The deterministic writing and longdistance shifting of skyrmionic bits can find potential applications in transformative skyrmionic memory,logic as well as the in-memory computing devices.

关键词： Skyrmions Racetrack memory Spintronics Surface-topography Indentations

Effects of Central Administration of Glutamine and Alanine on Feed Intake and Hypothalamic Expression of Orexigenic and Anorexigenic Neuropetides in Broiler Chicks

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Journal of Integrative Agriculture 2012年第7期11卷 1173-1180页

作者： Khondowe Paul WANG song-bo CHEN Sheng-feng yu Jian-jian ZHU Xiao-tong WANG Li-na GAO Ping XI Qian-yun ZHANG Yong-liang SHU Gang JIANG Qing-yan College of Animal Sciences South China Agricultural University Guangzhou 510642 P.R.China School of Natural Sciences Department of Biological Sciences University of Zambia PO. Box 32379 Lusaka Zambia

Different amino acids have been shown to affect feed intake when injected directly into the central nervous system of birds. In the present study, we investigated the effects of L-glutamine and L-alanine on feed intake and the mRNA expression levels of hypothalamic neuropeptides involved in feed intake regulation in broiler chicks. L-Glutamine or L- alanine was intra-cerebroventricularly （ICV） administered to 4-d-old broiler chicks and the feed intake were recorded at various time points. Quantitative PCR was performed to determine the hypothalamic mRNA expression levels of neuropeptide Y （NPY）, agouti related protein （AgRP）, pro-opiomelanocortin （POMC）, melanocortin receptor 4 （MC4R） and corticotropin releasing factor （CRF）. Our results showed that ICV administration of L-glutamine （0.55 or 5.5 pmol） significantly increased feed intake up to 2 h post-administration period and the hypothalamic NPY mRNA expression levels, while it markedly decreased hypothalamic POMC and CRF mRNA expression levels. In contrast, ICV administration of L-alanine （4 lamol） significantly decreased feed intake for the first 0.5 h post-administration period, and reduced the hypothalamic AgRP mRNA expression levels, while it remarkablely enhanced the mRNA expression levels of MC4R and CRF. These findings suggested that L-glutamine and L-alanine could act within the hypothalamus to influence feed intake in broiler chicks, and that both orexigenic and anorexigenic neuropeptide genes might contribute directly to these effects.

关键词： L-glutamine L-alanine intracerebroventricular (ICV) feed intake hypothalamus

Roles of autophagy and pattern recognition receptors in regulating the innate antiviral responses in adipocytes

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Roles of autophagy and pattern recognition receptors in regu...

Effects of a controlled-release fertilizer on yield, nutrient uptake, and fertilizer usage efficiency in early ripening rapeseed(Brassica napus L.)

第十届全国免疫学学术大会

作者： Lili yu Xiangfeng song Hui Wang Xinxiang Medical University

Background:Various viruses may infect adipose *** viral infections may cause chronic inflammatory *** antiviral responses in the adipose cells is important issues in the *** recent study demonstrated that pattern recognition receptor(PRR)can initiate innate antiviral responses in the adipose *** is an important mechanism underlying the maintains of intracellular *** also plays an important role in regulating PRR-initiated innate antiviral *** cells pose abundant autophagic ***,the interplay of autophage and PRR in adipose cells in regulating innate antiviral responses has not been investigated ***:The cells were stimulated with synthetic viral RNA analog poly(I:C).Gene expression at m RNA level was examined using Real-time q *** and Western blot were used for the determination of protein distribution and *** cytokine level was measured using *** Bafilomycin A1 were used to regulate ***:Viral sensors,including Toll-like receptor 3(TLR3),melanoma differentiation-associated antigen 5(MDA5),and retinoic acid-inducible gene I(RIG-I),can initiate innate immune responses in *** can directly eliminate invading pathogens and regulate innate immune responses against microbal ***3 and beclin-1,two key autophagy-related genes,were highly expressed in mouse ***-βand antiviral proteins,including IFNstimulated gene 15(ISG15),2’-5’-oligoadenylate synthetase(OAS1),and myxovirus resistence protein 1(Mx1),were significantly upregulated in WT mouse adipocytes after poly(I:C)***(I:C)promoted *** the innate antiviral ***:PRRs in adipocytes can be activated by poly(I:C)and then initiates innate antiviral *** enhanced the innate antiviral responses in adipocytes.

关键词： adipocytes innate antiviral responses pattern recognition receptors autophagy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2016年第10期17卷 775-786页

作者： Chang TIAN xuan ZHOU Qiang LIU Jian-wei PENG Wen-ming WANG Zhen-hua ZHANG Yong YANG Hai-xing song Chun-yun GUAN College of Resources and Environment Hunan Agricultural University/Hunan Provincial Key Laboratory of Farmland Pollution Control and Agricultural Resources Use / Hunan Provincial Key Laboratory of Plant Nutrition in Common University/National Engineering Laboratory of College of Resources and EnvironmentSouthern Regional Collaborative Innovation Center for Grain and Oil Crops in China College of Environmental Science and Resources Zhejiang University National Center of Oilseed Crops Improvement Hunan Branch

Background： Nitrogen（N）, phosphorous（P）, and potassium（K） are critical nutrient elements necessary for crop plant growth and development. However, excessive inputs will lead to inefficient usage and cause excessive nutrient losses in the field environment, and also adversely affect the soil, water and air quality, human health, and biodiversity. Methods： Field experiments were conducted to study the effects of controlled-release fertilizer（CRF） on seed yield, plant growth, nutrient uptake, and fertilizer usage efficiency for early ripening rapeseed（Xiangzayou 1613） in the red-yellow soil of southern China during 2011–2013. It was grown using a soluble fertilizer（SF） and the same amounts of CRF, such as SF1/CRF1（3750 kg/hm^2）, SF2/CRF2（3000 kg/hm^2）, SF3/CRF3（2250 kg/hm^2）, SF4/CRF4（1500 kg/hm^2）, SF5/CRF5（750 kg/hm^2）, and also using no fertilizer（CK）. Results： CRF gave higher seed yields than SF in both seasons by 14.51%. CRF4 and SF3 in each group achieved maximum seed yield（2066.97 and 1844.50 kg/hm^2, respectively）, followed by CRF3（1929.97 kg/hm^2） and SF4（1839.40 kg/hm^2）. There were no significant differences in seed yield among CK, SF1, and CRF1（P0.05）. CRF4 had the highest profit（7126.4 CNY/hm2） and showed an increase of 12.37% in seed yield, and it decreased by 11.01% in unit fertilizer rate compared with SF4. The branch number, pod number, and dry matter weight compared with SF increased significantly under the fertilization of CRF（P0.05）. The pod number per plant was the major contributor to seed yield. On the other hand, the N, P, and K uptakes increased at first and then decreased with increasing the fertilizer rate at maturity, and the N, P, and K usage efficiency decreased with increasing the fertilizer rate. The N, P, and K uptakes and usage efficiencies of the CRF were significantly higher than those of SF（P0.05）. The N accumulation and N usage efficiency of CRF increased by an average of 13.66% and 9.74 percentage points, respectively, compared to

关键词： Early ripening rapeseed Controlled-release fertilizer Yield Nutrient uptake Fertilizer usage efficiency

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球扁钢感应加热温度场模拟与工艺优化

材料热处理学报 2014年第5期35卷 214-218页

作者：原思宇宋华王旭鞍钢股份有限公司技术中心辽宁鞍山114009 辽宁科技大学辽宁鞍山114051

球扁钢采用电磁感应加热技术实现在线淬火热处理。感应加热过程中球头与腹板存在较大温差,导致淬火后性能不均匀。借助数值模拟方法建立感应加热过程有限元模型,获得不同时刻球扁钢断面温度场分布。进一步采用二位控温法进行感应加热工... 详细信息

球扁钢采用电磁感应加热技术实现在线淬火热处理。感应加热过程中球头与腹板存在较大温差,导致淬火后性能不均匀。借助数值模拟方法建立感应加热过程有限元模型,获得不同时刻球扁钢断面温度场分布。进一步采用二位控温法进行感应加热工艺优化,并借助有限元模型进行参数的设计和优化。模拟结果显示腹板与球头温度差由优化前的100℃左右,减少到优化后的少于30℃。采用新工艺进行实验,实验结果与模拟结果比较两者相差较小,验证了模型的准确性和新工艺的可行性。为实现球扁钢感应加热工艺快速选择和优化提供了可靠的数学模型。

关键词：球扁钢电磁感应数值模拟温度场

Transcriptomic Landscape Analysis Reveals a Persistent DNA Damage Response in Metabolic Dysfunction-associated Steatohepatitis Post-dietary Intervention

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Journal of Clinical and Translational Hepatology 2024年第9期12卷 765-779页

作者： Zi-yuan Zou Tian-Yi Ren Jia-Qi Li Ting-Ying Jiao Meng-yu Wang Lei-Jie Huang Shuang-Zhe Lin yuan-Yang Wang Xiao-Zhen Guo Ye-yu song Rui-Xu Yang Cen Xie Jian-Gao Fan Center for Fatty Liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina University of Chinese Academy of Sciences BeijingChina Human Phenome Institute School of Life SciencesFudan UniversityShanghaiChina Department of Gastroenterology Ningbo No.2 HospitalNingboZhejiangChina Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition ShanghaiChina

Background and Aims:Metabolic dysfunction-associated steatotic liver disease(MASLD)and its more advanced form,metabolic dysfunction-associated steatohepatitis,have emerged as the most prevalent liver diseases ***,lifestyle modification is the foremost guidelinerecommended management strategy for ***,it remains unclear which detrimental signals persist in MASLD even after disease ***,we aimed to examine the persistent changes in liver transcriptomic profiles following this ***:Male C57BL/6J mice were divided into three groups:Western diet(WD)feeding,chow diet(CD)feeding,or diet reversal from WD to *** 16 weeks of feeding,RNA sequencing was performed on the mice’s livers to identify persistent alterations characteristic of ***,RNA sequencing databases containing high-fat diet-fed P53-knockout mice and human MASLD samples were ***:WD-induced MASLD triggered persistent activation of the DNA damage response(DDR)and its primary transcription factor,P53,long after the resolution of the hepatic phenotype through dietary *** levels of P53 might promote apoptosis,thereby exacerbating metabolic dysfunction-associated steatohepatitis,as they strongly correlated with hepatocyte ballooning,an indicator of apoptosis ***,P53 knockout in mice led to downregulated expression of apoptosis signaling in the ***,P53 may regulate apoptosis by transcriptionally activating the expression of apoptosis-enhancing nuclease(AEN).Consistently,P53,AEN,and the apoptosis process all exhibited persistently elevated expression and showed a strong inter-correlation in the liver following dietary ***:The liver demonstrated upregulation of DDR signaling and the P53-AEN-apoptosis axis both during and after exposure to *** findings provide new insights into the mechanisms of MASLD relapse,highlighting DDR signaling as a promising target to prevent MASLD recu

关键词： Apoptosis DNA Damage Metabolic dysfunction-associated steatotic liver disease RNA-Seq Tumor suppressor protein P53 Western Diets

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微通道换热器大温差条件下流动换热研究

工程热物理学报 2022年第2期43卷 485-489页

作者：宋昱姜培学热科学与动力工程教育部重点实验室清华大学能源与动力工程系北京100084

随着高效预冷器在航天航空领域发挥越来越重要的作用,紧凑高效换热器的研究成为了人们关注的热点。本文基于紧凑微通道换热器的几何特征,针对矩形截面平行流道换热器内超临界压力低温流体(氢和氦)在大温差条件下的流动换热现象进行数值... 详细信息

随着高效预冷器在航天航空领域发挥越来越重要的作用,紧凑高效换热器的研究成为了人们关注的热点。本文基于紧凑微通道换热器的几何特征,针对矩形截面平行流道换热器内超临界压力低温流体(氢和氦)在大温差条件下的流动换热现象进行数值模拟研究。通道截面边长小于1 mm,热流体氦和冷流体氢的进出口温差均大于600 K。通道内流体换热系数在顺流和逆流条件下有不同的变化趋势,并出现峰值。换热量随着通道宽度的增大而增大,流动压降随着通道宽度的增大而减小。冷热流体逆流时换热量大,压降较小,但对换热器材料要求较高。

关键词：微通道大温差超临界低温流体换热器