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Expression,Purification and Anti-tumor Activity of Curcin

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Acta Biochimica et Biophysica Sinica 2006年第9期38卷 663-668页

作者： Meng-Jun LUO~1 xin-yu yang~1 Wei-xin LIU~2 Ying XU~1 Ping HUANG~2 Fang YAN~1 Fang CHEN~1* 1 College of Life Sciences,Sichuan University,Chengdu 610041,China 2 Chengdu Institute for Family Planning,Chengdu 610031,China College of Life Sciences Sichuan UniversityChengdu 610041 China Chengdu Institute for Family PlanningChengdu 610031 China

Curcin,purified from the seeds of Jatropha curcas,can be used as a cell-killing *** the anti-tumor activity of the recombinant protein of curcin is important for its application inclinical *** segment encoding the mature protein of curcin was inserted into Escherichia colistrain M 15,and the recombinant strain was induced to express by isopropyl-β-D-thiogalactopyranoside at aconcentration of 0.5 *** recombinant protein was expressed in the form of inclusion bodies andpurified by Ni-NTA affinity *** target protein was incubated with the tumor cells atdifferent concentrations for different times and the results demonstrated that the target protein could inhibitthe growth of tumor cells (NCL-H446,SGC-7901 and S180) at 5μg/ml.

关键词： curcin expression purification recombinant protein anti-tumor activity

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SCR脱硝中各物质热力学性质的预测

工程热物理学报 2015年第3期36卷 482-485页

作者： Reza Gholizadeh 于养信清华大学化学工程系化工热力学实验室北京100084

选择性催化还原脱硝技术效率高,有望应用于汽车尾气中NO_x的排放控制.本文采用5种不同的密度泛函理论,计入色散校正项的影响,预测了选择性催化还原脱硝反应体系中各种气体的标准生成焓以及温度从0 K到1000 K时各气体的焓变。与实验比较... 详细信息

选择性催化还原脱硝技术效率高,有望应用于汽车尾气中NO_x的排放控制.本文采用5种不同的密度泛函理论,计入色散校正项的影响,预测了选择性催化还原脱硝反应体系中各种气体的标准生成焓以及温度从0 K到1000 K时各气体的焓变。与实验比较结果表明,广义密度梯度近似中的BLYP泛函和B3LYP泛函对标准生成焓的预测偏差最小,而本文检验的所有密度泛函理论都能很好地预测气体在0~1000 K温度范围内的焓变,可以用于选择性催化还原脱硝反应体系的热量恒算。

关键词：密度泛函理论生成焓选择性催化还原脱硝

Endovascular coiling versus microsurgical clipping for ruptured intracranial aneurysms:a meta-analysis and systematic review

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Chinese Neurosurgical Journal 2022年第4期8卷 268-283页

作者： Chao Peng yu-hang Diao Shi-fei Cai xin-yu yang Department of Neurosurgery Tianjin Medical University General HospitalTianjinThe People’s Republic of China

Background:The purpose of this analysis is to evaluate the current evidence with regard to the effectiveness and safety between coiling and clipping in patients with ruptured intracranial aneurysms(RIAs).Methods:We performed a meta-analysis that compared clipping with coiling between July 2000 and September ***,EMBASE,and the Cochrane Library were searched for related articles *** the treatment efficacy and postoperative complications were ***:We identified three randomized controlled trials and thirty-seven observational studies involving 60,875 patients with ruptured cerebral *** summary results showed that coiling was related a better quality of life(mRS0-2;OR=1.327;CI=1.093-1.612;p<0.05),a higher risk of mortality(OR=1.116;CI=1.054-1.180;p<0.05),higher rate of rebleeding(RR=1.410;CI=1.092-1.822;p<0.05),lower incidence of vasospasm(OR=0.787;CI=0.649-0.954;p<0.05),higher risk of hydrocephalous(RR=1.143;CI=1.043-1.252;p<0.05),lower risk of cerebral infarction(RR=0.669;CI=0.596-0.751;p<0.05),lower risk of neuro deficits(RR=0.720;CI=0.582-0.892;p<0.05),and a lower rate of complete occlusion(OR=0.495;CI=0.280-0.876;p<0.05).Conclusion:Coiling was significantly associated with a better life quality(mRS0-2),a lower incidence of postoperative complications,and a higher rate of mortality,rebleeding,hydrocephalous,and a lower rate of complete occlusion than clipping.

关键词： Ruptured intracranial aneurysms Coiling Clipping Meta-analysis

A comparative study of biliary trace elements and clinical phenotypes in Wilson disease

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World Journal of Gastroenterology 1997年第4期3卷 62-64页

作者： REN MingShan1, FAN yuxin2, yang RenMin1, HAN YongZhu1, WU GuoJun2, xin yuRong2 and yu Long2

IM To further explore the etiological mechanism of Wilson disease (WD), by comparing the changes of biliary trace elements and its clinical phenotype.METHODS Wilson disease patients with different types and conditions (n=20), nonWD patients with chronic liver damage (n=22) and healthy volunteers (n=10) as controls were studied. Biliary samples were taken by duodenal drainage. Atom absorption spectrophotometer was used to assay the copper and zinc content of each sample.RESULTS In Wilson disease, the copper content and copper/zinc ratio of biliary juice were evidently lower than those of nonWD patients with chronic liver damage and healthy controls (F=1476, 254; 1492, 262; P005). There were significant differences in biliary copper excretion among patients with different types and conditions (F=375, P<005; F=620, P<001).CONCLUSION Copper excretion by liver and biliary system decreases obviously, which plays a key role in the copper retention of WD, and the biliary copper retention is closely related with the severity of hepatic injury and illness.

关键词： Wilson disease copper zinc duodenal drainage bile

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高压下长链分子的自扩散系数研究

高校化学工程学报 2001年第1期15卷 1-5页

作者：于养信高光华清华大学化学工程系北京100084

在Lennard-Jones流体自扩散系数方程的基础上，结合链状硬球流体自扩散系数的分子模拟数据，提出了链状Lennard-Jones流体的自扩散系数方程。将所提出的方程应用于计算长链烷烃和硅油在0.1~600MPa下的自扩散系数，其平均相对偏差在10%... 详细信息

在Lennard-Jones流体自扩散系数方程的基础上，结合链状硬球流体自扩散系数的分子模拟数据，提出了链状Lennard-Jones流体的自扩散系数方程。将所提出的方程应用于计算长链烷烃和硅油在0.1~600MPa下的自扩散系数，其平均相对偏差在10%以内，计算结果优于自扩散系数的粗糙Lennard-Jones模型。

关键词： LENNARD-JONES链方程长链烷烃硅油自扩散系数链状硬球流体

Efficacy and safety of Xileisan combined with mesalazine for ulcerative colitis:A meta-analysis and trial sequential analysis

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World Journal of Clinical Cases 2024年第21期12卷 4703-4716页

作者： xin-yu yang yun-Feng yu Ke-Ke Tong Gang Hu Rong yu Lian-Jun Su School of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The First Hospital of Hunan University of Chinese Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina

BACKGROUND The benefits and risks of Xileisan(XLS)in the treatment of ulcerative colitis(UC)remain *** The present study aimed to evaluate the efficacy and safety of the combination of XLS and mesalazine when treating *** We searched eight databases for clinical trials evaluating the combination of XLS and mesalazine in the treatment of UC,up to January ***-analysis and trial sequential analysis(TSA)were performed using Revman 5.3 and TSA 0.***.5.10 beta,*** The present study included 13 clinical studies involving 990 patients,of which 501 patients received XLS combined with mesalazine while 489 patients received mesalazine *** meta-analysis showed that,in terms of efficacy,the combination of XLS and mesalazine significantly improved the clinical efficacy rate by 22%[risk ratio(RR)=1.22;95%CI:1.15–1.28;P0.05).The TSA showed non conclusive findings in the meta-analysis of the safety ***’s test showed no publication bias(P=0.734).CONCLUSION Treatment with XLS alleviated the clinical symptoms,intestinal mucosal injury,and inflammatory response in patients with UC,while demonstrating good safety.

关键词： Xileisan Mesalazine Ulcerative colitis Meta-analysis Trial sequential analysis

以客户终身价值为准则的客户重要程度识别系统

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系统工程理论与实践 2005年第11期25卷 79-85页

作者：胡理增薛恒新于信阳南京理工大学江苏南京210024 南京财经大学江苏南京210046

以客户终身价值为准则对客户重要程度进行识别.首先吸收了复杂网络的研究成果,推出了客户终身价值的计算式;然后运用“忠诚度”映射此公式中几个无法直接观测到的影响因素,同时运用典型调查和综合评价法算出各类客户的忠诚度,从而建立... 详细信息

以客户终身价值为准则对客户重要程度进行识别.首先吸收了复杂网络的研究成果,推出了客户终身价值的计算式;然后运用“忠诚度”映射此公式中几个无法直接观测到的影响因素,同时运用典型调查和综合评价法算出各类客户的忠诚度,从而建立起客户特征集与忠诚度的分类回归树,获得客户终身价值的计算值;最后以某企业为例,运用BP人工神经网络训练出一个以客户终身价值为准则的客户识别系统.

关键词：客户终身价值客户识别系统人工神经网络复杂网络波及效应

Visible-light-responsive homologous heterostructure of oxynitrides constructed to boost charge separation and water splitting

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Science China Chemistry 2025年第1期68卷 186-191页

作者： Hai Zou yunfeng Bao Xueshang xin yu Qi Tengfeng Xie Fuxiang Zhang State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences School of Chemistry and Chemical Engineering Liaoning Normal University College of Chemistry Jilin University

Constructing type II heterostructures represents a widely recognized strategy for enhancing charge separation and photocatalytic efficiency,but it remains challenging to fabricate homologous heterostructures based on visible-light-responsive semiconductors,especially for popularly investigated （oxy）nitrides with low thermal ***,we synthesized a homologous heterostructure （denoted as YTON＿H） based on the oxynitrides of YTaO4-xNyand YTa *** heterostructure exhibits type II band structure alignment and intimate interface achieved through a magnesium （Mg） powder-assisted nitridation *** with widely reported heterologous heterostructures,the as-obtained YTON＿H homologous heterostructure could similarly exhibit enhanced charge separation as well as photocatalytic water splitting performance with respect to its counterparts(YTaO4-xNyand YTaON2).Meanwhile,detailed structural characterizations and spectroscopy analysis have been made to confirm the formation of heterostructure and promotion of spatial charge separation.

关键词： charge separation heterostructure oxynitride photocatalysis visible light

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基于多相关本体的模糊信息检索模型

计算机工程 2010年第20期36卷 68-70页

作者：俞扬信淮阴工学院计算机工程学院江苏淮安223003

根据概念及概念之间的语义,提出一种多相关本体的模糊信息检索模型,用本体的关系表示模糊关系。描述本体信息检索模型的处理过程及检索机制,讨论应用不同类型本体的检索效果和影响,并采用TREC的评价方法评估该模型。结果证明该模型具有... 详细信息

根据概念及概念之间的语义,提出一种多相关本体的模糊信息检索模型,用本体的关系表示模糊关系。描述本体信息检索模型的处理过程及检索机制,讨论应用不同类型本体的检索效果和影响,并采用TREC的评价方法评估该模型。结果证明该模型具有较好的整体性能比,能改善用户需要的检索结果。

关键词：多相关本体信息检索模糊关系