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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第7期14卷 520-534页

作者： Chu-dong TONG Xue-feng YAN yu-xin ma Key Laboratory of Advanced Control and Optimization for Chemical Processes of Ministry of Education East China University of Science and Technology

In this paper, a novel criterion is proposed to determine the retained principal components (PCs) that capture the dominant variability of online monitored data. The variations of PCs were calculated according to their mean and covariance changes between the modeling sample and the online monitored data. The retained PCs containing dominant variations were selected and defined as correlative PCs (CPCs). The new Hotelling's T2 statistic based on CPCs was then employed to monitor the process. Case studies on the simulated continuous stirred tank reactor and the well-known Tennessee Eastman process demonstrated the feasibility and effectiveness of the CPCs-based fault detection methods.

关键词： Fault detection Principal component analysis (PCA) Correlative principal components (CPCs) Tennessee Eastman process

A Survey of Visual Analytic Pipelines

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Journal of Computer Science & Technology 2016年第4期31卷 787-804页

作者： Xu-Meng Wang Tian-Ye Zhang yu-xin ma Jing Xia Wei Chen State Key Laboratory of Computer Aided Design and Computer Graphics Zhejiang University Hangzhou 310058 China Innovation Joint Research Center for Cyber-Physical-Society System Zhejiang University Hangzhou 310058 China

Visual analytics has been widely studied in the past decade. One key to make visual analytics practical for both research and industrial applications is the appropriate definition and implementation of the visual analytics pipeline which provides effective abstractions for designing and implementing visual analytics systems. In this paper we review the previous work on visual analytics pipelines and individual modules from multiple perspectives： data, visualization, model and knowledge. In each module we discuss various representations and descriptions of pipelines inside the module, and compare the commonalities and the differences among them.

关键词： visual analytics pipeline visualization model knowledge

Orthogonality of Redesigned tRNA Molecules with Three Stop Codons

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Chinese Journal of Chemistry 2022年第7期40卷 825-831页

作者： Zhao-Yang Zhang Dan-Ni Liao yu-xin ma Bin Jia Ying-Jin yuan Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin UniversityTianjin 300072China

The ability to expand genetic code in living cells has emerged as a powerful method with diverse ***,we design re-placement of the anticodons of *** tRNAs that recognize codons for 20 natural amino acids,with three anti-stop codons,resulting in a total of 60 engineered tRNA *** test these constructs one by one in ***,and found that six tRNAsCUA(tyrV,serX,hisR,trpT,glnV and leuX),two tRNAsUCA(trpT and leuX)and one tRNAUUA(tyrV)allowed efficient expression of Red Fluorescence Protein(RFP)with the presence of a corresponding stop codon in ***,we exploit the mutual orthogonality of tRNASer CUA,tRNATrpUCA and tRNATyrUUA with corresponding stop codons and demonstrated that the tRNASer CUA and the tRNATrp UCA can provide dynamic range and low ***,we show the TAG and TGA can not only be used as an"AND gate"circuit to control the translation of target gene,but also be used to control the translation of a prodeoxyviolacein(PDV)pathway and a reporter in ***,this work provides flexible tools for translational control and holds great potential to promote synthetic biology studies.

关键词： tRNA Orthogonality Synthetic biology Series control Parallel control Biosynthesis

The size effect and analogous boundary states in a circular non-Hermitian chain

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Communications in Theoretical Physics 2024年第2期76卷 157-165页

作者： xin-yu ma Yi-Han Guan Qiao-Nan Li Ai-Lei He Lu Qi School of Physical Science and Technology Yangzhou UniversityYangzhou 225002China

We investigate the size effect and boundary states based on a circular non-Hermitian chain under the nonreciprocal intra-cell coupling and inter-cell coupling *** find that the circular non-Hermitian chain exhibits an even–odd effect on the unit cell corresponding to a large chain,which is different from the open non-Hermitian chain only exhibiting the same effect for a small ***,we find that the originally localized bulk states become totally extended via designing the boundary coupling strength *** extended bulk states reveal the fact of the disappearance of the non-Hermitian skin *** particular,we show that the circular non-Hermitian chain also possesses the analogous edge states under some parameter regimes,which is pretty counterintuitive since the circular chain usually cannot define a *** investigations supply the different non-Hermitian phenomena in a circular non-Hermitian chain.

关键词： boundary states non-Hermitian chain topological state

Acrylamide neurotoxicity on the cerebrum of weaning rats

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Neural Regeneration Research 2015年第6期10卷 938-943页

作者： Su-min Tian yu-xin ma Jing Shi Ting-ye Lou Shuai-shuai Liu Guo-ying Li School of Basic Medicine Guangdong Pharmaceutical University Xiqiao People’s Hospital Clinical Laboratory of First Affiliated Hospital Xinxiang Medical University Guangzhou University of Chinese Medicine

The mechanism underlying acrylamide-induced neurotoxicity remains controversial. Previous studies have focused on acrylamide-induced toxicity in adult rodents, but neurotoxicity in weaning rats has not been investigated. To explore the neurotoxic effect of acrylamide on the developing brain, weaning rats were gavaged with 0, 5, 15, and 30 mg/kg acrylamide for 4 consecutive weeks. No obvious neurotoxicity was observed in weaning rats in the low-dose acrylamide group （5 mg/kg）. However, rats from the moderateand high-dose acrylamide groups （15 and 30 mg/kg） had an abnormal gait. Furthermore, biochemical tests in these rats demonstrated that glutamate concentration was significantly reduced, and ^-aminobutyric acid content was significantly increased and was dependent on acrylamide dose. Immunohis- tochemical staining showed that in the cerebral cortex, γ-aminobutyric acid, glutamic acid decarboxylase and glial fibrillary acidic protein expression increased remarkably in the moderate- and high-dose acrylamide groups. These results indicate that in weaning rats, acrylamide is positively associated with neurotoxicity in a dose-dependent manner, which may correlate with upregulation of γ-aminobutyric acid and subsequent neuronal degeneration after the initial acrylamide exposure.

关键词： nerve regeneration γ-aminobutyric acid glial fibrillary acidic protein glutamic aciddecarboxylase neurotoxicity weaning organ index cerebrum cortex glutamate neural regeneration

Toxic effect of acrylamide on the development of hippocampal neurons of weaning rats

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Neural Regeneration Research 2017年第10期12卷 1648-1654页

作者： Sheng-min Lai Zi-ting Gu Meng-meng Zhao Xi-xia Li yu-xin ma Li Luo Jing Liu Department of Human Anatomy and Histoembryology School of Basic CoursesGuangdong Pharmaceutical UniversityGuangzhouGuangdong ProvinceChina

Although numerous studies have examined the neurotoxicity of acrylamide in adult animals,the effects on neuronal development in the embryonic and lactational periods are largely ***,we examined the toxicity of acrylamide on neuronal development in the hippocampus of fetal rats during ***-Dawley rats were mated with male rats at a 1：1 *** were administered 0,5,10 or 20 mg/kg acrylamide intragastrically from embryonic days 6–*** gait scores were examined in pregnant rats in each group to analyze maternal *** weaning rats from each group were also euthanized on postnatal day 21 for follow-up *** staining was used to observe histological change in the *** was conducted to observe the condition of neurites,including dendrites and *** blot assay was used to measure the expression levels of the specific nerve axon membrane protein,growth associated protein 43,and the presynaptic vesicle membrane specific protein,*** gait scores of gravid rats significantly increased,suggesting that acrylamide induced maternal motor *** number of neurons,as well as expression of growth associated protein 43 and synaptophysin,was reduced with increasing acrylamide dose in postnatal day 21 weaning *** data suggest that acrylamide exerts dose-dependent toxic effects on the growth and development of hippocampal neurons of weaning rats.

关键词： nerve regeneration acrylamide hippocampus neurons developmental toxicity growth associated protein 43 synaptophysin weaning rats dentate gyrus protein developmental neurobiology neural regeneration

Extract of Ginkgo biloba promotes neuronal regeneration in the hippocampus after exposure to acrylamide

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Neural Regeneration Research 2017年第8期12卷 1287-1293页

作者： Wei-ling Huang yu-xin ma yu-bao Fan Sheng-min Lai Hong-qing Liu Jing Liu Li Luo Guo-ying Li Su-min Tian Department of Anatomy School of Basic Medicine Guangdong Pharmaceutical University Guangzhou Guangdong Province China Department of Physiology School of Basic Medicine Guangdong Pharmaceutical University Guangzhou Guangdong Province China

Previous studies have demonstrated a neuroprotective effect of extract of Ginkgo biloba against neuronal damage, but have mainly focused on antioxidation of extract of Ginkgo biloba. To date, limited studies have determined whether extrasct of Ginkgo biloba has a protective effect on neuronal damage. In the present study, acrylamide and 30, 60, and 120 mg/kg extract of Ginkgo biloba were administered for 4 weeks by gavage to establish mouse models. Our results showed that 30, 60, and 120 mg/kg extract of Ginkgo biloba effectively alleviated the abnormal gait of poisoned mice, and up-regulated protein expression levels of doublecortin（DCX）, brain-derived neurotrophic factor, and growth associated protein-43（GAP-43） in the hippocampus. Simultaneously, DCX-and GAP-43-immunoreactive cells increased. These findings suggest that extract of Ginkgo biloba can mitigate neurotoxicity induced by acrylamide, and thereby promote neuronal regeneration in the hippocampus of acrylamide-treated mice.

关键词： nerve regeneration brain injury extrat of Ginkgo biloba acrylamide doublecortin brain-derived neurotrophic factor growthassociated protein-43 neurons damage hippocampus mice neural regeneration

Cortical regulation of striatal projection neurons and interneurons in a Parkinson's disease rat model

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Neural Regeneration Research 2016年第12期11卷 1969-1975页

作者： Jia-jia Wu Si Chen Li-si Ouyang yu Jia Bing-bing Liu Shu-hua Mu yu-xin ma Wei-ping Wang Jia-you Wei You-lan Li Zhi Chen Wan-long Lei Department of Anatomy Zhongshan School of MedicineSun Yat-sen University Periodical Center the Third Affiliated HospitalSun Yat-sen University Department of Anesthesiology Guangdong No.2 Provincial People’s HospitalGuangdong Provincial Emergency Hospital Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen University

Striatal neurons can be either projection neurons or interneurons, with each type exhibiting distinct susceptibility to various types of brain damage. In this study, 6-hydroxydopamine was injected into the right medial forebrain bundle to induce dopamine depletion, and/or ibotenic acid was injected into the M1 cortex to induce motor cortex lesions. Immunohistochemistry and western blot assay showed that dopaminergic depletion results in significant loss of striatal projection neurons marked by dopamine- and cyclic adenosine monophosphate-regulated phosphoprotein, molecular weight 32 k Da, calbindin, and μ-opioid receptor, while cortical lesions reversed these pathological changes. After dopaminergic deletion, the number of neuropeptide Y-positive striatal interneurons markedly increased, which was also inhibited by cortical lesioning. No noticeable change in the number of parvalbumin-positive interneurons was found in 6-hydroxydopamine-treated rats. Striatal projection neurons and interneurons show different susceptibility to dopaminergic depletion. Further, cortical lesions inhibit striatal dysfunction and damage induced by 6-hydroxydopamine, which provides a new possibility for clinical treatment of Parkinson＇s disease.

关键词： nerve regeneration motor cortex lesions dopaminergic neurons GABAergic neurons Darpp32 calbindin μ-opioid receptor neuropeptide Y parvalbumin neural regeneration

A Quantitative Method for Simultaneous Determination of Four Anthraquinones with One marker in Rhei Radix et Rhizoma

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Chinese Herbal Medicines 2012年第2期4卷 157-163页

作者： Jing-jing ZHU[a][b] Zhi-min WANG[a][b] xin-yu ma[a] Wei-hong FENG[a][b] Qi-wei ZHANG[a][b] Institute of Chinese materia Medica China Academy of Chinese Medical Sciences Beijing 100700 China National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines Beijing 100700 China

Objective To develop a quantitative method for simultaneously determining multi-components in Rhei Radix et Rhizoma using one chemical reference *** The contents of multi-components were calculated by the UV relative correction factors(RCFs)of chrysophanol,physcion,and rhein to *** The values of RCFs at 274 nm for rhein,chrysophanol,and physcion to emodin were 0.712,0.674,and *** calibration curves were linear over the ranges of 0.02-4.08,0.02-4.12,0.07-12.92,and 0.02-3.68μg/mL for rhein,emodin, chrysophanol,and physcion,*** contents of emodin in 18 samples were determined by the external standard method,and the contents of the other three anthraquinone aglycones were calculated according to their RCFs. Conclusion No significant difference is found in comparison with the classical method,indicating that the RCFs have high reliability within their linear ranges and could be used in quality control of Rhei Radix et *** quantitative analysis of multi-component with a single marker is especially suitable for herbal medicines containing unstable or hard to be purified components as quality control markers.

关键词： anthraquinone multi-component quantitative analysis quality control Rhei Radix et Rhizoma UV relative correction factor

Vector meson's spin alignments in high energy reactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 5-20页

作者： Jin-Hui Chen Zuo-Tang Liang yu-Gang ma xin-Li Sheng Qun Wang Key Laboratory of Nuclear Physics and Ion-beam Application (MoE) Institute of Modern PhysicsFudan University Institute of Frontier and Interdisciplinary Science Key Laboratory of Particle Physics and Particle Irradiation (MOE)Shandong University INFN-Firenze Department of Modern Physics University of Science and Technology of China School of Mechanics and Physics Anhui University of Science and Technology

The global spin alignment of vector mesons has been observed by the STAR collaboration at the Relativistic Heavy Ion Collider （RHIC） at Brookhaven National Laboratory （BNL）.It provides a unique opportunity to probe the correlation between the polarized quark and antiquark in the strongly coupled quark-gluon plasma （sQGP） produced in relativistic heavy ion collisions,opening a new window to explore the properties of s *** addition,spin alignments of vector mesons have also been observed in other high-energy particle collisions such as e+e-annihilations at high energies where hadron production is dominated by quark fragmentation *** results obtained are quite different from those obtained in heavy ion collisions where quark coalescence/combination mechanism dominates suggesting strong dependence on hadronization *** comprehensive studies in different hadronization processes are *** this article,we present a brief review of theoretical and experimental advances in the study of vector meson’s spin alignments in a variety of high-energy particle collisions,with emphasis on hadronization mechanisms.

关键词： vector meson spin alignment global polarization relativistic heavy ion collisions fragmentation