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Myotonic dystrophy type 1 presenting with dyspnea:A case report

World Journal of Clinical Cases 2022年第20期10卷 7060-7067页

作者： yu-xi jia Chun-Ling Dong jia-Wei Xue xiao-Qin Duan Ming-yu Xu xiao-Min Su Ping Li Department of Orthopedics The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina Application Demonstration Center of Precision Medicine Molecular Diagnosis The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina Department of Respiratory and Critical Care Medicine The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina Department of Rehabilitation Medicine The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina Department of Developmental Pediatrics The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina

BACKGROUND Myotonic dystrophy type 1(DM1)is a genetic neuromuscular disease involving multiple systems,especially the cardiopulmonary *** clinical phenotype of DM1 patients is highly variable,which limits early diagnosis and *** the present study,we reported a 35-year-old female DM1 patient with dyspnea as the primary onset clinical manifestation,analyzed her family's medical history,and reviewed related *** SUMMARY A 35-year-old woman was admitted to the hospital with dyspnea of 1 mo duration,and sleep apnea for 3 *** respiratory pattern and effort were normal,but limb muscle tension was *** into the patient's medical history revealed that she might have hereditary neuromuscular *** showed that her myotonia potentials were visible in the resting state of the examined muscles,with decreased motor unit potential time limit and *** testing for DM1 revealed that the cytosine-thymine-guanine(CTG)repeat number of the DMPK gene exceeded 50,while cytosine-CTG expansion in intron 1 of ZNF9 gene was<30 *** patient was diagnosed with *** DM1 is a genetic neuromuscular disease involving multiple systems,and the clinical phenotype in DM1 is extremely *** patients with DM1 may be presented at the respiratory department because of dyspnea,which should be cautioned by the *** may be no obvious or specific symptoms in the early stage of disease,and clinicians should improve their understanding of DM1 and make an early diagnosis,which will improve patients’quality of life.

关键词： Myotonic dystrophy type 1 DMPK gene Respiratory insufficiency Sleep apnea Non-invasive ventilation

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Pyrolysis of Glucose over Two Amphoteric Metal Oxides

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Chemical Research in Chinese Universities 2009年第2期25卷 234-238页

作者： YANG yu xiANG xi LUO jia QI Wei-Yan YAN Hong-Peng LI Gui-Ying HU Chang-Wei Key Laboratory of Green Chemistry and Technology Ministry of Education College of Chemistry Sichuan University Chengdu 610064 P. R. China

The catalytic pyrolysis of glucose over amphoteric metal oxide, ZnO or γ-l2O3, was studied comparatively with direct pyrolysis. The effects of catalyst to glucose ratio on the yields of pyrolytic products and on the chemical composition of the liquid products were discussed. Compared with the pyrolytic products of direct pyrolysis, the amount of residual char decreased, whereas the gas yield increased in the presence of the catalysts. The highest liquid yield over ZNO（49.5%） was obtained when the ratio of ZnO to glucose was 5%, whereas over γ-Al2O3 the liquid yield increased with increasing the amount of γ-Al2O3 added. The presence of both the catalysts enhanced the selectivity to furans in liquid and reduced that of anhydro sugars. A selectivity of 69.7% to furans was obtained over 1% ZnO with a selectivity of 14.6% to 5-hydroxymethylfurfural（HMF）. The maximum selectivity to furans（74.9%） and that to HMF（25.6%） were obtained in the presence of 10% γ-Al2O3.

关键词： Glucose ZnO γ-Al2O3 Furans 5-Hydroxymethylfurfural

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Remnant-preserving posterior cruciate ligament reconstruction with graft tension-relieving： a comparative study with conventional technique

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Chinese Medical Journal 2013年第6期126卷 1155-1158页

作者： GONG xi yu jia-kuo AO Ying-fang Institute of Sports Medicine Peking University Third HospitalBeijing 100191 China

Background Posterior cruciate ligament （PCL） tear is a severe injury to the knee joint and often requires surgical reconstruction. A number of PCL reconstruction techniques have been reported. However, the problem of residual laxity after surgery is not unusual with conventional techniques. This study aims to introduce a modified PCL reconstruction with remnant preservation and graft tension relieving. Meltlods Between December 2008 and June 2011, 36 cases of PCL reconstruction were performed in our institute, 20 with conventional technique （Group I） and 16 with modified technique （Group II）. Pre- and post-operative results of the international knee documentation committee knee evaluation form （IKDC）, Lysholm, Tegner, and KT2000 side-to-side difference were obtained. Results Significant improvements of IKDC, Lysholm, Tegner, and KT2000 results after surgery were found in both groups. Group II showed better improvement in all subjective examinations and significantly more decrease of KT 2000 side-to-side difference. Conclusion Modified PCL reconstruction with remnant preservation and graft tension relieving showed better results in restoration of posterior stability compared to conventional technique.

关键词： posterior cruciate ligament reconstruction remnant preservation tension-relieving

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Prognostic Value of Feature-Tracking Circumferential Strain in Dilated Cardiomyopathy Patients with Severely Reduced Ejection Fraction Incremental to Late Gadolinium Enhancement

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Current Medical Science 2021年第1期41卷 158-166页

作者： Shcng-lei SHU Jing WANG Cheng WANG Feng ZHU yu-xi jia Lan ZHANG xiao-yue ZHOU Tian-jing ZHANG Chuan-sheng ZHENG Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Hubei Province Key Laboratory of Molecular Imaging Wuhan430022China Department of Cardiology Institute of CardiologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China MR Collaboration Siemens HealthineersShanghai201318China Philips Healthcare Guangzhou510055China

Myocardial fiber deformation measurements have been reported to be associated with adverse outcomes in patients with acute heart failure and those with myocardial ***,few studies have addressed the prognostic value of global circumferential strain(GCS)in dilated cardiomyopathy(DCM)patients with severely impaired systolic *** study aimed to evaluate the prognostic value of cardiac magnetic resonance(CMR)-derived GCS in DCM patients with severely reduced *** DCM patients with severely reduced ejection fraction(EF<35%)who underwent CMR were *** was calculated from CMR cine *** clinical endpoint was a composite of all-cause mortality,heart transplantation,implantable cardioverter defibrillator(ICD)implantation and aborted sudden cardiac death(SCD).A total of 129 patients with a mean EF of 15.33%(11.36%–22.27%)were *** a median follow-up of 518 days,endpoint events occurred in 50 *** with GCS≥the median(−5.17%)had significantly reduced event-free survival as compared with those with GCS

关键词： cardiac magnetic resonance imaging circumferential strain prognosis late gadolinium enhancement dilated cardiomyopathy

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出厂物流调度问题及其启发式算法

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上海交通大学学报 2008年第9期42卷 1520-1523页

作者：于希嘉陈峰上海交通大学工业工程与物流工程系上海200240

针对出厂物流调度问题,建立了一类出厂物流问题的调度理论模型,证明了该问题的强NP-hard特性.基于对问题的特征分析,提出求解问题的近似算法,证明了算法的最坏性能比为3且为紧界,并通过数值仿真验证了该算法的有效性.结果表明,所提出算... 详细信息

针对出厂物流调度问题,建立了一类出厂物流问题的调度理论模型,证明了该问题的强NP-hard特性.基于对问题的特征分析,提出求解问题的近似算法,证明了算法的最坏性能比为3且为紧界,并通过数值仿真验证了该算法的有效性.结果表明,所提出算法对两台流水作业机器的完工时间有一定的优化.

关键词：出厂物流调度启发式算法计算复杂性

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Pharmacological Mechanism of Chinese Medicine in Systemic Lupus Erythematosus:A Narrative Review

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Chinese Journal of Integrative Medicine 2025年第2期31卷 157-169页

作者： ZHU Bo-yu LIU Zhi-chao ZHAO Zhen-xi HUANG Hui-ping ZHANG Na xiA jia CHEN Wei-wei Department of Rheumatology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai(200071)China

Systemic lupus erythematosus(SLE)is a chronic autoimmune disorder affecting multiple systems,characterized by the development of harmful autoantibodies and immune complexes that lead to damage in organs and *** medicine(CM)plays a role in mitigating complications,enhancing treatment effectiveness,and reducing toxicity of concurrent medications,and ensuring a safe ***,CM mainly solves the disease comprehensively through multi-target and multi-channel regulation process,therefore,its treatment mechanism is often complicated,involving many molecular *** review introduces the research progress of pathogenesis of SLE from the aspects of genetics,epigenetics,innate immunity and acquired immunity,and then discusses the molecular mechanism and target of single Chinese herbal medicine and prescription that are commonly used and effective in clinic to treat SLE.

关键词： systemic lupus erythematosus Chinese medicine natural extracts treatment review

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How does Hedgehog signaling participate in the cross-interaction of hormones and testis development?

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BIOCELL 2025年第1期49卷 93-107页

作者： JUN-JIE yu WAN-xi YANG The Sperm Laboratory College of Life SciencesZhejiang UniversityHangzhou310058China

Hedgehog(HH)signaling has been researched for decades and Hedgehog has 3 homologs:Sonic Hedgehog(Shh),Indian Hedgehog(Ihh),and Desert Hedgehog(Dhh).Dhh is the one involved in male gonad and germ cell *** distribution of molecules in Hedgehog signaling in testis indicated that Hedgehog signaling executes important functions during testis *** patients with Dhh signaling deficiency develop dysgenesis of gonads and hormone production which demands further exploration of gonad HH *** results proved the indispensable roles of HH signaling in gonad and germ cell development and the interaction with *** review evaluates HH functions in the testis and how HH affects and is affected by hormones and provides novel insights about HH signaling to the readers.

关键词： Hedgehog signaling Hormone Testis Leydig cell Gonadal dysgenesis

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Preparation and Selectivity of Molecularly Imprinted Polymer Coating on the Micro Pore Membrane of Polytetrafluoroethylene

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Chinese Chemical Letters 2003年第9期14卷 979-982页

作者： Hong Sheng GUO, yu Mei jia, xi Wen HEState Key Laboratory of Functional Polymer Materials for Adsorption and Separation,Department of Chemistry, Nankai University, Tianjin 300071 The College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin 300072 State Laboratory of Functional Polymer Materials for Adsorption and Separation Department of Chemistry Nankai University The College of Pharmaceuticals and Biotechnology Tianjin University

In order to obtain mechanically stable membrane for practical application, the imprinted polymer was synthesized in the pores of polyfluoromembrane, the binding and transport ability of the membrane were studied.

关键词： Molecular imprinting trimethoprim membrane of polytetrafluoroethylene.

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Residual symmetry and interactions between solitons and periodic waves of the Drinfeld-Sokolov-Satsuma-Hirota system

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Communications in Theoretical Physics 2025年第1期77卷 1-10页

作者： Jie-tong Li Jun yu xi-zhong Liu Institute of Nonlinear Science Shaoxing UniversityShaoxing 312000China

In this paper,the Drinfeld-Sokolov-Satsuma-Hirota(DSSH)system is studied by using residual symmetry and the consistent Riccati expansion(CRE)method,*** residual symmetry of the DSSH system is localized to Lie point symmetry in a properly prolonged system,based on which we get a new Bäcklund transformation for this *** symmetry reduction solutions of the DSSH system are obtained by applying the classical Lie group approach on the prolonged ***,the DSSH system proves to be CRE integrable and new interesting interaction solutions between solitons and periodic waves are generated and analyzed.

关键词： Drinfeld-Sokolov-Satsuma-Hirota system residual symmetry consistent Riccati expansion

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Ferroptosis biomarkers predict tumor mutation burden's impact on prognosis in HER2-positive breast cancer

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World Journal of Clinical Oncology 2024年第3期15卷 391-410页

作者： Jin-yu Shi xin Che Rui Wen Si-jia Hou yu-jia xi Yi-Qian Feng Ling-xiao Wang Shi-jia Liu Wen-Hao Lv Ya-Fen Zhang Department of Breast Surgery The Fifth Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina The Fifth Clinical Medical College Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Colorectal Surgery The Fifth Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina College of Pharmacy Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Neurology The First Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Urology The Second Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Breast Surgery The First Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina

BACKGROUND Ferroptosis has recently been associated with multiple degenerative *** induction in cancer cells is a feasible method for treating neoplastic ***,the association of iron proliferation-related genes with prognosis in HER2+breast cancer(BC)patients is *** To identify and evaluate fresh ferroptosis-related biomarkers for HER2+*** First,we obtained the mRNA expression profiles and clinical information of HER2+BC patients from the TCGA and METABRIC public databases.A four gene prediction model comprising PROM2,SLC7A11,FANCD2,and FH was subsequently developed in the TCGA cohort and confirmed in the METABRIC *** were stratified into high-risk and low-risk groups based on their median risk score,an independent predictor of overall survival(OS).Based on these findings,immune infiltration,mutations,and medication sensitivity were analyzed in various risk ***,we assessed patient prognosis by combining the tumor mutation burden(TMB)with risk ***,we evaluated the expression of critical genes by analyzing single-cell RNA sequencing(scRNA-seq)data from malignant vs normal epithelial *** We found that the higher the risk score was,the worse the prognosis was(P<0.05).We also found that the immune cell infiltration,mutation,and drug sensitivity were different between the different risk *** highrisk subgroup was associated with lower immune scores and high ***,we found that the combination of the TMB and risk score could stratify patients into three groups with distinct ***-HTMB patients had the worst prognosis,whereas LRisk-LTMB patients had the best prognosis(P<0.0001).Analysis of the scRNAseq data showed that PROM2,SLC7A11,and FANCD2 were significantly differentially expressed,whereas FH was not,suggesting that these genes are expressed mainly in cancer epithelial cells(P<0.01).CONCLUSION Our model helps guide the prognosis of HER2+breast cancer pa

关键词： HER2+breast cancer Ferroptosis Tumor mutation burden Single-cell RNA sequencing Prognosis

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