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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing Xue yuejia Ma Ke Ye Xue zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang Jian Wu Hui Hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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A novel route to enhance high-temperature mechanical property and thermal shock resistance of low-carbon Mgo-C bricks by introducing ZrSiO_(4)

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Journal of Iron and Steel Research International 2024年第6期31卷 1436-1448页

作者： Chun-hui Sun Ling-ling Zhu Hao Yan Wei zhao Jing-xuan Liu Lin Ren Xian-tang zhao Xiao-song tong Shu-wen yu Beijing Lirr High-Temperature Materials Co. Ltd.Beijing 102211China School of Materials Science and Engineering Henan Province Industrial Technology Research Institute of Resources and MaterialsZhengzhou UniversityZhengzhou 450001HenanChina School of Chemistry and Chemical Engineering Suzhou UniversitySuzhou 234000AnhuiChina

Conventional MgO-C bricks(graphite content>14 wt.%)produce a great deal of greenhouse gas emission,while low-carbon MgO-C bricks have serious thermal shock resistance during high-temperature *** enhance the high-temperature mechanical property and thermal shock resistance of low-carbon MgO-C bricks,a novel route of introducing ZrSiO_(4) powder into low-carbon MgO-C bricks was reported in such refractories with 2 wt.% flaky *** results indicate that the low-carbon MgO-C brick with 0.5 wt.%ZrSiO_(4) addition has the maximum hot modulus of rupture at 1400℃ and the corresponding specimen fired in the carbon embedded atmosphere has the maximum residual strength ratio(98.6%)after three thermal shock *** is found that some needle-like AlON and plate-like Al_(2)O_(3)-ZrO_(2) composites were in situ formed in the matrices after the low-carbon MgO-C bricks were coked at 1400℃,which can enhance the high-temperature mechanical property and thermal shock resistance due to the effect of fiber toughening and particle ***,CO_(2) emission of the newly developed low-carbon MgO-C bricks is reduced by 58.3% per ton steel after using them as the working lining of a 90 t vacuum oxygen decarburization ladle.

关键词： Low-carbon MgO-C brick ZrsiO_(4) Synergistic toughening effect High-temperature mechanical property Thermal shock resistance Vacuum oxygen decarburization ladle

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Broadcasting of Entanglement in Three-Particle Greenberger-Horne-Zeilinger State via Quantum Copying

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Chinese Physics Letters 2000年第7期17卷 469-471页

作者： tong zhao-Yang KUANG Le-Man Department of Physics Hu'nan Normal UniversityChangsha 410081

We introduce entanglement measures to describe entanglement in a three-particle system and apply it to studying broadcasting of entanglement in the three-particle Greenberger-Horne-Zeilinger (GHZ) state. The results show that the entanglement of the three-qubit GHZ state can be partially broadcasted with the help of local or non-local copying processes. It is found that non-local cloning is much more efficient than local cloning for the broadcasting of entanglement.

关键词： processes state local

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Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： Jiali Chen Yiyang Li Xingping Quan Jinfen Chen Yan Han Li Yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua zhao Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina Department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

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Flexible quasi-solid-state sodium-ion full battery with ultralong cycle life,high energy density and high-rate capability

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Nano Research 2022年第2期15卷 925-932页

作者： Chen-De zhao Jin-Zhi Guo Zhen-Yi Gu Xiao-tong Wang Xin-Xin zhao Wen-Hao Li Hai-yue yu Xing-Long Wu Faculty of Chemistry Northeast Normal UniversityJilin 130024China MOE Key Laboratory for UV Light-Emitting Materials and Technology Northeast Normal UniversityJilin 130024China

Flexible power sources featuring high-performance,prominent flexibility and raised safety have received mounting attention in the area of wearable electronic ***,many great challenges remain to be overcome,notably the design and fabrication of flexible electrodes with excellent electrochemical performance and matching them with safe and reliable ***,a facile approach for preparing flexible electrodes,which employs carbon cloth derived from commercial cotton cloth as the substrate of cathode and a flexible anode,is proposed and *** promising cathode(NVPOF@FCC)with high conductivity and outstanding flexibility is prepared by efficiently coating Na_(3)V_(2)(PO_(4))_(2)O_(2)F(NVPOF)on flexible carbon cloth(FCC),which exhibits remarkable electrochemical performance and the significantly improved reaction *** importantly,a novel flexible quasi-solid-state sodium-ion full battery(QSFB)is feasibly assembled by sandwiching a P(VDF-HFP)-NaClO_(4) gel-polymer electrolyte film between the advanced NVPOF@FCC cathode and FCC *** the QSFBs are further evaluated in flexible pouch cells,which not only demonstrates excellent energy-storage performance in aspect of great cycling stability and high-rate capability,but also impressive flexibility and *** work offers a feasible and effective strategy for the design of flexible electrodes,paving the way for the progression of practical and sustainable flexible batteries.

关键词： flexible sodium-ion battery gel-polymer electrolyte quasi-solid-state carbon cloth Na_(3)V_(2)(PO_(4))_(2)O_(2)F

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Subnetwork-based federated few-shot semantic segmentation of organ images

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Optoelectronics Letters 2025年

作者： Wu Junpeng zhao Meng Zhang Huanping Key Laboratory of Computer Vision and System of Ministry of Education， School of Computer Science and Engineering， Tianjin University of Technology

Federated learning(FL)， as a distributed learning paradigm， allows multiple medical institutions to collaborate on learning without the need to centralize all client data. However， existing methods pay little attention to more challenging medical image semantic segmentation tasks， especially in the scenario of the imbalanced dataset in federated few-shot learning. In this paper， we propose a subnetwork-based federated few-shot organ image segmentation method. Firstly， individual clients train using local training samples and then upload local model gradients to the server. The server utilizes their respective local model gradients to update the subnetwork maintained on the server and generate aggregation weights for forming personalized model parameters. Through this method， we can learn the similarities between different clients to address data heterogeneity issues. In addition， to enhance the communication efficiency between clients and the server， we have also designed a personalized layer aggregation strategy， which only transmits partial layer model parameters during the communication process to improve communication efficiency. Finally， we conducted experiments on ABD-MRI and ABD-CT datasets to demonstrate the effectiveness of our method.

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A Virulent PEDV Strain FJzz1 with Genomic Mutations and Deletions at the High Passage Level Was Attenuated in Piglets via Serial Passage In Vitro

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Virologica Sinica 2021年第5期36卷 1052-1065页

作者： Pengfei Chen Xiongwei zhao Shuting Zhou Tianxing Zhou Xiangmei Tan Xia Wu Wu tong Fei Gao Lingxue yu Yifeng Jiang Hai yu Zhibiao Yang Guangzhi tong Yanjun Zhou Department of Swine Infectious Diseases Shanghai Veterinary Research InstituteChinese Academy of Agricultural SciencesShanghai 200241China Shanghai Key Laboratory of Veterinary Biotechnology School of Agriculture and BiologyShanghai JiaoTong UniversityShanghai 200240China College of Biological Science and Technology Beijing Forestry UniversityBeijing 100083China Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Yangzhou UniversityYangzhou 225009China

Highly virulent porcine epidemic diarrhea virus(PEDV)strains re-emerged and circulated in China at the end of 2010,causing significant economic losses in the pork industry *** understand the genetic dynamics of PEDV during its passage in vitro,the PEDV G2 strain FJzzl was serially propagated in Vero cells for up to 200 *** susceptibility and adaptability of the FJzzl strain increased gradually as it was serially passaged in *** analysis revealed that amino acid(aa)changes were mainly concentrated in the S glycoprotein,which accounted for 72.22%-85.71%of all aa changes.A continuous aa deletion(^(55)I^(56)G^(57)E→^(55)K^(56)Δ^(57)Δ)occurred in the N-terminal domain of S1(Sl-NTD).To examine how the aa changes affected its virulence,FJzzl-F20 and FJzzl-F200 were selected to simultaneously evaluate their pathogenicity in suckling *** the piglets in the FJzzl-F20-infected group showed typical diarrhea at 24 h postinfection,and the piglets died successively by 48 h ***,the clinical signs of the piglets in the FJzzl-F200-infected group were significantly weaker,and no deaths *** FJzzl-F200-infected group also showed a lower level of fecal viral shedding and lower viral loads in the intestinal tissues,and no obvious histopathological ***ⅠandⅢinterferon were induced in the FJzzl-F200 infection group,together with pro-inflammatory cytokines,such as TNF-α,IL-1βand *** results indicate that the identified genetic changes may contribute to the attenuation of FJzzl strain,and the attenuated FJzzl-F200 may have the potential for developing PEDV live-attenuated vaccines.

关键词： Porcine epidemic diarrhea virus(PEDV) Serially passage Genetic variation Pathogenicity

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武汉东湖底栖动物多样性分布的影响因素及历史变化

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湖泊科学 2025年第1期37卷 204-214页

作者：喻曾曾和雅静吴俊燕赵永晶崔永德中国科学院水生生物研究所武汉430072 中国科学院大学现代农业科学学院北京100049

探究城市湖泊物种和功能多样性分布及其历史变化有助于了解人类干扰对生态系统的影响。本研究于20202021年对武汉东湖不同湖区的底栖动物进行3次季节性调查,并搜集了19702020年文献中的历史数据,就底栖动物物种、功能和系统发育多样性... 详细信息

探究城市湖泊物种和功能多样性分布及其历史变化有助于了解人类干扰对生态系统的影响。本研究于20202021年对武汉东湖不同湖区的底栖动物进行3次季节性调查,并搜集了19702020年文献中的历史数据,就底栖动物物种、功能和系统发育多样性的空间分布和历史变化进行了比较,通过获取2000、2010及2020年东湖湖滨带1 km缓冲区的不同土地利用方式占比变化,分析了底栖动物多样性与环境因子之间的相关性。结果表明:调查共记录底栖动物97属种,团湖总种类数最高,后湖功能丰富度最高,功能均匀度在庙湖最高,在菱角湖最低,系统发育的分类多样性指数在团湖最高,分类差异指数在庙湖最高。总物种数与总氮、总磷呈负相关,耐污种种类数与总磷呈负相关,功能均匀度与耕地占比呈正相关,功能丰富度与总氮、总磷呈负相关,分类多样性指数与总氮、总磷呈负相关。结合历史数据,1970s 2020s水生昆虫占比呈现先下降后上升的趋势,到2010s底栖动物有个体小型化的趋势,后有所恢复。

关键词：底栖动物功能多样性土地利用历史变化东湖

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Properties and mechanism of ionic liquid/silicone oil based magnetorheological fluids

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International Journal of Smart and Nano Materials 2022年第2期13卷 263-272页

作者： yu tong Penghui zhao Xiaoguang Li Ning Ma Xufeng Dong Chenguang Niu Zhanjun Wu Min Qi School of Materials Science and Engineering Dalian University of TechnologyDalianPeople’s Republic of China School of Aeronautics and Astronautics Dalian University of TechnologyDalianPeople’s Republic of China School of Civil Engineering Dalian University of TechnologyDalianPeople’s Republic of China School of Mechanical and Transportation Engineering Taiyuan University of TechnologyTaiyuanPeople’s Republic of China Taiyuan tongze Heavy Industry Co LtdTaiyuanPeople’s Republic of China

A magnetorheological fluid(MRF)is a smart composite suspension composed of nonmagnetic liquid and soft magnetic *** fluids can considerably influence the performance of MRFs;therefore,to investigate the effect of carrier fluids on MRFs,an SO/IL-MRF was prepared by mixing an ionic liquid(IL)with silicone oil(SO)in this *** types of MRF samples were prepared for experiments(pure SO,pure IL,and SO/IL).According to the experi-mental results,the SO/IL-MRF has better sedimentation stability than those based on pure SO and pure ***,three methods were used to determine the shear yield stresses of the *** SO/IL-MRF achieved a higher shear yield stress than those of the other two because a network structure is formed between the ionic fragments and the molecular chains of the SO in the SO/*** increases the movement resistance of the particles in the carrier fluid,and it is unlike the mechanism of the IL-enhanced *** work provides new ideas for improving the MRF performance.

关键词： Magnetorheological fluids ionic liquid mixed carrier fluid sedimentation yield stress

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