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Evaluation of genotoxicity of combined soil pollution by cadmium and phenanthrene on earthworm

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Journal of Environmental Sciences 2006年第6期18卷 1210-1215页

作者： ZHU Jiang zhao Zuo-yuan LU Yi-tong School of Agriculture and Biology Shanghai Jiao Tong University Shanghai 201101 China

The DNA-damaging effects of the combined pollution of heavy metal and organic contamination on earthworms were evaluated by single cell gel electrophoresis （SCGE） assay. Earthworms Eisenia andrei were exposed to single or combined test compounds in different doses of cadmium （Cd） 5, 10, 50 mg/kg and phenanthrene （Phe） 0.5, 2.5, 12.5 mg/kg with a treatment of 14 d. In SCGE assay, isolated coelomcytes and electrophoresis were employed to determine DNA damage degree after a 14-d treatment by test compounds. The results showed that there was a significant statistical difference between earthworms treated with Cd combined Phe with them treated alone with Cd or Phe. The Olive tail moment （OTM） of SCGE assay using earthworm coelomcytes appears to be a sensitive biomarker for evaluating exposure to genotoxic compounds. These tests also revealed that the interaction between Cd and Phe to DNA damaging effects was negative, and was strongly dependent on the concentration of pollution. This study corresponds to exploratory phase in order to reveal interaction effects of heavy metal and organic contamination on earthworms and then to set up more in-depth analysis to increase progressively the understanding of the genotoxicity mechanisms involved.

关键词： Cd Phe earthworm combined pollution SCGE DNA damage

Premature deposition of lithium polysulfide in lithium-sulfur batteries

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Journal of Energy Chemistry 2023年第7期82卷 507-512,I0011页

作者： Zi-Xian Chen yu-tong Zhang Chen-Xi Bi Meng zhao Rui Zhang Bo-Quan Li Jia-Qi Huang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China

Lithium-sulfur(Li-S)batteries have attracted extensive attention due to ultrahigh theoretical energy density of 2600 Wh kg^(-1).Liquid-solid deposition from dissolved lithium polysulfides(LiPSs)to solid lithium sulfide(Li_(2)S)largely determines the actual battery ***,a premature liquidsolid deposition process of LiPSs is revealed at higher thermodynamic potential than Li_(2)S deposition in Li-S *** premature solid deposit exhibits higher chemical state and hemispherical morphology in comparison with Li_(2)S,and the premature deposition process is slower in kinetics and higher in deposition ***,a supersaturation deposition mechanism is proposed to rationalize the above findings based on thermodynamic *** work demonstrates a unique premature liquid-solid deposition process of Li-S batteries.

关键词： Lithium-sulfur batteries Lithium polysulfides Liquid-solid deposition Supersaturation

Boron-containing Phthalonitrile Resin:Synthesis,Curing Behavior,and Thermal Properties

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Chinese Journal of Polymer Science 2022年第11期40卷 1349-1359页

作者： Shu-Yi Zhan yue Han yu-Huan Wu Jiang-Nan Ding Xiang Liu Ying Guo Heng Zhou tong zhao Key Laboratory of Science and Technology on High-tech Polymer Materials Institute of Chemistry Chinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China South China Advanced Institute for Soft Matter Science and Technology South China University of TechnologyGuangzhou510640China

A novel boron-containing monomer,(4-(3,4-dicyanophenoxy)phenyl)boronic acid(BPhPN)was synthesized and used to promote the curing process of phthalonitrile monomer 1,3-bis(3,4-dicyanophenoxy)benzene(MPN).Differential scanning calorimetry and rheological analysis were used to study the curing behaviors of BPhPN/MPN(namely B-MPN),and results suggested that B-MPN systems have better *** spectra and solid-state 13C-NMR exhibited triazine and isoindoline have been formed in the curing ***-containing Lewis acid curing mechanism was preliminarily speculated and verified by two model compounds with different boron chemical *** thermogravimetric analysis and dynamic mechanical analysis demonstrated that the cured B-MPN polymers showed excellent thermal stability and heat resistance,which were comparable with conventional catalytic systems for phthalonitrile *** study not only presented a novel curing system for phthalonitrile resins,but also shed light on future design of high temperature thermosets.

关键词： Curing agent Phthalonitrile resins Thermosets Boron-containing polymer

Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu Wei Huang Jiayi Wen Xin Xiong Ting Xu Qi Wang Xiusheng Chen Xianxian zhao Shihua Li Xiaojiang Li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

Using X-ray computed tomography and micro-Raman spectrometry to measure individual particle surface area, volume, and morphology towards investigating atmospheric heterogeneous reactions

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Journal of Environmental Sciences 2018年第7期30卷 23-32页

作者： Mingjin Wang Nan Zheng tong Zhu Jing Shang Ting yu Xiaojuan Song Defeng zhao Yong Guan Yangchao Tian BIC-ESAT and SKL-ESPCl College of Environmental Sciences and Engineering Peking University Beijing 100871 China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029 China

Heterogeneous reactions on the aerosol particle surface in the atmosphere play important roles in air pollution, climate change, and global biogeochemical cycles. However, the reported uptake coefficients of heterogeneous reactions usually have large variations and may not be relevant to real atmospheric conditions. One of the major reasons for this is the use of bulk samples in laboratory experiments, while particles in the atmosphere are suspended individually. A number of technologies have been developed recently to study heterogeneous reactions on the surfaces of individual particles. Precise measurements on the reactive surface area, volume, and morphology of individual particles are necessary for calculating the uptake coefficient, quantifying reactants and products, and understanding the reaction mechanism better. In this study, for the first time we used synchrotron radiation X-ray computed tomography（XCT） and micro-Raman spectrometry to measure individual CaCO_3 particle morphology, with sizes ranging from 3.5–6.5 μm. Particle surface area and volume were calculated using a reconstruction method based on software threedimensional（3-D） rendering. The XCT was first validated with high-resolution fieldemission scanning electron microscopy（FE-SEM） to acquire accurate CaCO_3 particle surface area and volume estimates. Our results showed an average difference of only 6.1% in surface area and 3.2% in volume measured either by micro-Raman spectrometry or X-ray tomography. X-ray tomography and FE-SEM can provide more morphological details of individual Ca CO3 particles than micro-Raman spectrometry. This study demonstrated that X-ray computed tomography and micro-Raman spectrometry can precisely measure the surface area, volume, and morphology of an individual particle.

关键词： Heterogeneous reactions Individual CaCO3 particle Micro-Raman spectrometry Synchrotron radiation X-ray computed tomography Morphology Surface area Volume

Precipitation and heterogeneous strengthened CoCrNi-based medium entropy alloy with excellent strength-ductility combination from room to cryogenic temperatures

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Science China(Technological Sciences) 2022年第8期65卷 1780-1797页

作者： XIE yu zhao PengCheng tong YongGang TAN JianPing SUN BinHan CUI Yan WANG RunZi ZHANG XianCheng TU ShanTung Key Laboratory of Pressure Systems and Safety Ministry of EducationSchool of Mechanical and Power EngineeringEast China University of Science and TechnologyShanghai 200237China College of Automobile and Mechanical Engineering Changsha University of Science and TechnologyChangsha 410114China Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center Institute of Fine ChemicalsSchool of Chemistry&Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China

The improved understandings of the mechanical properties as well as deformation mechanisms at cryogenic temperatures are the prerequisite for realizing the application of any new engineering materials to cryogenic ***,a(CoCrNi)_(94)Al_(3)Ti_(3) medium entropy alloy(MEA)with nanoscale L12 coherent precipitates and heterogeneous grain structures was prepared by codoping Al and Ti elements with subsequent cold rolling and heat treatment *** mechanical properties were evaluated at the temperature range of 293–113 *** ultimate strength of the MEA increases almost linearly from 1326 to 1695 MPa as the temperature decreases from 293 to 113 K,while the total elongation remains approximately constant of~35%.The underlying deformation and strengthening mechanisms were investigated using various characterization *** to the effect of co-doped Al/Ti on channel width of the matrix and the increasing critical twinning stress induced by heterogeneous ultrafine grain size,the formation of deformation twins is inhibited at all ***,only a slight increase of the deformation twins and stacking faults in the deformed specimens with a decreasing temperature,which leads to the relative temperature-independence of the *** dislocation cutting mechanism of L1_(2) coherent precipitates and the heterodeformation induced(HDI)hardening both significantly contribute to the strain hardening so that an excellent combination of strength and ductility is ***,the evolution of lattice friction stress with deformation temperature is determined by quantitative analysis,indicating an approximately linear relationship between the lattice friction and *** present work provides new insights into the strategy of achieving outstanding strength-ductility synergy of the MEA under the wide temperature range by coupling heterogeneous ultrafine-grained structure and coherent precipitation strategy.

关键词： medium entropy alloy cryogenic temperature heterogeneous structure precipitation strengthening twinning

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Mid-infrared plasmonic silicon quantum dot/HgCdTe photodetector with ultrahigh specific detectivity

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Science China(Information Sciences) 2023年第4期66卷 286-292页

作者： yueying CUI Zhouyu tong Xinlei ZHANG Wenhui WANG Weiwei zhao yuanfang yu Xiaodong PI Jialin ZHANG Zhenhua NI School of Physics and Key Laboratory of MEMS of Ministry of Education Southeast University State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University

Highly sensitive photodetectors operating at mid-infrared(MIR) wavelengths are urgently required for the applications of astronomy, optical communication, security monitoring, and so forth. However,further promoting the sensitivity in conventional MIR devices for a higher detectivity is challenging. Among the potential strategies, integrating localized surface plasmon resonance with MIR semiconductors is a promising approach to developing high-performance optoelectronics. Here we demonstrate a high-sensitivity boron(B)-doped silicon quantum dot(Si-QD)/HgCdTe(MCT) MIR photodetector. Because of plasmon-induced hot-hole tunneling and enhanced light absorption, the hybrid photodetector exhibits a high specific detectivity of ～1.6×109cm·Hz1/2·W-1(Jones) and a high-speed response(～224 ns for the rise time and ～580 ns for the fall time) at room temperature. Furthermore, the device achieves high-performance spectral blackbody detection with a peak detectivity of up to 1.6×1011Jones at ～5.8 μm under a cryogenic environment of 77 K, higher than that of bare MCT. This prominent enhancement can be attributed to the further suppression of hot-hole cooling due to a reduced phonon population at low temperatures, which facilitates more efficient hot-carrier extraction and contributes to ultrahigh sensitivity. The plasmonic material-integrated MCT architecture can pave the way for developing high-performance MIR photodetection.

关键词： doped silicon quantum dots HgCdTe localized surface plasmon resonance hot-hole tunneling mid-infrared photodetector

Study on the prediction and inverse prediction of detonation properties based on deep learning

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Defence Technology（防务技术） 2023年第6期24卷 18-30页

作者： Zi-hang Yang Ji-li Rong Zi-tong zhao Department of Mechanics School of Aerospace EngineeringBeijing Institute of TechnologyBeijing100081China

The accurate and efficient prediction of explosive detonation properties has important engineering significance for weapon *** methods for predicting detonation performance include empirical formulas,equations of state,and quantum chemical calculation *** recent years,with the development of computer performance and deep learning methods,researchers have begun to apply deep learning methods to the prediction of explosive detonation *** deep learning method has the advantage of simple and rapid prediction of explosive detonation ***,some problems remain in the study of detonation properties based on deep *** example,there are few studies on the prediction of mixed explosives,on the prediction of the parameters of the equation of state of explosives,and on the application of explosive properties to predict the formulation of *** on an artificial neural network model and a one-dimensional convolutional neural network model,three improved deep learning models were established in this work with the aim of solving these *** training data for these models,called the detonation parameters prediction model,JWL equation of state(EOS)prediction model,and inverse prediction model,was obtained through the KHT thermochemical *** training,the model was tested for overfitting using the validation-set *** the model-accuracy test,the prediction accuracy of the model for real explosive formulations was tested by comparing the predicted value with the reference *** results show that the model errors were within 10%and 3%for the prediction of detonation pressure and detonation velocity,*** accuracy refers to the prediction of tested explosive formulations which consist of TNT,RDX and *** the prediction of the equation of state for explosives,the correlation coefficient between the prediction and the reference curves was above *** the prediction of the inverse predi

关键词： Deep learning Detonation properties KHT thermochemical Code JWL equation of states Artificial neural network One-dimensional convolutional neural network

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共病药物治疗决策--全科医生接诊病案研究

中国全科医学 2025年第1期28卷 119-124页

作者：罗原徐志杰夏瑀石佳娜蒋志志周馨媚赵洋童钰铃浙江大学医学院附属第二医院全科医学科浙江省杭州市310009 浙江省杭州市上城区小营街道社区卫生服务中心 310009 北京大学深圳医院全科医学科广东省深圳市518036 浙江省人民医院(杭州医学院附属人民医院)药学部浙江省杭州市310014 新南威尔士大学乔治全球健康研究院澳大利亚悉尼2050 墨尔本大学人口与全球健康学院澳大利亚墨尔本3010

慢性病共病患者常联合使用多种药物,疾病与药物之间潜在的复杂相互作用使全科医生面临着难以合理评估共病药物治疗获益与风险的决策困境。本文以1例在社区卫生服务中心就诊的慢性病共病患者为例,展示和阐述了全科医生运用共病药物治疗... 详细信息

慢性病共病患者常联合使用多种药物,疾病与药物之间潜在的复杂相互作用使全科医生面临着难以合理评估共病药物治疗获益与风险的决策困境。本文以1例在社区卫生服务中心就诊的慢性病共病患者为例,展示和阐述了全科医生运用共病药物治疗决策框架进行科学决策的过程,并基于阿里阿德涅原则为共病管理过程提出的多阶段目标,分析了全科医生在评估、沟通与制定治疗方案等方面的要点和注意事项。希望本文可以为改善社区慢性病共病药物治疗决策的质量提供借鉴。

关键词：慢性病共病接诊全科医生药物治疗决策病例报告