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体外膜肺氧合联合导管介入治疗在高危急性肺栓塞中的应用

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中国急救医学 2018年第3期38卷 232-236页

作者：稂与恒李彤赵成秀胡晓旻段大为魏锦吴鹏高文卿宁萌马群兴天津医科大学三中心临床学院天津市第三中心医院心脏中心天津市第三中心医院心血管研究中心天津市人工细胞重点实验室天津300170 天津市第三中心医院高干病房天津300170

目的总结体外膜肺氧合（ECMO）辅助下联合导管介入治疗在高危急性肺栓塞（APE）中的经验及治疗效果。方法我院于2014-08~2016-11为4例APE患者在经口气管插管接呼吸机辅助下，行ECMO辅助联合导管介入治疗。3例患者入院时处于心脏骤停... 详细信息

目的总结体外膜肺氧合（ECMO）辅助下联合导管介入治疗在高危急性肺栓塞（APE）中的经验及治疗效果。方法我院于2014-08~2016-11为4例APE患者在经口气管插管接呼吸机辅助下，行ECMO辅助联合导管介入治疗。3例患者入院时处于心脏骤停状态，1例患者处于心源性休克状态，均予以心外按压、经口气管插管接呼吸机及ECMO辅助，明确诊断为APE后均于ECMO辅助下行导管介入治疗。2例患者行机械碎、溶栓治疗，2例患者行机械碎栓治疗，其中1例患者介入后合并胸廓内动脉分支破裂出血同期行栓塞治疗。结果 2例患者未脱离ECMO，停机后死亡；2例顺利脱离ECMO及呼吸机辅助，其中1例并发多脏器功能衰竭死亡，1例无明显并发症顺利出院，随访良好。结论 ECMO辅助下联合导管介入治疗为APE患者提供了一种有效的治疗方法，具有较好的临床救治效果。

关键词：急性肺栓塞(APE) 体外膜肺氧合(ECMO) 经皮导管介入

A method to refine the start-up scheme of compression and refrigeration systems in ethylene plants via dynamic simulation

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Chinese Journal of Chemical Engineering 2016年第8期24卷 1007-1012页

作者： Shengfu Zhang Yongchen zhao tong Qiu Guang Song Jinsong zhao Department of Chemical Engineering Tsinghua University China Huanqiu Contracting & Engineering Corporation

Starting the cracking gas compressor and precooling the refrigeration system are keys to start-up of an ethylene plant and accounts for up to 50% of the total start-up time and plant flare emissions. Premature feeding of cracking furnaces can be avoided if the cracking gas compressor is started and the refrigeration system is precooled in advance using mixed gas as the start-up working medium(SWM). Start-up scenario with mixed gas as SWM could significantly reduce the emission loss and shorten the precooling time. Research shows that making appropriate start-up scheme is important not only to ensure operational safety and feasibility, but also to reduce energy consumption. In this paper, a method is proposed to select suitable start-up operational parameters of compression and refrigeration system with sufficient safe operating ranges and short precooling time. The complex interrelation among key parameters of start-up is analyzed. It is found that higher energy consumption, especially for super high-pressure steam(SS), can promote operational safety and shorten the precooling time during *** on steady-state and dynamic simulation, appropriate operating parameter ranges are determined with reasonable SS consumption. A real case study demonstrates that an appropriate start-up scheme will optimize the operation.

关键词： Start-up Ethylene plant Start-up working medium Mixed gas run Compression system

New route to synthesize preceramic polymers for zirconium carbide

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Chinese Chemical Letters 2012年第9期23卷 1075-1078页

作者： Xue yu Tao Wen Feng Qiu Hao Li tong zhao Xian Yong Wei School of Materials Science and Engineering China University of Mining and TechnologyChina Xuzhou 221116 Laboratory of Advanced Polymer Materials lnstute of ChemistryChinese Academy of SciencesChina Beijing 100190 School of Chemical Engineering and Technology China University of Mining and TechnologyChina Xuzhou 221116

A preceramic polymer, polyzirconosaal （PZSA）, was synthesized by the ligand-exchange reaction between polyzirconoxane （PZO） and salicyl alcohol （SA）. The precursor was air-stable and exhibited excellent solubility and rheology. These properties are useful for the processing of C/C-ZrC composites v/a precursor infiltration and pyrolysis （PIP） process. The polymer to ceramic conversion was investigated by TG, XRD and TEM. Nanosized ZrC was formed by pyrolysis of this precursor at 1300 ℃ in argon with ceramic yield of 57.8%.

关键词： Preceramic polymer Zirconium carbide Precursor infiltration and pyrolysis

Personalized federated few-shot node classification

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Science China(Information Sciences) 2025年第1期 204-218页

作者： yunfeng zhao Xintong HE Guoxian yu Jun WANG Yongqing ZHENG Carlotta DOMENICONI School of Software Shandong University Joint SDU-NTU Centre for Artificial Intelligence Research Shandong University Department of Mathematics National University of Singapore Department of Computer Science George Mason University

Personalized federated learning(PFL) aims to train customized models for individual clients in a decentralized setting, with the account of non-independent and identically distributed data across clients. However, most PFL methods adopt uniform classification layers for diverse clients and give rise to error-prone predictions, due to the task heterogeneity notably prominent in decentralized graph data scenarios. Although some PFL solutions setup client-specific classification layers for each client and optimize them only locally, they are corrupted with limited local training data. We propose an innovative solution called federated parameter decoupling and node augmentation(Fed PANo) to address these problems and to achieve personalized federated few-shot node classification, which is a prevalent and challenging but unexplored topic. Specifically, Fed PANo first separates the local model into the GNN and classifier to handle unique client-specific task variations. The GNN is trained through federated learning to capture shared knowledge of graph nodes across clients, while the classifier is custom-designed and trained individually for each client. Additionally, a generic classifier shared among clients is adopted to encourage the GNN's grasp of shared information. Then Fed PANo further proposes the node generator along with its local and collaborative training strategies to deal with the node scarcity of clients. Extensive experimental results on benchmark datasets confirm that Fed PANo outperforms eight competitive baselines across different settings.

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An Optimal Design of the Two-Staged Square Sectional Combined Energy Absorption Structure with Local Surface Nanocrystallization

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Acta Mechanica Solida Sinica 2021年第6期34卷 820-829页

作者： Xinsheng Xu Jianlong Qu tong Li Zhenzhen tong Zhen zhao Zhenhuan Zhou State Key Laboratory of Structural Analysis for Industrial Equipment and Department of Engineering Mechanics Dalian University of TechnologyDalian116024China College of Locomotive and Rolling Stock Engineering Dalian Jiaotong UniversityDalian116028China

In this paper,a local surface nanocrystallization technology is used for thin-walled structures with square cross sections,and an energy absorption device of two-staged combined energy absorption structure is *** virtue of the surface nanocrystallization that enables to change the material on local positions,the structural deformation is induced and controlled to maximize the energy absorption capacity.A numerical model of the two-staged combined energy absorption structure is established,and the local surface nanocrystallization layout is *** results show that the specific energy absorption of two-staged combined structure with local surface nanocrystallization can be increased by 34.36%compared with the untreated counterpart of the same material and structural *** ratio between the first and second peak crushing forces and the energy absorption allocation ratio between the two stages can be adjusted in the ranges of 0.26–0.55 and 0.31–0.45,respectively,which can be controlled by the local surface nanocrystallization *** numerical simulation and experimental results are in good agreement,which shows that the design for energy absorption device with local surface nanocrystallization is feasible and effective.

关键词： Local surface nanocrystallization Two-staged energy absorption Square cross-sectional thin-walled structure Specific energy absorption

Skull optical clearing window for in vivo imaging of the mouse cortex at synaptic resolution

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Light(Science & Applications) 2017年第1期6卷 150-158页

作者： Yan-Jie zhao Ting-Ting yu Chao Zhang zhao Li Qing-Ming Luo tong-Hui Xu Dan Zhu Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and TechnologyWuhan 430074China MoE Key Laboratory for Biomedical Photonics Collaborative Innovation Center for Biomedical EngineeringSchool of Engineering SciencesHuazhong University of Science and TechnologyWuhan 430074China

Imaging cells and microvasculature in the living brain is crucial to understanding an array of neurobiological ***,we introduce a skull optical clearing window for imaging cortical structures at synaptic *** with two-photon microscopy,this technique allowed us to repeatedly image neurons,microglia and microvasculature of *** applied it to study the plasticity of dendritic spines in critical periods and to visualize dendrites and microglia after laser *** its easy handling and safety,this method holds great promise for application in neuroscience research.

关键词： cranial window dendritic spines optical clearing synaptic resolution two-photon imaging

Acute lens opacity induced by different kinds of anesthetic drugs in mice

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International Journal of Ophthalmology(English edition) 2019年第6期12卷 904-908页

作者： Xiao-tong Li yu Qin Jiang-yue zhao Jin-Song Zhang Department of Ophthalmology the Fourth Affiliated Hospital of China Medical UniversityEye Hospital of China Medical UniversityKey Lens Research Laboratory of Liaoning ProvinceShenyang 110005Liaoning ProvinceChina Aier Eye Hospital Shenyang 110000Liaoning ProvinceChina

AIM: To study whether specific anesthetic drugs or tear layer evaporation was primarily responsible for the acute cataract and what the change of lens structure is in anesthetized ***: Five groups were set up in the experiment: Group A(topicamide and phenylephrine mixed eye drop+ chloral hydrate), Group B(tropicamide and phenylephrine mixed eye drop+sevoflurane), Group C(tropicamide and phenylephrine mixed eye drop), Group D(topicamide and phenylephrine mixed eye drop+chloral hydrate, carbomer eye drop in the right eyes), and Group E(tropicamide and phenylephrine mixed eye drop+sevoflurane, carbomer eye drop in the right eyes). A simple classification system was used to assess the severity of lens opacity. And a numerical value from 0 to 3 to each grade was assigned for the cataract index calculation and data analysis. The gross appearance and time course of development of lens opacity were assessed. Hematoxylin and eosin staining was used to observe the lens structure changes in the reversible ***: Tropicamide did not induce lens opacification in mice. Lens opacity caused by inhaled sevoflurane was similar to injected cholral hydrate. Both inhaled-anestheticinduced lens opacity and injected-anesthetic-induced lens opacity could be prevented by carbomer eye drop. In the severe opacity lens, a wide range of lens fiber cell structure had disordered. The fiber cells became uneven ***: The acute reversible lens opacity can unilaterally develop or be induced by a local cause. The structure of lens fiber cells changed in the lens opacity which may influence the permanent connection of the lens fiber cells. This study was not only of practical significance to help maintain lens transparency for eye research, but also of the deeper consideration about the reversible lens opacification phenomenon.

关键词： lens opacity anesthetic drugs tear film mice

Analytical Design of Fractional Order Proportional Integral Derivative Controller and Fuzzy Proportional Integral Derivative Controller for High Order System

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Journal of Harbin Institute of Technology(New Series) 2013年第4期20卷 21-25页

作者： Chun-Yang Wang tong Yi Xiao-yu zhao Yao-Wu Shi Dept.of Electronic and Information Engineering Changchun University of Science and Technology Dept.of Communication Engineering Jilin University

In this paper,three tuning methods of the integer order proportional integral derivative(IOPID)controller,the fuzzy proportional integral derivative(FPID)controller and the fractional order proportional integral derivative(FOPID)controller for high order system are presented *** IOPID controller and FOPID controller designed by the two tuning methods can satisfy all the three specifications proposed,which can guarantee the desired control performance and the robustness of the high order system to the loop gain *** the simulation results,the three controllers meet the dynamic performance requirements of high order ***,the FOPID controller,with the shortest overshoot and adjustment time,outperforms the IOPID controller and the FPID controller for the high order system.

关键词： IOPID controller FPID controller FOPID controller High order system

Application of mesenchymal stem cell therapy for the treatment of osteoarthritis of the knee: A concise review

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World Journal of Stem Cells 2019年第4期11卷 222-235页

作者： Ai-tong Wang Ying Feng Hong-Hong Jia Meng zhao Hao yu Cell Products of NationalEngineering Research Center National Stem Cell Engineering Research Center

Osteoarthritis(OA) refers to a chronic joint disease characterized by degenerative changes of articular cartilage and secondary bone hyperplasia. Since articular cartilage has a special structure, namely the absence of blood vessels as well as the low conversion rate of chondrocytes in the cartilage matrix, the treatment faces numerous clinical challenges. Traditional OA treatment(e.g., arthroscopic debridement, microfracture, autologous or allogeneic cartilage transplantation,chondrocyte transplantation) is primarily symptomatic treatment and pain management, which cannot contribute to regenerating degenerated cartilage or reducing joint inflammation. Also, the generated mixed fibrous cartilage tissue is not the same as natural hyaline cartilage. Mesenchymal stem cells(MSCs) have turned into the most extensively explored new therapeutic drugs in cell-based OA treatment as a result of their ability to differentiate into chondrocytes and their immunomodulatory properties. In this study, the preliminary results of preclinical(OA animal model)/clinical trials regarding the effects of MSCs on cartilage repair of knee joints are briefly summarized, which lay a solid application basis for more and deeper clinical studies on cell-based OA treatment.

关键词： Osteoarthritis Mesenchymal stem cells Stem cell therapy Clinical trials