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Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

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Neural Regeneration Research 2025年第2期20卷 491-502页

作者： Shuai Feng Juanji Li Tingting Liu Shiqi Huang Xiangliang Chen Shen Liu Junshan Zhou Hongdong zhao Ye Hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion ***-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s ***,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic *** address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke ***,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting *** observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/***,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated ***-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective ***,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte *** findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization

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Efficacy and Duration of Electro-Acupuncture Combined with Conventional Antipsychotics for Schizophrenia:A Meta-Analysis

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World Journal of Traditional Chinese Medicine 2023年第2期9卷 212-223页

作者： zhao-Han Huang yuan Fang Qi yu tong Wang College of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Shanghai Center for Women and Children's Health ShanghaiChina

Introduction:This study aimed to evaluate the effectiveness and optimal course time of electro-acupuncture(EA)combined with conventional antipsychotics in the treatment of schizophrenia(SZ)and to provide a basis for its clinical ***:Relevant databases and authoritative websites were retrieved,and references were screened up to May *** quality evaluation and data extraction were carried out according to the requirements of Cochrane version 5.1.0,and meta-analysis was conducted using Rav Man5.4 ***:In total,16 randomized controlled trails comprising 1352 patients were ***-analysis revealed that the observation group showed greater improvements than the control group in total clinical efficacy(P0.05).In the 4-6 weeks following treatment,a significant improvement in all the four components of the PANSS scores was observed in the observation ***:The efficacy of EA combined with conventional antipsychotics for SZ is better than that of psychiatric drugs *** addition,the effect of a 4-to 6-week treatment course on each outcome index is more significant,and the efficacy is higher.

关键词： Electro-acupuncture meta-analysis schizophrenia

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Research progress on semi-continuous casting of magnesium alloys under external field

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China Foundry 2024年第5期21卷 516-524页

作者： Qi-yu Liao Qi-chi Le Da-zhi zhao Lei Bao tong Wang Yong-hui Jia Key Laboratory of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang 110819China School of Materials Science and Engineering Northeastern UniversityShenyang 110819China Key Laboratory of Lightweight Structural Materials Liaoning ProvinceNortheastern UniversityShenyang 110819China Key Laboratory of Light-weight Materials Nanjing Tech UniversityNanjing 210009China

High-performance magnesium alloys are moving towards a trend of being produced on a large scale and in an integrated *** foundational key to their successful production is the high-quality cast *** alloys produced through the conventional semi-continuous casting process inevitably contain casting defects,which makes it challenging to manufacture high-quality *** integration of external field assisted controlled solidification technology,which combines physical fields such as electromagnetic and ultrasonic fields with traditional semi-continuous casting processes,enables the production of high-quality magnesium alloy ingots characterized by a homogeneous microstructure and absence of *** article mainly summarizes the technical principles of those external field assisted casting *** focus is on elaborating the refinement mechanism of different types of electromagnetic fields,ultrasonic fields,and combined physical fields during the solidification of magnesium ***,the development prospects of producing highquality magnesium alloy ingots through semi-continuous casting under the external field were discussed.

关键词： semi-continuous casting electromagnetic field ultrasonic field magnesium alloys refinement mechanism

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Alteration of functional connectivity in patients with Alzheimer’s disease revealed by resting-state functional magnetic resonance imaging

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Neural Regeneration Research 2020年第2期15卷 285-292页

作者： Jie zhao yu-Hang Du Xue-tong Ding Xue-Hu Wang Guo-Zun Men School of Electronic and Information Engineering Hebei UniversityBaodingHebei ProvinceChina Research Center of Machine Vision Engineering & Technology of Hebei Province BaodingHebei ProvinceChina Key Laboratory of Digital Medical Engineering of Hebei Province BaodingHebei ProvinceChina School of Economics Hebei UniversityBaodingHebei ProvinceChina

The main symptom of patients with Alzheimer’s disease is cognitive dysfunction. Alzheimer’s disease is mainly diagnosed based on changes in brain structure. Functional connectivity reflects the synchrony of functional activities between non-adjacent brain regions, and changes in functional connectivity appear earlier than those in brain structure. In this study, we detected resting-state functional connectivity changes in patients with Alzheimer’s disease to provide reference evidence for disease prediction. Functional magnetic resonance imaging data from patients with Alzheimer’s disease were used to show whether particular white and gray matter areas had certain functional connectivity patterns and if these patterns changed with disease severity. In nine white and corresponding gray matter regions, correlations of normal cognition, early mild cognitive impairment, and late mild cognitive impairment with blood oxygen level-dependent signal time series were detected. Average correlation coefficient analysis indicated functional connectivity patterns between white and gray matter in the resting state of patients with Alzheimer’s disease. Functional connectivity pattern variation correlated with disease severity, with some regions having relatively strong or weak correlations. We found that the correlation coefficients of five regions were 0.3–0.5 in patients with normal cognition and 0–0.2 in those developing Alzheimer’s disease. Moreover, in the other four regions, the range increased to 0.45–0.7 with increasing cognitive impairment. In some white and gray matter areas, there were specific connectivity patterns. Changes in regional white and gray matter connectivity patterns may be used to predict Alzheimer’s disease;however, detailed information on specific connectivity patterns is needed. All study data were obtained from the Alzheimer’s Disease Neuroimaging Initiative Library of the Image and Data Archive Database.

关键词： Alzheimer's disease blood oxygen level-dependent signal correlation coefficient functional connectivity pattern functional magnetic resonance imaging gray matter resting state white matter

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Role of brahma-related gene 1/brahma-associated factor subunits in neural stem/progenitor cells and related neural developmental disorders

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World Journal of Stem Cells 2023年第4期15卷 235-247页

作者： Nai-yu Ke Tian-Yi zhao Wan-Rong Wang yu-tong Qian Chao Liu The First Clinical Medical College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Institute of Stem cells and Tissue Engineering School of Basic Medical SciencesAnhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Histology and Embryology School of Basic Medical SciencesAnhui Medical UniversityHefei 230032Anhui ProvinceChina

Different fates of neural stem/progenitor cells(NSPCs)and their progeny are determined by the gene regulatory network,where a chromatin-remodeling complex affects synergy with other ***,we review recent research progress indicating that the BRG1/BRM-associated factor(BAF)complex plays an important role in NSPCs during neural development and neural developmental *** studies based on animal models have shown that mutations in the BAF complex may cause abnormal neural differentiation,which can also lead to various diseases in *** discussed BAF complex subunits and their main characteristics in *** advances in studies of human pluripotent stem cells and the feasibility of driving their differentiation into NSPCs,we can now investigate the role of the BAF complex in regulating the balance between self-renewal and differentiation of *** recent progress in these research areas,we suggest that three approaches should be used in investigations in the near *** of whole human exome and genome-wide association studies suggest that mutations in the subunits of the BAF complex are related to neurodevelopmental *** insight into the mechanism of BAF complex regulation in NSPCs during neural cell fate decisions and neurodevelopment may help in exploiting new methods for clinical applications.

关键词： Neural stem/progenitor cell BRG1/BRM-associated factor complex Subunit Proliferation Differentiation Neural developmental disorde

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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan Li Peng Hao Hongmei Duan Fei Hao Wen zhao yudan Gao zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

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From traditional Chinese medicine formulations to effective anticancer agents:Insights from Calculus bovis

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World Journal of Gastroenterology 2024年第35期30卷 4011-4013页

作者： He-tong zhao Department of Traditional Chinese Medicine Navy No.905 HospitalShanghai 200050China

This editorial examines the therapeutic potential of traditional Chinese medicine(TCM)for aggressive cancers,particularly liver *** highlights the study by Huang et al,which shows how Calculus bovis,a component of the TCM Pien Tze Huang,suppresses liver cancer by inhibiting M2 macrophage polarization via the Wnt/β-catenin *** research emphasizes the importance of transitioning from effective TCM formulations to isolating active components and understanding their *** the study provides valuable insights,it primarily focuses on the Wnt/β-catenin pathway and does not delve deeply into the mechanisms of individual *** research should aim to comprehensively study these components,explore their interactions,and validate findings through clinical *** approach will integrate traditional wisdom with modern scientific validation,advancing the development of innovative cancer treatments based on TCM formulations.

关键词： Calculus bovis Traditional Chinese medicine Liver cancer Tumor microenvironment M2 tumor-associated macrophages Wnt/β-catenin pathway

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Permanent Magnet Axial Section Shaping Optimization Surface-mounted Permanent Magnet Synchronous Motor

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CES Transactions on Electrical Machines and Systems 2023年第4期7卷 366-371页

作者： Shengnan Wu Qifeng zhao Wenming tong the School of Electrical Engineering Shenyang University of TechnologyShengyang 110870China IEEE

In this paper, a new type of harmonic injection permanent magnet shape optimization method is proposed to suppress the torque ripple of surface-mounted permanent magnet synchronous motor. The sinusoidal waveform shaping of the axial section of the permanent magnet is added with the third harmonic shaping, and the sine wave and the third harmonic are derived. The optimal ratio is 6:1. The permanent magnet no shaping, sinusoidal shaping and sinusoidal combined third harmonic shaping are compared. The results show that the sinusoidal combined third harmonic shaping design can effectively suppress the torque ripple of the surface mounted permanent magnet synchronous motor and obtain a relatively large output torque. At the same time, a method of using permanent magnet segmentation to approximately equivalently replace sine combined with third harmonic shaping design is proposed, which effectively saves the manufacturing cost of permanent magnets and provides design and research ideas for more economical and effective optimization of surface-mounted permanent magnet motors.

关键词： Permanent Magnet Synchronous Motor Harmonic Injection Torque Ripple Segmented Magnet

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Liquid-liquid phase separation in tumor biology

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Signal Transduction and Targeted Therapy 2022年第8期7卷 2841-2862页

作者： Xuhui tong Rong Tang Jin Xu Wei Wang Yingjun zhao Xianjun yu Si Shi Department of Pancreatic Surgery Fudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina Shanghai Pancreatic Cancer Institute ShanghaiChina Pancreatic Cancer Institute Fudan UniversityShanghaiChina Institutes of Biomedical Sciences Shanghai Medical CollegeFudan UniversityShanghai 200032China

Liquid–liquid phase separation(LLPS)is a novel principle for explaining the precise spatial and temporal regulation in living *** compartmentalizes proteins and nucleic acids into micron-scale,liquid-like,membraneless bodies with specific functions,which were recently termed biomolecular *** condensates are executors underlying the intracellular spatiotemporal coordination of various biological activities,including chromatin organization,genomic stability,DNA damage response and repair,transcription,and signal *** of these cellular processes is a key event in the initiation and/or evolution of cancer,and emerging evidence has linked the formation and regulation of LLPS to malignant transformations in tumor *** this review,we comprehensively summarize the detailed mechanisms of biomolecular condensate formation and biophysical function and review the recent major advances toward elucidating the multiple mechanisms involved in cancer cell pathology driven by aberrant *** addition,we discuss the therapeutic perspectives of LLPS in cancer research and the most recently developed drug candidates targeting LLPS modulation that can be used to combat tumorigenesis.

关键词： separation liquid phase

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Preparation and Characterization of Polyborosiloxanes and Their Blends with Phenolic Resin as Shapeable Ceramic Precursors

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Chinese Journal of Polymer Science 2014年第2期32卷 187-196页

作者： Hong-ying zhao 赵京波 Hao Li tong zhao Key Laboratory of Carbon Fiber and Functional Polymers Ministry of Education College of Materials Science and Engineering Beijing University of Chemical Technology Laboratory of Advanced Polymer Materials Institute of Chemistry Chinese Academy Science

Two polyborosiloxanes （PBSis） with char yield up to 74.13% at 800 ℃ were synthesized by the direct polycondensation of boric acid with phenyltrimethoxysilane in diglyme. The PBSis were characterized by gel permeation chromatography, IR spectroscopy as well as ^1H-, ^29Si- and ^11B-NMR. PBSi modified phenol-formaldehyde resins （PBSi/PFs） were prepared at different PBSi/PF mass ratios and were cured at 150 ℃. The PBSi/PFs were characterized by IR spectroscopy, scanning electron microscopy, thermogravimetric analysis and tensile test. The results revealed that the cured PBSi/PFs had sea-island morphology and higher char yield than the common PF. PBSi/PF blend with PBSi/PF mass ratio of 0.4：1 had char yield up to 70.83% at 800 ℃. The PBSi/PFs had tensile strength similar to PF. The ceramization of PBSi/PFs was also studied. The silicon boron oxycarbide （SiBOC） ceramics formed were characterized by IR spectroscopy and elemental analysis. This method provided a valuable way to prepare easily shapeable polymer blends as ceramic precursors.

关键词： Polyborosiloxane Phenolic resin Preparation Ceramic precursors SiBOC ceramics.

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