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Connectivity Map of Subthalamic Corticotropin-releasing Hormone Neurons in the Mouse Brain

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Neuroscience Bulletin 2023年第2期39卷 292-296页

作者： yu-ting tseng Lisha Liang Binghao Zhao Jialin Ye Liping Wang CAS Key Laboratory of Brain Connectome and Manipulation the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China

Dear Editor,The subthalamic nucleus(STN)is a major component of the evolutionarily-conserved basal ganglia structures[1].While the beneficial effects of deep brain stimulation(DBS)of the STN on motor symptoms in patients with Parkinson's disease(PD)are indisputable,several non-motor symptoms can arise following DBS,including elevated depression and perception of fear in addition to altered sleep-wake parameters.

关键词： stimulation elevated releasing

Chemical Profile of the Liuwei Dihuang Active Formula for Neuronal Protection

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Chemical Profile of the Liuwei Dihuang Active Formula for Ne...

Time Parameter Based Low-Energy Data Encryption Method for Mobile Applications

第十四届全国中药和天然药物学术研讨会

作者： Fang-Rong Chang yu-ting tseng Yi-Ching Lo Kaohsiung Medical University

＜正＞Liuwei dihuang（LWDH）,a widely used traditional Chinese medicine（TCM）,is employed in a common adult-onset neurodegenerative disorder,Parkinson’s disease（PD）,characterized by the degeneration of dopaminergic nigrostriatal neurons with complex pathological *** evidence indicates that TCM has the potential in neuron protection

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2779-2794页

作者： Li-Woei Chen Kun-Lin Tsai Fang-Yie Leu Wen-Cheng Jiang Shih-ting tseng Department of Computer and Information Sciences Chinese Military AcademyKaohsiung830TaiwanChina Department of Electrical Engineering Tunghai UniversityTaichung407TaiwanChina Department of Computer Science Tunghai UniversityTaichung407TaiwanChina

Various mobile devices and applications are now used in daily *** devices require high-speed data processing,low energy consumption,low communication latency,and secure data transmission,especially in 5G and 6G mobile ***-security cryptography guarantees that essential data can be transmitted securely;however,it increases energy consumption and reduces data processing ***,this study proposes a low-energy data encryption(LEDE)algorithm based on the Advanced Encryption Standard(AES)for improving data transmission security and reducing the energy consumption of encryption in Internet-of-Things(IoT)*** the proposed LEDE algorithm,the system time parameter is employed to create a dynamic S-Box to replace the static S-Box of *** indicated that six-round LEDE encryption achieves the same security level as 10-round conventional AES *** reduction in encryption time results in the LEDE algorithm having a 67.4%lower energy consumption and 43.9%shorter encryption time than conventional AES;thus,the proposed LEDE algorithm can improve the performance and the energy consumption of IoT edge devices.

关键词： Mobile application security AES data encryption time parameter mobile device

Automated Visual Inspection of Contact Gap and Contact Malposition of Automotive Relay

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Biological scaffold as potential platforms for stem cells:Current development and applications in wound healing

第三届数字制造与自动化国际会议

作者： Chen-Huei Hsieh Chi-Sheng Tsai ting-yu tseng Yi-Sheng Wong Shi-Zhen Zhou Department of Automation Engineering and Institute of Mechatronoptic Systems Chienkuo Technology University

The gap and the malposition of the contact of automotive relay would heavily influence its life. If the gap and the malposition of all relays can be fully inspected and the inspection operation can be incorporated into the existing automated manufacturing and testing equipment, the quality will thus be significantly promoted. To reach this goal, a visual inspection system based on the platform of LabVIEW has been developed in this paper. The visual inspection system is capable of performing the inspection of the gap and the malposition of electrical contact in 1.6 seconds for one relay, and the whole automation system can manufacture one relay for every 2 seconds.

关键词： Contact Gap Contact malposition LabVIEW Visual inspection Automotive relay

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World Journal of Stem Cells 2024年第4期16卷 334-352页

作者： Jie-yu Xiang Lin Kang Zi-Ming Li Song-Lu tseng Li-Quan Wang Tian-Hao Li Zhu-Jun Li Jiu-Zuo Huang Nan-Ze yu Xiao Long Department of Plastic and Reconstructive Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Biomedical Engineering Facility Institute of Clinical MedicinePeking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100021China

Wound repair is a complex challenge for both clinical practitioners and *** approaches for wound repair have several *** cell-based therapy has emerged as a novel strategy to address this issue,exhibiting significant potential for enhancing wound healing rates,improving wound quality,and promoting skin ***,the use of stem cells in skin regeneration presents several ***,stem cells and biomaterials have been identified as crucial components of the wound-healing *** therapy involving the development of biocompatible scaffolds,accompanying cells,multiple biological factors,and structures resembling the natural extracellular matrix(ECM)has gained considerable *** scaffolds encompass a range of biomaterials that serve as platforms for seeding stem cells,providing them with an environment conducive to growth,similar to that of the *** scaffolds facilitate the delivery and application of stem cells for tissue regeneration and wound *** article provides a comprehensive review of the current developments and applications of biological scaffolds for stem cells in wound healing,emphasizing their capacity to facilitate stem cell adhesion,proliferation,differentiation,and paracrine ***,we identify the pivotal characteristics of the scaffolds that contribute to enhanced cellular activity.

关键词： Stem-cell-based therapy Biological scaffolds Wound healing Extracellular matrix mimicry Cellular activities enhancement Scaffold characteristics

Aldo-keto reductase family member C3(AKR1C3)promotes hepatocellular carcinoma cell growth by producing prostaglandin F2α

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Oncology Research 2024年第1期32卷 163-174页

作者： KUO-SHYANG JENG PO-yu CHENG yuEH-HSIEN LIN PO-CHUN LIU PING-HUI tseng yu-CHAO WANG CHIUNG-FANG CHANG CHUEN-MIIN LEU Division of General Surgery Far Eastern Memorial HospitalNew Taipei City22060Taiwan Institute of Microbiology and Immunology National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Institute of Biochemistry and Molecular Biology National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Institute of Biomedical Informatics National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Department of Medical Research Far Eastern Memorial HospitalNew Taipei City22060Taiwan

Hepatocellular carcinoma(HCC)is a leading cause of death *** therapies are effective for HCC patients with early disease,but many patients suffer recurrence after surgery and have a poor response to ***,new therapeutic targets are *** analyzed gene expression profiles between HCC tissues and normal adjacent tissues from public databases and found that the expression of genes involved in lipid metabolism was significantly *** analysis showed that AKR1C3 was upregulated in tumors,and high AKR1C3 expression was associated with a poorer prognosis in HCC *** vitro,assays demonstrated that the knockdown of AKR1C3 or the addition of the AKR1C3 inhibitor indomethacin suppressed the growth and colony formation of HCC cell *** of AKR1C3 in Huh7 cells reduced tumor growth in *** explore the mechanism,we performed pathway enrichment analysis,and the results linked the expression of AKR1C3 with prostaglandin F2 alpha(PGF2a)downstream target *** of AKR1C3 activity reduced the production of PGF2a,and supplementation with PGF2a restored the growth of indomethacin-treated Huh7 *** of the PGF receptor(PTGFR)and treatment with a PTGFR inhibitor significantly reduced HCC *** showed that indomethacin potentiated the sensitivity of Huh7 cells to *** summary,our results indicate that AKR1C3 upregulation may promote HCC growth by promoting the production of PGF2α,and suppression of PTGFR limited HCC ***,targeting the AKR1C3-PGF2a-PTGFR axis may be a new strategy for the treatment of HCC.

关键词： Hepatocellular carcinoma Aldo-keto reductase family member C3 Prostaglandin F2 alpha Prostaglandin F receptor

Adipose-derived stem cells in diabetic foot care:Bridging clinical trials and practical application

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World Journal of Diabetes 2024年第6期15卷 1162-1177页

作者： Song-Lu tseng Lin Kang Zhu-Jun Li Li-Quan Wang Zi-Ming Li Tian-Hao Li Jie-yu Xiang Jiu-Zuo Huang Nan-Ze yu Xiao Long Department of Plastic and Reconstructive Surgery Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Plastic and Reconstructive Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Biomedical Engineering Facility Institute of Clinical MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences BeijingBeijing 100021China

Diabetic foot ulcers(DFUs)pose a critical medical challenge,significantly impairing the quality of life of ***-derived stem cells(ADSCs)have been identified as a promising therapeutic approach for improving wound healing in *** extensive exploration of the mechanical aspects of ADSC therapy against DFU,its clinical applications remain *** this review,we aimed to bridge this gap by evaluating the use and advancements of ADSCs in the clinical management of *** review begins with a discussion of the classification and clinical management of diabetic foot *** then discusses the current landscape of clinical trials,focusing on their geographic distribution,reported efficacy,safety profiles,treatment timing,administration techniques,and dosing ***,the review discusses the preclinical strategies to enhance ADSC *** review shows that many trials exhibit biases in study design,unclear inclusion criteria,and intervention *** conclusion,this review underscores the potential of ADSCs in DFU treatment and emphasizes the critical need for further research and refinement of therapeutic approaches,with a focus on improving the quality of future clinical trials to enhance treatment outcomes and advance the field of diabetic wound care.

关键词： Adipose-derived stem cells Diabetic foot ulcers Wound healing Clinical

Self-healing hydrogel for tissue repair in the central nervous system

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Neural Regeneration Research 2015年第12期10卷 1922-1923页

作者： Fu-yu Hsieh ting-Chen tseng Shan-hui Hsu Institute of Polymer Science and Engineering National Taiwan University Research Center for Developmental Biology and Regenerative Medicine National Taiwan University Research and Development Center for Medical Devices National Taiwan University

Neurological disorders are diseases of the central and peripheral nervous *** disorders include Alzheimer＇s disease,epilepsy,brain tumor,and cerebrovascular diseases（stroke,migraine and other headache disorders,mult... 详细信息

关键词： NSCs Self-healing hydrogel for tissue repair in the central nervous system CNS

Size-dependent activity of Fe-N-doped mesoporous carbon nanoparticles towards oxygen reduction reaction

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Green Carbon 2024年第2期2卷 221-230页

作者： Yilun Zhao Zhengbin Tian Wenquan Wang Xiaohui Deng Jo-Chi tseng Guanghui Wang Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of SciencesQingdao 266101China Shandong Energy Institute Qingdao 266101China Qingdao New Energy Shandong Laboratory Qingdao 266101China University of Chinese Academy of Sciences Beijing 100049China Japan Synchrotron Radiation Research Institute Hyogo 679-5198Japan

The rational design of Fe–N–C catalysts that possess easily accessible active sites and favorable mass transfer,which are usually determined by the structure of catalyst supports,is crucial for the oxygen reduction reaction(ORR).In this study,an oleic acid-assisted soft-templating approach is developed to synthesize size-controlled nitrogen-doped carbon nanoparticles(ranging from 130 nm to 60 nm and 35 nm,respectively)that feature spiral mesopores on their surface(SMCs).Next,atomically dispersed Fe–Nx sites are fabricated on the size-tunable SMCs(Fe1/SMC-x,where x represents the SMC size)and the size-dependent activity toward ORR is *** is found that the catalytic performance of Fe1/SMCs is significantly influenced by the size of SMCs,where the Fe1/SMC-60 catalyst shows the highest ORR activity with a half-wave potential of 0.90 V *** in KOH electrolyte,indicating that the gas-liquid-solid three-phase interface on the Fe1/SMC-60 enhances the accessibility of Fe–Nx *** addition,when using Fe1/SMC-60 as the cathode catalyst in aqueous zinc-air batteries(ZABs),it delivers a higher open-circuit voltage(1.514 V),a greater power density(223 mW cm^(−2)),and a larger specific capacity/energy than Pt/C-based *** results further highlight the potential of Fe1/SMC60 for practical energy devices associated with ORR and the importance of size-controlled synthesis of SMCs.

关键词： Soft-templating approach Size-dependent activity Fe-N-C catalyst Oxygen reduction reaction Zinc-air battery