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Effect of inflammatory response on joint function after hip fracture in elderly patients:A clinical study

World Journal of Orthopedics 2024年第4期15卷 337-345页

作者： Jia-Ming Wang yu-tao pan Chen-Song Yang Ming-Chong Liu Sheng-Chao Ji Ning Han Fang Liu Gui-Xin Sun Department of Traumatic Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200092China

BACKGROUND Excellent hip joint function facilitates limb recovery and improves the quality of *** study aimed to investigate the potential risk factors affecting postoperative joint functional activity and outcomes in elderly hip fractures patients and to provide evidence for patient rehabilitation and clinical *** To explore the relationship between inflammatory factors and hip function and the interaction between inflammation and health after hip fracture in elderly *** The elderly patients who had hip fracture surgery at our hospital between January 1,2021,and December 31,2022 were chosen for this retrospective clinical *** with excellent and fair postoperative hip function had their clinical information and characteristics gathered and ***,gender,fracture site,surgical technique,laboratory indices,and other variables that could have an impact on postoperative joint function were all included in a univariate *** further identify independent risk factors affecting postoperative joint function in hip fractures,risk factors that showed statistical significance in the univariate analysis were then included in a multiple logistic regression *** addition to this,we also compared other outcome variables such as visual analogue scale and length of hospital stay between the two *** A total of 119 elderly patients with hip fractures were included in this study,of whom 37 were male and 82 were *** results of univariate logistic regression analysis after excluding the interaction of various factors showed that there was a statistically significant difference in interleukin(IL)-6,IL-8,IL-10,C-reactive protein(CRP),and complement C1q(C1q)between the fair and excellent joint function groups(P20 pg/mL[Odds ratio(OR)3.070,95%CI:1.243-7.579],IL-8>21.4 pg/mL(OR 3.827,95%CI:1.498-9.773),CRP>10 mg/L(OR 2.142,95%CI:1.

关键词： Hip function Fracture Inflammatory factors Risk factors Prevention

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Multi-physical fields distribution in billet during helical electromagnetic stirring:A numerical simulation research

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China Foundry 2024年第1期21卷 51-59页

作者： Dong pan Qing-tao Guo Kai-lun Zhang Fu-zhi yu yu-ying Li yu-bao Xiao State Key Laboratory of Metal Materials for Marine Equipment and Application Anshan 114009LiaoningChina Ansteel Beijing Research Institute Co. Ltd.Beijing 102200China

Electromagnetic stirring is one of the widely applied techniques to modify the quality of casting *** from conventional rotate stirring,the helical stirring is more professional in assisting multi-dimensional flow of molten metal and eliminating solidification *** this study,the single-winding helical stirring(SWHS)was introduced,offering advantages such as smaller volume and lower electromagnetic shielding compared to traditional helical stirring *** a comprehensive numerical simulation,the stirring parameters of SWHS were adjusted to yoke inclination angle of 43°and frequency of 12 *** higher electromagnetic force and flow velocity in drawing direction,as well as the lower temperature gradient induced by the SWHS,are positive factors for homogeneous solidification of *** experimental results on Al-8%Si alloy and 0.4%C-1.1%Mn steel demonstrate that compared to rotate stirring,the SWHS process can induce better billet quality and is more effective in accelerating the equiaxed expansion and reducing element *** SWHS process can enhance the equiaxed ratio of the billet by 58.3%and reduce segregation degree of carbon element by 10.97%.Consequently,SWHS holds great promise as a potential approach for improving the quality of continuous casting billets.

关键词： billet electromagnetic stirring helical solidification element segregation numerical simulation

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miR319-TCPs-TGA9/TGA10/ROXY2 regulatory module controls cell fate specification in early anther development in Arabidopsis

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Science China(Life Sciences) 2024年第4期67卷 839-842页

作者： Jinyuan tao Zijie pan Wenwen Kong Beixin Mo Xuemei Chen yu yu Guangdong Provincial Key Laboratory for Plant Epigenetics Longhua Bioindustry and Innovation Research InstituteCollege of Life Sciences and OceanographyShenzhen UniversityShenzhen 518060China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China School of Life Sciences Peking-Tsinghua Joint Center for Life SciencesPeking UniversityBeijing 100871China

Dear Editor,The process of anther development is generally conserved across plant species(Ma,2005).Many protein-coding genes and noncoding RNAs have been identified to participate in early anther development in Arabidopsis(Walbot and Egger,2016).mi R319 is one of the most ancient and conserved mi RNA families in land plants(Chávez Montes et al.,2014).

关键词： Arabidopsis miR319 ancient

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State-sensitive convolutional sparse coding for potential biomarker identification in brain signals

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Science China(Information Sciences) 2024年第5期67卷 270-286页

作者： Puli WANG yu QI Gang pan College of Computer Science and Technology Zhejiang University State Key Laboratory of Brain-Machine Intelligence Zhejiang University MOE Frontier Science Center for Brain Science and Brain-machine Integration Zhejiang University Affiliated Mental Health Center & Hangzhou Seventh People's Hospital Zhejiang University School of Medicine

The identification of prototypical waveforms, such as sleep spindles and epileptic spikes, is crucial for the diagnosis of neurological disorders. These prototypical waveforms are usually recurrently presented in certain brain states, serving as potential biomarkers for clinical evaluations. Convolutional sparse coding(CSC) approaches have demonstrated strength in identifying recurrent patterns in time-series. However,existing CSC approaches do not explicitly explore state-specific patterns, making it difficult to identify state-related biomarkers. To address this problem, we propose state-sensitive CSC to learn state-specific prototypical waveforms. Specifically, we model signals of a certain state with specific waveforms that only appear frequently in this state and background waveforms that are independent of states. Based on this,state-sensitive CSC separates state-specific waveforms from background ones explicitly by incorporating incoherence constraints into optimizations. Experiments with epilepsy brain signals demonstrate that our approach can effectively identify prototypical waveforms in pre-ictal states, providing potential biomarkers for seizure prediction. Our approach provides a promising tool for automatic biomarker candidate identification.

关键词： convolutional sparse coding prototypical waveforms state-specific dictionary biomarker identification neural signal processing

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Electrochemical chemoselective thiocarbamylation of late-stage Tyr-containing drugs and peptides

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Science China Chemistry 2024年第10期67卷 3382-3388页

作者： Wan-Jie Wei Xin-yu Wang Hai-tao Tang Fei-Hu Cui yun-Qi Wu Ying-Ming pan State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Ministry of Education of China)Collaborative Innovation Center for Guangxi Ethnic MedicineSchool of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China

The synthesis and modification of peptides occupy a unique position in the field of drug development,and the functionalization of amino acids is a valuable strategy as an alternative to peptide ***,the development of tyrosine(Tyr)as a target amino acid is a major challenge in the field of ***,we report an electrochemical radical coupling reaction of labeling tyrosine-containing active drugs and peptides with thiocarbamate derivatives for the first *** tri-component,onepot reaction can be performed smoothly under simple,gentle,and clean electrochemical conditions and is suitable for the functionalization of various Tyr-containing drug molecular derivatives and peptides.

关键词： tyrosine electrochemical radical coupling chemical modification peptides

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A new liquid membrane diffusion model for characterizing the adsorption kinetics of europium by using a continuous measurement of adsorption platform

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Nuclear Science and Techniques 2024年第1期35卷 59-72页

作者： Hao-Qi yu tao yu Jian-Hua Ye State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China CGN Cangnan Nuclear Power Co. Ltd.Cangnan 325800China Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices East China University of TechnologyNanchang 330013China School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China

To explore the kinetic adsorption under continuous and nonequilibrium states, an integration of continuous measurement and adsorption platform kinetics method was proposed, which was initially called the ICM-AP kinetics method, and a corresponding kinetic adsorption experimental method was developed. Adsorption experiments of europium(Eu) on Ca-bentonite,Na-bentonite, and the D231 cation exchange resin were performed using the ICM-AP kinetics method and continuous measurements. Because the kinetic experimental results observed in this study were different from those of traditional batch adsorption data, pseudo-first-order or pseudo-second-order kinetic models were unsuitable for fitting the experimental ***, a liquid membrane diffusion(LMD) model was developed based on the assumption of simultaneous adsorption/desorption to discuss the mechanism of kinetic adsorption. The kinetic adsorption mechanism was also studied by using *** results indicated that the proposed adsorption model can fit the experimental data more suitably, and the adsorption/desorption behaviors of Eu on bentonite and the D231 resin were simultaneously observed, suggesting that the adsorption kinetics of Eu(Ⅲ) was mainly dominated by hydrated Eu(Ⅲ) ions on the liquid membrane.

关键词： ICM-AP method LMD model Adsorption mechanism Eu(Ⅲ)

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Changes in arterial blood pressure induced by passive leg raising predict hypotension during the induction of sedation in critically ill patients without severe cardiac dysfunction

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Chinese Medical Journal 2013年第13期126卷 2445-2450页

作者： yu tao pan Chun GUO Feng-mei YANG Yi QIU Hai-bo Department of Critical Care Medicine Nanjing Zhongda Hospital Southeast University School of Medicine Nanjing 210009 China

Background Hypotension due to the induction of sedation with dexmedetomidine infusion may be harmful in critically ill patients. Changes in pulse pressure induced by the passive leg raising test （PLR-APP） as marker of fluid responsiveness, assessed prior to sedation, may predict hemodynamic changes. The present study was to investigate the power of the PLR test in critically ill patients in predicting hypotension induced by the induction of dexmedetomidine sedation. Methods Fluid responsiveness was estimated by a passive leg raising （PLR） test before dexmedetomidine sedation. Patients were assigned to either the ＂Nonresponders＂ or ＂Responders＂ group according to their hemodynamic responses to the PLR test （＂Nonresponders＂, PLR-APP 〈10.3%; ＂Responders＂, PLR-APP 〉10.3%）. Sedation was performed with a dexmedetomidine infusion （0.5 pg/kg over a 10-minute loading period, then 0.2-0.7 ***-l.h1） and titrated to maintain the target Richmond agitation sedation scale （RASS） score in the range of -2 to -1 and the bispectral index value in the range of 60 to 75. Radial artery pulse pressure, heart rate （HR）, and central venous pressure （CVP） were measured at each phase of the study procedure. Hemodynamic fluctuations during the use of dexmedetomidine sedation were recorded and compared between the two groups. Results Fifty patients had a median （25%-75% interquartile range） of 71 （61-78） years old were studied. At baseline, 39 of the 50 patients were ＂Nonresponders＂ and 11 were ＂Responders＂. Following dexmedetomidine sedation, patients classified as ＂Responders＂ had a significantly greater systolic blood pressure decrease during the induction of dexmedetomidine sedation than the ＂Nonresponders＂（（-26.3 ＋ 6.8）% vs. （-11.8 ＋ 8.5）%, P 〈0.001）. In addition, the ＂Responders＂ group required significantly more fluid boluses （8 vs. 3; P 〈0.001） and vasopressors （2 vs. 0; P 〈0.05） than the ＂Nonresponders＂ group to restore blood pressure. Finally, PLR-APP was positively correlated with

关键词： passive leg raising test, dexmedetomidine hypotension intensive care unit

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Essentially Commuting Truncated Toeplitz Operators

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Acta Mathematica Sinica,English Series 2024年第10期40卷 2453-2480页

作者： Xi ZHAO tao yu School of Mathematics and Science Hebei GEO University School of Mathematical Sciences Dalian University of Technology

A model space is a subspace of the Hardy space which is invariant under the backward shift,and a truncated Toeplitz operator is the compression of a Toeplitz operator on some model space. In this paper we prove a necessary and sufficient condition for the commutator of two truncated Toeplitz operators on a model space to be compact.

关键词： 47B32 47B35 commutator compact operator maximal ideal space model space Truncated Toeplitz operator

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Advanced nanofabrication for elastic inorganic aerogels

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Nano Research 2024年第10期17卷 8842-8862页

作者： Xiaota Cheng Xinyi Chang Fan Wu Yalong Liao Kai pan Hao Fong Jianyong yu Yi-tao Liu Bin Ding Innovation Center for Textile Science and Technology College of TextilesDonghua UniversityShanghai 201620China Aerospace Institute of Advanced Material and Processing Technology Beijing 100074China College of Materials Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China

Inorganic aerogels with low density,high porosity,large specific surface area,and superior mechanical properties are excellent candidate materials in fields such as thermal management,energy,catalysis,and biomedical applications.A comprehensive overview of existing elastic inorganic aerogels is provided,covering their structural units,preparation methods,mechanical performances,and ***,based on the constituent building blocks and microstructures,a detailed analysis of the mechanical properties and guidelines for elastic design of aerogels is *** with a succinct summary of prospective developmental direction,this review deliberates on the challenges and potential opportunities of elastic inorganic aerogels,with the intent of providing a versatile platform for designing new types of elastic inorganic aerogels for various applications.

关键词： inorganic aerogels compressive stretchable fabrication mechanical performances applications

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Relative Broken Family Sensitivity

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2297-2306页

作者： Zhuo Wei LIU tao yu Department of Mathematics Shantou UniversityShantou 515063P.R.China

Letπ:(X,T)→(Y,S)be a factor map between two topological dynamical systems,and F_(a) Furstenberg family of *** introduce the notion of relative broken *** Fs(***,Finf)be the families consisting of all syndetic subsets(*** upper Banach density subsets,infinite subsets).We show that for a factor mapπ:(X,T)→(Y,S)between transitive systems,πis relatively broken F-sensitive for F=Fs or Fpubd if and only if there exists a relative sensitive pair which is an F-recurrent point of(R_(π),T^((2)));is relatively broken Finf-sensitive if and only if there exists a relative sensitive pair which is not *** a factor mapπ:(X,T)→(Y,S)between minimal systems,we get the structure of relative broken F-sensitivity by the factor map to its maximal equicontinuous factor.

关键词： Relative sensitivity recurrent points Furstenberg family relative sensitive pairs maximal equicontinuous factor

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