检索结果-南通市图书馆

Corilagin alleviates podocyte injury in diabetic nephropathy by regulat.ng autophagy via the SIRt1-AMPK pathway

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第9期15卷 1916-1931页

作者： yu lou yu-t.ng Luan Wen-Qing Rong yun Gai Department of Preventive treatment of Disease Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200137China Department of Infectious Diseases Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200137China Department of General Practice(Including Medical Oncology) Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200137China

BACKGROUND Diabetic nephropathy(DN)is the most frequent chronic microvascular consequence of diabetes,and podocyte injury and malfunction are closely related to the development of *** have shown that corilagin(Cor)has hepatoprotective,anti-inflammatory,antibacterial,antioxidant,anti-hypertensive,antidiabetic,and anti-tumor *** to explore the protective effect of Cor against podocyte injury in DN mice and the underlying *** Streptozotocin and a high-fat diet were combined to generate DN mice models,which were then divided into either a Cor group or a DN group(n=8 in each group).Mice in the Cor group were intraperitoneally injected with Cor(30 mg/kg/d)for 12 wk,and mice in the DN group were treated with *** analysis was used to measure the blood lipid *** and eosin staining was used to detect pathological changes in kidney *** and Western blott.ng were used to assess the protein expression of nephrin and *** podocyte cells(MPC5)were cultured and treated with glucose(5 mmol/L),Cor(50μM),high glucose(HG)(30 mmol/L),and HG(30 mmol/L)plus Cor(50μM).Real-time quantitative PCR and Western blott.ng RESULtS Compared with the control group,the DN mice models had increased fast.ng blood glucose,glycosylated hemoglobin,triglycerides,and total cholesterol,decreased nephrin and podocin expression,increased apoptosis rate,elevated inflammatory cytokines,and enhanced oxidative *** of the conditions mentioned above were alleviated after intervention with *** addition,Cor therapy improved SIRt1 and AMPK expression(Pted reactive oxygen species and oxidative stress,and elevated autophagy in HG-induced podocytes(Ptes podocyte injury by regulat.ng autophagy via the SIRt1-AMPK pathway,thereby exert.ng its protective impact on renal function in DN mice.

关键词： Corilagin Podocyte injury Diabetic nephropathy Autophagy High glucose SIRt1-AMPK pathway

Investigation on occupant presence and appliance operation schedules for university campus in south China sub-tropical area

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Building Simulation 2024年第2期17卷 301-318页

作者： Siwei lou Zhongyuan Lin yukai Zou Dawei Xia yu Huang Zhuohong Li Zhaowen Gu School of Civil Engineering Guangzhou UniversityGuangzhou Higher Edu.Mega CenterGuangzhouChina School of Architecture and Urban Planning Guangzhou UniversityGuangzhou Higher Edu.Mega CenterGuangzhouChina

Building occupant presence during varying periods is crucial to the performance studies of buildings and city ***,the understanding of the building occupancies on the university campus remains *** address this gap,our study employs field measurements,payment records,course arrangements,and building access systems to depict the occupancy patterns of the canteen,dormitory,library,and teaching and lab buildings during weekdays and *** found that the occupancy rates across different buildings are somehow interrelated,given that the total number of occupants on campus is generally ***,dormitory occupancy rates tend to be low during the morning and afternoon course hours,which inversely correlates with the high occupancy rates in the teaching and lab buildings during these ***,canteens experience surges in occupancy during meal times,which coincide with a decrease in library ***,we established appliance operation schedules for dormitories through surveys and on-site *** dispensers and electronic devices were identified as the primary energy consumers for both male and female occupants,with desk-top fans and hairdryers being significant energy users for male and female occupants,*** findings are essential for energy studies within a campus sett.ng,underlining the importance of considering occupant behaviors on a regional scale.

关键词： building occupant behavior university campus occupancy schedule appliance operation schedule

Enhanced potassium storage of carbon nanofibers as binderfree anodes enabled by coupling ultra-small amorphous Sb_(2)O_(3),graphene modification and sulfur doping

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第1期43卷 51-64页

作者： Zhao Huang yu-Kang lou Lin Peng yuan Peng Meng-Meng Wang Ming Zhang College of Railway transportation Hunan University of TechnologyZhuzhou 412007China College of Semiconductors(College of Integrated Circuits) Changsha Semiconductor Technology and Application Innovation Research InstituteHunan UniversityChangsha 410082China Key Laboratory for Micro-Nano Optoelectronic Devices of Ministry of Education College of Semiconductors(College of Integrated Circuits)Hunan UniversityChangsha 410082China

Considering the intrinsic advantages of natural copiousness and cost-effectiveness of potassium resource,potassium-ion batteries(KIBs) are booming as prospective alternatives to lithium-ion batteries(LIBs) in large-scale energy storage scenarios. Nevertheless, lacking desirable electrodes for reversibly host.ng the bulky K+hinders the widespread application of KIBs, and it needs to be urgently solved. Hereon, the porous S-doped Sb_(2)O_(3)-graphene-carbon(SAGC) nanofibers are manufactured through an adjustable and facile approach, which involves electrospinning, in situ etching and sulfuration. the synthesized SAGC is featured by the ultra-small amorphous Sb_(2)O_(3) homogeneously wrapped inside the carbon matrix, as well as the co-incorporation of graphene and sulfur. tentatively,the SAGC nanofiber sheets are applied as binder-free anodes for KIBs, exhibit.ng a prominent cycling life(256.72 m Ah·g^(-1) over 150 cycles at 100 m A·g^(-1)) and rate·g^(-1) over 100 cycles at 1 A·g^(-1)). the positive synergy among all the active components accounts for the dist.nguished performances of the SAGC. By reinforcing the tolerability to the swelling stress, producing the valid electrochemical active sites, and promot.ng the charge transferring for reversible K+uptake, the SAGC finally renders the excellent cyclability, capacity, and rate capability. Moreover, the extrinsic electrochemical pseudocapacitance characteristics induced by the porous carbon substrate elevate the K-storage capacity of the SAGC as well. It is hoped that the conclusions drawn may offer new insights into a direction for the high-performance binderfree KIB anodes.

关键词： S-doped Sb_(2)O_(3)-graphene-carbon Nanofibers Binder-free Anodes Potassium-ion batteries

Effects of deformation temperatures on microstructures,aging behaviors and mechanical properties of Mg-Gd-Er-Zr alloys fabricated by hard-plate rolling

在线全文

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2024年第6期12卷 2345-2359页

作者： Ke Liu Dalong Hu Feng lou Zijian yu Shubo Li Xian Du Wenbo Du Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing 100124China

In this investigation,a high-strength Mg-12Gd-1.0Er-0.5Zr(wt.%)alloy sheet was produced by hot extrusion(HE)and subsequent hard-plate rolling(HPR)at different *** results indicate that the microstructures of these final-rolled sheets are inhomogeneous,mainly including coarse deformed grains and dynamic recrystallized(DRXed)grains,and the volume fraction of these coarse deformed grains increases as the rolling temperature ***,more DRXed grains can be found in R-385℃sheet,result.ng in a smaller average grain size and weaker basal texture,while the biggest grains and the highest strong basal texture are present in R-450℃*** of dynamic precipitation ofβphases which are mainly determined by the rolling temperature are present in these sheets,and its precipitation can consume the content of Gd solutes in the *** a result,the lowest number density ofβphase in R-450℃sheet is beneficial to modify the age hardening ***,the R-450℃sheet displays the best age hardening response because of a severe traditional precipitation ofβ’(more)andβH/βM(less)precipitates,result.ng in a sharp improvement in strength,*** tensile strength(UtS)of∼518±17 MPa and yield strength(YS)of∼438±18 ***,the elongation(EL)of this sheet reduces greatly,and its value is∼2.7±0.3%.By contrast.ng,the EL of the peak-aging R-385℃sheet keeps better,changing from∼4.9±1.2%to∼4.8±1.4%due to a novel dislocation-induced chain-like precipitate which is helpful to keep good balance between strength and ductility.

关键词： Mg-Gd-Er-Zr sheets Age hardening response Precipitates Mechanical properties

Pharmacotherapy of urethral stricture

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2024年第1期26卷 1-9页

作者： Hui Luo Ke-Cheng lou Ling-yu Xie Fei Zeng Jun-Rong Zou the First Clinical College Gannan Medical UniversityGanzhou 341000China Department of Urology The First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000China Institute of Urology The First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000China Jiangxi Engineering technology Research Center of Calculi Prevention Ganzhou 341000China

Urethral stricture is characterized by the chronic formation of fibrous tissue,leading to the narrowing of the urethral *** the availability of various endoscopic treatments,the recurrence of urethral strictures remains a common *** pharmacotherapy target.ng tissue fibrosis is a promising option for reducing recurrence *** drugs cannot replace surgery,they can be used as adjuvant therapies to improve *** this regard,many drugs have been proposed based on the mechanisms underlying the pathophysiology of urethral *** studies have obtained substantial progress in treat.ng urethral strictures,highlight.ng the potential for improved drug effectiveness through appropriate clinical delivery ***,this review summarizes the latest researches on the mechanisms related to the pathophysiology of urethral stricture and the drugs to provide a theoretical basis and new insights for the effective use and future advancements in drug therapy for urethral stricture.

关键词： adjuvant therapy pathophysiology pharmacotherapy urethra urethral stricture

Single depth image 3D face reconstruction via domain adaptive learning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Computer Science 2024年第1期18卷 259-261页

作者： Xiaoxu CAI Jianwen lou Jiajun BU Junyu DOng Haishuai WAng Hui yu College of Computer Science and technology Zhejiang UniversityHangzhou 310013China School of Creative technologies University of PortsmouthPortsmouth PO12DJUK College of Computer Science and technology Ocean University of ChinaQingdao 266100China

1 Introduction In this paper,we propose a novel domain-adaptive reconstruction method that effectively leverages deep learning and synthetic data to achieve robust 3D face reconstruction from a single depth *** method applies two domain-adaptive neural networks for predict.ng head pose and facial shape,*** networks undergo training with a customized domain adaptation strategy,using a combination of auto-labeled synthetic and unlabeled real data.

关键词： networks image learning

Research on Hepatocyte Regulation of PCSK9-LDLR and Its Related Drug targets

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第7期30卷 664-672页

作者： LIU Su-su yu t.ng QIAO Yan-fang GU Shu-xiao CHAI Xin-lou School of traditional Chinese Medicine Beijing University of Traditional Chinese MedicineBeijing102401China

the prevalence of hyperlipidemia has increased significantly due to genetic, dietary, nutritional and pharmacological factors, and has become one of the most common pathological conditions in humans. Hyperlipidemia can lead to a range of diseases such as atherosclerosis, stroke, coronary heart disease, myocardial infarction, diabetes, and kidney failure, etc. High circulat.ng low-density lipoprotein cholesterol (LDL-C) is one of the causes of hyperlipidemia. LDL-C in the blood binds to LDL receptor (LDLR) and regulates cholesterol homeostasis through endocytosis. In contrast, proprotein convertase subtilisin/kexin type 9 (PCSK9) mediates LDLR degradation via the intracellular and extracellular pathways, leading to hyperlipidemia. target.ng PCSK9-synthesizing transcription factors and downstream molecules are important for development of new lipid-lowering drugs. Clinical trials regarding PCSK9 inhibitors have demonstrated a reduction in atherosclerotic cardiovascular disease events. the purpose of this review was to explore the target and mechanism of intracellular and extracellular pathways in degradation of LDLR and related drugs by PCSK9 in order to open up a new pathway for the development of new lipid-lowering drugs.

关键词： hyperlipidemia proprotein convertase subtilisin/kexin type 9 low-density lipoprotein receptor intracellular pathway extracellular pathway

Residual inflammatory risk predicts long-term outcomes following stent.ng for symptomatic intracranial atherosclerotic stenosis

在线全文

学校读者我要写书评

暂无评论

Stroke & Vascular Neurology 2024年第4期9卷 407-417页

作者： Ying yu Yake lou yuesong Pan Long Yan Weilun Fu Zhikai Hou Rongrong Cui Zhongrong Miao Yongjun Wang Xin lou Ning Ma Department of Interventional Neuroradiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Cardiology The Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Neurology Beijing Daxing District People's HospitalBeijingChina Radiology Chinese PLA General HospitalBeijingChina

Background and purpose Residual inflammatory risk(RIR)can predict the unfavourable outcomes in patients with minor ischaemic ***,the impact of preprocedural RIR on long-term outcomes in patients with symptomatic intracranial atherosclerotic stenosis(sICAS)who underwent stent.ng remains *** this retrospective,single-centre cohort study evaluated consecutive patients with severe sICAS who underwent intracranial *** were categorised into four groups based on preprocedural high-sensitivity C-reactive protein(hs-CRP)and low-density lipoprotein cholesterol(LDL-C):residual cholesterol inflammatory risk(RCIR,hs-CRP≥3 mg/L and LDL-C≥2.6 mmol/L),RIR(hs-CRP≥3 mg/L and LDL-Cterol risk(RCR,hs-CRPthe long-term clinical outcomes included recurrent ischaemic stroke and *** long-term imaging outcomes consisted of in-stent restenosis(ISR)and symptomatic ISR(sISR)after *** In this study,952 patients were included,with 751(78.9%)being ***-six cases were categorised into the RCIR group,211 into the RIR group,107 into the RCR group and 588 into the NRR *** with RCIR(adjusted HR 6.163;95%CI 2.603 to 14.589;pted HR 2.205;95%CI 1.294 to 3.757;p=0.004)had higher risks of recurrent ischaemic stroke than those with NRR during the 54 months of median follow-up *** with RCIR(adjusted HR 3.604;95%CI 1.431 to 9.072;p=0.007)were more likely to occur ISR,and patients in the RIR group showed a significant increase in the risk of sISR(adjusted HR 2.402;95%CI 1.078 to 5.351;p=0.032)compared with those in the NRR group with a median follow-up time of 11.9 *** In patients with sICAS,preprocedural RIR may predict long-term recurrent ischaemic stroke,ISR and sISR following intracranial stent.ng.

关键词： intracranial stenosis symptomatic

Ren-integrable and ren-symmetric integrable systems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in theoretical Physics 2024年第3期76卷 62-69页

作者： S Y lou School of Physical Science and technology Ningbo UniversityNingbo315211China

A new type of symmetry,ren-symmetry,describing anyon physics and corresponding topological physics,is ***-symmetry is a generalization of super-symmetry which is widely applied in super-symmetric physics such as super-symmetric quantum mechanics,super-symmetric gravity,super-symmetric string theory,super-symmetric integrable systems and so *** and Grassmann numbers are,in some sense,dual conceptions,and it turns out that these conceptions coincide for the ren situation,that is,a similar conception of ren-number(R-number)is devised for *** particular,some basic results of the R-number and ren-symmetry are exposed which allow one to derive,in principle,some new types of integrable systems including ren-integrable models and ren-symmetric integrable *** examples of ren-integrable KdV-type systems and ren-symmetric KdV equations are explicitly given.

关键词： symmetries integrable systems anyon physics extended supersymmetry ren-symmetry