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应用海洋学学报 1989年第4期31卷 54-60页

作者：余兆康史磷华王屏路福建省地震局

本文对福建地区的航磁资料进行了不同高度的延拓处理,并给出了福建地区的居里等温面的计算结果。在此基础上,对福建地区的居里等温面及其与地震的关系作了初步探讨。

关键词：居里等温面福建地区磁性体磁异常航磁磁测磁性基底化极高频段深度分布

环境空气质量新标准对“十二五”目标完成的影响

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环境保护科学 2017年第1期43卷 26-29页

作者：史宇王宁杨丽阎中国环境监测总站北京100012 环境保护部环境规划院北京100012

十二五"期间全国PM_(10)浓度陡增导致了达标城市比例降低,影响了《国家环境保护"十二五"规划》空气质量指标的完成。通过对PM_(10)浓度时间和空间变化分析,得出《环境空气质量标准》(GB3095-2012)的逐步实施对全国PM_(10)浓度的异常变... 详细信息

十二五"期间全国PM_(10)浓度陡增导致了达标城市比例降低,影响了《国家环境保护"十二五"规划》空气质量指标的完成。通过对PM_(10)浓度时间和空间变化分析,得出《环境空气质量标准》(GB3095-2012)的逐步实施对全国PM_(10)浓度的异常变化有着显著影响。新标准的发布施行,促进了PM_(10)监测仪器和方法更新升级,大幅收严了监测数据统计的有效性,提升了监测数据的质量控制水平,从主观和客观上更加有效的提高了监测数据的精度。

关键词：环境空气质量新标准监测仪器监测方法数据统计有效性质量控制

Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期 369-376页

作者： Song-Meng wang Hao Nian Yan-Fang wang Li-Shuo Zheng yu-Tao Zheng Yi-Wei Dong Liping Huang Xiaoping wang Wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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中国农村生活垃圾的产生量与物理特性分析及处理建议

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农业工程学报 2017年第15期33卷 1-14页

作者：韩智勇费勇强刘丹旦增张嵛施国中王加雷谢燕华地质灾害防治与地质环境保护国家重点实验室(成都理工大学) 成都610059 国家环境保护水土污染协同控制与联合修复重点实验室(成都理工大学) 成都610059 农业部沼气科学研究所成都610041 西南交通大学地球科学与环境工程学院成都610031 西藏大学理学院拉萨850002 中国城市建设研究院有限公司北京100120

中国农村生活垃圾对生态环境的污染日益严重,为给农村生活垃圾的管理提供相应的理论支撑和技术支持,促进"新农村"的建设,该文基于对西部6省18县59村580户农户的现场调研和全国25个省(市)128篇文献调研的数理统计,对中国农村生活垃圾的... 详细信息

中国农村生活垃圾对生态环境的污染日益严重,为给农村生活垃圾的管理提供相应的理论支撑和技术支持,促进"新农村"的建设,该文基于对西部6省18县59村580户农户的现场调研和全国25个省(市)128篇文献调研的数理统计,对中国农村生活垃圾的来源、产生率、产生量、组分、容重、可压缩性等特征进行了全面、系统的归纳总结与分析。结果表明:中国农村生活垃圾产生率介于0.034~3.000 kg/(人·d)之间,中位值为0.521 kg/(人·d),2014年产生量达到1.48亿t,具有来源广泛且分散、产率低、产量高、增长迅速、区域差异显著等特点。生活垃圾主要组分包括厨余类、灰土类、橡塑类和纸类,其湿基质量累计百分比达到了83.61%,区域差异显著;与城市生活垃圾组分相比,具有低厨余和金属、高灰土含量的特点,并逐渐趋于城市化。生活垃圾的容重介于40~650 kg/m^3之间,平均值为263 kg/m^3,可压缩性较好。根据生活垃圾特性,在实施"村收集-镇运输-县处理"管理模式的农村,建议采用压缩式中转站和垃圾车进行收运;在有条件的农村地区,可逐步开展垃圾分类收集,将厨余和灰土从生活垃圾中分离后就地消纳。

关键词：垃圾农村物理特性产生量垃圾组分容重可压缩性

FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao yuan Li Xi Liu Wenping Liang yu Li Liyong Wu Zhe wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

Successful emergency surgical intervention in acute non-STsegment elevation myocardial infarction with rupture:A case report

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World Journal of Clinical Cases 2025年第4期13卷 41-47页

作者： Xing-Po Li Zi-Shan wang Hong-Xia yu Shan-Shan wang Department of Cardiovascular Medicine Huantai County Hospital of Traditional Chinese MedicineZibo 256400Shandong ProvinceChina Department of Cardiovascular Medicine Zibo Hospital of Integrated Traditional Chinese and Western MedicineZibo 255500Shandong ProvinceChina

BACKGROUND The incidence of acute myocardial infarction(AMI)is rising,with cardiac rupture accounting for approximately 2%of deaths in patients with acute ST-segment elevation myocardial infarction(STEMI).Ventricular free wall rupture(FWR)occurs in approximately 2%of AMI patients and is notably rare in patients with *** of cardiac rupture include left ventricular FWR,ventricular septal rupture,and papillary muscle *** FWR usually leads to acute cardiac tamponade or electromechanical dissociation,where standard resuscitation efforts may not be *** septal rupture and papillary muscle rupture often result in refractory heart failure,with mortality rates over 50%,even with surgical or percutaneous repair *** SUMMARY We present a rare case of an acute non-STEMI patient who suffered sudden FWR causing cardiac tamponade and loss of consciousness immediate before undergoing coronary *** resuscitation and emergency open-heart repair along with coronary artery bypass grafting resulted in successful patient *** This case emphasizes the risks of AMI complications,shares a successful treatment scenario,and discusses measures to prevent such complications.

关键词： Acute non-ST segment elevation myocardial infarction Cardiac rupture Acute myocardial infarction Free wall rupture Case report

基于超声波A/D采样法的相位差位移测量方法

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计量学报 2016年第6期37卷 559-562页

作者：徐从裕王诗豪吴晓凤刘治国徐慧君合肥工业大学仪器科学与光电工程学院

为了提高超声波位移测量分辨率，提出一种基于超声波A／D采样法的超声波相位差位移测量方法，利用超声波信号的相邻采样数据之差，消除了超声波信号中的直流成分对相位差位移测量的影响，再通过不同相邻采样数据之差的比值建立了相位差... 详细信息

为了提高超声波位移测量分辨率，提出一种基于超声波A／D采样法的超声波相位差位移测量方法，利用超声波信号的相邻采样数据之差，消除了超声波信号中的直流成分对相位差位移测量的影响，再通过不同相邻采样数据之差的比值建立了相位差位移测量的数学模型，由此获得较高的相位差位移测量分辨率。该方法的采样电路简单，不需要高倍数超声波信号采样率，仅需在一个超声波信号周期里采样10几个数据，就可获得亚微米级的位移测量分辨率。实验结果验证了该方法的有效性。基于该方法研制的超声波位移测量平台，若超声波频率选用40kHz，则位移测量分辨率可达1μm。

关键词：计量学位移测量超声波 A/D采样相位差

Mainchain conformation ordering self-assembly tailored room temperature phosphorescence emission

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Science China Chemistry 2025年第01期 329-336页

作者： yuzhu Li yumeng Gao Feng Tian yu wang yuan Yao Shaoliang Lin Xiang Ma Binbin Xu Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Key Laboratory for Advance Materials and Feringa Noble Prize Scientist Joint Research Centre Frontiers Science for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science & Technology

Developing organic room-temperature phosphorescence （RTP） materials with a wide range of tunable-emission is significant in expanding the applications of RTP ***,we rationally designed amphiphilic alternating copolymers poly(1,2-bis（4-alkoxyphenyl）ethane-1,2-dione-alt-（ethylene glycol）x)(P（Bz-alt-EGx）) that combined the advantage of alternating benzil and EGxskeleton,and tunable mainchain *** a mainchain conformation ordering assembly （COA） process,P（Bz-alt-EGx） self-assembled into well-defined platelets,and such assemblies emitted blue RTP at ca.425 nm due to the ordered folded-chain conformation and confined *** contrast,traditional self-assembly （TA） of P（Bz-alt-EGx） obtained less ordered aggregates,such as asymmetric worms,vesicles,and rod-like *** resultant less ordered aggregates exhibited yellow-green RTP at ca.550 *** wide-tuning RTP emission in solution （between blue and yellow-green,over125 nm） is realized using the P（Bz-alt-EGx） alternating copolymers under the treatment of different self-assembly *** study uncovers a new strategy to tailor the RTP emission through different self-assembly pathways and holds great promise for the fabrication of advanced optical materials.

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PM_(2.5)对人体的危害

辽宁化工 2017年第6期46卷 618-620页

作者：吕勇付玉辛士刚王莹沈阳师范大学化学化工学院辽宁沈阳110034

主要介绍了什么是PM_(2.5)、什么是细颗粒物,并对PM_(2.5)的形成原因和PM_(2.5)对人体的危害进行了探讨,对于PM_(2.5)的防治提出了一些建议和措施。

关键词： PM2.5 雾霾细颗粒物新能源

Cobalamin-dependent radical S-adenosyl-L-methionine protein functions with a partner to successively methylate tricyclic indole alkaloid for chuangxinmycin maturation and derivatization

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Science China Chemistry 2025年第1期 308-316页

作者： Sili wang Jiancheng Huang Yanan Du Wei Huang yufeng Xue Xiaokun Xu Guannan Zhong yuanyuan shi Bin Hong Xiaoying Bian Wen Liu State Key Laboratory of Chemical Biology Shanghai Institute of Organic Chemistry University of Chinese Academy of SciencesChinese Academy of Sciences State Key Laboratory of Microbial Technology Shandong University National Health Commission (NHC) Key Laboratory of Biotechnology for Microbial Drugs Institute of Medicinal BiotechnologyChinese Academy of Medical Science & Peking Union Medical College

Cobalamin(Cbl)-dependent radical S-adenosyl-L-methionine(SAM) proteins constitute the largest collection of the radical SAM superfamily that has hundreds of thousands of individual members. Many of these proteins are involved in the biosynthesis of pharmaceutically important natural products to catalyze chemically demanding reactions. In the biosynthetic pathway of chuangxinmycin(CXM), a unique indole alkaloid antibiotic with potent anti-infective activity, functionalization of the characteristic thiopyrano[4,3,2-cd]indole scaffold by regio-and stereoselective C3-methylation is believed to rely on a Cbl-dependent radical process, which, however, remained to be reconstituted biochemically. We here report the dissection of this enzymatic process, which requires the incorporation of Cxm8, a Cbl-dependent radical SAM protein, with Cxm9, a DUF5825family protein that shares no homology to any proteins of known functions. Cxm8 and Cxm9 function together by forming an unexpected heterodimeric complex that selectively catalyzes C3-methylation of the tricyclic indole-S-hetero ring system in a successive manner, achieving CXM and a recently identified, C3-dimethylated congener. Detailed biochemical characterization,isotope labeling, structural simulation and bioinformatics analysis rationalized the catalysis of the Cxm8/Cxm9 complex and particularly the necessity of the DUF5825 protein for C3-methylase activity. This is the first example that a Cbl-dependent protein acts with a partner to exhibit radical SAM activity.

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