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Rare Metals 2022年第5期41卷 1406-1409页

作者： Kang Liang yu-rong ren School of Materials Science and Engineering Jiangsu Province Engineering Research Center of Intelligent Manufacturing Technology for the New Energy Vehicle Power BatteryChangzhou UniversityChangzhou 213164China

Sodium-ion batteries(SIBs)have received much attention as a potential energy storage system to replace lithium-ion batteries(LIBs)due to the abundant sodium resources and low cost[1,2].Recently,conversion materials[3]... 详细信息

关键词： replace insertion lithium

Enhancing lithium-ion and electric conductive Li_(2)FeSiO_(4)cathode through in situ boron-doping and carbon-coating strategy

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Rare Metals 2022年第12期41卷 4055-4064页

作者： Hao-Xiang Li Jia-Hui Zhu Xiao-Bing Huang Tao Zhou yu-rong ren Hunan Provincial Key Laboratory of Chemical Power Sources College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China Hunan Provincial Key Laboratory of Water Treatment Functional Materials Hunan Provincial Key Laboratory for Control Technology of Distributed Electric Propulsion AircraftCollege of Chemistry and Materials EngineeringHunan University of Arts and ScienceChangde 415000China Jiangsu Province Engineering Research Center of Intelligent Manufacturing Technology for the New Energy Vehicle Power Battery Changzhou Key Laboratory of Intelligent Manufacturing and Advanced Technology for Power BatterySchool of Materials Science and EngineeringChangzhou UniversityChangzhou 213164China

The extremely low electrical conductivity and ion-diffusion coefficient of Li_(2)FeSiO_(4)limits its application as a cathode material in lithium-ion batteries.Therefore,in situ boron-doped Li_(2)FeSi_(1)-xB_(x)O_(4-δ)/C(x=0,0.01,0.03,0.05 and 0.07)at the Si site was prepared via the solid-state reaction method using pitch as the c arbon source.B doping in the lattice structure and a c arbon coating on the surface of the composites could effectively enhance the Li^(+)/electron conductivity.Moreover,the reduced particle size of the active material with the relatively high specific area via borondoped modification could improve the wettability between the electrolyte and cathode.With the synergistic effect of appropriate boron doping and carbon coating,it exhibits a good rate performance,specific capacity,and cycling performance.As a result,the as-prepared Li_(2)FeSi_(0.95)B_(0.05)O_(4-δ)/C cathode showed a high discharge capacity of 160.7mAh·g^(-1)at 0.2C,and the capacity retention rate was 96%after 100 cycles at 1.0C.This work presents an effective path for designing advanced cathode materials for lithium-ion batteries.

关键词： Li_(2)FeSiO_(4) Carbon coating Boron doping Synergistic effect Lithium-ion battery

Phosphorus-doping and oxygen vacancy endowing anatase TiO_(2) with excellent sodium storage performance

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Rare Metals 2022年第4期41卷 1284-1293页

作者： Hong-Shun Zhao Yan-Li Qi Kang Liang Wei-Kai Zhu Hao-Bin Wu Jian-Bin Li yu-rong ren School of Materials Science and Engineering Changzhou UniversityChangzhou 213164China Changzhou Key Laboratory of Intelligent Manufacturing and Advanced Technology for Power Battery Changzhou 213164China Jiangsu Province Engineering Research Center of Intelligent Manufacturing Technology for the New Energy Vehicle Power Battery Changzhou 213164China Institute for Composites Science Innovation(InCSI) School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China

Titanium dioxide is considered to be promising anode for sodium-ion batteries due to stable structure during the charge/discharge process.However,its practical application is hindered by the slow electron/ion transport.Herein,phosphorus-doped anatase TiO_(2) nanoparticles with oxygen vacancies are successfully synthesized and utilized as high-performance sodium-storage materials.The dual strategy of phosphorus-doping and oxygen vacancies can concurrently boost electronic conductivity and adjust ion diffusion kinetics.They significantly contribute to the improved rate performance(167 mAh·g^(-1) at 20.0C)and stable cycling(95.9%after 2000 cycles at 20.0C).The proposed dual strategy can be potentially used to improve other oxide anodes for rechargeable batteries.

关键词： Titanium dioxide Phosphorus doping Oxygen vacancy Anode Sodium-ion batteries

Tetra(acetylacetonato) tin(Ⅳ) as new catalyst for polytrimethylene terephthalate synthesis

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Chinese Chemical Letters 2010年第3期21卷 357-360页

作者： Shu Yong Jia yu rong ren Gong Ying Wang College of Chemistry Jilin Normal UniversitySiping 136000China Chengdu Institute of Organic Chemistry Chinese Academy of SciencesChengdu 610041China

Chelate tetra(acetylacetonato) tin(Ⅳ) was prepared and used as catalyst for polytrimethylene terephthalate synthesis.It exhibited higher catalytic activity than tetrabutyl titanate,butyltinhydroxide oxide and dibutyltin oxide.Decrease in reaction time, content of terminal carboxyl group,color intensity and increase in intrinsic viscosity were observed.The unique molecular structure can be considered as factor remarkably improving the catalytic activity of tetra(acetylacetonato) tin(Ⅳ).

关键词： Tetra(acetylacetonato) tin(Ⅳ) Polytrimethylene terephthalate Terephthalic acid 1,3-Propanediol

Stannous-acetylacetonate:A new catalyst for poly(trimethylene terephthalate) synthesis

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Chinese Chemical Letters 2007年第7期18卷 827-830页

作者： Shu Yong Jia yu rong ren Liang Ming Liu Dan Zhang Yi Zeng Gong Ying Wang Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China College of Chemistry Jilin Normal University Siping 136000 China Graduate University of Chinese Academy of Sciences Beijing 100039 China

Stannous-acetylacetonate was prepared efficiently and characterized by ^1H NMR and FT-IR. Its catalytic activity for poly（trimethylene terephthalate）（PTT） synthesis was investigated. By this catalyst, the degree of esterification of pure terephthalic acid was up to 91.7% after reaction at 260 ℃ for 2 h, while the intrinsic viscosity and content of terminal carboxyl groups of the corresponding PTT polymerized at 260 ℃, 60 Pa for 2 h was 0.8816 dL/g and 17 mol/t,respectively. Stannous-acetylacetonate was more active and promising than tetrabutyl titanate and stannous octoate for PTT synthesis.

关键词： Poly（trimethylene terephthalate） Stannous-acetylacetonate 1,3-Propanediol

Efficacy and safety of Y- 2 sublingual tablet for patients with acute ischaemic stroke: protocol of a phase III randomised double- blind placebo- controlled multicentre trial

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Stroke & Vascular Neurology 2024年第1期9卷 90-95页

作者： yu Fu renhong Tang rong Chen Anxin Wang Jinsheng ren Shunwei Zhu Xiaofei Feng Dongsheng Fan Deparment of Neurology Peking University Third HospitalBeijingChina State Key Laboratory of Neurology and Oncology Drug Development NanjingJiangsuChina Simcere Pharmaceutical Group Limited NanjingJiangsuChina Neurodawn Pharmaceutical Co. LtdNanjingJiangsuChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background and purpose Clinical studies have demonstrated that edaravone dexborneol can improve the functional outcomes in patients with acute ischaemic stroke(AIS).The present clinical trial aimed at testing the efficacy and safety of Y-2 sublingual tablet on 90-day functional outcome in patients with AIS.Methods and design This is a randomised,double-blind,placebo-controlled,multicentre,parallel-group trial of Y-2 sublingual tablet on patients with AIS.An estimated 914 patients at age of 18–80 years with AIS within 48 hours after symptom onset from 40 hospitals will be randomly assigned to receive Y-2 sublingual tablet or placebo for 14 days.Patients are at score 6–20 points on National Institutes of Health Stroke Scale(NIHSS)and had a modified Rankin Scale(mRS)≤1 before this stroke,except mechanical thrombectomy and neuroprotective agents treatment.Study outcomes The primary outcome is the proportion of patients with mRS≤1 on day 90 after randomisation.Secondary efficacy outcomes include mRS score on day 90,the proportion of patients with mRS≤2 on day 90;the change of NIHSS score from baseline to day 14 and the proportion of patients with NIHSS score≤1 at the days 14,30 and 90.Discussion This trial will provide valuable evidence for the efficacy and safety of Y-2 sublingual table for improving 90 days the functional outcomes in patients with AIS.Trial registration number NCT04950920.

关键词： patients protective centre

Expression and clinical significance of short-chain fatty acids in patients with intrahepatic cholestasis of pregnancy

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World Journal of Hepatology 2024年第4期16卷 601-611页

作者： Shuai-Jun ren Jia-Ting Feng Ting Xiang Cai-Lian Liao yu-Ping Zhou rong-rong Xuan Department of Obstetrics and Gynecology The First Affiliated Hospital of Ningbo UniversityNingbo 315100Zhejiang ProvinceChina Health Science Center Ningbo UniversityNingbo 315211Zhejiang ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Ningbo UniversityNingbo 315211Zhejiang ProvinceChina Institute of Digestive Disease Ningbo UniversityNingbo 315020Zhejiang ProvinceChina

BACKGROUND Intrahepatic cholestasis of pregnancy(ICP)is a pregnancy-specific liver condition that typically arises in the middle and late stages of pregnancy.Short-chain fatty acids(SCFAs),prominent metabolites of the gut microbiota,have significant connections with various pregnancy complications,and some SCFAs hold potential for treating such complications.However,the metabolic profile of SCFAs in patients with ICP remains unclear.AIM To investigate the metabolic profiles and differences in SCFAs present in the maternal and cord blood of patients with ICP and determine the clinical significance of these findings.METHODS Maternal serum and cord blood samples were collected from both patients with ICP(ICP group)and normal pregnant women(NP group).Targeted metabolomics was used to assess the SCFA levels in these samples.RESULTS Significant differences in maternal SCFAs were observed between the ICP and NP groups.Most SCFAs exhibited a consistent declining trend in cord blood samples from the ICP group,mirroring the pattern seen in maternal serum.Correlation analysis revealed a positive correlation between maternal serum SCFAs and cord blood SCFAs[r(Pearson)=0.88,P=7.93e-95].In both maternal serum and cord blood,acetic and caproic acids were identified as key metabolites contributing to the differences in SCFAs between the two groups(variable importance for the projection>1).Receiver operating characteristic analysis demonstrated that multiple SCFAs in maternal blood have excellent diagnostic capabilities for ICP,with caproic acid exhibiting the highest diagnostic efficacy(area under the curve=0.97).CONCLUSION Compared with the NP group,significant alterations were observed in the SCFAs of maternal serum and cord blood in the ICP group,although they displayed distinct patterns of change.Furthermore,the SCFA levels in maternal serum and cord blood were significantly positively correlated.Notably,certain maternal serum SCFAs,specifically caproic and acetic acids,demonstrated excellent diagnostic efficiency for ICP.

关键词： Intrahepatic cholestasis of pregnancy Short-chain fatty acids Maternal serum Cord blood Caproic acid

Research progress in failure mechanisms and electrolyte modification of high-voltage nickel-rich layered oxide-based lithium metal batteries

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InfoMat 2024年第2期6卷 57-75页

作者： Jiandong Liu Xinhong Hu Shihan Qi yurong ren Yong Li Jianmin Ma School of Chemistry Tiangong UniversityTianjinthe People's Republic of China School of Physics and Electronics Hunan UniversityChangshathe People's Republic of China School of Materials Science and Engineering Jiangsu Collaborative Innovation Center of Photovoltaic Science and EngineeringChangzhou UniversityChangzhouthe People's Republic of China State Key Laboratory of Space Power-Sources Technology Shanghai Institute of Space Power SourcesShanghaithe People's Republic of China

High-voltage nickel(Ni)-rich layered oxide-based lithium metal batteries(LMBs)exhibit a great potential in advanced batteries due to the ultra-high energy density.However,it is still necessary to deal with the challenges in poor cyclic and thermal stability before realizing practical application where cycling life is considered.Among many improved strategies,mechanical and chemical stability for the electrode electrolyte interface plays a key role in addressing these challenges.Therefore,extensive effort has been made to address the challenges of electrode-electrolyte interface.In this progress,the failure mechanism of Ni-rich cathode,lithium metal anode and electrolytes are reviewed,and the latest breakthrough in stabilizing electrode-electrolyte interface is also summarized.Finally,the challenges and future research directions of Ni-rich LMBs are put forward.

关键词： electrode-electrolyte interface electrolyte modification failure mechanisms high voltage lithium metal anode nickel-rich layered oxide cathode

TRAIL and Celastrol Combinational Treatment Suppresses Proliferation, Migration, and Invasion of Human Glioblastoma Cells via Targeting Wnt/β-catenin Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 322-329页

作者： QIN Jing-jing NIU Meng-da CHA Zhe GENG Qing-hua LI yu-lin ren Chun-guang David P.Molloy yu Hua-rong Research Center of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China Laboratory of Developmental Biology Department of Cell Biology and GeneticsSchool of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China

Objective To investigate the mechanistic basis for the anti-proliferation and anti-invasion effect of tumor necrosis factor-related apoptosis-induced ligand(TRAIL)and celastrol combination treatment(TCCT)in glioblastoma cells.Methods Cell counting kit-8 was used to detect the effects of different concentrations of celastrol(0-16µmol/L)and TRAIL(0-500 ng/mL)on the cell viability of glioblastoma cells.U87 cells were randomly divided into 4 groups,namely control,TRAIL(TRAIL 100 ng/mL),Cel(celastrol 0.5µmol/L)and TCCT(TRAIL 100 ng/mL+celastrol 0.5µmol/L).Cell proliferation,migration,and invasion were detected by colony formation,wound healing,and Transwell assays,respectively.Quantitative reverse transcription polymerase chain reaction and Western blotting were performed to assess the levels of epithelial-mesenchymal transition(EMT)markers(zona occludens,N-cadherin,vimentin,zinc finger E-box-binding homeobox,Slug,and β-catenin).Wnt pathway was activated by lithium chloride(LiCl,20 mol/L)and the mechanism for action of TCCT was explored.Results Celastrol and TRAIL synergistically inhibited the proliferation,migration,invasion,and EMT of U87 cells(P<0.01).TCCT up-regulated the expression of GSK-3β and down-regulated the expression of β-catenin and its associated proteins(P<0.05 or P<0.01),including c-Myc,Cyclin-D1,and matrix metalloproteinase(MMP)-2.In addition,LiCl,an activator of the Wnt signaling pathway,restored the inhibitory effects of TCCT on the expression of β-catenin and its downstream genes,as well as the migration and invasion of glioblastoma cells(P<0.05 or P<0.01).Conclusions Celastrol and TRAIL can synergistically suppress glioblastoma cell migration,invasion,and EMT,potentially through inhibition of Wnt/β-catenin pathway.This underlies a novel mechanism of action for TCCT as an effective therapy for glioblastoma.

关键词： celastrol Chinese medicine tumor necrosis factor-related apoptosis-induced ligand glioblastoma β-catenin Tripterygium wilfordii

Prognostic significance and relationship of SMAD3 phosphoisoforms and VEGFR-1 in gastric cancer:A clinicopathological study

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 118-132页

作者： Shi-Lin Lv Pei Guo Jun-rong Zou ren-Sheng Chen Ling-yu Luo De-Qiang Huang Hospital of Gastroenterology Institute of Digestive DiseasesThe First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Pathology Shenzhen Hospital of Southern Medical UniversityShenzhen 518000Guangdong ProvinceChina Institute of Urology The First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000Jiangxi ProvinceChina Department of Pathology The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND The TGF-β/SMAD3 and VEGFR-1 signaling pathways play important roles in gastric cancer metastasis.SMAD3 phosphorylation is a crucial prognostic marker in gastric cancer.AIM To determine the prognostic value and relationship of SMAD3 phospho-isoforms and VEGFR-1 in gastric cancer.METHODS This was a single-center observational study which enrolled 98 gastric cancer patients and 82 adjacent normal gastric tissues from patients aged 32-84 years(median age 65)between July 2006 and April 2007.Patients were followed up until death or the study ended(median follow-up duration of 28.5 mo).The samples were used to generate tissue microarrays(TMAs)for immunohistochemical(IHC)staining.The expressions of TGF-β1,pSMAD3C(S423/425),pSMAD3L(S204),and VEGFR-1 in gastric cancer(GC)tumor tissue and normal tissue were measured by IHC staining using TMAs obtained from 98 GC patients.Prognosis and survival information of the patients was recorded by Outdo Biotech from May 2007 to July 2015.The relationship between TGF-β1,pSMAD3C(S423/425),pSMAD3L(S204),and VEGFR-1 protein expression levels was analyzed using Pearson's correlation coefficient.The relationship between protein expression levels and clinicopathological parameters was analyzed using the Chi-squared test.A survival curve was generated using the Kaplan-Meier survival analysis.RESULTS TGFβ-1 and VEGFR-1 expression was significantly upregulated in gastric cancer tissue compared to adjacent noncancerous tissue.The positive expression of phosphorylated isoforms of Smad3 varied depending on the phosphorylation site[pSMAD3C(S423/425):51.0%and pSMAD3L(S204):31.6%].High expression of pSMAD-3L(S204)was significantly correlated with larger tumors(P=0.038)and later N stages(P=0.035).Additionally,high expression of VEGFR-1 was closely correlated with tumor size(P=0.015)and pathological grading(P=0.013).High expression of both pSMAD3L(S204)and VEGFR-1 was associated with unfavorable outcomes in terms of overall survival(OS).Multivariate analysis indicated that high expression of

关键词： Gastric cancer pSMAD3L(S204) pSMAD3C(S423/425) Survival Transforming growth factor-β1 VEGFR-1