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数字静止图象传输设备总体方案设计中的若干问题

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国防科技大学学报 1982年第1期 73-87页

作者：李情与许织新

本文首先综合比较了目前国外静止图象传输设备的性能和体制。然后根据自己工作中的不完全的体会,就总体方案设计中的若干问题,诸如图象参数、编码方法、存贮方法、同步系统、传输方式等等,提出一些探讨性的看法。最后,列举了今后的发展... 详细信息

本文首先综合比较了目前国外静止图象传输设备的性能和体制。然后根据自己工作中的不完全的体会,就总体方案设计中的若干问题,诸如图象参数、编码方法、存贮方法、同步系统、传输方式等等,提出一些探讨性的看法。最后,列举了今后的发展方向。

关键词：图象传输电视图象电视图像图象编码总体方案设计若干问题

Optimization Strategies of Na_(3)V_(2)(PO_(4))_(3) Cathode Materials for Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 204-251页

作者： Jiawen Hu Xinwei Li Qianqian Liang Li xu Changsheng Ding yu Liu Yanfeng Gao School of Materials Science and Engineering Shanghai UniversityShanghai 200444People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China

Na_(3)V_(2)(PO_(4))_(3)(NVP)has garnered great attentions as a prospective cathode material for sodium-ion batteries(SIBs)by virtue of its decent theoretical capacity,superior ion conductivity and high structural ***,the inherently poor electronic conductivity and sluggish sodium-ion diffusion kinetics of NVP material give rise to inferior rate performance and unsatisfactory energy density,which strictly confine its further application in ***,it is of significance to boost the sodium storage performance of NVP cathode *** to now,many methods have been developed to optimize the electrochemical performance of NVP cathode *** this review,the latest advances in optimization strategies for improving the electrochemical performance of NVP cathode material are well summarized and discussed,including carbon coating or modification,foreign-ion doping or substitution and nanostructure and morphology *** foreign-ion doping or substitution is highlighted,involving Na,V,and PO_(4)^(3−)sites,which include single-site doping,multiple-site doping,single-ion doping,multiple-ion doping and so ***,the challenges and prospects of high-performance NVP cathode material are also put *** is believed that this review can provide a useful reference for designing and developing high-performance NVP cathode material toward the large-scale application in SIBs.

关键词： Sodium-ion batteries Na_(3)V_(2)(PO_(4))_(3) Cathode materials Electrochemical performance Optimization strategies

32通道光纤阵列式高灵敏飞秒激光光谱分析仪

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光电子．激光 2015年第1期26卷 116-121页

作者：陈珂刘学聪罗先卫周新磊彭伟于清旭大连理工大学物理与光电工程学院辽宁大连116023

针对飞秒激光光谱学研究中对微弱光信号的多通道光谱分析的需求,提出了一种32通道光纤阵列-锁相放大光谱分析仪（OSA）设计方案。32通道光纤阵列用于传输线型分布光谱信号,经光电探测器（PD）转换的电信号由32通道同步数字锁相放大器进... 详细信息

针对飞秒激光光谱学研究中对微弱光信号的多通道光谱分析的需求,提出了一种32通道光纤阵列-锁相放大光谱分析仪（OSA）设计方案。32通道光纤阵列用于传输线型分布光谱信号,经光电探测器（PD）转换的电信号由32通道同步数字锁相放大器进行处理。基于现场可编程门阵列（FPGA）设计的32通道同步数字锁相放大器,实现了各路独立的微弱光谱信号同时检测功能。针对飞秒激光光谱测量中重复频率为1kHz的强干扰,设计1kHz陷波器,提高信号测量的动态范围。设计的OSA的测量光谱范围为400-1100nm,通道光谱间隔为4nm。实验结果表明：32通道光纤阵列OSA的通道隔离度大于80dB,输入光噪声密度为37.9fW/槡Hz,各通道极限检测灵敏度可达18.9fW,动态储备达到120dB。应用于飞秒时间分辨荧光光谱测量,对超荧光干扰抑制效果明显,同时极大地提高了测量灵敏度并缩短动力学测量时间至6 min。本文实现的OSA具有灵敏度高、体积小和性价比高等优点,适用于对微弱光谱信号的高灵敏与快速检测分析。

关键词：光纤阵列光谱分析仪(OSA) 锁相放大器多通道同步检测飞秒时间分辨光谱

基于光学相关的光纤法布里-珀罗传感器解调仪

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光子学报 2018年第6期47卷 60-65页

作者：陈珂郭珉王泽霖刘伯文周新磊于清旭大连理工大学光电工程与仪器科学学院辽宁大连116024

针对当前光纤法布里-珀罗(F-P)传感器解调仪存在的结构复杂和成本较高等问题,提出一种基于光学相关原理的新型解调方案.采用平板玻璃作为光学互相关器,利用平板玻璃与F-P腔的互相关关系解调出光纤F-P传感器的腔长.建立仿真模型对解调光... 详细信息

针对当前光纤法布里-珀罗(F-P)传感器解调仪存在的结构复杂和成本较高等问题,提出一种基于光学相关原理的新型解调方案.采用平板玻璃作为光学互相关器,利用平板玻璃与F-P腔的互相关关系解调出光纤F-P传感器的腔长.建立仿真模型对解调光路进行优化设计,搭建了结构简单的单模光纤F-P传感器解调仪,该仪器仅由宽谱光源、平板玻璃、线阵CCD、柱面镜和单模光纤搭建而成.实验结果表明,腔长解调分辨率达到0.72 nm.该解调仪在光纤测井、液位测量和结构健康监测等领域中的温度、压力和位移测量中有着广阔的应用前景.

关键词：光纤传感光学相关光纤法布里-珀罗干涉仪平板玻璃线阵电荷耦合元件

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun xu-Fang Ying Zhi-qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing xue yuejia Ma Ke Ye xue Zhao Fangliang Ge Feifei Zheng Lulu Liu xu Gao Dayong Wang qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan xu Kang He Chang-qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan xu Jie Mu yu Leng Lei Ma yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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影像密集匹配点云的单体化提取

测绘通报 2016年第12期 51-55页

作者：陈宇徐青姚富山施群山吕亮卢万杰信息工程大学河南郑州450001

以倾斜影像密集匹配点云数据为研究对象,提出了一种快速提取建筑物单体点云模型的方法。首先通过过滤地面点云数据以实现地物分离,采用高程频率直方图确定植被点云的高程区间并予以剔除。然后采用基于密度的聚类分析算法对剩余建筑物顶... 详细信息

以倾斜影像密集匹配点云数据为研究对象,提出了一种快速提取建筑物单体点云模型的方法。首先通过过滤地面点云数据以实现地物分离,采用高程频率直方图确定植被点云的高程区间并予以剔除。然后采用基于密度的聚类分析算法对剩余建筑物顶部点云进行了聚类。最后根据每栋独立建筑物屋顶点云的坐标范围,从原始点云数据中提取了每栋独立建筑物的完整点云,实现了对于倾斜影像密集匹配点云的单体化提取。

关键词：倾斜影像密集匹配点云聚类分析高程频率直方图单体化