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Chinese Journal of Chemistry 2013年第6期31卷 764-772页

作者： Quan Liu Zhongxiang Lu Wenfei Ren Kaibo Shen yu Wang qing xu College of Chemistry and Materials Engineering Wenzhou University Wenzhou Zhejiang 325035 China

By optimizing the reaction conditions via a careful screening of the bases and solvents, we developed an efficient transition metal-free method for C--O cross-coupling of activated and unactivated heteroaryl chlorides with primary and secondary alcohols and phenols, providing a simple, efficient, and practical method for synthesis of the useful unsymmetrical heteroaryl alkyl and heteroaryl aryl ethers.

关键词： alcohols C--O cross coupling heteroaryl ethers heteroaryl halides phenols transition metal-free

Ecdysone receptor isoforms play distinct roles in larval–pupal–adult transition in Leptinotarsa decemlineata

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Insect Science 2020年第3期27卷 487-499页

作者： qing-yu xu Pan Deng Qiong Zhang Ang Li Kai-yun Fu Wen-Chao Guo Guo-qing Li Education Ministry Key Laboratory of Integrated Management of Crop Diseases and Pests College of Plant ProtectionNanjing Agricultural UniversityNanjingChina Institute of Plant Protection Xinjiang Academy of Agricultural SciencesUrumqiChina Institute of Microbiological Application Xinjiang Academy of Agricultural ScienceUrumqiChina

A heterodimer of two nuclear receptors,ecdysone receptor(EcR)and ultraspiracle,mediates 20‐hydroxyecdysone(20E)signaling to modulate many aspects in insect life,such as molting and metamorphosis,reproduction,diapause and innate *** the present paper,we intended to determine the isoform‐specific roles of EcR during larval–pupal–adult transition in the Colorado potato ***‐stranded RNAs(dsRNAs)were prepared using the common(dsEcR)or isoform‐specific(dsEcRA,dsEcRB1)regions of EcR as *** of either dsEcR or dsEcRA,rather than dsEcRB1,by the penultimate(3rd)and final(4th)instar larvae caused failure of larval–pupal and pupal–adult *** RNA interference(RNAi)larvae remained as prepupae,or became deformed pupae and *** of messenger RNA(mRNA)levels of EcR isoforms found that LdEcRA regulates the expression of ***,silencing the two EcR transcripts,LdEcRA or LdEcRB1 reduced the mRNA levels of Ldspo and Ldsad,and lowered 20E *** contrast,the expression levels of HR3,HR4,E74 and E75 were significantly decreased in the LdEcR or LdEcRA RNAi larvae,but not in LdEcRB1 depleted *** supplement with 20E did not restore the expression of five 20E signaling genes(USP,HR3,HR4,E74 and E75),and only partially alleviated the pupation defects in dsEcR‐or dsEcRA‐fed *** data suggest that EcR plays isoform‐specific roles in the regulation of ecdysteroidogenesis and the transduction of 20E signal in ***.

关键词： ecdysone receptor Leptinotarsa decemlineata metamorphosis RNA interference

Epigenetic therapies in acute myeloid leukemia: the role of hypomethylating agents, histone deacetylase inhibitors and the combination of hypomethylating agents with histone deacetylase inhibitors

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Chinese Medical Journal 2020年第6期133卷 699-715页

作者： qing-yu xu Li yu Department of Hematology-Oncology International Cancer CenterShenzhen University General HospitalShenzhen University Health Science CenterShenzhenGuangdong 518000China Department of Hematology and Oncology Medical Faculty MannheimHeidelberg UniversityMannheim 68169Germany

Epigenetic regulation includes changes of DNA methylation and modifications of histone proteins and is essential for normal physiologic functions,especially for controlling gene *** dysregulation plays a key role in disease pathogenesis and progression of some malignancies,including acute myeloid leukemia(AML).Epigenetic therapies,including hypomethylating agents(HMAs)and histone deacetylase(HDAC)inhibitors,were developed to reprogram the epigenetic abnormalities in ***,the molecular mechanisms and therapeutic effects of the two agents alone or their combination remain *** overview of these epigenetic therapies is given here.A literature search was conducted through PubMed database,looking for important biological or clinical studies related to the epigenetic regimens in the treatment of AML until October 15th,*** types of articles,including original research and reviews,were assessed,identified,and eventually summarized as a collection of data pertaining the mechanisms and clinical effects of HMAs and HDAC inhibitors in AML *** provided here an overview of the current understanding of the mechanisms and clinical therapeutic effects involved in the treatment with HMAs and HDAC inhibitors alone,the combination of epigenetic therapies with intensive chemotherapy,and the combination of both types of epigenetic *** clinical trials were also *** speaking,the large number of studies and their varied outcomes demonstrate that effects of epigenetic therapies are heterogeneous,and that HMAs combination regimens probably contribute to significant response ***,more research is needed to explore therapeutic effects of HDAC inhibitors and various combinations of HMAs and HDAC inhibitors.

关键词： Acute myeloid leukemia Decitabine 5-azacytidine Histone deacetylase inhibitors Intensive chemotherapy

Rhodium-catalyzed aerobic N-alkylation of sulfonamides with alcohols

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Chinese Chemical Letters 2011年第9期22卷 1021-1024页

作者： Sun Lin Feng Chuan Zhi Liu Qiang Li Xiao Chun yu qing xu College of Chemistry and Materials Engineering Wenzhou University Wenzhou 325035 China

By using the famous Wilkinson＇s catalyst, N-alkylation of sulfonamides can be easily realized under mild aerobic conditions by using alcohols as the alkylating reagent, giving monoalkylated sulfonamides in high yields and selectivities with water produced as the only byproduct. This advantageous aerobic method is potentially general in substrate scope that it can also be applied to other amides, amines and alcohols.

关键词： Alcohols Sulfonamides Rhodium catalyst N-Alkylation reaction Aerobic reaction

Surgical treatment of anomalous origin of coronary artery from the pulmonary artery

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Chinese Medical Journal 2008年第8期121卷 721-724页

作者： WU qing-yu xu Zhong-hua Cardiac Center First Hospital of Tsinghua University School of Medicine Tsinghua University Beijing 100016 China

Background Anomalous origin of coronary artery from the pulmonary artery is a rare congenital cardiac malformation with a mortality rate of up to 90% within the first year of life without surgical intervention. Direct implantation of the anomalous coronary artery （ACA） into the aorta is successful in early life, but it may have increased surgical difficulty and risk with age. This retrospective study summarized our operative experience in direct implantation for treatment of this coronary anomaly in pediatric and adult patients. Methods From August 2000 to January 2003, 4 consecutive patients aged from 9 months to 41 years underwent dual coronary repair. Among them, two children and one infant with anomalous origin of the left coronary artery from the pulmonary artery （ALCAPA） and one adult was anomalous origin of right coronary artery from the pulmonary artery （ARCAPA）. Coronary arteries were directly implanted into the ascending aorta in 4 patients. In a boy with ALCAPA associated with moderate mitral insufficiency （MI）, whose ACA arose remotely from the ascending aorta, we created a tube-shaped graft using part of the pulmonary arterial wall in continuity with the origin of the left coronary artery （LCA）. Concomitant moderate MI was repaired in 2 patients, including this boy, after a dual-coronary repair. Results All patients survived. There were no hospital or late deaths and no major complications as well. Echocardiography revealed that the left ventricular （LV） function including LV end-diastolic dimension （EDD） and ejection fraction （EF） was markedly improved at hospital discharge. At 3-6 years follow-up after surgery all patients were asymptomatic and currently in NYHA class 1. Conclusions The best results are achieved with direct implantation of the ACA into the ascending aorta and simultaneous mitral valve repair if needed. Direct implantation is feasible in pediatric and adult patients with ALCAPA or ARCAPA including the coronary artery in a locatio

关键词： congenital coronary anomaly surgical treatment

Surgical treatment of myocardial bridging:report of 31 cases

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Chinese Medical Journal 2007年第19期120卷 1689-1693页

作者： WU qing-yu xu Zhong-hua Cardiac Center First Hospital of Tsinghua University School of Medicine Tsinghua University Beijing 100016 China

Background Myocardial bridging （MB） is usually considered a benign condition but may result in myocardial ischemia, myocardial infarction （MI）, exercise-induced tachycardia, atrioventricular conduction block or even sudden cardiac death. This retrospective study summarizes our operative methods and outcomes for treatment of 31 cases of MB. Methods From January 1997 to December 2006, 31 consecutive patients （24 men and 7 women; aged 35-67 years; mean 52.3 years） with MB underwent surgical treatment. Thirteen patients had MB only and 18 patients had MB associated with other heart diseases. In preoperative cardiac function grading, 5 patients were in NYHA class Ⅰ and 18 in NYHA class Ⅱ and 8 in NYHA class Ⅲ. Among them, 15 underwent myotomy and 16 underwent coronary artery bypass grafting （CABG）. Results All patients survived and recovered uneventfully. Neither hospital or late death nor major complications occurred. Postoperative exercise testing in all patients failed to reveal any persistent ischemia. Follow-up time was 3-115 months （mean 31 months）. Follow-up angiographic studies in 21 patients （68%） demonstrated restoration of coronary blood flow and myocardial perfusion without significant residual compression of the artery. All patients were symptom-free and currently in NYHA class Ⅰ-Ⅱ. Conclusion The patients who are refractory to medication should actively undergo the surgical procedures such as myotomy and CABG. Myotomy should be advocated as the first choice because of its safety and satisfactory results.

关键词： congenital myocardial bridging surgical treatment

Breast Milk Lead and Cadmium Levels in Suburban Areas of Nanjing,China

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Chinese Medical Sciences Journal 2013年第1期28卷 7-15页

作者： Kang-sheng Liu Jia-hu Hao yu-qing xu Xiao-qi Gu Juan Shi Chun-fang Dai Fei xu Rong Shen State Key Laboratory of Reproductive Medicine Department of Clinical LaboratoryNanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University Department of Maternity and Child Health Care School of Public HealthAnhui Medical University Director's Office Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University Child Health Care Department Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University Obstetrical Department Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University Department of Clinical Laboratory Nanjing Children's Hospital

Objective To evaluate levels of lead(Pb) and cadmium(Cd) in the breast milk in the second postpartum month,to investigate the relationship between Pb/Cd levels in breast milk and some sociodemographic parameters,and to explore whether these levels affect the infants' physical status or the mothers' psychological status(postpartum depression).Methods A cross-sectional study was conducted between November 2009 and December *** 170 healthy mothers were enrolled from Nanjing Maternity and Child Health Care *** inclusion criteria were:voluntary to participate in this study,healthy,with no chronic disease,breastfeeding in the second postpartum month,living in a suburban but not non-industrial area of Nanjing,and not occupationally exposed to toxic *** the mothers completed a questionnaire and were evaluated based on the Edinburgh Postpartum Depression Scale(EPDS) to identify the risk of postpartum *** and Cd levels in breast milk were determined by inductively coupled plasma mass *** infants of these mothers were examined for their z scores of weight for age,length for age,head circumference for age,and body mass index for *** The median breast milk levels of Pb and Cd were 40.6 μg/L and 0.67 μg/L,*** 164(96.5%) of the 170 samples,Pb levels were higher than the limit reported by the World Health Organization(> 5 μg/L).Breast milk Cd level was > 1 μg/L in 54(31.8%) *** mothers with a history of anemia had a higher breast milk Pb level than those without a history of anemia(41.1 μg/L vs.37.9 μg/L,P = 0.050).The median breast milk Cd level in those who were active and passive smokers during pregnancy was significantly higher than that in non-smokers(0.88 μg/L vs.0.00 μg/L,P = 0.025).The breast milk Cd level in the mothers not taking iron and vitamin supplements for 2 months postpartum was higher than in those taking the supplements(iron supplement:0.74 μg/L vs.0.00 μg/L,P = 0.025;vitamin supplemen

关键词： lead cadmium suburban areas breast milk Edinburgh Postpartum Depres-sion Scale

THE SYNTHESIS OF A NOVEL HETEROPOLYCOMPOUND BY HYDROTHERMAL METHOD

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Chinese Chemical Letters 1994年第5期5卷 441-442页

作者： Jia Ning xu Guo yu YANG and Ji qing xu (Department of Chemistry, Jilin University, Changchun,130023)

In this paper, the synthesis of a novel heteropolycompound (Chemical formula VOHPO4·0.4en) containing ethylenediamine by hydrothermal method is reported. The X-Ray diffraction pattern and the SEM picture of the sing...

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Perpendicular magnetization and exchange bias in epitaxial NiO/[Ni/Pt]_(2)multilayers

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Chinese Physics B 2022年第2期31卷 587-592页

作者： Lin-Ao Huang Mei-yu Wang Peng Wang yuan yuan Ruo-Bai Liu Tian-yu Liu yu Lu Jia-Rui Chen Lu-Jun Wei Wei Zhang Biao You qing-yu xu Jun Du National Laboratory of Solid State Microstructures and Department of Physics Nanjing UniversityNanjing 210093China College of Engineering and Applied Sciences Nanjing UniversityNanjing 210093China School of Science Nanjing University of Posts and TelecommunicationsNanjing 210046China School of Physics Southeast UniversityNanjing 211189China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China

The realization of perpendicular magnetization and perpendicular exchange bias(PEB)in magnetic multilayers is important for the spintronic ***(t)/[Ni(4 nm)/Pt(1 nm)]_(2)multilayers with varying the NiO layer thickness t have been epitaxially deposited on SrTiO;(001)*** magnetization can be achieved when t<25 *** magnetization originates from strong perpendicular magnetic anisotropy(PMA),mainly resulting from interfacial strain induced by the lattice mismatch between the Ni and Pt *** PMA energy constant decreases monotonically with increasing t,due to the weakening of Ni(001)orientation and a little degradation of the Ni–Pt ***,significant PEB can be observed though NiO layer has spin compensated(001)crystalline *** PEB field increases monotonically with increasing t,which is considered to result from the thickness dependent anisotropy of the NiO layer.

关键词： perpendicular magnetic anisotropy perpendicular exchange bias epitaxial growth random field model

基于可调谐光纤激光器的C_2H_2气体光声光谱检测

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光谱学与光谱分析 2009年第8期29卷 2030-2033页

作者：彭勇于清旭大连理工大学光电工程学院辽宁大连116023 大连海事大学物理系辽宁大连116026

研制了基于可调谐掺Er光纤激光器的共振式光声光谱乙炔气体检测系统,结合波长调制和锁相放大器的二次谐波信号检测技术,有效地消除了光声池窗片和池壁吸收入射光而引起的背景噪声,通过对该系统的光学、声学和电子检测系统的优化,实现了... 详细信息

研制了基于可调谐掺Er光纤激光器的共振式光声光谱乙炔气体检测系统,结合波长调制和锁相放大器的二次谐波信号检测技术,有效地消除了光声池窗片和池壁吸收入射光而引起的背景噪声,通过对该系统的光学、声学和电子检测系统的优化,实现了低浓度乙炔气体的流动式检测。实验结果证明,当气体浓度较低时,二次谐波振幅与气体浓度成正比,其线性响应相关度达到0.99953。在常温常压和3.5mW平均光功率以及100ms锁相积分时间条件下,乙炔气体的极限检测灵敏度达到了0.3ppm(1ppm=1μg·mL-1)(SNR=1时),系统用可调谐掺Er光纤激光器代替半导体激光器作光源,降低了成本,为发展低成本、实用、便携式微量气体光谱检测仪器奠定了基础。若采用多光程光声池,或者采用EDFA提高激光功率,可大幅度提高信噪比,将极限检测灵敏度提高至ppb(1ppb=1ng·mL-1)量级。

关键词：波长调制光声光谱共振式光声池可调谐掺Er光纤激光器二次谐波检测乙炔