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Automated synthesis of gadopentetate dimeglumine through solid-liquid reaction in femtosecond laser fabricated microfluidic chips

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Chinese Chemical Letters 2022年第2期33卷 1077-1080页

作者： Difeng Yin yucen Li Lingling Xia Wenbo Li Wei chu Jianping yu Miao Wu Ya Cheng ming Hu State Key Laboratory of High Field Laser Physics and CAS Center for Excellence in Ultra-intense Laser Science Shanghai Institute of Optics and Fine Mechanics(SIOM)Chinese Academy of Sciences(CAS)Shanghai 201800China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Precision Spectroscopy School of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China School of Physical Science and Technology ShanghaiTech UniversityShanghai 200031China XXL–The Extreme Optoelectromechanics Laboratory School of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China

Despite the continuously increased requirement on automated synthesis of medicines for distributed manufacturing and personal care, it remains a challenge to realize automated synthesis which requires solid-liquid phase reactions. In this work, we demonstrated an automated solid-liquid synthesis for gadopentetate dimeglumine, the most widely used magnetic resonance imaging(MRI) contrast agent. The high-efficiency reaction was performed in a 3D microfluidic chip which was fabricated by femtosecond laser micromachining. The structure of the chip realized 3D shear flow which was essential for highly efficient mixing and movement of the solid-liquid mixtures. Ultraviolet visible(UV-vis) spectrometer was employed for in-line analysis to help automation of this system. Comparing with the round-bottom flask system, this synthetic system showed significantly higher reaction rate, indicating the advantage of the3D microfluidic technology in micro chemical engineering.

关键词： Automated synthesis Femtosecond laser micromachining Microfluidics MRI imaging UV–vis absorption spectrum

Preparation and corrosion resistance of the micro-arc oxidation coating on Al_2O_3f/ZL109 composites

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Rare Metals 2013年第3期32卷 290-293页

作者： ming-Chao yu Wei Liang School of Materials Science and Engineering Taiyuan University of Technology

A ceramic layer was prepared on the surface of Al2O3f/ZL109 composites by means of micro-arc oxidation （MAO） technique. The surface morphology and phase constituent of the ceramic layer were analyzed using scanning electron microscope and X-ray diffraction. The polarization curves of the composites before and after MAO treatment were measured and analyzed. The results showed that after Al2O3f/ZL109 composites were treated using MAO technique in silicate solution, the ceramic layer formed, and it was composed of Al, Si, and mullite phase. Al and Si came from Al alloy matrix of the composites, and the mullite phase formed in process of MAO. Al2O3 fiber in the composites affects the electric conductivity of the composites, the MAO reaction is promoted, and the cera- mic layer forming on the composite material side is slightly thicker than that on the Al alloy side. After Al2O3f/ZL109 composites were treated using MAO technique, the corro- sion resistance of the composites is significantly improved.

关键词： Micro-arc oxidation Al alloy composites Ceramic layer Corrosion resistance

Hepatitis B and C viruses are not risks for pancreatic adenocarcinoma

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World Journal of Gastroenterology 2014年第17期20卷 5060-5065页

作者： ming-chu Chang Chien-Hung Chen Ja-Der Liang yu-Wen Tien Chiun Hsu Jau-Min Wong yu-Ting Chang Department of Internal Medicine National Taiwan University HospitalCollege of MedicineNational Taiwan University Department of Surgery National Taiwan University HospitalCollege of MedicineNational Taiwan University Graduate Institute of Oncology College of MedicineNational Taiwan University

AIM: To investigate whether hepatitis B virus (HBV) and hepatitis C virus (HCV) increase risk of pancreatic ductal adenocarcinoma (PDAC).

关键词： Hepatitis B virus Hepatitis C virus Pancreatic ductal adenocarcinoma Risk Endemic disease Diabetes mellitus

Degradation of chlorpyrifos in laboratory soil and its impact on soil microbial functional diversity

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Journal of Environmental Sciences 2009年第3期21卷 380-386页

作者： FANG Hua yu yunlong chu Xiaoqiang WANG Xiuguo YANG Xiaoe yu Jingquan Department of Plant Protection College of Agriculture & Biotechnology Zhejiang University Hangzhou 310029 China MOE Key Lab of Environment Remediation & Ecosystem Health College of Environmental and Resource Sciences Zhejiang University Hangzhou 310029 China Department of Horticulture College of Agriculture and Biotechnology Zhejiang University Hangzhou 310029 China

Degradation of chlorpyrifos at different concentrations in soil and its impact on soil microbial functional diversity were investigated under laboratory condition. The degradation half-live of chlorpyrifos at levels of 4, 8, and 12 mg/kg in soil were calculated to be 14.3, 16.7, and 18.0 d, respectively. The Biolog study showed that the average well color development （AWCD） in soils was significantly （P 〈 0.05） inhibited by chlorpyrifos within the first two weeks and thereafter recovered to a similar level as the control. A similar variation in the diversity indices （Simpson index lID and McIntosh index U） was observed, but no significant difference among the values of the Shannon-Wiener index H＇ was found in chlorpyrifos-treated soils. With an increasing chlorpyrifos concentration, the half-life of chlorpyrifos was significantly （P ≤ 0.05） extended and its inhibitory effect on soil microorganisms was aggravated. It is concluded that chlorpyrifos residues in soil had a temporary or short-term inhibitory effect on soil microbial functional diversity.

关键词： Biolog chlorpyrifos community-level physiological profile microbial functional diversity

Heterogeneity of tumor-infiltrating myeloid cells in era of single-cell genomics

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Chinese Journal of Cancer Research 2022年第6期34卷 543-553页

作者： Xiaojing chu yu Zhang Sijin Cheng Changping Laboratory Beijing 102206China

Tumor microenvironment(TME)is highly heterogeneous and composed of complex cellular components,including multiple kinds of immune *** all immune cells in TME,tumor-infiltrating myeloid cells(TIMs)account for a large proportion and play roles as key regulators in a variety of functions,ranging from immune-mediated tumor killing to tumor immune *** the heterogeneity of TIMs will provide valuable insights for new therapeutic targeting of myeloid ***-cell genomic technologies deciphering cell composition and gene expression at single-cell resolution have largely improved our understanding of the cellular heterogeneity of TIMs and highlighted several novel cell subtypes contributing to the variation of patient survival and treatment ***,these cell subtypes were defined based on limited data without a concordant nomenclature,which makes it difficult to understand whether they exist in different ***,in this review,we comprehensively summarized the common agreements and current different opinions on the heterogeneity of TIMs gained from single-cell studies;evaluated the feasibility of current myeloid cell targets at single-cell level and proposed a uniform nomenclature for TIM subsets.

关键词： Single-cell genomics tumor-infiltrating myeloid cells tumor microenvironment tumor immunotherapy

MHD simulations of inward shocks in Cassiopeia A

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Research in Astronomy and Astrophysics 2020年第4期20卷 39-43页

作者： chu-yuan Yang Bi-Wen Bao Si-ming Liu yunnan Observatories Chinese Academy of SciencesKunming 650216China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China Center for Astronomical Mega-Science Chinese Academy of SciencesBeijing 100101China Department of Astronomy Key Laboratory of Astroparticle Physics of Yunnan ProvinceYunnan UniversityKunming 650091China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210033China

Cassiopeia A,the brightest radio supernova remnant(SNR)in the sky,has several unique characteristics in comparison to its *** its radio brightness and prominent soft-concave radio spectrum,itsγ-ray spectrum appears to have a low-energy cutoff near 2 GeV,and it is the only SNR with prominent hard X-ray *** the unusual radio properties may be attributed to strong emission from reverse shocks,the hard X-ray emission has been associated with high-speed inward shocks induced by high density ***,the low-energyγ-ray spectral cutoff could be attributed to slow penetration of lower energy particles accelerated near the inward shocks into high-density emission *** this paper,we carry out magneto-hydrodynamic(MHD)simulations of shocks in Cassiopeia A and demonstrate that its inward shock structure can indeed be reproduced via shock interactions with clumps of gases with a density of 20 cm-3.

关键词： acceleration of particles supernovae:individual(Cassiopeia A) ISM:supernova remnants X-rays:ISM

Error model identification of inertial navigation platform based on errors-in-variables model

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Journal of Systems Engineering and Electronics 2009年第2期20卷 388-393页

作者： Liu ming Liu yu Su Baoku Space Control and Inertial Technology Research Center Harbin Inst. of Technology Harbin 150001 P. R. China

Because the real input acceleration cannot be obtained during the error model identification of inertial navigation platform, both the input and output data contain noises. In this case, the conventional regression model and the least squares （LS） method will result in bias. Based on the models of inertial navigation platform error and observation error, the errors-in-variables （EV） model and the total least squares （TLS） method axe proposed to identify the error model of the inertial navigation platform. The estimation precision is improved and the result is better than the conventional regression model based LS method. The simulation results illustrate the effectiveness of the proposed method.

关键词： errors-in-variables model total least squares method inertial navigation platform error model identification

Mechanism,Kinetics,and Thermodynamic Characteristics for the Demetallization of Used Lubricating Oil via Pyrolysis

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China Petroleum Processing & Petrochemical Technology 2023年第2期25卷 113-127页

作者： Yang Haiyu Jiang Zhenxin chu Qingyan Jiang Peng Wang ming School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo 255049China Shandong Qinghe Chemical Technology Co. LtdZibo 256405China School of Chemistry and Chemical Engineering Qingdao UniversityQingdao 266071China

This study analyzed the pyrolysis mechanism,developed a pyrolysis kinetic model,and determined the corresponding thermodynamic parameters for the removal of calcium from used lubricating oil using sulfurized calcium alkyl phenolate(T-115B)as a model *** pyrolysis process and products were evaluated by Fourier transform infrared spectroscopy and X-ray photoelectron *** inspection indicated that the removal of calcium from T-115B depended primarily on the destruction of micelles caused by the pyrolysis of compounds at high *** pyrolysis characteristics of T-115B at different heating rates were investigated by thermogravimetry and differential thermal analysis,which revealed two distinct pyrolysis ***,the pyrolysis mechanism can be described by a twostep *** activation energy and thermodynamic parameters(ΔH,ΔG,andΔS)were determined by applying the Kissinger-Akahira-Sunose,Flynn-Wall-Ozawa,Friedman,and Starink methods;the average activation energies for T-115B pyrolysis obtained using these methods were 115.80,119.84,124.96,and 116.14 kJ/mol,***,both stages of the pyrolysis reaction followed Fn mechanisms with n=1.39 in the first stage and n=0.86 in the second *** study provides reliable and effective pyrolysis models along with kinetic and thermodynamic parameters to facilitate the largescale industrial application of used lubricating oil.

关键词： used lubricating oil sulfurized calcium alkyl phenolate pyrolysis decomposition kinetics thermodynamics non-isothermal method

Quantum Chemistry Calculation of Quercetin-silver Complex

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Chinese Journal of Structural Chemistry 2005年第11期24卷 1340-1346页

作者： JIANG Liu-yun LIU yu-ming Analytical and Testing Center of Sichuan University Chengdu 610064 China

Three possible molecular structures of quercetin-silver complexes obtained from the reaction of quercetin and Ag^＋ in equivalent molar ratio were designed and optimized by using Gaussian 98 program at the B3LYP/LanL2DZ basis set. Through theoretical analysis, one of the three designed structures is discovered to have the most stable coordination position. Then its geometry structure, natural bond orbital analyses, vibrational frequency and biological activity were performed. The results show that it has good stability and relatively stronger antioxidative activity because it is favorably attacked by O2^-. Therefore theoretical foundation is provided for the development of new quercetin metal complexes with higher activity antioxidants.

关键词： quercetin,silver-complex quantum chemistry