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Risk Factors and Predictive Nomogram for Survival in Elderly Patients with Brain Glioma

当代医学科学（英文） 2024年第4期44卷 759-770页

作者： Zhi-cheng FAN Wen-jian ZHAO Yang JIAO Shao-chun GUO yun-peng KOU Min CHAO Na WANG Chen-chen ZHOU yuan WANG Jing-hui LIU yu-long zhai Pei-gang JI Chao FAN Liang WANG Department of Neurosurgery Tangdu HospitalFourth Military Medical UniversityXi'an 710038China Department of Neurosurgery Tangdu HospitalFourth Military Medical UniversityXi'an 710038China Department of Neurosurgery Shannxi University of Chinese MedineXianyang 712046China Department of Neurosurgery Tangdu HospitalFourth Military Medical UniversityXi'an 710038China Department of Neurosurgery Xi'an Medical UniversityXi'an 710021China

Objective:To determine the factors that contribute to the survival of elderly individuals diagnosed with brain glioma and develop a prognostic ***:Data from elderly individuals(age ≥65 years)histologically diagnosed with brain glioma were sourced from the Surveillance,Epidemiology,and End Results(SEER)*** dataset was randomly divided into a training cohort and an internal validation cohort at a 6:4 ***,data obtained from Tangdu Hospital constituted an external validation cohort for the *** identification of independent prognostic factors was achieved through the least absolute shrinkage and selection operator(LASSO)and multivariate Cox regression analysis,enabling the construction of a *** performance was evaluated using C-index,ROC curves,calibration plot and decision curve analysis(DCA).Results:A cohort of 20 483 elderly glioma patients was selected from the SEER *** prognostic factors(age,marital status,histological type,stage,and treatment)were found to significantly impact overall survival(OS)and cancer-specific survival(CSS),with tumor location emerging as a sixth variable independently linked to ***,nomogram models were developed to predict the probabilities of survival at 6,12,and 24 *** assessment findings from the validation queue indicate a that the model exhibited strong ***:Our nomograms serve as valuable prognostic tools for assessing the survival probability of elderly glioma *** can potentially assist in risk stratification and clinical decision-making.

关键词： Surveillance, Epidemiology, and End Results (SEER) elderly brain glioma nomogram prediction model prognosis

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Narrative review of latest research progress about robotic percutaneous coronary intervention

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Journal of Geriatric Cardiology 2024年第8期21卷 816-825页

作者： Zhen-yu LIU Guang-Yao zhai Department of Clinical Medicine Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Cardiology Beijing Luhe HospitalCapital Medical UniversityBeijingChina

Robotic percutaneous coronary intervention(R-PCI)is a novel technology in which operators can manipulate guidewires and catheter devices in interventional *** approach provides great benefits to interventional cardiologists in terms of reducing both radiation exposure and orthopedic *** large,high-quality cohort studies have confirmed the short-term safety and high technical success rate of ***,randomized long-term data are still needed before adopting them as part of standard coronary ***,tele-stenting for complex coronary lesions has significant potential for *** need to overcome the present relevant challenges for its application such as inherent delays,bedside care for unstable patients from R-PCIs to manual PCIs(M-PCIs),incompatibility for a thrombus aspiration catheter and heavily calcified *** is a great future in laboratory workflow teams,3D-printed anatomical models and multiple joint collaborative control *** narrative review summarizes the latest developments in R-PCI,with a focus on developments in robotic technology,and discusses the current and future potential use of R-PCI in clinical practice globally.

关键词： coronary injuries unstable

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Cucurbit[8]uril-regulated face-to-face dimerization assembly enhanced photosensitization and photocatalysis

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Science China Chemistry 2024年第5期67卷 1605-1612页

作者： Haigen Nie Die Hu Zhiyao Zeng Yan Fan Yaxin zhai Xin-long Ni Key Laboratory of Chemical Biology and Traditional Chinese Medicine Ministry of Educational of ChinaKey Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan ProvinceCollege of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of PhysicsHunan Normal UniversityChangsha 410081China

In water, N,N′-diarylpyridinium thiazolo[5,4-d]thiazole guests(G1–G3) were encapsulated by cucurbit[8]uril(Q[8]) to construct Q[8]_(3)/G_(2) complexes, in which the encapsulated G molecules exist as an exact face-to-face dimer. These complexation behaviors have been indicated by proton nuclear magnetic resonance(~1H NMR) spectroscopy and isothermal titration calorimetry(ITC),and have been confirmed by X-ray single crystal structural analysis of Q[8]_(3)/G2_(2). While free guests G1–G3 have no ability to sensitize singlet oxygen, they all become effective singlet oxygen sensitizers when complexed with Q[8]. By irradiation of white light, Q[8]_(3)/G_(2) complexes induced selective oxidation of aryl sulfide to aryl sulfoxide in good yields and selective oxidation of dimethyl sulfide(DMS) to dimethyl sulfoxide(DMSO) in excellent yields without over-oxidation to dimethyl sulfone(DMSO_(2))even for elongated irradiation. High-yield photo-oxidation of DMS to DMSO_(2) was only achieved by irradiation of blue light in the presence of Q[8]_(3)/G1_(2), which was also effective in photobleaching of Rhodamine B in water. The higher photo-oxidation power of Q[8]_(3)/G1_(2) has been ascribed to an additional generation of reactive oxygen species besides singlet oxygen.

关键词： host-guest interaction dimerization macrocycles photosensitization

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Effect of Iron on the Stability of Rhodochrosite at the Topmost Lower Mantle Conditions

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Journal of Earth Science 2024年第2期35卷 504-513页

作者： Tianlei zhai Fei Qin Shengxuan Huang Shan Qin yu Gong Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of EducationSchool of Earth and Space SciencesPeking UniversityBeijing100871China School of Earth Sciences and Resources China University of GeosciencesBeijing100083China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China

Carbonates are viewed as the principal oxidized carbon carriers during subduction,and thus the stability of subducted carbonates has significant implications for the deep carbon *** we investigate the high pressure-temperature behaviors of rhodochrosite in the presence of iron up to∼34 GPa by in-situ X-ray diffraction and ex-situ Raman *** relatively low temperature below∼1500 K,MnCO_(3)breaks down into MnO and CO_(2).Upon heating to∼1800 K,however,the MnCO_(3)-Fe^(0)reactions occur with the formation of Mn_(3)O_(4),Fe^(O)and reduced carbon.A'three-stage'reaction mechanism is proposed to understand the kinetics of the carbon-iron-manganese redox *** results suggest that Fe^(0)can serve as a reductant to greatly affect the stability of rhodochrosite,which implies that the effect of Fe-metal should be seriously considered for the high pressure-temperature behaviors of other predominant carbonates at Earth's mantle conditions,particularly at depths greater than∼250 km.

关键词： deep carbon cycle rhodochrosite reduced mantle diamond formation high pressure tectonics geochemistry

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Extraordinary hot extreme in summer 2022 over the Yangtze River basin modulated by the La Nina condition under global warming

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Advances in Climate Change Research 2024年第1期15卷 21-30页

作者： Zhen LIAO yu-Feng yuAN Yang CHEN Pan-Mao zhai State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China

A widespread and prolonged hot extreme hit the Yangtze River basin in summer 2022,with 300 sites established new temperature records and nearly 96%stations endured more than 40 hot *** the perspective of the combination effect of the global warming and La Nina condition,potential mechanisms of the hot extreme were *** a record-breaking hot extreme was caused by an extremely strong and westward-shifted western Pacific subtropical high(WPSH).The global warming effect contributed primarily to the abnormal hot days in the Yangtze River basin,coupled with the modulation of the La Nina *** sea surface temperature anomaly pattern under La Nina condition favored more convection activities over the western Pacific,encouraging an enhanced and westward-extended *** addition,an observation-based attribution analysis indicates that anthropogenic warming may increase the probability of such extensively persistent hot extremeby1.8 times.

关键词： Hot extreme The Yangtze River basin Global warming Tropical Pacific forcing

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FE65:a hub for neurodevelopment

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Neural Regeneration Research 2024年第9期19卷 1883-1884页

作者： yuqi zhai Laura Lok-Haang Ng Dennis Dik-long Chau Kwok-Fai Lau School of Life Sciences Faculty of ScienceThe Chinese University of Hong KongHong Kong Special Administrative RegionChina

FE65,initially identified as a binding partner of amyloid precursor protein(APP),is an adaptor protein enriched in the brain and regulated during ***65 belongs to the FE65 protein *** family is comprised of three memb... 详细信息

关键词： family development partner

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Dual-objective two-photon microscope for volumetric imaging of dense scattering biological samples by bidirectional excitation and collection

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Photonics Research 2024年第6期12卷 1351-1361页

作者： MUyuE zhai JING yu YANHUI HU HANG yu BEICHEN XIE YI yu DAWEI LI AIMIN WANG HEPING CHENG National Biomedical Imaging Center College of Future TechnologyPeking UniversityBeijing 100871China Research Unit of Mitochondria in Brain Diseases Chinese Academy of Medical SciencesPKU-Nanjing Institute of Translational MedicineNanjing 211500China Beijing Transcend Vivoscope Biotech Beijing 100085China College of Engineering Peking UniversityBeijing 100871China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China Center for Quantitative Biology Peking UniversityBeijing 100871China School of Electronics Peking UniversityBeijing 100871China State Key Laboratory of Advanced Optical Communication System and Networks Peking UniversityBeijing 100871China

Full view observation throughout entire specimens over a prolonged period is crucial when exploring the physiological functions and system-level ***-photon microscopy(MPM)has been widely employed for such purposes owing to its deep penetration ***,the current MPM struggles with balancing the imaging depth and quality while avoiding photodamage for the exponential increasement of excitation power with the imaging ***,we present a dual-objective two-photon microscope(Duo-2P),characterized by bidirectional two-photon excitation and fluorescence collection,for long-duration volumetric imaging of dense scattering ***-2P effectively doubles the imaging depth,reduces the total excitation energy by an order of magnitude for samples with a thickness five times the scattering length,and enhances the signal-to-noise ratio up to 1.4 *** these advantages,we acquired volumetric images of a 380-μm suprachiasmatic nucleus slice for continuous 4-h recording at a rate of 1.67 s/volume,visualized the calcium activities over 4000 neurons,and uncovered their state-switching *** conclude that Duo-2P provides an elegant and powerful means to overcome the fundamental depth limit while mitigating photodamages for deep tissue volumetric imaging.

关键词： excitation overcome exponential

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Programmable silicon-photonic quantum simulator based on a linear combination of unitaries

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Photonics Research 2024年第8期12卷 1760-1767页

作者： yuE yu yuLIN CHI CHONGHAO zhai JIESHAN HUANG QIHUANG GONG JIANWEI WANG State Key Laboratory for Mesoscopic Physics School of PhysicsPeking UniversityBeijing 100871China Frontiers Science Center for Nano-optoelectronics&Collaborative Innovation Center of Quantum Matter Peking UniversityBeijing 100871China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Yangtze Delta Institute of Optoelectronics Peking UniversityNantong 226010China Hefei National Laboratory Hefei 230088China Department of Electrical and Computer Engineering University of WashingtonSeattleWashington 98195USA China Mobile Research Institute Beijing 100053China

Simulating the dynamic evolution of physical and molecular systems in a quantum computer is of fundamental interest in many *** implementation of dynamics simulation requires efficient quantum *** Lie-Trotter-Suzuki approximation algorithm,also known as the Trotterization,is basic in Hamiltonian dynamics simulation.A multi-product algorithm that is a linear combination of multiple Trotterizations has been proposed to improve the approximation ***,implementing such multiproduct Trotterization in quantum computers remains challenging due to the requirements of highly controllable and precise quantum entangling operations with high success ***,we report a programmable integrated-photonic quantum simulator based on a linear combination of unitaries,which can be tailored for implementing the linearly combined multiple Trotterizations,and on the simulator we benchmark quantum simulation of Hamiltonian *** modify the multi-product algorithm by integrating it with oblivious amplitude amplification to simultaneously reach high simulation precision and high success *** quantum simulator is devised and fabricated on a large-scale silicon-photonic quantum chip,which allows the initialization,manipulation,and measurement of arbitrary four-qubit states and linearly combined unitary *** an example,the quantum simulator is reprogrammed to emulate the dynamics of an electron spin and nuclear spin coupled *** work promises the practical dynamics simulations of real-world physical and molecular systems in future large-scale quantum computers.

关键词： quantum Hamiltonian linearly

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Achieving laparoscopic anatomic resection for hepatocellular carcinoma by fluorescence guided positive staining of hepatic cone unit

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 406-411页

作者： Jun-Fang Deng Chuan-Hui Peng yu Zhang Xiao-Feng Xu Rong-Liang Tong Zheng-long zhai Di-yu Chen Cheng Zhang Li-Ming Wu Jian Wu Division of Hepatobiliary Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Laparoscopic anatomical liver resection has been increasingly reported worldwide,but how to demarcate the resection planes is technically challenging[1].Positive staining technique with intraoperative indocyanine green(ICG)-fluorescence imaging has been introduced as an effective tool for real-time intraoperative guidance[2].Liver anatomy is ***,liver is composed of 9 segments,each is composed of two to three subsegments,and each subsegment contains several hepatic cone units.A hepatic cone unit is dominated by a tertiary or quaternary hepatic pedicles[3].

关键词： hepatic resection anatomy

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Elemental Compositions of Clinopyroxenes from Southern Okinawa Trough Basalt:Implications for Magmatism and Structural Environment in an Initial Back-Arc Basin

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Journal of Ocean University of China 2024年第3期23卷 643-653页

作者： GUO Kun zhai Shikui FAN Di ZHANG Xia ZHANG yu ZHU Zhimin Laoshan Laboratory Qingdao 266237China Key Laboratory of Submarine Geosciences and Prospecting Techniques Ministry of EducationCollege of Marine GeosciencesOcean University of ChinaQingdao 266100China Key Laboratory of Submarine Geosciences&Second Institute of Oceanography Ministry of Natural ResourcesHangzhou 310012China

The major and trace elemental compositions of clinopyroxene from basalt were used to characterize the nature of the primitive magma and structural environment beneath the southern Okinawa Trough(SOT),which is an initial back-arc basin at a continental *** clinopyroxenes in the basalt were augite with variable Mg^(#)contents(73.37-78.22).The regular variations in major oxide contents(i.e.,CaO,FeO,TiO_(2),and Cr)with decreasing Mg#implied that the clinopyroxenes evolved from being enriched in Mg,Ca,and Cr to being enriched in Fe and *** clinopyroxenes had relatively low rare earth element concentrations(7.51×10^(-6) to 12.68×10^(-6))and negative Eu anomalies(δEu=0.67-0.95).The Kd_(cpx) values of clinopyroxenes(0.2-0.26),which were used to examine whether the clinopyroxene was equilibrated with its host basalt,demonstrate that these clinopyroxene phenocrysts were not captured crystals but were instead produced by crystallization differentiation of the *** calculated clinopyroxene crystallization temperatures showed a narrow range of 990-1061℃,and their crystallization pressures ranged from 2.0 to 3.2 *** geochemistry features of these clinopyroxenes indicated that the parent magma belonged to the subalkaline tholeiitic magma series and suggested that the magma experienced crystallization differentiation of olivine,plagioclase,and clinopyroxene,where the crystallization of plagioclase occurred earlier than that of *** with geophysical data,this research on primitive magma and its crystallization differentiation from clinopyroxene indicates that the SOT is in the stage of‘seafloor spreading’and that basaltic rocks produced from tholeiitic magma represent the generation of oceanic crust.

关键词： trace elements clinopyroxenes southern Okinawa Trough seafloor spreading back-arc basin

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