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Association of therapeutic occasion, gross motor function grading and developmental level with gross motor functional recovery in children with cerebral palsy

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Neural Regeneration Research 2007年第9期2卷 548-551页

作者： Hongying Li Huafeng yu lin Sang Haixia ma Rehabifitation Center Qilu Children＇s Hospital of Shandong University Ji＇nan 250022 Shandong Province China

BACKGROUND： The abnormal posture and motor pattern have not stabilized in children with cerebral palsy at early period, thus timely treatment can establish normal postural reflex and motor pattern, and prevent complications of muscle contracture, ankylosis, skeletal deformity, etc. The clinical factors affecting the rehabilitative efficacy of gross motor function in children with cerebral palsy should be observed. OBJECTIVE： To observe the effects of therapeutic occasion, grading of gross motor function and developmental level on the rehabilitative efficacy in children with cerebral palsy. DESIGN： A case-controlled analysis. SETTING： Qilu Children＇s Hospital of Shandong University. PARTICIPANTS： Totally 138 children with cerebral palsy, who were hospitalized for 12 months in the Rehabilitation Center of Qilu Children＇s Hospital, Shandong University, were selected from April 2004 to September 2006, and all the children were diagnosed to be accorded with the standard set by the national seminar on cerebral palsy in 2004. There were 97 males and 41 females, including 55 cases of 0-2 years old, 47 cases of 2-4 years and 36 cases of 4-6 years. Informed contents were obtained from relatives of all the children. METHODS： ① Comprehensive rehabilitation treatment： Vojta method was to induce the children to turn over the body and crawl by stimulating reflective turn over and crawling on belly. Bobath method including trainings of head control, turning over body, keeping sitting position, keeping balance, crawling, keeping standing position, and walking, etc.; The children were massaged by using the maneuvers of push, press, rub, pull, wave, etc. according to the sites and types of palsy. Acupuncture was performed mainly at bilateral motor areas, the needle was retained for 1 hour per time, 6 days continuously every week, and followed by a 1-day interval. ② Prognosis assessment： The gross motor functional grading of the children with cerebral palsy at admission was asses

关键词： cerebral palsy age started to accept treatment developmental level rehabilitation

Effect of cooling rate on microstructure and mechanical properties of CB2 tempered martensitic steel

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China Foundry 2020年第2期17卷 158-166页

作者： yu-lin ma yue Liu Li-ping Zhang Xu Jiang Chun-ming Liu School of materials Science and Engineering Northeastern UniversityShenyang 110189China The Key Laboratory for Anisotropy and Texture of materials(Ministry of Education) Northeastern UniversityShenyang 110189China

The cooling rate of casting has a significant effect on microstructure and mechanical properties of *** 9Cr-1.5Mo-1Co cast steel,referred to as CB2,is one of the most promising alloys for various cast components to be used under ultrasupercritical *** this study,HRTEM,SEM,and XRD methods were used for qualitative and quantitative analyses of contents,phases,and sizes of the inclusions and precipitates,as well as microstructure observation of the tempered martensitic steel at different cooling *** tensile tests were conducted to characterize the material mechanical *** show that the size of the boron nitride and precipitate,the width of the martensite lath and the content of theδ-ferrite are reduced as the cooling rate increases from 5-8℃·min^-1(CB2-S steel)to 50-60℃·min^-1(CB2-F steel).The precipitates are mainly composed of M23C6 and a small amount of *** average diameters of the M23C6 precipitates in CB2-F and CB2-S are 202 nm and 209 nm,*** inclusions are mainly composed of BN,Al2O3 and MnO2,and the inclusion ratios are 0.1969%for the CB2-F and 0.06556%for CB2-S *** average martensite lath widths of CB2-F and CB2-S steels are 289 nm and 301 nm,***,the M3C having a diameter of about 150 nm and a thickness of 20 nm is observed in theδ-ferrite of the tempered CB2-S *** presence of theδ-ferrite reduces the precipitation strengthening and dislocation density in CB2-S *** addition,the lower cooling rate stabilizes theδ-ferrite structure at room temperature.

关键词： tempered martensitic steel casting microstructure M23C6 mechanical properties inclusions δ-ferrite

Effect of ultrasonic field treatment on degassing of 2024 alloy

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China Foundry 2021年第2期18卷 124-130页

作者： Zheng Jia Bing yu Qing Lan Tong Wang Li Fu yu-lin ma Qi-chi Le Jian-zhong Cui College of Mechanical Engineering Shenyang UniversityShenyang 110044China Key Laboratoiy of Electromagnetic Processing of materials Ministry of EducationNortheastern UniversityShenyang 110819China

The 2024 aluminum alloy was prepared with different ultrasonic *** of ultrasonic treatment parameters including ultrasonic power,treatment time,treatment temperature,and frequency resonance,as well as C_(2)Cl_(6) degasser on degassing of the 2024 aluminum alloy were *** indicate that increasing ultrasonic power at the same ultrasonic treatment time can improve the degassing *** optimum degassing efficiency can be obtained under the resonant ultrasound *** the combination of 1%C_(2)Cl_(6) addition and 150 W ultrasonic treatment for 40 s,the hydrogen content of the alloy is decreased by 52.9%.At the same time,the tensile strength and elongation are increased by 28.3%and 92.3%,respectively,and the yield strength is slightly increased by 6.7%.The degassing mechanism is also discussed.

关键词： ultrasonic degassing C_(2)Cl_(6)degasser hydrogen content tensile properties

mainchain conformation ordering self-assembly tailored room temperature phosphorescence emission

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Science China Chemistry 2025年第1期68卷 329-336页

作者： yuzhu Li yumeng Gao Feng Tian yu Wang yuan Yao Shaoliang lin Xiang ma Binbin Xu Shanghai Key Laboratory of Advanced Polymeric materials Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Key Laboratory for Advance materials and Feringa Noble Prize Scientist Joint Research Centre Frontiers Science for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science & Technology

Developing organic room-temperature phosphorescence （RTP） materials with a wide range of tunable-emission is significant in expanding the applications of RTP ***,we rationally designed amphiphilic alternating copolymers poly(1,2-bis（4-alkoxyphenyl）ethane-1,2-dione-alt-（ethylene glycol）x)(P（Bz-alt-EGx）) that combined the advantage of alternating benzil and EGxskeleton,and tunable mainchain *** a mainchain conformation ordering assembly （COA） process,P（Bz-alt-EGx） self-assembled into well-defined platelets,and such assemblies emitted blue RTP at ca.425 nm due to the ordered folded-chain conformation and confined *** contrast,traditional self-assembly （TA） of P（Bz-alt-EGx） obtained less ordered aggregates,such as asymmetric worms,vesicles,and rod-like *** resultant less ordered aggregates exhibited yellow-green RTP at ca.550 *** wide-tuning RTP emission in solution （between blue and yellow-green,over125 nm） is realized using the P（Bz-alt-EGx） alternating copolymers under the treatment of different self-assembly *** study uncovers a new strategy to tailor the RTP emission through different self-assembly pathways and holds great promise for the fabrication of advanced optical materials.

关键词： self-assembly conformation ordering alternating copolymer phosphorescence emission

Conversion-type cathode materials for high energy density solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 409-425页

作者： yuhao ma Shihong Qing Hongyu Liu Chuntao ma yuan yu Chuang yu Liping Wang School of materials and Energy University of Electronic Science and Technology of China Zhejiang Provincial Key Laboratory of Fiber materials and manufacturing Technology Zhejiang Sci-Tech University State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic Engineering Huazhong University of Science and Technology

Solid-state lithium batteries （SSLBs） are regarded as an essential growth path in energy storage systems due to their excellent safety and high energy *** particular,SSLBs using conversion-type cathode materials have received widespread attention because of their high theoretical energy densities,low cost,and *** the great progress in research and development of SSLBs based on conversiontype cathodes,their practical applications still face challenges such as blocked ionic-electronic migration pathways,huge volume change,interfacial incompatibility,and expensive processing *** review focuses on the advantages and critical issues of coupling conversion-type cathodes with solid-state electrolytes （SSEs）,as well as state-of-the-art progress in various promising cathodes （e.g.,FeS2,CuS,FeF3,FeF2,and S） in ***,representative research on conversion-type solid-state full cells is discussed to offer enlightenment for their practical ***,the energy density exhibited by the S cathode stands out impressively,while sulfide SSEs and halide SSEs have demonstrated immense potential for coupling with conversion-type ***,perspectives on conversion-type cathodes are provided at the material,interface,composite electrode,and battery levels,with a view to accelerating the development of conversion-type cathodes for high-energy–density SSLBs.

关键词： Sulfur compounds

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan Xu Jie Mu yu Leng Lei ma yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

New glucocerebrosidase antibodies can advance research in the field of neurodegenerative disorders

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Neural Regeneration Research 2025年第4期20卷 1085-1086页

作者： Charis ma Krystyna Rytel yu Chen Ellen Sidransky Medical Genetics Branch National Human Genome Research InstituteNational Institutes of HealthBethesdaMDUSA

In medical research,there are times when the introduction of a new tool can launch scientific discovery in new *** antibody development may be considered mundane,in the field of glucocerebrosidase(GCase)research,the dearth of validated antibodies for different applications has impeded progress in studies of disease pathogenesis and therapeutic *** recent introduction of new,rigorously evaluated antibodies can now propel research into the link between glucocerebrosidase and Parkinson’s disease(PD)as well as aspects of the pathobiology of Gaucher disease(Jong et al.,2024).

关键词： antibodies cerebro

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创新主体子场域及主导效应模式分析

自然辩证法研究 2017年第8期33卷 61-66页

作者：伍玉林马馨雨哈尔滨理工大学STS研究中心哈尔滨150080

在皮埃尔·布迪厄的实践社会学理论中,以实践为中介,将场域与惯习相互关联,最终形成紧密相关的互动结构。区域科技创新系统作为一个场域,对场域中各个创新主体的惯习有着重要影响,而惯习反作用于场域,指导各个创新主体形成以自身为主导... 详细信息

在皮埃尔·布迪厄的实践社会学理论中,以实践为中介,将场域与惯习相互关联,最终形成紧密相关的互动结构。区域科技创新系统作为一个场域,对场域中各个创新主体的惯习有着重要影响,而惯习反作用于场域,指导各个创新主体形成以自身为主导的子场域来更好地进行实践创新活动。根据场域-惯习理论,从多维创新主体视觉出发对科技创新进行了分析,明确了科技创新主体内涵;在把握创新子场域的主体——企业、高校、科研机构、政府以及科技服务中介等科技活动主体现状与惯习动态的发展过程中,研究了五大主体在科技创新活动中各自发挥的主导效用以及相互之间关联性、互补性和协调性模式;基于对创新子场域的主体主导效用分析,建立了评价模型,可以为现实中的科技创新场域提供一种便于操作的惯习方法。

关键词：创新场域创新主体模式主导效用

Boosting bidirectional sulfur conversion enabled by introducing boron-doped atoms and phosphorus vacancies in Ni2P for lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 760-769页

作者： lin Peng yu Bai Hang Li Meixiu Qu Zhenhua Wang Kening Sun Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Beijing Key Laboratory of Chemical Power Source and Green Catalysis School of Chemistry and Chemical Engineering Beijing Institute of Technology

Lithium-sulfur （Li-S） batteries have gained great attention due to the high theoretical energy density and low cost,yet their further commercialization has been obstructed by the notorious shuttle effect and sluggish redox ***,we supply a strategy to optimize the electron structure of Ni2P by concurrently introducing B-doped atoms and P vacancies in Ni2P （Vp-B-Ni2P）,thereby enhancing the bidirectional sulfur *** study indicates that the simultaneous introduction of B-doped atoms and P vacancies in Ni2P causes the redistribution of electron around Ni atoms,bringing about the upward shift of d-band center of Ni atoms and effective d-p orbital hybridization between Ni atoms and sulfur species,thus strengthening the chemical anchoring for lithium polysulfides （LiPSs） as well as expediting the bidirectional conversion kinetics of sulfur ***,theoretical calculations reveal that the incorporation of B-doped atoms and P vacancies in Ni2P selectively promotes Li2S dissolution and nucleation ***,the Li-S batteries with Vp-B-Ni2P-separators present outstanding rate ability of 777 m A h g-1at 5 C and high areal capacity of 8.03 ma h cm-2under E/S of 5μL mg-1and sulfur loading of 7.20 mg *** work elucidates that introducing heteroatom and vacancy in metal phosphide collaboratively regulates the electron structure to accelerate bidirectional sulfur conversion.

关键词： Lithium sulfur batteries