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World Journal of Traditional Chinese Medicine 2024年第2期10卷 180-190页

作者： Meng-yuan Hu Tian-Xing Yi Qi-Rui Liu Xin-yu Zhang Ai-Ping Chen yu-Ying wang Yi Lu School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina

Objective: The objective of this study was to explore the medication rules and academic ideas of Professor wang yu-Ying in the treatment of climacteric syndrome(CLS) and to predict new prescriptions. Materials and Methods: The characteristics of frequency, clustering, four properties, and five flavors were analyzed, and new prescriptions were predicted through an artificial intelligence(AI)-based method. The potential pathways of new prescriptions were explored through network pharmacology-based analysis. Results: The top 16 medicinals used by Professor wang yu-Ying in the treatment of CLS included Danggui, Longgu, Muli, Fuling, Chuanxiong, Gancao, Xiangfu, and Tusizi. The AI method was applied to predict the basic prescription for treating CLS: Danggui 15 g, Duanlonggu 30 g, Duanmuli 30 g, Fuling 28 g, Chuanxiong 10 g, Gancao 6 g, Xiangfu 12 g, Tusizi 14 g, etc., Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses showed that the pathogenesis of CLS might be related to the estrogen pathway, involving typical steroid responses. Conclusions: This study summarized Professor wang's medication experience in the treatment of CLS based on the data mining of clinical diagnoses and treatment cases. The AI method was used to predict the new prescription of CLS treatment, which was found to be reasonable by network pharmacology studies on its multi-target and multi-pathway mechanisms.

关键词： Artificial intelligence climacteric syndrome medication rules network pharmacology Professor wang yu-Ying

Identification of carbonate sedimentary facies from well logs with machine learning Author links open overlay panel

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Petroleum Research 2024年第2期9卷 165-175页

作者： Xianmu Hou Peiqing lian Jiuyu Zhao yun Zai Weiyao Zhu Fuyong wang School of Civil and Resources Engineering University of Science and Technology BeijingBeijing100083China Sinopec Chongqing Fuling Shale Gas Exploration and Development Co. Ltd.Chongqing408000China Sinopec Petroleum Exploration&Production Research Institute SINOPECBeijing100083China National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China ChinKunlun Digital Technology Co.Ltd. Beijing102206China

Sedimentary facies identification is critical for carbonate oil and gas reservoir *** traditional method of sedimentary facies identification not only be affected by the engineer's experience but also takes a long *** carbonate sedimentary facies based on machine learning is the trend of future development and has the advantages of short time consuming and reliable results without engineers'subjective *** many references reported the application of machine learning to identify lithofacies,but identifying sedimentary facies of carbonate reservoirs is much more challenging due to the complex sedimentary environment and tectonic *** paper compares the performance of the carbonate sedimentary facies identification using four different machine learning models,and the optimal machine learning with the highest prediction accuracy is ***,the carbonate sedimentary facies are classified into the lagoon,shallow sea,shoal,fore-shoal,and inter-shoal five tags based on the well ***,five well log curves including spectral gamma ray(SGR),uranium-free gamma ray(CGR),photoelectric absorption cross-section index(PE),true formation resistivity(RT),shallow lateral resistivity(RS)are used as the input,and the manual identified carbonate sedimentary facies are used as the output of the machine learning *** performance of four different machine learning algorithms,including support vector machine(SVM),deep neural network(DNN),long short-term memory(LSTM)network,and random forest(RF)are *** other two wells are used for model *** research results show that the RF method has the highest accuracy of sedimentary facies prediction,and the average prediction accuracy is 78.81%;the average accuracy of sedimentary facies prediction using SVM is 77.93%.The sedimentary facies predictions using DNN and LSTM are less satisfying compared with RF and SVM,and the average accuracy is 69.94%and 73.05%,respect

关键词： Carbonate Sedimentary facies Well logs Machine learning Deep learning

Design of High Performance MXene/Oxide Structure Memristors for Image Recognition Applications

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Chinese Journal of Electronics 2024年第2期33卷 336-345页

作者： Xiaojuan lian yuelin SHI Xinyi SHEN Xiang WAN Zhikuang CAI Lei wang The College of Integrated Circuit Science and Engineering Nanjing University of Posts and Telecommunications The National and Local Joint Engineering Laboratory of RF Integration and Micro-Assembly Technology Nanjing University of Posts and Telecommunications

Recent popularity to realize image recognition by memristor-based neural network hardware systems has been witnessed owing to their similarities to neurons and ***,the stochastic formation of conductive filaments inside the oxide memristor devices inevitably makes them face some drawbacks,represented by relatively higher power consumption and severer resistance switching *** this work,we design and fabricate the Ag/MXene（Ti3C2）/SiO2/Pt memristor after considering the stronger interactions between Ti3C2and Ag ions,which lead to a Ti3C2/SiO2structure memristor owning to much lower "SET" voltage and smaller resistance switching fluctuation than pure ***,the conductances of the Ag/Ti3C2/SiO2/Pt memristor have been modulated by changing the number of the applied programming pulse,and two typical biological behaviors,i.e.,longterm potentiation and long-term depression,have been ***,device conductances are introduced into an integrated device-to-algorithm framework as synaptic weights,by which the MNIST hand-written digits are recognized with accuracy up to 77.39%.

关键词： Performance evaluation Silicon compounds Image recognition Power demand Memristors Switches Programming

Sensitive and Specific Y-Shaped Ratio Biosensor for Detecting Serum mi R-18a:Potential Early Scanning Tool for Non-Small Cell Lung Cancer

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Journal of Analysis and Testing 2024年第2期8卷 237-244页

作者： Fei yu yue wang Caiyuan yu Wei Zhang Xuefeng Bai State Key Laboratory of Quality Research in Chinese Medicines Macao Institute for Applied Research in Medicine and HealthMacao University of Science and TechnologyTaipaMacao999078China Baotou Cancer Hospital Baotou014040Inner MongoliaChina

miR-18a has been identified as a significantly expressed microRNA(miRNA)in non-small cell lung cancer(NSCLC)and plays a vital role in cancer cell transformation,metastasis,and ***,a pair of binary probes from numerous probe pairs based on single nucleotide polymorphism analyses of miR-18a and miR-18b was first designed and screened to develop a Y-shaped ratio biosensor for accurate detection of serum miR-18a in *** special structure of the binary probes combined with the hairpin showed strong specificity for miR-18a,which was confirmed by polyacrylamide gel electrophoresis assay and square wave voltammetry ***,it is beneficial to immobilize single-stranded DNA(ssDNA)probes due to the large specific surface area of nanoporous gold,thereby improving the sensitivity of the *** Y-shaped ratio biosensor exhibited a wide detection range and can quantify the concentration of miR-18a in the range of 10 fmol/L–100 pmol/L,with a limit of detection of 0.211 fmol/L(S/N=3).Moreover,it exhibits excellent detection capabilities in serum samples since the biosensor showed a high selectivity toward the coexistence of miR-18a and ***,the prepared Y-shaped ratio biosensor is a highly sensitive and specific miR-18a detection tool,capable of identifying microscopic amounts of miR-18a in serum samples,providing great potential for early screening of NSCLC.

关键词： Nanoporous gold Y-shaped biosensor miR-18a NSCLC

Characterization of the pheromone receptors in Mythimna loreyi reveals the differentiation of sex pheromone recognition in Mythimna species

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Insect Science 2024年第1期31卷 173-185页

作者： Chan wang Lei Liu Tian-yu Huang yu Zhang Yang Liu Gui-Rong wang State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijingChina Guangdong Laboratory of Lingnan Modern Agriculture ShenzhenGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenChina School of Forestry Northeast Forestry UniversityHarbinChina Key Laboratory of Biohazard Monitoring Green Prevention and Control for Artificial GrasslandMinistry of Agriculture and Rural AffairsInstitute of Grassland Research of Chinese Academy of Agricultural SciencesInner Mongolia HohhotChina

Pheromone receptors(PRs)are key proteins in the molecular mechanism of pheromone recognition,and exploring the functional differentiation of PRs between closely related species helps to understand the evolution of moth mating *** components of the agricultural pest Mythimna loreyi have turned into(Z)-9-tetradecen-1-yl acetate(Z9-14:OAc),(Z)-7-dodecen-1-yl acetate(Z7-12:OAc),and(Z)-11-hexadecen-1-yl acetate,while the composition differs from that of *** in the genus *** understand the molecular mechanism of pheromone recognition,we sequenced and analyzed antennal transcriptomes to identify 62 odorant receptor(OR)*** expression levels of all putative ORs were analyzed using differentially expressed gene *** candidate PRs were quantified and functionally characterized in the Xenopus oocytes ***6 and MlorPR3 were determined to be the receptors of major and minor components Z9-14:OAc and Z7-12:***1 and female antennae(FA)-biased MlorPR5 both possessed the ability to detect pheromones of sympatric species,including(Z,E)-9,12-tetradecadien-1-ol,(Z)-9-tetradecen-1-ol,and(Z)-*** on the comparison of PR functions between *** and ***,we analyzed the differentiation of pheromone recognition mechanisms during the evolution of the mating systems of 2 Mythimna species.

关键词： antennal transcriptome Mythimna loreyi pheromone receptor sex pheromone Xenopus oocyte

Preparation and properties of poly(ethylene glycol)-bpoly( 3-acrylamidophenylboronic acid) glucose responsive particles and their hyaluronic acid-based microneedle patches

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第5期25卷 395-410页

作者： Yichuan HONG Haojie yu Li wang Xiang CHEN Di SHEN yu wang Shuning REN yudi HUANG Jian YANG State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China Zhejiang-Russia Joint Laboratory of Photo-Electro-Magnetic Functional Materials College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China

To overcome the pain and risk of hypoglycemia in insulin administration,glucose-responsive microneedles have been developed by researchers,which could release insulin according to the blood glucose *** designed a kind of particles by a reversible addition-fragmentation chain transfer(RAFT)method containing a phenylboronic acid group as the sensor of glucose and carrier of ***(ethylene glycol)(PEG)-2-(dodecylthio(thiocarbonyl)thio)-2-methylpropionic acid(DDMAT)was synthesized as a macromolecular RAFT agent,which was then reacted with 3-acrylamidophenylboronic acid(AAPBA)to synthesize the block copolymer ***-responsive particles loaded with insulin were prepared by self-assembly based on hydrophilic-hydrophobic *** patches loaded with glucose-responsive particles were prepared using hyaluronic acid as the *** insulin release behavior of the particles in glucose solutions of 0,100,and 400 mg/dL showed significant glucose responsiveness and good *** results of blood glucose control experiments in rats indicate that a single microneedle patch can effectively maintain normal blood glucose for over 7 h.

关键词： Diabetes Hyaluronic acid Phenylboronic acid(PBA) Glucose responsive hydrogel Microneedles

Ultracycles consisting of macrocycles

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Chinese Chemical Letters 2024年第5期35卷 183-188页

作者： Wen-Hui Mi Teng-yu Huang yu-Fei Ao Xu-Dong wang Qi-Qiang wang De-Xian wang Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Presented here is a one-pot strategy starting from rationally designed macrocyclic precursors for the diverse construction of sophisticated *** type and amount of the base were found to significantly influence the macrocyclization *** use of 4.0 *** resulted in ultracycles of both types A and B while the presence of CsF larger than 6.0 *** only type B *** of anion template increased the total yields and affected the distribution of the *** ultracycles can accommodate large organic dicarboxylates anions via multiple anion-πand hydrogen bonds,and show selectivity to the size-matched heptanedioate(C7^(2−)).Based on all possible species and relevant equilibrium constants as well as material and charge balances,a numerical iterative algorithm was developed and applied to fit the association constants of B2H with dicarboxylates from glutarate(C5^(2−))to octanedioate(C8^(2−)),which gave association constants up to 10^(3) L/mol.

关键词： Ultracycles Diversity-oriented synthesis Anion recognition Anion-πinteraction

Influence of High-Density Bedding Plane Characteristics on Hydraulic Fracture Propagation in Shale Oil Reservoir

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 3051-3071页

作者： Xiao Yan Di wang Haitao yu State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Beijing102206China State Energy Center for Shale Oil Research and Development Beijing102206China Department of Geotechnical Engineering College of Civil Engineering Tongji UniversityShanghai200092China Petroleum Exploration and Production Research Institute SINOPECBeijing102206China Key Laboratory of Deep Earth Science and Engineering(Sichuan University) Ministry of EducationChengdu610065China

The existence of high-density bedding planes is a typical characteristic of shale oil *** the behavior of hydraulic fracturing in high-density laminated rocks is significant for promoting shale oil *** this study,a hydraulic fracturing model considering tensile failure and frictional slip of the bedding planes is established within the framework of the unified pipe-interface element method(UP-IEM).The model developed for simulating the interaction between the hydraulic fracture and the bedding plane is validated by comparison with experimental *** hydraulic fracturing patterns in sealed and unsealed bedding planes are ***,the effects of differential stress,bedding plane permeability,spacing,and the friction coefficient of the bedding plane are *** results showed that a single main fracture crossing the bedding planes is more likely to form in sealed bedding planes under high differential *** decrease in bedding plane permeability and the increase in the friction coefficient also promote the fracture propagating perpendicular to the bedding *** with high-density bedding planes has a poorer fracturing effect than that with low-density bedding planes,as the hydraulic fracture is prone to initiate and propagate along the bedding ***,higher injection pressure is needed to maintain fracture propagation along the *** increase in bedding density will lead to a smaller fracturing *** fluid seepage into the bedding planes slows shale *** is recommended that increasing the injection flow rate,selecting alternative fracturing fluids,and employing multi-well/multi-cluster fracturing may be efficient methods to improve energy production in shale oil reservoirs.

关键词： Hydraulic fracturing bedding planes shale unified pipe-interface element method

Highly Porous Yet Transparent Mechanically Flexible Aerogels Realizing Solar-Thermal Regulatory Cooling

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Nano-Micro Letters 2024年第7期16卷 231-243页

作者： Meng lian Wei Ding Song Liu yufeng wang Tianyi Zhu yue-EMiao Chao Zhang Tianxi Liu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620People’s Republic of China Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122People’s Republic of China

The demand for highly porous yet transparent aerogels with mechanical flexibility and solar-thermal dual-regulation for energy-saving windows is significant but ***,a delaminated aerogel film(DAF)is fabricated through filtration-induced delaminated gelation and ambient *** delaminated gelation process involves the assembly of fluorinated cellulose nanofiber(FCNF)at the solid-liquid interface between the filter and the filtrate during filtration,resulting in the formation of lamellar FCNF hydrogels with strong intra-plane and weak interlayer hydrogen *** exchanging the solvents from water to hexane,the hydrogen bonding in the FCNF hydrogel is further enhanced,enabling the formation of the DAF with intra-layer mesopores upon ambient *** resulting aerogel film is lightweight and ultra-flexible,which pos-sesses desirable properties of high visible-light transmittance(91.0%),low thermal conductivity(33 mW m^(-1) K^(-1)),and high atmospheric-window emissivity(90.1%).Furthermore,the DAF exhibits reduced surface energy and exceptional hydrophobicity due to the presence of fluorine-containing groups,enhancing its durability and UV ***,the DAF has demonstrated its potential as solar-thermal regulatory cooling window materials capable of simultaneously providing indoor lighting,thermal insulation,and daytime radiative cooling under direct ***,the enclosed space protected by the DAF exhibits a temperature reduction of 2.6℃ compared to that shielded by conventional architectural glass.

关键词： Transparent aerogel Cellulose nanofiber aerogel Delaminated gelation Thermal insulation Passive daytime radiative cooling

Reliability analysis of carbon fiber rod-reinforced umbilical cable under tension using an improved sampling method

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Petroleum Science 2024年第4期21卷 2769-2778页

作者： yu Zhang Hong-yu Zhang Ran Xia Si-Ao Jiang Fang wang College of Safety and Ocean Engineering China University of Petroleum China Academy of Aerospace Aerodynamics China Aerospace Science and Technology Group College of Engineering Science and Technology Shanghai Ocean University

The umbilical cable is a vital component of subsea production systems that provide power, chemical agents, control signals et al., and its requirement for reliability is exceedingly high. However, as the umbilical cable is a composite structure comprising multiple functional units, the reliability analysis of such cables involves numerous parameters that can impact calculation efficiency. In this paper, the reliability analysis of a new kind of umbilical cable with carbon fiber rod under tension is analyzed. The global dynamic analytical model is first established to determine the maximum tension load, then the local analytical model of umbilical cable including each unit are constructed by finite element method(FEM). Based on the mechanical analytical model, the reliability of umbilical cable under tension load is studied using response surface method(RSM) and Monte Carlo method. During the calculation process, a new tangent plane sampling method to calculate the response surface function(RSF) is proposed in this paper, which could make sampling points faster come close to the RSF curve, and it is proved that the calculation efficiency increases about 33% comparing with traditional method.

关键词： Umbilical cable Carbon fiber rod Failure analysis Response surface method Reliability