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Accuracy of a combined score of zygote and embryo morphology for selecting the best embryos for IVF

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第8期9卷 649-655页

作者： yu-li qian ying-hui ye chen-ming xu fan jin he-feng huang Department of Reproductive Endocrinology Women＇s Hospital School of Medicine Zhejiang University Hangzhou 310006 China

Objective:To evaluate the accuracy of a scoring system combining zygote and embryo morphology in predicting the outcome of in vitro fertilization (IVF) treatment. Methods: In a study group, 117 consecutive IVF or intracytoplasmic sperm injection (ICSI) cycles with embryo transfer were carried out and 312 embryos were scored using a combined scoring system (CSS) of zygote and embryo morphology before transplantation. In a control group, a total of 420 IVF or ICSI cycles were carried out and 1176 embryos were scored using a cumulative embryo score (CES). The effects of the combined scoring system on the embryo implantation rate and pregnancy rate per cycle were analyzed. Results: Using the combined scoring system, the embryo implan-tation rate (27.6%) and the clinical pregnancy rate (48.7%) were significantly higher than those in the control group (20.8% and 38.6%, respectively). Also, the implantation rate of embryos scoring ≥70 (38.5%: 82 sacs/213 embryos) was significantly higher (Phe pregnancy rate of patients with embryos scoring ≥70 using the combined scoring system (66.7%) was significantly higher (Phe cumulative embryo score (59.0%). Conclusion: The results suggest that selecting embryos with a high score (≥70) using the combined scoring system could increase the implantation rate and pregnancy rate, and that using a scoring system combining assessments of human zygotes and pre-implantation embryos might predict IVF outcomes more accurately than using a cumula-tive embryo score.

关键词： Embryo score Combined scoring system (CSS) Implantation In vitro fertilization (IVF) Pregnancy

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Boosting Sodium Storage of Fe1?xS/MoS2 Composite via heterointerface Engineering

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Nano-Micro Letters 2019年第4期11卷 425-438页

作者： Song chen Shaozhuan huang Junping Hu Shuang fan Yang Shang Mei Er Pam Xiaoxia li ye Wang Tingting xu yumeng Shi hui ying Yang International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education College of Optoelectronic EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Pillar of Engineering Product Development Singapore University of Technology and Design8 Somapah RoadSingapore 487372Singapore Engineering Technology Research Center for 2D Material Information Function Devices and Systems of Guangdong Province College of Optoelectronic EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Key Laboratory of Material Physics of Ministry of Education School of Physics and EngineeringZhengzhou UniversityZhengzhou 450052People’s Republic of China

Improving the cycling stability of metal sulfide-based anode materials at high rate is of great significance for advanced sodium ion ***,the sluggish reaction kinetics is a big obstacle for the development of high-performance sodium storage ***,we have rationally engineered the heterointerface by designing the Fe1?xS/MoS2 heterostructure with abundant“ion reservoir”to endow the electrode with excellent cycling stability and rate capability,which is proved by a series of in and ex situ electrochemical *** functional theory calculations further reveal that the heterointerface greatly decreases sodium ion diffusion barrier and facilitates charge-transfer *** present findings not only provide a deep analysis on the correlation between the structure and performance,but also draw inspiration for rational heterointerface engineering toward the next-generation high-performance energy storage devices.

关键词： heterostructure heterointerface Diffusion barrier Ion reservoir Sodium ion battery

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Development and Validation of a Nomogram Based on Perioperative Factors to Predict Post-hepatectomy liver Failure

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Journal of Clinical and Translational hepatology 2021年第3期9卷 291-300页

作者： Bin xu Xiao-Long li feng ye Xiao-Dong Zhu ying-Hao Shen cheng huang Jian Zhou Jia fan Yong-Jun chen hui-Chuan Sun Department of liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghaiChina Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education ShanghaiChina Department of hepatobiliary Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

(PHLF)is a severe complication and main cause of death in patients undergoing *** aim of this study was to build a predictive model of PHLF in patients undergoing ***:We retrospectively analyzed patients undergoing hepatectomy at Zhongshan Hospital,Fudan University from July 2015 to June 2018,and randomly divided them into development and internal validation *** validation was performed in an independent *** absolute shrinkage and selection operator(commonly referred to as LASSO)logistic regression was applied to identify predictors of PHLF,and multivariate binary logistic regression analysis was performed to establish the predictive model,which was visualized with a ***:A total of 492 eligible patients were *** and multivariate analysis identified three preoperative variables,total bilirubin(p=0.001),international normalized ratio(phe predictive model was 0.838 and outperformed the model for end-stage liver disease score,albumin-bilirubin score and platelet-albumin-bilirubin score(AUROCs:0.723,0.695 and 0.663,respectively;phe optimal cut-off value of the predictive model was *** validation showed the model could predict PHLF accurately and distinguish high-risk ***:PHLF can be accurately predicted by this model in patients undergoing hepatectomy,which may significantly contribute to the postoperative care of these patients.

关键词： hepatectomy Post-hepatectomy liver failure LASSO Nomogram

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Room-Temperature Multi-Peak NDR in nc-Si Quantum-Dot Stacking MOS Structures for Multiple Value Memory and Logic

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Chinese Physics Letters 2013年第7期30卷 181-184页

作者： qian Xin-ye chen Kun-Ji huang Jian WANG yue-Fei fanG Zhong-hui xu Jun huang Xin-fan State Key Laboratory of Solid State Microstructures Jiangsu Province Key Laboratory of Photonic and Electronic Material Science and TechnologySchool of Electron Science and EngineeringNanjing UniversityNanjing 210093

Room-temperature negative differential resistance(NDR)characteristics are observed in a nanocrystalline Si quantum dot(nc-Si QD)floating-gate MOS structure,which is fabricated by plasma-enhanced chemical vapor *** multi-NDR peaks for the electrons and holes,shown in the I–V curves,which are significant for the application of multiple value memory and logic,are proved to be induced by electron and hole resonant tunneling into the nc-Si QDs from the *** calculation results indicate that these NDR characteristics should be associated with the Coulomb blockade effect and the quantum confinement effect of the nc-Si ***,low-temperature I–V characteristics are also investigated to confirm the room-temperature results.

关键词： deposition. floating effect

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Do the existing staging systems for primary liver cancer apply to combined hepatocellular carcinoma-intrahepatic cholangiocarcinoma?

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hepatobiliary & Pancreatic Diseases International 2021年第1期20卷 13-20页

作者： qiang Zhou Hao Cai ming-Hao xu Yao ye Xiao-Long li Guo-ming Shi a cheng huang Xiao-Dong Zhu Jia-Bin Cai Jian Zhou Jia fan yuan Ji hui-Chuan Sun ying-Hao Shen Department of liver Surgery Liver Cancer InstituteZhongshan Hospitaland Key Laboratory of Carcinogenesis and Cancer Invasion(Ministry of Education)Fudan UniversityShanghai 200032China Department of Pathology Zhongshan HospitalFudan UniversityShanghai 200032China

Background:The incidence of combined hepatocellular carcinoma-intrahepatic cholangiocarcinoma(cHCC-ICC)is relatively low,and the knowledge about the prognosis of cHCC-ICC remains *** the study,we aimed to screen existing primary liver cancer staging systems and shed light on the prognosis and risk factors for ***:We retrospectively reviewed 206 cHCC-ICC patients who received curative surgical resection from April 1999 to March *** correlation of survival measures with the histological types or with tumor staging systems was determined and predictive values of tumor staging systems with cHCC-ICC prognosis were ***:The histological type was not associated with overall survival(OS)(P=0.338)or disease-free survival(DFS)(P=0.843)of patients after curative surgical ***,TNM for HCC,and TNM for ICC stages correlated with both OS and DFS in cHCC-ICC(all Phe predictive values of TNM for HCC and TNM for ICC stages were similar in terms of predicting postoperative OS(P=0.798)and DFS(P=0.191)in *** for HCC was superior to BCLC for predicting postoperative OS(P=0.022)in ***:The TNM for HCC staging system should be prioritized for clinical applications in predicting cHCC-ICC prognosis.

关键词： hepatocellular carcinoma Intrahepatic cholangiocarcinoma Histological type Tumor staging system Prognosis Risk stratification

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Different sperm sources and parameters can influence intracytoplasmic sperm injection outcomes before embryo implantation

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第1期13卷 1-10页

作者： yue-hong LU1,2, hui-juan GAO1, Bai-jia li1, ying-ming ZheNG1, ying-hui ye1, yu-li qian1, chen-ming xu1, he-feng huang1, fan jin1 (1Department of Reproductive Endocrinology, Key Laboratory of Reproductive Genetics, Ministry of Education, and Key Laboratory of Women’s Reproductive health of Zhejiang Province, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China) (2Department of Reproductive health, Shaoxing Women and Children Hospital, Shaoxing 312000, China) Department of Reproductive Endocrinology Key Laboratory of Reproductive Genetics Ministry of Education Women's Hospital School of Medicine Zhejiang University Hangzhou 310006 China.

To evaluate the effects of sperm with different parameters and sources on the outcomes of intracytoplasmic sperm injection (ICSI), 1972 ICSI cycles were analyzed retrospectively. Groups 1 to 5 were composed of cycles using ejaculated sperm and were grouped according to sperm quantity, quality, and morphology into normal (288 cycles), or mild (329 cycles), moderate (522 cycles), severe (332 cycles), and extremely severe (171 cycles) oligozoospermia and/or asthenozoospermia and/or teratozoospermia (OAT) groups. Group 6 was composed of 250 cycles using testicular or epididymal sperm, and Group 7 consisted of 80 cycles using frozen-thawed sperm. We found that fertilization rates were gradually reduced from Groups 1 to 6, and reached statistical difference in Groups 5 and 6 (Phe high-quality embryo rate was higher in Group 1 than in Groups 2, 3, 5, 6, and 7 (Phe rates of embryo cleavage, clinical pregnancy, miscarriage, live-birth, premature birth, low birth weight, weeks of premature birth, average birth weight, or sex ratio for all seven groups (P>0.05). A total of nine cases of malformation were observed, with a malformation rate of 1.25% (9/719). In conclusion, different sperm sources and parameters can affect ICSI outcomes before embryo implantation. A full assessment of offspring mal-formation will require further study using a larger sample size.

关键词： Intracytoplasmic sperm injection (ICSI)i Sperm Sperm source Sperm parameters Malformation

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Different sperm sources and parameters can influence intracytoplasmic sperm injection outcomes before embryo implantation

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第5期14卷 381-381页

作者： yue-hong LU hui-juan GAO Bai-jia li ying-ming ZheNG ying-hui ye yu-li qian chen-ming xu he-feng huang fan jin

To evaluate the effects of sperm with different parameters and sources on the outcomes of intracytoplasmic sperm injection (ICSI), 1972 ICSI cycles were analyzed retrospectively. Groups 1 to 5 were composed of cycles using ejaculated sperm and were grouped according to sperm quantity, quality, and morphology into normal (288 cycles), or mild (329 cycles), moderate (522 cycles), severe (332 cycles), and extremely severe (171 cycles) oligozoospermia and/or asthenozoospermia and/or teratozoospermia (OAT) groups. Group 6 was composed of 250 cycles using testicular or epididymal sperm, and Group 7 consisted of 80 cycles using frozen-thawed sperm. We found that fertilization rates were gradually reduced from Groups 1 to 6, and reached statistical difference in Groups 5 and 6 (Phe high-quality embryo rate was higher in Group 1 than in Groups 2, 3, 5, 6, and 7 (Phe rates of embryo cleavage, clinical pregnancy, miscarriage, live-birth, premature birth, low birth weight, weeks of premature birth, average birth weight, or sex ratio for all seven groups (P>0.05). A total of nine cases of malformation were observed, with a malformation rate of 1.25% (9/719). In conclusion, different sperm sources and parameters can affect ICSI outcomes before embryo implantation. A full assessment of offspring malformation will require further study using a larger sample size.

关键词：胚胎植入显微注射精子低出生体重胞浆 ICSI 畸形率循环使用

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Alcohol consumption in relation to the incidence of atrial fibrillation in an elderly Chinese population

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Journal of Geriatric Cardiology 2022年第1期19卷 52-60页

作者： Xiao-Fei ye Wei ZHANG Yi chen Chao-ying MIAO Qi-fang huang Chang-Sheng SheNG Shuai SHAO Dian WANG Shao-Kun xu Lei LEI Di ZHANG Yi-lin chen Lei-Xiao HU Jia-hui XIA Yi-Bang chenG ying WANG qian-hui GUO Yan li Nicole Lowres Ben Freedman Ji-Guang WANG School of Public health Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Cardiovascular Medicine The Shanghai Institute of HypertensionRuijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina heart Research Institute Sydney Medical SchoolCharles Perkins Centerand Cardiology DepartmentConcord HospitalUniversity of SydneySydneyAustralia

BACKGROUND Alcohol consumption is a known modifiable risk factor for atrial *** association,however,might differ according to *** investigated gender-specific associations between alcohol consumption and incident atrial fibrillation in an elderly Chinese *** Our study participants were elderly residents(≥65 years)recruited from five community health centers in the urban area of Shanghai(n=6,618).Alcohol intake was classified as never drinkers and current light-to-moderate(heavy drinkers(≥40 g/day).Atrial fibrillation was detected by a 30-s single-lead electrocardiography(ECG,AliveCor®heart Monitor)and further evaluated with a regular 12-lead *** During a median of 2.1 years(interquartile range:2.0−2.2)follow-up,the incidence rate of atrial fibrillation was 1.10%in all study *** was slightly but non-significantly higher in men(n=2849)than women(n=3769,1.30%vs.0.96%,P=0.19)and in current drinkers(n=793)than never drinkers(n=5825,1.64%vs.1.03%,P=0.12).In both unadjusted and adjusted analyses,there was interaction between sex and current alcohol intake in relation to the incidence of atrial fibrillation(Pher incidence rate of atrial fibrillation than never drinkers in women(12.96%[7/54]vs.0.78%[29/3715],adjusted odds ratio[OR]=10.25,95%confidence interval[CI]:3.54−29.67,Phe incidence of atrial fibrillation in elderly Chinese women,but not men.

关键词： fibrillation intake Alcohol

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Realization of Fast All-Microwave Controlled-Z Gates with a Tunable Coupler

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Chinese Physics Letters 2022年第3期39卷 6-11页

作者： Shaowei li Daojin fan ming Gong Yangsen ye Xiawei chen yulin Wu huijie Guan hui Deng Hao Rong he-liang huang chen Zha Kai Yan Shaojun Guo Haoran qian Haibin Zhang Fusheng chen Qingling Zhu Youwei Zhao Shiyu Wang Chong ying Sirui Cao Jiale yu Futian liang yu xu jin lin cheng Guo lihua Sun Na li lianchen Han cheng-Zhi Peng Xiaobo Zhu Jian-Wei Pan Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Shanghai Branch CAS Center for Excellence in Quantum Information and Quantum PhysicsUniversity of Science and Technology of ChinaShanghai 201315China Shanghai Research Center for Quantum Sciences Shanghai 201315China

The development of high-fidelity two-qubit quantum gates is essential for digital quantum ***,we propose and realize an all-microwave parametric controlled-Z(CZ)gates by coupling strength modulation in a superconducting Transmon qubit system with tunable *** optimizing the design of the tunable coupler together with the control pulse numerically,we experimentally realized a 100 ns CZ gate with high fidelity of 99.38%±0.34%and the control error being 0.1%.We note that our CZ gates are not affected by pulse distortion and do not need pulse correction,providing a solution for the real-time pulse generation in a dynamic quantum feedback *** the expectation of utilizing our all-microwave control scheme to reduce the number of control lines through frequency multiplexing in the future,our scheme draws a blueprint for the high-integrable quantum hardware design.

关键词： quantum microwave scheme

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A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)

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Military Medical Research 2020年第1期7卷 1-22页

作者： ying-hui jin lin Cai Zhen-Shun cheng Hong cheng Tong Deng Yi-Pin fan cheng fang Di huang Lu-Qi huang Qiao huang Yong Han Bo Hu Fen Hu Bing-hui li Yi-Rong li Ke liang li-Kai lin li-Sha Luo jing Ma lin-Lu Ma Zhi-Yong Peng yun-Bao Pan Zhen-yu Pan xue-Qun Ren hui-Min Sun ying Wang yun-yun Wang Hong Weng Chao-Jie Wei Dong-fang Wu Jian Xia Yong Xiong Hai-Bo xu Xiao-Mei Yao yu-feng yuan Tai-Sheng ye Xiao-Chun Zhang ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Hospital Management Wuhan UniversityWuhan 430071China Department of Respiratory Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Pharmacy Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Evidence-Based Medicine and Knowledge Translation Henan UniversityKaifeng 475000China China Academy of Chinese Medical Sciences Beijing 100700China China Center for Evidence Based Traditional Chinese Medicine(CCEBTCM) Beijing 100700China Department of Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Clinical Laboratory Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Infectious Diseases Zhongnan Hospital of Wuhan UniversityWuhan 430071China Division of Medical Affairs Zhongnan Hospital of Wuhan UniversityWuhan 430071China Division of Nursing Affairs Zhongnan Hospital of Wuhan UniversityWuhan 430071China Office of Nosocomial Infection Control Zhongnan Hospital of Wuhan UniversityWuhan 430071China Emergency Center Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Radiology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of health Research Methods Evidenceand ImpactMcMaster UniversityHamiltonON L8S 4L8Canada Department of Traditional Chinese Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Global health Institute Wuhan UniversityWuhan 430072China the Zhongnan Hospital of Wuhan University Novel Coronavirus Management and Research Team Evidence-Based Medicine Chapter of China International Exchange and Promotive Association for Medical and health Care(CPAM)

In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named "2019 novel coronavirus(2019-nCoV)" by the World health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV.

关键词： 2019 novel coronavirus 2019-nCoV Respiratory disease Pneumonia Infectious diseases Rapid advice guideline Clinical practice guideline Evidence-based medicine

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