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Probiotics intervention in colorectal cancer:From traditional approaches to novel strategies

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Chinese Medical Journal 2024年第1期137卷 8-20页

作者： Suki Ha Xiang Zhang jun yu Institute of Digestive Disease and Department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong SARChina

The intestine harbors a large population of microorganisms that interact with epithelial cells to maintain host healthy physiological *** intestinal microbiota engage in the fermentation of non-digestible nutrients and produce beneficial metabolites to regulate host homeostasis,metabolism,and immune *** disruption of microbiota,known as dysbiosis,has been implicated in many intestinal diseases,including colorectal cancer(CRC).As the third most common cancer and the second leading cause of cancer-related death worldwide,CRC poses a significant health *** is an urgent need for novel interventions to reduce CRC incidence and improve clinical *** the intestinal microbiota has emerged as a promising approach for CRC prevention and *** research efforts in CRC probiotics primarily focus on reducing the incidence of CRC,alleviating treatment-related side effects,and potentiating the efficacy of anticancer therapy,which is the key to successful translation to clinical *** paper aims to review the traditional probiotics and new interventions,such as next-generation probiotics and postbiotics,in the context of *** underlying mechanisms of probiotic anti-cancer effects are also discussed,including the restoration of microbial composition,reinforcement of gut barrier integrity,induction of cancer cell apoptosis,inactivation of carcinogens,and modulation of host immune *** paper further evaluates the novel strategy of probiotics as an adjuvant therapy in boosting the efficacy of chemotherapy and *** all the promising findings presented in studies,the evaluation of potential risks,optimization of delivery methods,and consideration of intra-patient variability of gut microbial baseline must be thoroughly interpreted before bench-to-bedside translation.

关键词： colorectal cancer probiotics gut microbiota dysbiosis adjuvant therapy immune modulation gut barrrier

Derivatives of Intersection Local Time for Two Independent Symmetricα-stable Processes

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1273-1292页

作者： Huan ZHOU Guang jun SHEN Qian yu Department of Mathematics Anhui Normal UniversityWuhu 241002P.R.China Department of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 211106P.R.China Key Laboratory of Mathematical Modelling and High Performance Computing of Air Vehicles(NUAA) MIITNanjing 211106P.R.China

In this paper,we consider the derivatives of intersection local time for two independent d-dimensional symmetricα-stable processes X^(α) and X^(α)with respective indices α and α.We first study the sufficient condition for the existence of the derivatives,which makes us obtain the exponential integrability and H?lder *** we show that this condition is also necessary for the existence of derivatives of intersection local time at the ***,we also study the power variation of the derivatives.

关键词： Symmetric stable processes intersection local time exponential integrability power variation

B-COPNA resin formation from ethylene tar light fractions:Process development and mechanical exploration by molecular simulation

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Chinese Journal of Chemical Engineering 2024年第6期70卷 118-129页

作者： Hongyan Shen Lingrui cui Xingguo Wei yuanqin Zhang Lian Cen jun Xu Fahai Cao Engineering Research Center of Large Scale Reactor East China University of Science and TechnologyShanghai 200237China

An efficient utilization strategy of ethylene tar(ET),the main by-product of the ethylene cracking unit,is urgently required to meet demands for modern petrochemical *** the other hand,condensed polynuclear aromatic resin of moderate condensation degree(B-COPNA)is a widely used carbon material due to its superb processability,the production of which is,however,seriously limited by the high cost of raw *** such context,an interesting strategy was proposed in this study for producing B-COPNA resin using crosslinked light fractions of ethylene tar(ETLF,boiling point<260℃)facilitated by molecular simulation.1,4-Benzenedimethanol(PXG)was first selected as the crosslinking agent according to the findings of molecular *** effects of operating conditions,including reactions temperature,crosslinking agent,and catalyst content on the softening point and yield of B-COPNA resin products were then investigated to optimize the *** reaction mechanism of resin production was studied by analyzing the molecular structure and transition state of ETLF and crosslinking *** was shown that PXG exhibited a superior capacity of withdrawing electrons and a higher electrophilic reactivity than other crosslinking *** addition to the highest yield and greatest heat properties,PXG-prepared resin contained the most condensed *** corresponding optimized conditions of resin preparation were 180℃,1:1.9(PXG:ETLF),and 3%(mass)of catalyst content with a resin yield of 78.57%.It was the electrophilic substitution reaction that occurred between the ETLF and crosslinking agent molecules that were responsible for the resin formation,according to the experimental characterization and molecular ***,it was confirmed that the proposed strategy and demonstrated process can achieve a clean and high value-added utilization of ETLF via B-COPNA resin preparation,bringing huge economic value to the current petrochemical industry.

关键词： Ethylene tar Crosslinking COPNA resin Molecular simulation Transient state

Luminescence properties and optical sensing behaviors of Sr_(2)GdSbO_(6):Eu^(3+) phosphors

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Journal of Rare Earths 2024年第8期42卷 1458-1469,I0002页

作者： Youfa Tai Ruirui cui jun Zhang Chunkai Wang Tingyu Zhao Beiqiao Zhang Chaoyong Deng Key Laboratory of Functional Composite Materials of Guizhou Province College of Big Data and Information EngineeringGuizhou UniversityGuiyang550025China College of Computer and Information Enginering Guizhou University of CommerceGuiyang550014China School of Electronics and Information Engineering Guiyang UniversityGuiyang550005China

Novel orange-red Sr^(2)GdSbO^(6):xEu^(3+)(x=0,0.05,0.1,0.2,0.3,0.4,0.5 and 0.6) phospho rs were successfully prepared by the traditional high-temperature solid-state *** results of Rietveld refinement,energy dispersive spectroscopy(EDS) spectrum and elemental mapping demonstrate that Eu^(3+) successfully replaces the Gd^(3+) sites and distributes uniformly in the particles of *** luminescence properties of Sr_(2)GdSbO_(6):Eu_(3+)phosphors were investigated in *** emission spectra of the strongest emission peak is the ^(5)D_(0)→^(7)F_(1)(593 nm) transition,which can emit orange-red light under393 nm *** the doping concentration of Eu3+ions is x=0.2,the luminescence intensity of the phosphors reaches the *** detailed mechanism of concentration quenching is attributed to dipole-dipole *** thermal stability values of Sr_(2)GdSbO_(6):0.2Eu^(3+) phosphors are 87%,82% and114% under 393,467 and 527 nm excitations,*** causes of the abnormal thermal quenching under 527 nm excitation were *** on the abnormal thermal quenching under527 nm excitation,the optical thermometry properties of Sr_(2)GdSbO_(6):0.2Eu^(3+)phosphors were investigated by fluorescence intensity ratio(FIR) technique,and appreciable relative sensitivity was *** results suggest that Sr_(2)GdSbO_(6):0.2Eu^(3+)phosphors can be potentially applied to w-LEDs and optical thermometers.

关键词： Sr_(2)GdSbO_(6):Eu^(3+) Phosphors Luminescence properties Abnormal thermal quenching Rare earths

Enhancement of Activity of SnO_(2)-doped In_(2)O_(3)/Al_(2)O_(3) Catalyst for NO Reduction with Propene in the Presence of H_(2)O and SO_(2)

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Chinese Chemical Letters 2005年第11期16卷 1535-1538页

作者： Xiang yu cui jun Hua LI Ji Ming HAO Li Xin FU Department of Environmental Science and Engineering Tsinghua University Beijing 100084

The novel bimetallic Sn-Im/Al2O3 catalysts prepared by three methods for NO reduction by propene were investigated. The results showed that the catalytic activity was enhanced significantly in the presence of H2O on sol-gel catalyst, and the maximum NO conversion increased from 46% to 92%, even in the presence of 100 ppm SO2, NO conversion was still 80%.

关键词： Selective catalytic reduction De-NOx lean burn In2O3/Al2O3 Sn-Ir/A12O3.

The anisotropy of suprathermal electrons in the Martian ionosphere

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Earth and Planetary Physics 2024年第3期8卷 459-471页

作者： yuTian Cao jun cui XiaoShu Wu Wenjun Liang RuiQi Fu Haoyu Lu Planetary Environmental and Astrobiological Research Laboratory(PEARL) School of Atmospheric SciencesSun Yat-sen UniversityZhuhai 519082China Key Laboratory of Geospace Environment University of Science&Technology of ChinaChinese Academy of SciencesHefei 230026China Center for Excellence in Comparative Planetology Chinese Academy of SciencesHefei 230026China School of Space and Environment Beihang UniversityBeijing 102206China

Suprathermal electrons are an important population of the Martian ionosphere, either produced by photoionization of atmospheric neutrals or supplied from the Solar Wind (SW). This study is dedicated to an in-depth investigation of the pitch angle distribution of suprathermal electrons at two representative energies, 19−55 eV and 124−356 eV, using the extensive measurements made by the Solar Wind Electron Analyzer on board the Mars Atmosphere and Volatile Evolution. Throughout the study, we focus on the overall degree of anisotropy, defined as the standard deviation of suprathermal electron intensity among different directions which is normalized by the mean omni-directional intensity. The available data reveal the following characteristics: (1) In general, low energy electrons are more isotropic than high energy electrons, and dayside electrons are more isotropic than nightside electrons;(2) On the dayside, the anisotropy increases with increasing altitude at low energies but remains roughly constant at high energies, whereas on the nightside, the anisotropy decreases with increasing altitude at all energies;(3) Electrons tend to be more isotropic in strongly magnetized regions than in weakly magnetized regions, especially on the nightside. These observations indicate that the anisotropy is a useful diagnostic of suprathermal electron transport, for which the conversion between the parallel and perpendicular momenta as required by the conservation of the first adiabatic invariant, along with the atmospheric absorption at low altitudes, are two crucial factors modulating the observed variation of the anisotropy. Our analysis also highlights the different roles on the observed anisotropy exerted by suprathermal electrons of different origins.

关键词： Mars ionosphere suprathermal electron pitch angle distribution

A novel approach towards the selection of regenerators for optimal Stirling engine performance based on energy and exergy analyses

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Science China(Technological Sciences) 2024年第1期67卷 295-310页

作者： yu MinJie ZHANG MingHui XU Lei cui HaiChuan LIU ZhiChun LIU Wei School of Energy and Power Engineering Huazhong University of Science and TechnologyWuhan 430074China

Regenerators play a vital role in enhancing the overall performance of Stirling ***,this paper performed an energy and exergy analysis to elucidate the significance of regenerator characteristics concerning system performance,contributing to the optimal regenerator’s design and *** relationship between regenerator structure,regenerator exergy destruction,and output power,thermal efficiency,and exergy efficiency for Stirling engines was established by integrating the thermal model of Stirling engines with a mathematical model of *** contrast to cross-flow and parallel-flow regenerators,a novel concept of inclined-flow regenerators,featuring a matrix surface inclined in the direction of gas flow,was developed to achieve higher and more balanced engine output power and energy utilization efficiency.A comprehensive investigation was conducted into the effects of matrix structure types and regenerator geometries on the performance of both regenerators and *** results reveal that,following structural optimization,Stirling engines equipped with the inclined-flow regenerator demonstrate a substantial 16.6%,38.3%,and 37.2%increase in power output,thermal efficiency,and exergy efficiency,respectively,compared to those equipped with cross-flow *** contrast,when compared to engines fitted with parallel-flow regenerators,they experience a 13.5%reduction in power output but achieve remarkable enhancements of 45.4%and 36.7%in thermal and exergy efficiency,*** study introduces new insights into selecting regenerator structures for enhancing the output performance of Stirling engines.

关键词： Stirling engine inclined-flow regenerator adiabatic model exergy analysis

SAM Era:Can It Segment Any Industrial Surface Defects?

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Computers, Materials & Continua 2024年第3期78卷 3953-3969页

作者： Kechen Song Wenqi cui Han yu Xingjie Li yunhui Yan National Key Laboratory of Advanced Casting Technologies Shenyang110022China School of Mechanical Engineering&Automation Northeastern UniversityShenyang110819China

Segment Anything Model(SAM)is a cutting-edge model that has shown impressive performance in general object *** birth of the segment anything is a groundbreaking step towards creating a universal intelligent *** to its superior performance in general object segmentation,it quickly gained attention and *** makes SAM particularly attractive in industrial surface defect segmentation,especially for complex industrial scenes with limited training ***,its segmentation ability for specific industrial scenes remains ***,in this work,we select three representative and complex industrial surface defect detection scenarios,namely strip steel surface defects,tile surface defects,and rail surface defects,to evaluate the segmentation performance of *** results show that although SAM has great potential in general object segmentation,it cannot achieve satisfactory performance in complex industrial *** test results are available at:https://***/VDT-2048/SAM-IS.

关键词： Segment anything SAM surface defect detection salient object detection

Strategies for improving extraction capacity through preorganization structure:A novel 5,6-bicyclicmalonamide extractant(THPPD)

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Journal of Rare Earths 2024年第4期42卷 768-774页

作者： Miaomiao Zhang Zhen Yang yuhua cui Jianhui Su Heng Zhao Chengjin Xu Xiaolei Liu Guoxin Sun Xiujing Peng yu cui School of Chemistry and Chemical Engineering University of JinanJinan250022China Institute for Smart Materials&Engineering University of JinanJinan250022China Shandong Institute for Food and Drug Control Jinan250101China

Rational design of extractant structure to improve the extraction and separation capacity of rare earth elements(REEs)is a long-standing ***,a new strategy was proposed to improve the stability of the chelating structure formed by malonamide and *** stability of the chelating structure is greatly improved by using a double-ring framework structure which makes the two carbonyl groups of malonamide unable to rotate freely and both of them point to the metal ion *** benzyl groups were used to construct the hydrophobicity of the extractant and the organic shell of the extracted ***-pyrrolo-pyridine-dione(THPPD)was designed and *** structure reduces the energy consumed by rotating carbonyl group in the coordination with metal ions and then improves the extraction ability of *** crystal structure was preorganized as expected,with the two carbonyls pointing in a favorable coordination direction to the structural complement of the metal *** extraction behaviors of REEs with THPPD in a nitric acid medium were *** with N,N’-dibenzyl-N,N’-dimethylmalonamide(DBDM-MA)with a chain structure,the extraction capacity of THPPD is 360 times higher than that of DBDM-MA at 5.0 mol/L sodium ***,the binding energy and Gibbs free energy were investigated by density functional theory(DFT)in conjunction with the *** theoretical results show that THPPD has more effective interaction with Pr(NO_(3))3 than *** construction of chelating groups conformation is a worthy direction to improve the coordination ability and even selectivity of extractant.

关键词： Rare earth elements Extraction separation 5,6-bicyclicdiamide extractant