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An enriched environment promotes synaptic plasticity and cognitive recovery after permanent middle cerebral artery occlusion in mice

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Neural Regeneration Research 2019年第3期14卷 462-469页

作者： Chuan-jie Wang Yi Wu Qun Zhang Ke-Wei yu yu-Yang Wang Department of Rehabilitation Medicine Huashan Hospital Fudan University

Cerebral ischemia activates an endogenous repair program that induces plastic changes in neurons. In this study, we investigated the effects of environmental enrichment on spatial learning and memory as well as on synaptic remodeling in a mouse model of chronic cerebral ischemia, produced by subjecting adult male C57 BL/6 mice to permanent left middle cerebral artery occlusion. Three days postoperatively, mice were randomly assigned to the environmental enrichment and standard housing groups. Mice in the standard housing group were housed and fed a standard diet. Mice in the environmental enrichment group were housed in a cage with various toys and fed a standard diet. Then, 28 days postoperatively, spatial learning and memory were tested using the Morris water maze. The expression levels of growth-associated protein 43, synaptophysin and postsynaptic density protein 95 in the hippocampus were analyzed by western blot assay. The number of synapses was evaluated by electron microscopy. In the water maze test, mice in the environmental enrichment group had a shorter escape latency, traveled markedly longer distances, spent more time in the correct quadrant(northeast zone), and had a higher frequency of crossings compared with the standard housing group. The expression levels of growth-associated protein 43, synaptophysin and postsynaptic density protein 95 were substantially upregulated in the hippocampus in the environmental enrichment group compared with the standard housing group. Furthermore, electron microscopy revealed that environmental enrichment increased the number of synapses in the hippocampal CA1 region. Collectively, these findings suggest that environmental enrichment ameliorates the spatial learning and memory impairment induced by permanent middle cerebral artery occlusion. Environmental enrichment in mice with cerebral ischemia likely promotes cognitive recovery by inducing plastic changes in synapses.

关键词： nerve regeneration environmental enrichment cerebral ischemia cognitive recovery brain plasticity and reorganization synaptic plasticity electron microscopy growth-associated protein 43 synaptophysin postsynaptic density protein 95 permanent middle cerebral artery occlusion neural regeneration

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Directional Design of Materials Based on Multi-Objective Optimization:A Case Study of Two-Dimensional Thermoelectric SnSe

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Chinese Physics Letters 2021年第2期38卷 84-90页

作者： Shenshen Yan Yi Wang Zhibin gao Yang Long jie Ren Center for Phononics and Thermal Energy Science China-EU Joint Lab on NanophononicsShanghai Key Laboratory of Special Artificial Microstructure Materials and TechnologySchool of Physics Science and EngineeringTongji UniversityShanghai 200092China Department of Physics National University of SingaporeSingapore 117551Republic of Singapore Shanghai Research Institute for Intelligent Autonomous Systems Tongji UniversityShanghai 200092China

The directional design of functional materials with multi-objective constraints is a big challenge,in which performance and stability are determined by a complicated interconnection of different physical *** apply multi-objective optimization,based on the Pareto Efficiency and Particle-Swarm Optimization methods,to design new functional materials *** a demonstration,we achieve the thermoelectric design of 2D SnSe materials via the above *** identify several novel metastable 2D SnSe structures with simultaneously lower free energy and better thermoelectric performance in their experimentally reported monolayer *** hope that the results of our work on the multi-objective Pareto Optimization method will represent a step forward in the integrative design of future multi-objective and multi-functional materials.

关键词： materials. methods. directional

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Friction and wear behavior of Mg–11Y–5Gd–2Zn–0.5Zr(wt%)alloy with oil lubricant

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Rare Metals 2013年第5期32卷 453-458页

作者： Li-jie Cao Qu-Dong Wang yu-Juan Wu Bing Ye College of Mechanical Engineering Shanghai University of Engineering Science National Engineering Research Center of Light Alloy Net Forming Shanghai Jiao Tong University

The sliding friction and wear behaviors of Mg-11Y-5Gd-2Zn-0.5Zr （wt%） alloy were investigated under oil lubricant condition by pin-on-disk configuration with a constant sliding distance of 1,000 m in the temperature range of 25-200℃. Results indicate that the volumetric wear rates and average friction coefficients decrease with the increase of sliding speeds, and increase with the increase of test temperature below 150℃. The hard and thermally stable Mg12（Y,Gd）Zn phase with long-period stacking order structure in the alloy presents significant wear resistance, The wear mechanism below 100℃ is abrasive wear as a result of plastic extrusion deformation. The corporate effects of severe abrasive, oxidative, and delaminating wear result in the tribological mechanism above 100℃.

关键词： Mg-11Y-5Gd-2Zn-0.5Zr alloy Long-period stacking order (LPSO) structure Lubricated Friction and wear

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不同降压速率下天然气水合物垂直井分段降压开采特性试验研究

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岩土力学 2024年第9期45卷 2682-2694页

作者：蒋宇静颜鹏栾恒杰刘明康梁伟杜晓宇马先壮史一辰山东科技大学矿山灾害预防控制省部共建国家重点实验室培育基地山东青岛266590 山东科技大学能源与矿业工程学院山东青岛266590 长崎大学工学研究科日本长崎中国矿业大学深部岩土力学与地下工程国家重点实验室江苏徐州221116 新加坡国立大学土木与环境工程系新加坡

认识分段降压法对天然气水合物储层开采特性的影响规律,能够为提高天然气水合物开采的效率和可控性提供科学依据。为此,利用自主研发的大尺寸二维天然气水合物开采模拟试验装置,开展了3种不同降压速率下的天然气水合物单一垂直井分段降... 详细信息

认识分段降压法对天然气水合物储层开采特性的影响规律,能够为提高天然气水合物开采的效率和可控性提供科学依据。为此,利用自主研发的大尺寸二维天然气水合物开采模拟试验装置,开展了3种不同降压速率下的天然气水合物单一垂直井分段降压开采模拟试验,研究了降压速率对降压开采过程中储层的压力响应、温度响应、产气量、瞬时产气速率以及平均产气速率等的影响情况。结果表明:压力变化速率的异常峰值现象的产生与回压阀密切相关,且其持续时间之比约等于降压速率的反比;相同降压幅度下,降压速率越小时,降压持续的时间越长,外部热量传递越多,促使更多的水合物在降压阶段发生分解,使得总产气占比越高;随着降压速率减小,峰值产气速率在第2次降压阶段内出现的时间越来越晚,水合物分解速率达到最大值的时间逐渐推后。

关键词：天然气水合物分段降压降压速率温压响应产气特性

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A One-pot-synthesized Double-layered Anticoagulant Hydrogel Tube

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Chemical Research in Chinese Universities 2021年第5期37卷 1085-1091页

作者： SUN Di gao Wenqing WU Peng LIU jie LI Shengmei LI Shilin yu Meili NING Meng BAI Ru LI Tong LIU Ying CHEN Chunying GBA Research Innovation Institute for Nanotechnology Guangzhou510700P.R.China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaBeijing100190P.R.China Department of Cardiac Center Tianjin Third Central HospitalTianjin300170P.R.China Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases Tianjin300170P.R.China Department of Vascular and Endovascular Surgery Chinese PLA General HospitalBeijing100853P.R.China

Extracorporeal membrane oxygenation(ECMO)has emerged as a viable treatment in severe cases of acute respiratory distress syndrome,acute respiratory failure,and adult respiratory distress ***,thromboembolic events stemming from the use of ECMO devices results in significant morbidity and mortality rates;the inner surface of the ECMO tubing comes into contact with the blood and can readily initiate *** addition,the tubing needs to be continually replaced due to thromboses on the inner tube wall.

关键词： acute distress respiratory

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Towards a more flexible representation of water stress effects in the nonlinear Jarvis model

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Journal of Integrative Agriculture 2017年第1期16卷 210-220页

作者： yu Lian-yu CAI Huan-jie ZHENG Zhe LI Zhi-jun WANG Jian Key Laboratory of Agricultural Soil and Water Engineering in Arid Area Ministry of Education/Northwest A&F UniversityYangling 712100P.R.China Institute of Water Saving Agriculture in Arid Regions of China(IWSA) Northwest A&F UniversityYangling 712100P.R.China

To better interpret summer maize stomatal conductance （gs） variation under conditions of changing water status at different growth stages, three water stress indicators, soil water content （SWC）, leaf-air temperature difference （AT） and leaf level water stress index （CWSIL） were employed in Jarvis model, which were Js, JT and Jc models respectively. Measurements of gs were conducted in a summer maize field experiment during the year 2012-2013. In the insufficient irrigation exper- iment, three levels of irrigation amount were applied at four different growth stages of summer maize. We constructed three scenarios to evaluate the performance of the three water stress indicators for estimating maize gs in a modified Jarvis model. Results showed that JT and Jc models had better simulation accuracy than the Js model, especially at the late growth stage （Scenario 1） or considering the plant recovery compensation effects （Scenario 2）. Scenario 3 indicated that the more environmental factors were adopted, the better prediction performance would be for Js model. While for JT model, two environmental factors （photosynthesis active radiation （PAR）, and vapor pressure deficit （VPD）） seemed good enough to obtain a reliable simulation. When there were insufficient environmental data, CWSI, would be the best option. This study can be useful to understand the response of plant stomatal to changing water conditions and will further facilitate the application of the Jarvis model in various environments.

关键词： summer maize stomatal conductance water status recovery compensation water stress indicators Jarvis model

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DNA Hydrogels Formed of Bended DNA Scaffolds and Properties Study

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Chinese Journal of Polymer Science 2017年第10期35卷 1307-1314页

作者： hao-yang jia jie-zhong shi yu shao 刘冬生 Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education Department of Chemistry Tsinghua University Beijing 100084 China

In recent years, DNA supramolecular hydrogels have attracted much attention due to their injectability, biocompatibility, responsiveness and self-healing properties. In this work, we designed a linear DNA brick containing one duplex with two cytosine（C）-rich sequence on both ends. This brick can first assemble to form duplex under p H 8 condition. After adjusting the p H to 5, the C-rich sequence tends to form intermolecular i-motif structure, which joins the linear DNA molecules together to form interlocked cyclic structures and yield the DNA hydrogel. By adjusting the length and bending curvature of the duplex part of the molecule, one can change the basic unit of the hydrogel structure to tune the properties of the DNA hydrogel.

关键词： Linear DNA Hydrogel Bended structures

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低剂量放疗缓解骨关节炎

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生物化学与生物物理进展 2024年第6期51卷 1382-1392页

作者：马国榕杨永泽孟欣高玉婷李树直郭洪章金晓东甘肃中医药大学第一临床医学院兰州730000 中国科学院近代物理研究所兰州730030 甘肃省人民医院骨科兰州730099 西安交通大学第二附属医院急诊科西安710004 西北师范大学生命科学学院兰州730070

骨关节炎(osteoarthritis,OA)是一种慢性退行性关节疾病,也是最常见的关节炎类型,几乎涉及任何关节,可导致患者慢性疼痛和残疾。19世纪末期伦琴发现了X射线,到20世纪80年代Luckey认为低水平辐射(LDRT)对生物可能有益,逐步应用于一些疾... 详细信息

骨关节炎(osteoarthritis,OA)是一种慢性退行性关节疾病,也是最常见的关节炎类型,几乎涉及任何关节,可导致患者慢性疼痛和残疾。19世纪末期伦琴发现了X射线,到20世纪80年代Luckey认为低水平辐射(LDRT)对生物可能有益,逐步应用于一些疾病的治疗,但目前LDRT的运用并未得到普及。本文介绍了OA的流行病学、危险因素、临床表现、治疗方法以及发病机制,重点讨论了LDRT缓解OA的可能机制以及临床研究进展,还探讨了LDRT治疗OA引起的不良反应(急性反应和致癌风险)。在临床上,LDRT本身具有非侵入性、不良反应较小等优势,在治疗OA展现出疼痛缓解、运动改善等疗效,因此LDRT在治疗OA中有广阔的应用前景。

关键词：低剂量放疗骨关节炎炎症抑制临床研究不良反应

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口服中成药辅助治疗慢性前列腺炎/慢性盆腔疼痛综合征的网状Meta分析

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中国实验方剂学杂志 2024年第9期30卷 174-185页

作者：于滨洋杨静代欣玥许嘉芯吕行王一名高蕊北京中医药大学研究生院北京100029 中国中医科学院研究生院北京100700 中国中医科学院西苑医院北京100091

目的:运用网状Meta分析对不同口服中成药辅助治疗慢性前列腺炎/慢性盆腔疼痛综合征(CP/CPPS)的疗效和安全性进行评价。方法:检索中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed、Cochrane Libr... 详细信息

目的:运用网状Meta分析对不同口服中成药辅助治疗慢性前列腺炎/慢性盆腔疼痛综合征(CP/CPPS)的疗效和安全性进行评价。方法:检索中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed、Cochrane Library、EMbase、Web of Science数据库,从建库至2022年11月所收录的口服中成药辅助治疗CP/CPPS的随机对照试验(RCT),运用Cochrane风险偏倚工具对纳入文献进行质量评价,采用RevMan 5.4、Stata 16软件进行数据分析。结果:最终纳入63项RCT包含前列舒通胶囊、宁泌泰胶囊、前列倍喜胶囊、三金片等13种口服中成药。网状Meta分析结果显示,在临床有效率方面,排名第1的干预措施为前列倍喜胶囊联合常规西医治疗;在降低疼痛症状评分方面,排名第1的干预措施为三金片联合常规西医治疗;在降低排尿障碍评分方面,排名第1的干预措施为热淋清颗粒联合常规西医治疗;在改善生活质量评分方面,排名第1的干预措施为前列倍喜胶囊联合常规西医治疗;在降低美国国立卫生研究院慢性前列腺炎症状评分(NIH-CPSI)总分方面,排名第1的干预措施为银花泌炎灵片联合常规西医治疗;在降低前列腺液白细胞计数方面,排名第1的干预措施为前列解毒胶囊联合常规西医治疗;在安全性方面,不良反应最少的干预措施为前列舒通胶囊联合常规西医治疗;聚类分析显示前列舒通胶囊联合常规西医疗效突出,安全性高。结论:口服中成药辅助治疗CP/CPPS能够提高综合疗效,降低患者NIH-CPSI评分和前列腺液白细胞计数,改善患者的生活质量。临床治疗时,可优先选择前列倍喜胶囊或者前列舒通胶囊联合常规西医治疗。由于纳入研究样本量及文献质量等限制,结论有待更多大样本、高质量的研究加以验证。

关键词：中成药慢性前列腺炎慢性盆腔疼痛综合征网状Meta分析

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UPLC-QQQ-MS/MS同时测定黄花蒿中7个青蒿素类相关化合物的含量

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中国中药杂志 2024年第5期49卷 1260-1265页

作者：王梦月万会花向丽蒲雨婷尹青岗高冉冉师玉华邬兰中国中医科学院、中药研究所、青蒿素研究中心、中药鉴定与安全性评估北京市重点实验室北京100700

同时检测黄花蒿Artemisia annua中多个化合物,以对黄花蒿的品质进行多角度评价。建立超高效液相色谱-三重四极杆串联质谱(UPLC-QQQ-MS/MS)同时检测黄花蒿中紫穗槐-4,11-二烯、青蒿醛、双氢青蒿酸、青蒿酸、青蒿素B、青蒿烯和青蒿素7个... 详细信息

同时检测黄花蒿Artemisia annua中多个化合物,以对黄花蒿的品质进行多角度评价。建立超高效液相色谱-三重四极杆串联质谱(UPLC-QQQ-MS/MS)同时检测黄花蒿中紫穗槐-4,11-二烯、青蒿醛、双氢青蒿酸、青蒿酸、青蒿素B、青蒿烯和青蒿素7个青蒿素类相关化合物的方法,并对黄花蒿不同组织部位(根、茎、叶和侧枝)中这7个化合物含量进行差异比较,检测其在黄花蒿中的累积情况。采集生长盛期4月龄黄花蒿的根、茎、叶和侧枝,检测黄花蒿不同组织部位7个青蒿素类相关化合物的含量。采用UPLC-QQQ-MS/MS的多反应监测(MRM)采集模式,大气压力化学离子源(APCI)正离子模式,色谱柱为Eclipse Plus RRHD C_(18)(2.1 mm×50 mm,1.8μm),流动相为含甲酸(0.1%)-甲酸铵(5 mmol·L^(-1))水溶液(A)和甲醇(B),梯度洗脱(0~8 min,55%~100%B;8~11 min,100%B;平衡3 min)。流速0.6 mL·min^(-1),柱温40℃,进样量5μL,检测时间8 min。通过方法学考察,建立了基于UPLC-QQQ-MS/MS同时定量检测青蒿素生物合成途径中7个代表性化合物含量的方法。对黄花蒿根、茎、叶和侧枝的含量比较分析结果表明:黄花蒿中青蒿素含量高于青蒿素B,且青蒿素和双氢青蒿酸在黄花蒿各部位的含量相对较高;7个化合物在各部位的含量存在较大差异,均在叶片中最高,且青蒿烯和青蒿醛在根中未检测到。该研究建立了基于UPLC-QQQ-MS/MS同时检测青蒿素生物合成途径上7个代表性化合物的定量方法,准确、灵敏且高效,可用于黄花蒿中青蒿素类相关化合物的含量测定、新品种选育和中药材质量控制等。

关键词： UPLC-QQQ-MS/MS 黄花蒿青蒿素青蒿素B 多反应监测(MRM)

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