检索结果-南通市图书馆

Liu-Jun-Zi decoction alleviates chemotherapy-induced anorexia by regulating gut microbiota and TLR4/MyD88/NF-κB p65 signaling pathway

引用

Traditional Medicine Research 2024年第8期9卷 47-58页

作者： yu-jie gao Xi-Pei Wu Bin-Bin Ye Yong-Zhao Dai Yao-Zhong Zhao Xiu-Xiu Liao Ke Nie School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China

Background:Liu-Jun-Zi decoction(LJZD),a classical nourishing formula in China,has been proven to be effective in treating chemotherapy-induced *** this study,the mechanism of LJZD in alleviating chemotherapy-induced anorexia was discussed from the aspects of regulating gut microbiota,repairing intestinal barrier injury and inhibiting inflammatory ***:A rat model of chemotherapy-induced anorexia was established using *** study evaluated the therapeutic effects of LJZD by observing the weight,food intake,and intestinal pathology of *** impact of LJZD on gut microbiota and metabolites,specifically short-chain fatty acids,was investigated through gut microbiota analysis and targeted *** anti-inflammatory and intestinal protective effects of LJZD were assessed by examining the expression of intestinal tight junction proteins associated with the inflammatory ***:LJZD alleviated cisplatin-induced inflammation and intestinal barrier disruption,as evidenced by upregulated expression of tight junction protein 1(TJ-1)and occludin,along with reduced serum levels of interleukin 6(IL-6),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),and ***,LJZD alleviated microbiota imbalance and regulated the levels of short-chain fatty acids,especially increased the relative abundance of Coriobacteriales Incertae Sedis,Lactabacillus johnsonii F19785,Parasutterella,and reduced the *** the hypothalamus,LJZD exerts suppressive effects on the toll-like receptor 4(TLR4)/myeloid differentiation factor 88(MyD88)/nuclear factor-κB(NF-κB)p65 signaling pathway,leading to a downregulation in the transcriptional activity of IL-6 and IL-1β,as well as Interleukin 6 receptors(IL-6R)and Interleukin-1βreceptors(IL-1R1)mRNA expression ***:In summary,LJZD alleviate chemotherapy-induced anorexia by modulating the gut microbiota,repairing the intestinal mechanical barriers,and suppressing the TLR4

关键词： Liu-Jun-Zi decoction chemotherapy-induced anorexia cisplatin TLR4/MyD818/NF-κB p65 gut microbiota rat

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

DNA Damage-driven Inflammatory Cytokines:Reprogramming of Tumor Immune Microenvironment and Application of Oncotherapy

引用

Current Medical Science 2024年第2期44卷 261-272页

作者： Meng-jie WANG yu XIA Qing-lei gao Department of Obstetrics and Gynecology National Clinical Research Center for Obstetrics and GynecologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Key Laboratory of Cancer Invasion and Metastasis(Ministry of Education) Hubei Key Laboratory of Tumor Invasion and MetastasisTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

DNA damage occurs across tumorigenesis and tumor *** intrinsic DNA damage can not only increase the risk of mutations responsible for tumor generation but also initiate a cellular stress response to orchestrate the tumor immune microenvironment(TIME)and dominate tumor *** evidence documents that multiple signaling pathways,including cyclic GMP-AMP synthase-stimulator of interferon genes(cGAS-STING)and ataxia telangiectasia-mutated protein/ataxia telangiectasia and Rad3-related protein(ATM/ATR),are activated downstream of DNA damage and they are associated with the secretion of diverse *** cytokines possess multifaced functions in the anti-tumor immune ***,it is necessary to deeply interpret the complex TIME reshaped by damaged DNA and tumor-derived cytokines,critical for the development of effective tumor *** manuscript comprehensively reviews the relationship between the DNA damage response and related cytokines in tumors and depicts the dual immunoregulatory roles of these *** also summarize clinical trials targeting signaling pathways and cytokines associated with DNA damage and provide future perspectives on emerging technologies.

关键词： DNA damage tumor immune microenvironment inflammatory cytokines cancer therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Climatic impacts induced by winter wheat irrigation over North China simulated by the nonhydrostatic RegCM4.7

引用

Advances in Climate Change Research 2024年第2期15卷 197-210页

作者： Jia WU Zhen-yu HAN Xue-jie gao Zheng-Jia LIU National Climate Centre China Meteorological AdministrationBeijing 100081China Key Laboratory for Climate Studies China Meteorological AdministrationBeijing 100081China Climate Change Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China

Quantification of the impact of winter wheat irrigation on the climate and the occurrence of extreme climatic events over North China is crucial for regional adaptation *** related studies mainly focused on the impact on surface processes;however,few focused on the effects of extreme events using high-resolution nonhydrostatic regional climate ***,the 9-km-resolution nonhydrostatic RegCM4.7 was coupled with a crop irrigation scheme and an updated winter wheat irrigation dataset to better simulate irrigation *** experiments were conducted with and without winter wheat irrigation to isolate the effects of *** showed that irrigation simulation reduces the model biases in temperature,precipitation,latent heat flux,soil moisture,sensitive heat flux,and top-layer soil ***,it also reduces the bias and increases the correlation with observations obtained in irrigated areas,especially in summer,indicating better representation of irrigation *** wheat irrigation tends to cause substantial cooling of the local surface maximum,minimum,and mean air temperatures(by-1.68,-0.34,and-0.79℃,respectively)over irrigated areas of North China,with the largest changes observed in relation to maximum ***,precipitation is found to increase during spring and summer,which is strongly related to water vapor transport in the lower levels of the *** analyses indicated that the number of annual mean hot days decrease(-13.9 d),whereas the number of both comfort days(+10.2 d)and rainy days(days with total precipitation greater than 1 mm:+6.6 d)increase over irrigated areas,demonstrating beneficial feedback to human perception and ***,although the heat wave risk increases(number of annual mean heat wave days:+5.8 d),the impact is limited to small areas within irrigated ***,no notable change was found in terms of heavy rainfall events and precipitation intensity

关键词： Nonhydrostatic regional climate model Irrigation effect Extreme events North China

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sequential enantioselective Ugi-4CR/post-Ugi transformation strategy:a precise construction of structurally diverse azaspiro polycyclic scaffolds

引用

Science China Chemistry 2024年第2期67卷 576-586页

作者： Xiao-Bao Wu Jun-Xiu Shi Yi-Ming Ou Hua-jie Jiang Yi-Jun Fang Qi-Ming Wang Quan gao jie yu Department of Applied Chemistry Anhui Province Engineering Laboratory for Green Pesticide Development and ApplicationAnhui Province Key Laboratory of Crop Integrated Pest ManagementAnhui Agricultural UniversityHefei230036China

A privileged strategy has been developed for the precise construction of enantioenriched azaspiro polycyclic *** diverse azaspiro polycycles bearing multiple contiguous stereocenters are obtained with excellent results(up to 99:1 e.r.,>95:5 d.r.) via sequential enantioselective four-component Ugi reactions/post-Ugi transformations with substrates containing prerequisite functional groups in the presence of anionic stereogenic-at-cobalt(Ⅲ) complexes.

关键词： asymmetric catalysis post-Ugi transformation anionic stereogenic-at-cobalt(Ⅲ)complex azaspiro polycyclic scaffold one-pot synthesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Exclusive enteral nutrition for treating pediatric Crohn’s disease

引用

World Journal of Pediatrics 2024年第9期20卷 869-871页

作者： yu yu jie Chen Department of Gastroenterology Children’s HospitalNational Clinical Research Center for Child HealthZhejiang University School of MedicineHangzhou 310052China

Crohn's disease(CD),an enduring and relapsing condition afecting the gastrointestinal tract,manifests in a spectrum of symptoms and clinical manifestations that can profoundly afect quality of life[1].Recently,CD has emerged as a global burden of *** China,the prevalence and incidence of childhood infammatory bowel disease(IBD)have steadily increased,from 0.5 per 1 million in 2001 to 6.0 per 1 million in 2010[2].Pediatric patients often face a longer treatment duration than adults.

关键词： Crohn pediatric nutrition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Boson star superradiance

引用

Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 69-78页

作者： He-yu gao Paul M.Saffin Yi-jie Wang Qi-Xin Xie Shuang-Yong Zhou School of Physical Sciences University of Science and Technology of ChinaHefei 230026China School of Physics and Astronomy University of NottinghamUniversity ParkNottingham NG72RDUK Interdisciplinary Center for Theoretical Study University of Science and Technology of ChinaHefei 230026China Peng Huanwu Center for Fundamental Theory Hefei 230026China

Recently,it has been realized that in some systems internal space rotation can induce energy amplification for scattered waves,similar to rotation in real *** particularly,it has been shown that energy extraction is possible for a Q-ball,a stationary non-topological soliton that is coherently rotating in its field *** this paper,we generalize the analysis to the case of boson stars,and show that the same energy extraction mechanism still works for boson stars.

关键词： superradiance boson star field space rotation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Real-time Operation Optimization in Active Distribution Networks Based on Multi-agent Deep Reinforcement Learning

引用

Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 886-899页

作者： jie Xu Hongjun gao Renjun Wang Junyong Liu the College of Electrical Engineering Sichuan UniversityChengduChina

The increasing integration of intermittent renewable energy sources(RESs)poses great challenges to active distribution networks(ADNs),such as frequent voltage *** paper proposes a novel ADN strategy based on multiagent deep reinforcement learning(MADRL),which harnesses the regulating function of switch state transitions for the realtime voltage regulation and loss *** deploying the calculated optimal switch topologies,the distribution network operator will dynamically adjust the distributed energy resources(DERs)to enhance the operation performance of ADNs based on the policies trained by the MADRL *** to the model-free characteristics and the generalization of deep reinforcement learning,the proposed strategy can still achieve optimization objectives even when applied to similar but unseen ***,integrating parameter sharing(PS)and prioritized experience replay(PER)mechanisms substantially improves the strategic performance and *** framework has been tested on modified IEEE 33-bus,IEEE 118-bus,and three-phase unbalanced 123-bus *** results demonstrate the significant real-time regulation capabilities of the proposed strategy.

关键词： Reconfiguration active distribution network distributed energy resource real-time control deep reinforcement learning parameter sharing scalability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High-precision analytical solutions for Earth coverage of constellation equipped with reentry glide vehicles

引用

Chinese Journal of Aeronautics 2024年第9期37卷 385-398页

作者： Ping MA Weibo SUN jie gao Tao CHAO Control and Simulation Center Harbin Institute of TechnologyHarbin 150001China Beijing Institute of Spacecraft System Engineering Beijing 100094China

To efficiently and accurately design satellite constellations equipped with Reentry Glide Vehicles(RGVs),new analytical solutions are developed for calculating their coverage ***,a new coverage model is established by approximating the Reentry Reachable Domain(RRD).However,the computation of real-time relative distances between satellites and targets,which is essential for coverage analysis based on this model,imposes a significant compu-tational *** address this challenge,a coverage analysis method based on two-dimensional map theory is *** method represents the coverage conditions of a target as a fixed area on a two-dimensional map and transforms the satellite trajectory into a series of parallel *** determining the intersection points between these lines and the area boundaries,the coverage ana-lytical solutions for a target point are *** this basis,coverage theorems are presented for rapid calculation of the constellation coverage performance for an *** results demon-strate the effectiveness and high precision of the proposed analytical solutions.

关键词： Constellation Analytical solutions Reentry glide vehicle Reentry reachable domain Two-dimensional map

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Lignin-reinforced PVDF electrolyte for dendrite-free quasi-solid-state Li metal battery

引用

Rare Metals 2024年第3期43卷 1006-1016页

作者： Xin-Yang Chen Xue-jie gao Han-Yan Wu yu-Long Liu Xiao-Fei Yang Run-Cang Sun Center for Lignocellulosic Chemistry and Biomaterials College of Light Industry and Chemical EngineeringDalian Polytechnic UniversityDalian116034China Division of Energy Storage Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China School of Chemistry Northeast Normal UniversityChangchun130024China

Quasi-solid-state lithium metal batteries(QSSLMBs)assembled with polyvinylidene fluoride(PVDF)are a promising class of next-generation rechargeable batteries due to their safety,high energy density,and superior interfacial ***,PVDF has a series of inherent drawbacks such as low ionic conductivity,ease of crystallization,and hydrophobic character that leading to poor cell *** tackle these issues,a lignin-reinforced PVDF electrolyte is proposed in this work to solve these drawbacks of PVDF and enhance the comprehensive performance of *** lithophilic polar groups of lignin can promote uniform deposition of Li on the *** with the improved mechanical properties can efficiently prevent Li dendrites penetration through the *** addition,more active sites provided by lignin can also enhance Li^(+)transport and lead to a faster electrochemical reaction *** from the ingenious design,Li symmetric cells with 5%lignin-PVDF quasi-solid-state electrolyte can operate for 900 h at a high current density/capacity of 5 mA·cm^(-2)/5 mAh·cm^(-2),while shortcircuiting occurs after 56 h for the counterpart(pure PVDF).Moreover,a full cell of Li/5%lignin-PVDF/LFP cell demonstrates a high capacity of 96.2 mAh·g^(-1)after 2000 cycles at 10 *** work is expected to open up promising opportunities to develop other high-energy/power-density QSSLMBs.

关键词： Quasi-solid-state electrolyte Lignin PVDF Dendrite-free Li metal battery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Projected changes in Köppen-Trewartha climate zones under 1.5-4℃global warming targets over mid-high latitudes of Northern Asia using an ensemble of RegCM4 simulations

引用

Advances in Climate Change Research 2024年第2期15卷 185-196页

作者： jie WU Xue-jie gao Xian-Bing TANG Filippo GIORGI School of Geography and Environmental Engineering Gannan Normal UniversityGanzhou 341000China Climate Change Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjing 210044China University of Chinese Academy of Sciences Beijing 100049China The Abdus Salam International Centre for Theoretical Physics Trieste 34100Italy

Mid-high latitude Northern Asia is one of the most vulnerable and sensitive areas to global warming,but relatively less studied *** used an ensemble of a regional climate model(RegCM4)projections to assess future changes in surface air temperature,precipitation and Köppen-Trewartha(K-T)climate types in Northern Asia under the 1.5-4℃global warming ***4 is driven by five CMIP5 global models over an East Asia domain at a grid spacing of 25 *** of the present day(1986-2005)simulations shows that the ensembles of RegCM4(ensR)and driving GCMs(ensG)reproduce the major characters of the observed temperature,precipitation and K-T climate zones reasonably *** and more realistic spatial detail is found in RegCM4 compared to the driving GCMs.A general warming and overall increases in precipitation are projected over the region,with these changes being more pronounced at higher warming *** projected warming by ensR shows different spatial patterns,and is in general lower,compared to ensG in most months of the year,while the percentage increases of precipitation are maximum during the cold *** future changes in K-T climate zones are characterized by a substantial expansion of Dc(temperature oceanic)and retreat of Ec(sub-arctic continental)over the region,reaching∼20%under the 4℃warming *** most notable change in climate types in ensR is found over Japan(∼60%),followed by Southern Siberia,Mongolia,and the Korean Peninsula(∼40%).The largest change in the K-T climate types is found when increasing from 2 to 3℃.The results will help to better assess the impacts of climate change and in implementation of appropriate adaptation measures over the region.

关键词： Mid-high latitudes of Northern Asia Köppen climate zones Global warming targets Regional climate model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：