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Chinese Journal of Chemistry 2020年第6期38卷 543-552页

作者： Cong-Shuai Wang Tian-Zhen Li Si-jia Liu yu-Chen Zhang Shuang Deng Yinchun jiao Feng Shi School of Chemistry and Materials Science Jiangsu Normal UniversityXuzhouJiangsu 221116China Key Laboratory of Theoretical Organic Chemistry and Functional Molecule Ministry of EducationSchool of Chemistry and Chemical EngineeringHunan University of Science and TechnologyXiangtanHunan 411201China

A new class of axially chiral aryl-alkene-indole frameworks have been designed,and the first catalytic asymmetric construction of such scaffolds has been established by the strategy of organocatalytic(Z/E)-selective and enantioselective(4+3)cyclization of 3-alkynyl-2-indolylmethanols with 2-naphthols or phenols(all>95:5 E/Z,up to 98% yield,97% ee).This reaction also represents the first catalytic asymmetric construction of axially chiral alkene-heteroaryl scaffolds,which will add a new member to the atropisomeric *** approach has not only confronted the great challenges in constructing axially chiral alkene-heteroaryl scaffolds but also provided a powerful strategy for the enantioselective construction of axially chiral aryl-alkene-indole frameworks.

关键词： chiral Catalytic asymmetric

Design of BiOBr_(0.25)I_(0.75) for synergy photoreduction Cr(Ⅵ) and capture Cr(Ⅲ) over wide pH range

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Chinese Chemical Letters 2022年第6期33卷 3053-3060页

作者： Lixia jia Xin Tan Yanfang Li Yizhong Zhang Shiqian Cao Wei Zhou Xiang Huang Lequan Liu Tao yu School of Environmental Science and Engineering Tianjin UniversityTianjin 300350China School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China School of Science Tianjin UniversityTianjin 300350China School of Science Tibet UniversityLhasa 850000China School of Materials Science and Engineering Tianjin UniversityTianjin 300350China

Conversion of hexavalent chromium(Cr(Ⅵ))to trivalent chromium(Cr(Ⅲ))is an effective way to reduce its environmental risk,especially via photoreduction ***,over a wide range of pH values,it is still a great challenge to achieve a high removal rate,and the disposal of produced Cr(Ⅲ)should be *** this work,we implemented a high removal rate at 98%for Cr(Ⅵ)and total chromium(Cr(T))over a wide pH range(4–10)through the synergistic effect of adsorption,photoreduction and immobilization on the surface of Bi OBr_(0.25)I_(0.75).The substitution of bromine by iodine reduced the adsorption energy of Cr(Ⅵ)on Bi OBr_(0.25)I_(0.75),promoting the adsorption of Cr(Ⅵ).Meanwhile,the introduced iodine upshifted the conduction band(CB),enhancing the reduction ability for Cr(Ⅵ)to Cr(Ⅲ).The negative surface of Bi OBr_(0.25)I_(0.75)can capture Cr(Ⅲ),achieving a high removal rate for Cr(T).The p H-independent feature for Cr(Ⅵ)and Cr(Ⅲ)removal make Bi OBr_(0.25)I_(0.75)a potential material for chromium-containing wastewater *** work provides an effective strategy for removing chromium over a wide p H range.

关键词： Adsorption Photoreduction BiOBr_(0.25)I_(0.75) Chromium

广西壮族自治区西部地区β-地中海贫血基因检测结果分析

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中华地方病学杂志 2024年第2期43卷 104-112页

作者：农雪娟黄瑜贾吉宏雷茗许桂丹韦武均常正义谢丽秋梁菊华王春芳右江民族医学院附属医院检验科百色533000

目的了解广西壮族自治区(简称广西)西部地区β-地中海贫血(简称地贫)的阳性检出率和主要基因型。方法选择2013年1月至2019年12月在右江民族医学院附属医院进行地贫基因检测的26189例受检者作为研究对象,回顾性分析其外周血样本地贫基因... 详细信息

目的了解广西壮族自治区(简称广西)西部地区β-地中海贫血(简称地贫)的阳性检出率和主要基因型。方法选择2013年1月至2019年12月在右江民族医学院附属医院进行地贫基因检测的26189例受检者作为研究对象,回顾性分析其外周血样本地贫基因检测结果,通过跨越断裂点PCR(Gap-PCR)法和DNA芯片反向点杂交(RDB)技术检测我国常见的7种α-地贫和17种β-地贫基因型,对常规基因型未检出的疑似β-地贫患者进行缺失型基因检测(Gap-PCR法),对疑似罕见β-地贫患者进行基因高通量测序(Sanger法)。结果26189例受检者中,确诊β-地贫4495例,阳性检出率为17.16%。共检出20种6177个β-地贫等位基因,主要为CD17(2712个,43.90%)和CD41-42(2240个,36.26%),并见7种罕见等位基因:^(G)γ^(+)(^(A)γδβ)^(0)、SEA-HPFH、Hb New York、Hb G-Taipei、Hb Hezhou、Hb G-Coushatta及IVS-Ⅱ-81。4495例β-地贫患者中,杂合子3903例(86.83%),双重杂合子273例(6.07%),纯合子319例(7.10%)。β-地贫患者共检出48种基因型,常见的2种基因型分别为CD17/β^(N)(1890例,42.05%)和CD41-42/β^(N)(1212例,26.96%),共占69.01%(3102/4495);7种罕见基因型分别为^(G)γ^(+)(^(A)γδβ)^(0)/β^(N)(3例),Hb New York/β^(N)(3例),Hb G-Taipei/β^(N)(2例),SEA-HPFH/β^(N)、Hb Hezhou/β^(N)、Hb G-Coushatta/β^(N)、IVS-Ⅱ-81/β^(N)(各1例)。共检出αβ复合地贫1041例(3.97%,1041/26189),涉及116种复合基因型,以--^(SEA)/αα复合CD17/β^(N)为主(144例,13.83%),其次为-α^(3.7)/αα复合CD17/β^(N)(112例,10.76%)。结论广西西部地区是β-地贫高发区,基因型以CD17/β^(N)及CD41-42/β^(N)为主,变异谱复杂多样,基因型丰富。

关键词：地中海贫血基因型构成比

PCR-RFLP and AP-PCR of rbcL and ITS of rDNA Show That × Taxodiomeria peizhongii （ Taxodium × Cryptomeria） Is not an Intergeneric Hybrid

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Journal of Integrative Plant Biology 2006年第4期48卷 468-472页

作者： Yan Ling Wei-Feng Lu Fan Lu yu-Guo Wang jia-Kuan Chen Wen-Ju Zhang The Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering Institute of Biodiversity Science Fudan University Shanghai 200433 China

Taxodiorneria peizhongii Z. J. Ye, J. J. Zhang et S. H. Pan was regarded as a new Intergenerlc hybrid between Taxodlum mucronatum Tenore （as the female donor） and Cryptomeria fortunei Hoolbrenk ex Otto et Dletr （as the male donor）. To confirm the authenticity of the intergeneric hybrid, we analyzed the rbcL gene and the Internal transcribed spacer （ITS） of 26S-18S ribosomal RNA gene of the three species using polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） and arbitrarily primed PCR （AP-PCR）, and ob- tained the following results：i） Taxodiomeria peizhongii had the same RFLP maps of the rbcL gene and the ITS as Taxodlum mucronatum, but was different from C. fortunei; II） a 311-bp PCR amplification product was obtained In C. fortunei by AP-PCR of ITS, but was not found in Taxodiomeria peizhongii. Our results have demonstrated that C. fortunei did not provide any genome for Taxodiomeria peizhongii, Implying that T. peizhongii Is not an Intergenerlc hybrid between the two species.

关键词： Arbitrary Primed-Polymerase Chain Reaction (AP-PCR) intergeneric hybrid nuclear and chloroplast genome pater- nally inherited polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) × Taxodiomeria peizhongii.

面向SW26010Pro处理器的全局符号重定位优化

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计算机系统应用 2024年第2期33卷 62-71页

作者：钱宏王飞刘沙郑天宇宋佳伟安虹中国科学技术大学计算机科学与技术学院合肥230026 清华大学计算机科学与技术系北京100084 之江实验室杭州311121 国家超级计算无锡中心无锡214000

申威异构众核处理器运算核心访问主存的延迟很大,程序中应尽量避免运算核心代码访问主存的操作.全局偏移表存放程序中全局变量和函数的地址,不适合保存在珍稀的运算核心局部存储空间中,并且其访问模式通常比较离散,因而也不适合对其做Ca... 详细信息

申威异构众核处理器运算核心访问主存的延迟很大,程序中应尽量避免运算核心代码访问主存的操作.全局偏移表存放程序中全局变量和函数的地址,不适合保存在珍稀的运算核心局部存储空间中,并且其访问模式通常比较离散,因而也不适合对其做Cache预取,访问全局偏移表引入的访问主存操作对程序性能影响较大.本文针对异构众核程序静态链接与动态链接的使用场景,分析链接器relaxation优化的使用限制,通过“gp基地址+扩展偏移”的方法实现避免访问主存操作的全局符号重定位优化.实验结果表明,该重定位优化方法能够以增加少量代码为代价,在运算核心代码调用函数与访问全局变量时有效避免访问全局偏移表引入的访问主存的操作,提高众核程序的运行性能.

关键词：众核处理器全局偏移表重定位链接器优化性能

Effect of calibration data series length on performance and optimal parameters of hydrological model

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Water Science and Engineering 2010年第4期3卷 378-393页

作者： Chuan-zhe LI Hao WANG jia LIU Deng-hua YAN Fu-liang yu Lu ZHANG Department of Water Resources China Institute of Water Resources and Hydropower Research Beijing 100038 P. R. China Water and Environmental Management Research Centre Department of Civil Engineering University of Bristol Bristol BS8 1TR UK CSIRO Land and Water Canberra ACT 2601 Australia

In order to assess the effects of calibration data series length on the performance and optimal parameter values of a hydrological model in ungauged or data-limited catchments （data are non-continuous and fragmental in some catchments）, we used non-continuous calibration periods for more independent streamflow data for SIMHYD （simple hydrology） model calibration. Nash-Sutcliffe efficiency and percentage water balance error were used as performance measures. The particle swarm optimization （PSO） method was used to calibrate the rainfall-runoff models. Different lengths of data series ranging from one year to ten years, randomly sampled, were used to study the impact of calibration data series length. Fifty-five relatively unimpaired catchments located all over Australia with daily precipitation, potential evapotranspiration, and streamflow data were tested to obtain more general conclusions. The results show that longer calibration data series do not necessarily result in better model performance. In general, eight years of data are sufficient to obtain steady estimates of model performance and parameters for the SIMHYD model. It is also shown that most humid catchments require fewer calibration data to obtain a good performance and stable parameter values. The model performs better in humid and semi-humid catchments than in arid catchments. Our results may have useful and interesting implications for the efficiency of using limited observation data for hydrological model calibration in different climates.

关键词： calibration data series length model performance optimal parameter hydrological model data-limited catchment

Effect of silencing of high mobility group A2 gene on gastric cancer MKN-45 cells

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World Journal of Gastroenterology 2013年第8期19卷 1239-1246页

作者： Chun-Hui Wei Li-Xiu Wei Ming-yu Lai jia-Zhuang Chen Xi-Jing Mo Department of Geriatric Gastroenterology the First Affiliated Hospital of Guangxi Medical University Department of Gastroenterology the First Affiliated Hospital of Guangxi Chinese Medical University

AIM:To investigate the effect of high mobility group A2(HMGA2) gene silencing on gastric cancer MKN-45 cells in ***:HMGA2 short hairpin RNA(shRNA) expression plasmids were constructed,including a pair of random scrambled *** gastric cancer cell line MKN-45 cells were divided into three groups:blank control group(non-transfected cells),transfected group(cells transfected with HMGA2 shRNA recombinant plasmid) and scrambled sequence group(transfected with random scrambled plasmid).Cells were transfected with HMGA2 shRNA recombinant plasmids and scrambled plasmid in vitro,and the cells transfection efficiency was assayed by fluorescence *** HMGA2 messenger RNA(mRNA) expression was detected by reverse transcription polymerase chain reaction,gastric cancer cells apoptosis was detected by flow cytometry,cell proliferation was detected by methyl thiazol tetrazolium,and the protein expression of phosphatidylinositol 3-kinase(PI3K),protein kinase B(Akt),P27,caspase-9 and B-cell leukemia/lymphoma-2(Bcl-2) were analyzed by Western ***:Compared with the blank control group and the scrambled sequence group,the levels of HMGA2 mRNA and protein expression in the transfected group were significantly reduced(P < 0.05).The relative HMGA2 mRNA expression levels of the blank control group,transfected group and scrambled sequence group were 0.674 ± 0.129,0.374 ± 0.048 and 0.689 ± 0.124,*** relative HMGA2 protein expression levels of the blank control group,transfected group and scrambled sequence group were 0.554 ± 0.082,0.113 ± 0.032 and 0.484 ± 0.123,***,transfection with the scrambled sequence had no effect on the expression of *** being transfected with shRNA for 24,48 and 72 h,the cell apoptotic rates of the transfected group were 21.65% ± 0.28%,39.98% ± 1.82% and 24.51% ± 0.93%,respectively,which significantly higher than those of blank control group(4.72% ± 1.34%,5.83% ± 0.13% and 5.22% ± 1.07%) a

关键词： Gastric cancer cells RNA interference High mobility group A2 Proliferation Apoptosis

双阳离子液体分离甲苯-正庚烷共沸体系——综合实验的设计与探索

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日用化学品科学 2024年第6期47卷 31-33,37页

作者：么聪菲李晓宇黄维佳程平李云缪煜清上海理工大学材料与化学学院上海200093 上海理工大学能源与动力工程学院上海200093 上海理工大学环境与建筑学院上海200093

构建了一种全新的专业设计型实验体系:双阳离子液体的制备及萃取分离甲苯-正庚烷共沸体系。合成并表征新型“绿色溶剂”双阳离子液体;以双阳离子液体作为萃取剂,测定其对甲苯-正庚烷共沸体系的分离能力并进行相图绘制。通过该综合实验教... 详细信息

构建了一种全新的专业设计型实验体系:双阳离子液体的制备及萃取分离甲苯-正庚烷共沸体系。合成并表征新型“绿色溶剂”双阳离子液体;以双阳离子液体作为萃取剂,测定其对甲苯-正庚烷共沸体系的分离能力并进行相图绘制。通过该综合实验教学,既促进学生对多学科基础知识的掌握,又能激发学生科研探索兴趣,培养其绿色化学意识与理念。

关键词：双阳离子液体萃取分离共沸体系相平衡

Prenatal diagnosis of isolated lateral facial cleft by ultrasonography and three-dimensional printing:A case report

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World Journal of Clinical Cases 2021年第24期9卷 7196-7204页

作者： Wen-Ling Song Hai-Ou Ma yu Nan yu-jia Li Na Qi Li-Ying Zhang Xin Xu yuan-Yi Wang Department of Obstetrics The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Prenatal Diagnosis Center The Second Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Spine Surgery The First Hospital of Jilin UniversityJilin Engineering Research Center for Spine and Spinal CordChangchun 130021Jilin ProvinceChina

BACKGROUND Lateral facial clefts are atypical with a low incidence in the facial cleft *** the development of ultrasonography(US)prenatal screening,such facial malformations can be detected and diagnosed prenatally rather than at *** three-dimensional US(3DUS)can render the fetus'face via 3D reconstruction,the 3D images are displayed on two-dimensional screens without field depth,which impedes the understanding of untrained *** contrast,a 3D-printed model of the fetus'face helps both parents and doctors develop a more comprehensive understanding of the facial malformation by creating more interactive ***,we present an isolated lateral facial cleft case that was diagnosed via US combined with a 3D-printed *** SUMMARY A 31-year-old G2P1 patient presented for routine prenatal screening at the 22nd wk of *** coronal nostril-lip section of two-dimensional US(2DUS)demonstrated that the fetus'bilateral oral commissures were asymmetrical,and left oral commissure was abnormally *** left oblique-coronal section showed a cleft at the left oral commissure which extended to the left *** results of 3DUS confirmed the ***,we created a model of the fetal face using 3D printing technology,which clearly presented facial *** fetus was diagnosed with a left lateral facial cleft,which was categorized as a No.7 facial cleft according to the Tessier facial cleft *** parents terminated the pregnancy at the 24th wk of gestation after parental *** In the diagnostic course of the current case,in addition to the traditional application of 2D and 3DUS,we created a 3D-printed model of the fetus,which enhanced diagnostic evidence,benefited the education of junior doctors,improved parental counseling,and had the potential to guide surgical planning.

关键词： Prenatal diagnosis Isolated lateral facial cleft Three-dimensional printing Facial malformations Ultrasonography Tessier No.7 facial cleft Case report

Leaf stage-associated resistance is correlated with phytohormones in a pathosystem-dependen manner

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Journal of Integrative Plant Biology 2018年第8期60卷 703-722页

作者： You-Ping Xu Lin-Hui Lv Ya-Jing Xu Juan yang jia-Yi Cao Xin-Zhong Cai State Key Laboratory of Rice Biology Institute of Biotechnology College of Agriculture and Biotechnology Zhejiang University 866 Yu Hang Tang Road Hangzhou 310058 China Centre of Analysis and Measurement Zhejiang University 866 Yu Hang Tang Road Hangzhou 310058 China

It has been reported in several pathosystems that disease resistance can vary in leaves at different stages. However, how general this leaf stage-associated resistance is, and the molecular mechanism（s） underly- ing it, remain largely unknown. Here, we investigated the effect of leaf stage on basal resistance, effector- triggered immunity （ETI） and nonhost resistance, using eight pathosystems involving the hosts Arabidopsis thaliana, Nicotiana tabacum, and N. benthamiana and the pathogens Sclerotinia sclerotiorum, Pseudomonas syringae pv. tabaci, P. syringae pv. tomato DC3000, and Xanthomonas oryzae pv. oryzae （Xoo）. We show evidence that leaf stage-associated resistance exists ubiquitously in plants, but with varying intensity at different stages in diverse pathosystems. Microarray expression profiling assays demonstrated that hundreds of genes involved indefense responses, phytohormone biosynthesis and signaling, and calcium signaling, were differentially expressed between leaves at different stages. The Arabidopsis mutants sid1, sid2-3, ein2, jar1-1, abal and aao3 lost leaf stage-associated resistance to S. sclerotiorum, and the mutants abal and sid2-3 were affected in leaf stage-associated RPS2/AvrRpt2＋-con- ferred ETI, whereas only the mutant sid2-3 influenced leaf stage-associated nonhost resistance to Xoo. Our results reveal that the phytohormones salicylic acid, ethylene, jasmonic acid and abscisic acid likely play an essential, but pathosystem-dependent, role in leaf stage- associated resistance.

关键词： Xoo Figure Leaf stage-associated resistance is correlated with phytohormones in a pathosystem-dependen manner