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Ascophyllum nodosum and Fucus vesiculosus ameliorate restenosis via improving inflammation and regulating the PTEN/PI3K/AKT signaling pathway

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Food Science and Human Wellness 2024年第3期13卷 1711-1728页

作者： Crystal Ngofi Zumbi Chun-Hsu Pan hui-yu huang Chieh-Hsi Wu Program in Clinical Drug Development from Herbal Medicine College of PharmacyTaipei Medical UniversityTaipei 11031China Program in Drug Discovery and Development Industry College of PharmacyTaipei Medical UniversityTaipei 11031China School of Pharmacy Taipei Medical UniversityTaipei 11031China Graduate Institute of Metabolism and Obesity Sciences Taipei Medical UniversityTaipei 11031China

Restenosis is a common complication following coronary *** traditional use of seaweeds for health benefits has increasingly been explored,however few studies exist reporting its protective effects on the development of restenosis and gut *** aim of this study was to investigate the potential of seaweed extracts(SE) of Ascophyllum nodosum and Fucus vesiculosus in inhibiting intimal hyperplasia in a rat model of restenosis and its underlying mechanisms in macrophages and vascular smooth muscle cells(vSMCs).16S rRNA sequencing was done to investigate the regulatory effect of SE on the gut microbiome of injured *** indicated by the results,SE significantly inhibited the progression of intimal hyperplasia in vivo,attenuated inflammation in macrophages and could inhibit the proliferation,dedifferentiation and migration of *** was observed through immunoblotting assays that treatment with SE significantly upregulated PTEN expression in macrophages and inhibited the upregulation of PI3K and AKT expression in ***,according to the 16S rRNA gene sequencing analysis,supplementation with SE modulated gut microbiota composition in injured *** conclusion,SE could ameliorate intimal hyperplasia by inhibiting inflammation and vSMCs proliferation through the regulation of the PTEN/PI3K/AKT pathway and modulating the gut microbiome.

关键词： Ascophyllum nodosum Fucus vesiculosus PTEN/PI3K/AKT Restenosis Macrophage Vascular smooth muscle cells Gut microbiota

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Combined effect of cortical superficial siderosis and cerebral microbleed on short-term and long-term outcomes after intracerebral haemorrhage

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Stroke & Vascular Neurology 2024年第4期9卷 429-438,I0131-I0146页

作者： yujia Jin yu-hui huang yu-ping Chen Yao-dan Zhang Jiawen Li Kai-cheng Yang Xianghua Ye Lu-hang Jin Jian Wu Chang-zheng yuan Feng Gao Lu-sha Tong Neurology Department The Second Affiliated Hospital of Zhejiang UniversitySchool of MedicineHangzhouChina School of Public Health Zhejiang UniversityHangzhouChina Department of Neurology Tiantai People's Hospital of Zhejiang ProvinceTaizhouChina

Background and purpose Cortical superficial siderosis(cSS)and cerebral microbleed(CMB)have distinct effects on intracerebral haemorrhage(ICH).We aim to investigate the combined effect of cSS and CMB on outcomes after *** Based on a single-centre stroke registry database,patients with spontaneous ICH who had CT scan within 48 hours after ictus and MRI subsequently were *** patients were divided into four groups(cSS-CMB−,cSS-CMB+,cSS+CMB−,cSS+CMB+)according to cSS and CMB on susceptibility-weighted image of *** outcomes were haematoma volume on admission and unfavourable outcome defined as modified Rankin Scale scores≥3 at 3 *** outcomes were all-cause death,recurrence of stroke and ICH during follow-up(median follow-up 2.0 years,IQR 1.0-3.0 years).Results A total of 673 patients were identified from 1044 patients with spontaneous ICH.131(19.5%)had cSS and 468(69.5%)had *** with cSS+CMB+had the highest rate of poor outcome at 3 months,as well as all-cause death,recurrent stroke and ICH during *** cSS−patients,CMB was associated with smaller haematoma(β−0.13;95%CI−0.22 to−0.03;p=0.009),but it still increased risks of recurrent ICH(OR 4.6;95%CI 1.3 to 15.6;p=0.015)and stroke(OR 2.0;95%CI 1.0 to 4.0;p=0.049).These effects of CMB became unremarkable in the context of cSS+.Conclusions Patients with different combinations of cSS and CMB have distinct patterns of short-term and long-term *** CMB is related to restrained haematoma,it does not improve long-term outcomes.

关键词： superficial cerebral effect

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Tumor microenvironment reprogramming by nanomedicine to enhance the effect of tumor immunotherapy

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Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 1-37页

作者： yu huang hui Fan huihui Ti School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China Guangdong Province Precise Medicine Big Date of Traditional Chinese Medicine Engineering Technology Research Center Guangdong Pharmaceutical UniversityGuangzhou 510006China School of Pharmacy Guangdong Pharmaceutical UniversityGuangzhou 510006China

With the rapid development of the fields of tumor biology and immunology, tumor immunotherapy has been used in clinical practice and has demonstrated significant therapeutic potential, particularly for treating tumors that do not respond to standard treatment options. Despite its advances, immunotherapy still has limitations, such as poor clinical response rates and differences in individual patient responses, largely because tumor tissues have strong immunosuppressive microenvironments. Many tumors have a tumor microenvironment (TME) that is characterized by hypoxia, low pH, and substantial numbers of immunosuppressive cells, and these are the main factors limiting the efficacy of antitumor immunotherapy. The TME is crucial to the occurrence, growth, and metastasis of tumors. Therefore, numerous studies have been devoted to improving the effects of immunotherapy by remodeling the TME. Effective regulation of the TME and reversal of immunosuppressive conditions are effective strategies for improving tumor immunotherapy. The use of multidrug combinations to improve the TME is an efficient way to enhance antitumor immune efficacy. However, the inability to effectively target drugs decreases therapeutic effects and causes toxic side effects. Nanodrug delivery carriers have the advantageous ability to enhance drug bioavailability and improve drug targeting. Importantly, they can also regulate the TME and deliver large or small therapeutic molecules to decrease the inhibitory effect of the TME on immune cells. Therefore, nanomedicine has great potential for reprogramming immunosuppressive microenvironments and represents a new immunotherapeutic strategy. Therefore, this article reviews strategies for improving the TME and summarizes research on synergistic nanomedicine approaches that enhance the efficacy of tumor immunotherapy.

关键词： Tumor immunotherapy Tumor micr oenvir onment Nanomedicine Tumor repr ogramming

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Relationships between Terrain Features and Forecasting Errors of Surface Wind Speeds in a Mesoscale Numerical Weather Prediction Model

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Advances in Atmospheric Sciences 2024年第6期41卷 1161-1170页

作者： Wenbo XUE hui yu Shengming TANG Wei huang Chinese Academy of Meteorological Sciences Beijing 100081China University of Chinese Academy of Sciences Beijing 101408China Shanghai Typhoon Institute/CMA Shanghai 200030China Key Laboratory of Numerical Modeling for Tropical Cyclone/CMA Shanghai 200030China

Numerical weather prediction(NWP)models have always presented large forecasting errors of surface wind speeds over regions with complex *** this study,surface wind forecasts from an operational NWP model,the SMS-WARR(Shanghai Meteorological Service-WRF ADAS Rapid Refresh System),are analyzed to quantitatively reveal the relationships between the forecasted surface wind speed errors and terrain features,with the intent of providing clues to better apply the NWP model to complex terrain *** terrain features are described by three parameters:the standard deviation of the model grid-scale orography,terrain height error of the model,and slope *** results show that the forecast bias has a unimodal distribution with a change in the standard deviation of *** minimum ME(the mean value of bias)is 1.2 m s^(-1) when the standard deviation is between 60 and 70 m.A positive correlation exists between bias and terrain height error,with the ME increasing by 10%−30%for every 200 m increase in terrain height *** ME decreases by 65.6%when slope angle increases from(0.5°−1.5°)to larger than 3.5°for uphill winds but increases by 35.4%when the absolute value of slope angle increases from(0.5°−1.5°)to(2.5°−3.5°)for downhill *** sensitivity experiments are carried out with a model output statistical(MOS)calibration model for surface wind speeds and ME(RMSE)has been reduced by 90%(30%)by introducing terrain parameters,demonstrating the value of this study.

关键词： surface wind speed terrain features error analysis MOS calibration model

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Electromagnetic fields in ultra-peripheral relativistic heavy-ion collisions

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Nuclear Science and Techniques 2024年第2期35卷 103-109页

作者： Jie Zhao Jin-hui Chen Xu-Guang huang yu-Gang Ma Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics NSFC and Fudan UniversityShanghai 200438China Physics Department and Center for Particle Physics and Field Theory Fudan UniversityShanghai 200438China

Ultra-peripheral heavy-ion collisions(UPCs)offer unique opportunities to study processes under strong electromagnetic *** these collisions,highly charged fast-moving ions carry strong electromagnetic fields that can be effectively treated as photon *** exchange of photons can induce photonuclear and two-photon interactions and excite *** excitation of the ions results in Coulomb dissociation with the emission of photons,neutrons,and other ***,the electromagnetic fields generated by the ions can be sufficiently strong to enforce mutual interactions between the two colliding ***,the two colliding ions experience an electromagnetic force that pushes them in opposite directions,causing a back-to-back correlation in the emitted *** a Monte Carlo simulation,we qualitatively demonstrate that the above electromagnetic effect is large enough to be observed in UPCs,which would provide a clear means to study strong electromagnetic fields and their effects.

关键词： Electromagnetic fields Neutrons Ultra-peripheral relativistic heavy-ion collisions(UPC)

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The new challenges for the development of NH_(3)-SCR catalysts under new situation of energy transition in power generation industry

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Chinese Chemical Letters 2024年第6期35卷 95-103页

作者： Feibin Wei Yongfang Rao yu huang Wei Wang hui Mei Science and Technology on Thermostructural Composite Materials Laboratory School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Key Laboratory of Aerosol Chemistry and Physics State Key Laboratory of Loess and Quaternary Geology(SKLLQG)Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China Center of Excellence in Quaternary Science and Global Change Chinese Academy of SciencesXi’an 710061China University of Chinese Academy of Sciences Beijing 100049China Department of Environmental Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China

NH_(3)-SCR was one of the most promising de NO_x technologies and it has been widely applied in industrial NO_x ***,with the further development of energy transformation in power generation sector,the development of NH_(3)-SCR catalysts is facing some new *** is becoming an urgent problem to solve low catalytic activity and stability of NH_(3)-SCR catalysts at the working condition of ultra-low temperature(≤200℃)and high concentrations of H_(2)O+SO_(2) due to the gradual deployment of new energy power ***,the traditional coal-fired power plants would need flexible operation with the increasing share of renewable energy *** NH_(3)-SCR catalysts which were applied in coal-fired power industry would be requested to work in a wide temperature window from 200℃ to 500℃ in the near ***,in this review,we summarized the progress of NH_(3)-SCR catalysts in solving these different industrial problems in recent *** the research directions which were deserved to be focused on the development of NH_(3)-SCR catalysts for the energy transition of power generation sector are proposed.

关键词： NH_(3)-SCR NOx reduction Power generation Ultra-low temperature Wide temperature windows

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Giant room temperature elastocaloric effect in metal-free thinfilm perovskites

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npj Computational Materials 2021年第1期7卷 1194-1201页

作者： Cheng Li yu hui huang Jian-Jun Wang Bo Wang Yong Jun Wu He Tian Long-Qing Chen Zijian Hong Laboratory of Dielectric Materials School of Materials Science and EngineeringZhejiang UniversityHangzhouChina Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPAUSA Cyrus Tang Center for Sensor Materials and Applications State Key Laboratory of Silicon MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhouChina Center of Electron Microscopy State Key Laboratory of Silicon MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhouChina

Solid-state refrigeration which is environmentally benign has attracted considerable ***(mC)materials,in which the phase transitions can be induced by mechanical stresses,represent one of the most promising types of solid-state caloric ***,we have developed a thermodynamic phenomenological model and predicted extraordinarily large elastocaloric(eC)strengths for the(111)-oriented metal-free perovskite ferroelectric[MDABCO](NH_(4))I_(3)*** predicted room temperature isothermal eC ΔS_(eC)/Δσ(eC entropy change under unit stress change)and adiabatic eCΔTeC/Δσ(eC temperature change under unit stress change)for[MDABCO](NH_(4))I_(3) are−60.0 J K^(−1)kg^(−1)GPa^(−1) and 17.9 K GPa^(−1),respectively,which are 20 times higher than the traditional ferroelectric oxides such as BaTiO_(3) thin *** have also demonstrated that the eC performance can be improved by reducing the Young’s modulus or enhancing the thermal expansion coefficient(which could be realized through chemical doping,etc.).We expect these discoveries to spur further interest in the potential applications of metal-free organic ferroelectrics materials towards next-generation eC refrigeration devices.

关键词： ferroelectric perovskite free

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Adjuvant Chemotherapy versus Radiotherapy in High-risk,Early-stage Endometrioid Endometrial Carcinoma

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Current Medical Science 2022年第1期42卷 185-191页

作者： Min WU Ya-nan YANG yu-hui huang Jing CAI Xiao-qi HE Ze-hua WANG Department of Obstetrics and Gynecology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Objective:The present study was designed to evaluate the effects of adjuvant chemotherapy(CT)***(RT,alone or combined with CT)on the prognosis of patients with high-risk,early-stage(stage I and stage II)endometrioid endometrial ***:This single-center retrospective clinical study was conducted in Union Hospital,Tongji Medical College,Huazhong University of Science and Technology between 2010 and 2019.

关键词： endometrioid endometrial carcinoma chemotherapy radiotherapy

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WeldNet:A voxel-based deep learning network for point cloud annular weld seam detection

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Science China(Technological Sciences) 2024年第4期67卷 1215-1225页

作者： WANG hui RONG YouMin XU JiaJun XIANG SongMing PENG YiFan huang yu State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China School of Mechanical Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China

Weld seam detection is an important part of automated *** present,few studies have been conducted on annular weld seams,and a lot of defects exist in the point cloud model of the tube sheet obtained by RGB-D cameras and photography *** at the above problems,this paper proposed an annular weld seam detection network named WeldNet where a voxel feature encoding layer was adaptively improved for annular weld seams,the sparse convolutional network and region proposal network(RPN)were used to detect annular weld seam position,and an annular weld seam detection loss function was ***,an annular weld seam dataset was established to train the *** with the random sampling consistency(RANSAC)method,WeldNet has a higher detection accuracy,as well as a higher detection success rate which has increased by 23%.Compared with U-Net,WeldNet has been proven to achieve a better detection result,and the intersection over the union of the weld seam detection is improved by 17.8%.

关键词： deep learning point cloud weld seam detection welding annular weld seam

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Primary Treatment for Clinically Early Cervical Cancer with Lymph Node Metastasis:Radical Surgery or Radiation?

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当代医学科学(英文) 2023年第3期43卷 551-559页

作者： Xin-yi LI Jia-yi WEN yu-hui huang Wen-wen WANG Zheng WEI yu-jia MA Xiang KANG Ze-hua WANG Department of Obstetrics and Gynecology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Gynecology the Sixth Afiliated HospitalSun Yat-sen UniversityGuangzhou 510655China

Objective To compare survival outcomes between primary radical surgery and primary radiation in early cervical *** Patient information was extracted from the Surveillance,Epidemiology,and Results *** diagnosed with early cervical cancer of stage T1a,T1b,and T2a(American Joint Committee on Cancer,7th edition)from 1998 to 2015 were included in this study after propensity score *** survival(OS)was analyzed using the Kaplan-Meier *** Among the 4964 patients included in the study,1080 patients were identified as having positive lymph nodes(N1),and 3884 patients were identified as having negative lymph nodes(N0).Patients with primary surgery had significantly longer 5-year OS than those with primary radiotherapy in both the N1 group(P<0.001)and N0 group(P<0.001).In the subgroup analysis,similar results were found in patients with positive lymph nodes of stage T1a(100.0%vs.61.1%),T1b(84.1%vs.64.3%),and T2a(74.4%vs.63.8%).In patients with T1b1 and T2a1,primary surgery resulted in longer OS than primary radiation,but not in patients with T1b2 and *** multivariate analysis,the primary treatment was identified as an independent prognostic factor in both N1 and N0 patients(HR_(N1)=2.522,95%CI=1.919–3.054,PN1<0.001;HR_(N0)=1.895,95%CI=1.689–2.126,PN0<0.001).Conclusion In early cervical cancer stage T1a,T1b1,and T2a1,primary surgery may result in longer OS than primary radiation for patients with and without lymph node metastasis.

关键词： early cervical cancer overall survival primary treatment lymph node status radical surgery radiation

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