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Cost-effectiveness analysis of different anesthesia strategies for transperineal MRI/US fusion prostate biopsy

Asian Journal of Andrology 2024年第4期26卷 409-414页

作者： Di Jin Xiao-Qi Kong Ya-Juan Zhu Zong-Xin Chen Xi-Ming Wang Cai-hua Xu Jin-Xian Pu Jian-Quan Hou yu-hua huang Fu-Hai Ji Chen huang Department of Anesthesiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Urology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Oncology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Urology Dushu Lake Hospital Affiliated to Soochow UniversitySuzhou 215000China.

This study aims to conduct a cost-effectiveness analysis of three different anesthesia strategies,namely chatting while under local anesthesia(Chat-LA),total intravenous anesthesia(TIVA),and general anesthesia with laryngeal mask airway(GA-LMA),employed in transperineal magnetic resonance imaging(MRI)/ultrasound(US)fusion prostate biopsy(TP-MUF-PB).A retrospective study was conducted involving 1202 patients who underwent TP-MUF-PB from June 2016 to April 2023 at The First Affiliated Hospital of Soochow University(Suzhou,China).Clinical data and outcomes,including total costs,complications,and quality-adjusted life years(QALYs),were *** sensitivity and subgroup analyses were also ***-LA was found to be the most cost-effective option,outperforming both TIVA and ***,subgroup analyses revealed that in younger patients(under 65 years old)and those with smaller prostate volumes(<40 ml),TIVA emerged as a more cost-effective *** Chat-LA may generally be the most cost-effective and safer anesthesia method for TP-MUF-PB,personalization of anesthesia strategies is crucial,considering specific patient demographics such as age and prostate volume.

关键词： anesthesia strategy cost-effectiveness analysis economic evaluation prostate biopsy prostate cancer

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Neuroendocrine cells of prostate cancer: biologic functions and molecular mechanisms

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Asian Journal of Andrology 2019年第3期21卷 291-295页

作者： yu-hua huang Ya-Qun Zhang Jiao-Ti huang Department of Urology The First Affiliated Hospital of Soochow University Suzhou 215006 China Department of Urology Beijing Hospital National Center of Gerontology Beijing 100730 China Department of Pathology Duke University School of Medicine Durham NC 27514 USA

Prostate cancer (PCa) is a major health risk for older men worldwide. Existing systemic therapies mostly target androgen receptor (AR). Although treatments are initially effective, the disease always recurs. A potential mechanism for the treatment failure is that PCa contains, in addition to the AR-positive luminal type tumor cells, a small component of neuroendocrine (NE) cells. The function of NE cells in PCa remains poorly understood, and one important characteristic of these cells is their lack of expression of AR and resistance to hormonal therapy. In addition, many patients develop the more aggressive small-cell neuroendocrine carcinoma (SCNC) after hormonal therapy. Although this clinical phenomenon of disease transformation from adenocarcinoma to SCNC is well established, the cell of origin for SCNC remains unclear. Recently, loss of function of Rb and TP53 and amplification and overexpression of MYCN and Aurora A kinase have been identified as important biomarkers and potential disease drivers. In this article, we systematically review the histology of normal prostate and prostate cancer including the main histologic types: adenocarcinoma and SCNC. We also review the findings from many studies using cellular and animal models as well as human specimens that attempt to understand the molecular mechanisms of treatment failure, disease progression, and tumor transformation from adenocarcinoma to SCNC.

关键词： adenocarcinoma neuroendocrine prostate small-cell carcinoma

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Open abdomen in trauma patients:a double-edged sword

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Journal of Medical Colleges of PLA(China) 2016年第2期31卷 59-65页

作者： yu-hua huang You-sheng Li Department of General Surgery Jinling Hospital School of Medicine Nanjing University

The use of open abdomen(OA) as a technique in the treatment of exsanguinating trauma patients was first described in the mid-19 th century. Since the 1980 s, OA has become a relatively new and increasingly common strategy to manage massive trauma and abdominal catastrophes. OA has been proven to help reduce the mortality of trauma. Nevertheless, the OA method may be associated with terrible and devastating complications such as enteroatmospheric fistula(EAF). As a result, OA should not be overused, and attention should be given to critical care as well as special management. The temporary abdominal closure(TAC) technique after abbreviated laparotomy was used to improve wound healing and facilitate final fascial closure of OA. Negative pressure therapy(NPT) is the most commonly used TAC method.

关键词： Open abdomen Abdominal compartment syndrome Damage control Enteroatmospheric fistula Negative pressure therapy

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Clinical association between pre-treatment levels of plasma fibrinogen and bone metastatic burden in newly diagnosed prostate cancer patients

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Chinese Medical Journal 2019年第22期132卷 2684-2689页

作者： Gan-Sheng Xie Gang Li yu Li Jin-Xian Pu yu-hua huang Jin-Hu Li Hu-Ming Yin Department of Urology The First Affiliated Hospital of Soochow UniversitySuzhou.Jiangsu 215031China

Background:Due to the different treatments for low-volume metastatic prostate cancer(PCa)as well as high-volume evaluation of bone metastatic status is clinically *** this study,we evaluated the correlation between pre-treatment plasma fibrinogen and the burden of bone metastasis in newly diagnosed PCa ***:A single-center retrospective analysis,focusing on prostate biopsies of newly diagnosed PCa patients,was performed.A total of 261 patients were enrolled in this study in a 4-year *** subjects were submitted to single-photon emission computerized tomography-computed tomography to confirm the status of bone metastasis and,if present,the number of metastatic lesions would then be *** information such as age,prostate-specific antigen(PSA),fibrinogen,clinical T stage,and Gleason score were *** were divided into three groups:(i)a non-metastatic group,(ii)a high volume disease(HVD)group(>3 metastases with at least one lesion outside the spine),and(iii)a low volume disease(LVD)group(metastatic patients excluding HVD ones).The main statistical methods included non-parametric Mann-Whitney test,Spearman correlation,receiver operating characteristic(ROC)curves,and logistic ***:Fibrinogen positively correlated with Gleason score(r=0.180,P=0.003),PSA levels(r=0.216,P7(86.8%).Both univariate(odds ratio[OR]=2.16,95%confidential interval[CI]:1.536-3.038,P<0.001)and multivariate(OR=1.726,95%CI:1.206-2.472,P=0.003)logistic regressions showed that fibrinogen was independently associated with *** ROC curve suggested that fibrinogen acts as a predictor of HVD patients,yielding a cut-off of 3.08 g/L,with a sensitivity of 0.684 and a specificity of 0.760(area

关键词： Prostate cancer Fibrinogen Prostate-specific antigen Metastasis Biopsy

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Escape probability for isotropic emitters near Kerr black hole with astrometric

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Communications in Theoretical Physics 2024年第5期76卷 128-133页

作者： yu-Xuan Han Qing-hua Zhu Qing-Guo huang CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesNo.19A Yuquan RoadBeijing 100049China Department of Physics Chongqing UniversityChongqing 401331China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced Study UCASHangzhou 310024China

The paper investigates the escape probability for isotropic emitters near a Kerr black *** propose a new approach to obtain the escape probability in a general manner,going beyond previous case-by-case *** approach is based on studies of the black hole shadow with astrometric observable and can be applied to emitters with an arbitrary 4-velocities and locations,even to the emitters outside of the equatorial *** also consider representative examples illustrating how escape probabilities vary with distance,velocity,and inclination ***,this new approach provides an effective method for studying escape probabilities near Kerr black holes.

关键词： Kerr black hole photon escape probability isotropic emitters

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A correlative study of iron metabolism based on q-Dixon MRI in benign prostatic hyperplasia and prostate cancer

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Asian Journal of Andrology 2022年第6期24卷 671-674页

作者： Zhen Tian Yong-Gang Li Guang-Zheng Li Zhi-Hao huang Wen-Hao Dail Xue-Dong Wei Wei-Jie Zhang Zhen-yu Fu yu-hua huang Department of Urology The First Affiliated Hospital of Soochow UniversitySuzhou 215000China Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhou 215000China Department of Urology Changshu No.2 People's HospitalChangshu 215500China

Clinical staging,Gleason score,and prostate-specific antigen(PSA)have been accepted as factors for evaluating the prognosis of prostate cancer(PCa).With the in-depth study of iron metabolism and the development of multiparametric magnetic resonance imaging technology,we used q-Dixon magnetic resonance imaging(MRI)to measure the iron content of the PCa patients'lesions,and used enzyme-linked immunosorbent assay(ELISA)to measure the iron metabolism indicators in the patients'serum samples,combined with the patients'postoperative clinical data for *** found that the serum indexes were correlated with the T2 star values,International Society of Urological Pathology(ISUP)grade,and pathological classification in PCa patients(all PO.05).The utilization of q-Dixon-based MRI and serum indexes allows the noninvasive measurement of iron content in prostate lesions and the assessment of differential iron metabolism between PCa and BPH,which may be helpful for evaluating the prognosis of PCa.

关键词： iron metabolism prostate cancer q-Dixon MRl serum index

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Garnet and Zircon U-Pb Geochronology and Geochemistry Reveal Genesis of the Dafang Au-Pb-Zn-Ag Deposit,Southern Hunan

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Acta Geologica Sinica(English Edition) 2024年第3期98卷 717-735页

作者： JIANG hua KONG hua LIU Biao TAN Fucheng QIN Yixue huang Jingang ZHU yu Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring Ministry of EducationSchool of Geosciences and Info-PhysicsCentral South UniversityChangsha 410083China School of Geosciences and Info-Physics Central South UniversityChangsha 410083China Hunan Baoshan Nonferrous Metals and Minerals Co. Ltd.ChenzhouHunan 424402China

Garnet is a primary mineral in skarn deposits and plays a significant role in recording copious mineralization and metallogenic *** study systematically investigates the geochemistry and geochronology of garnet and zircon in the Dafang Au-Pb-Zn-Ag deposit,which represents prominent gold mineralization in southern Hunan,*** samples with distinct zoning patterns and compositional variations were identified using various analytical techniques,including Backscattered Electron(BSE)imaging,Cathodoluminescence(CL)response,textural characterization,and analysis of rare-earth elements(REE),major contents,and trace element *** garnet was dated U-Pb dating,which yielded a lower intercept age of 161.06±1.93 *** age is older than the underlying granodiorite porphyry,which has a concordia age of 155.13±0.95 Ma determined by zircon U-Pb *** results suggest that the gold mineralization may be related to the concealed *** groups of garnet changed from depleted Al garnet to enriched Al garnet,and the rare earth element(REE)patterns of these groups were converted from light REE(LREE)-enriched and heavy REE(HREE)-depleted with positive europium(Eu)anomalies to medium REE(MREE)-enriched from core to rim *** different REE patterns of garnet in various zones may be attributed to changes in the fluid environment and late superposition *** development of distal skarn in the southern Hunan could be a significant indicator for identifying gold mineralization.

关键词： garnet and zircon U-Pb dating LA-ICP-MS mapping Dafang Southern Hunan

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Potential therapeutic effect of epigenetic therapy on Ireatment-induced neuroendocrine prostate cancer

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Asian Journal of Andrology 2017年第6期19卷 686-693页

作者： Xiang Xu yu-hua huang Yan-Jing Li Alexa Cohen Zhen Li Jill Squires Wei Zhang Xu-Feng Chen Min Zhang Jiao-Ti huang School of Life Sciences Anhui University Hefei China Department of Pathology and Laboratory Medicine University of California at Los Angeles Los Angeles California USA Department of Urology The First Affiliated Hospital of SooChow University Suzhou China Department of Medical Oncology Rutgers Cancer Institute of New Jersey New Brunswick New Jersey USA Department of Pathology Beijing Hospital Beijing China

Although adenocarcinomas of the prostate are relatively indolent, some patients with advanced adenocarcinomas show recurrence of treatment-induced neuroendocrine prostate cancer, which is highly aggressive and lethal. Detailed biological features of treatment-induced neuroendocrine prostate cancer have not been characterized owing to limited biopsies/resections and the lack of a cellular model. In this study, we used a unique cellular model （LNCaP/NE1.8） to investigate the potential role of cancer stem cells in treatment-induced neuroendocrine prostate cancer with acquired resistance to hormonal therapy and chemotherapy. We also studied the role of cancer stem cells in enhancing invasion in treatment-induced neuroendocrine prostate cancer cells that recurred after long-term androgen-ablation treatment. Using an in vitro system mimicking clinical androgen-ablation, our results showed that the neuroendocrine-like subclone NE1.8 cells were enriched with cancer stem cells. Compared to parental prostate adenocarcinoma LNCaP cells, NE1.8 cells are more resistant to androgen deprivation therapy and chemotherapeutic agents and show increased cancer cell invasiveness. Results from this study also suggest a potential epigenetic therapeutic strategy using suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, as a chemotherapeutic agent for therapy-resistant treatment-induced neuroendocrine prostate cancer cells to minimize the risk of prostate cancer recurrence and metastasis.

关键词： cancer stem cell epigenetic therapy hormonal therapy neuroendocrine prostate cancer suberoylanilide hydroxamic acid

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Microsurgical subinguinal varicocelectomy with spermatic cord double traction and vein stripping

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Asian Journal of Andrology 2020年第2期22卷 208-212页

作者： Ru-Hui Tian Liang-yu Zhao Hui-Xing Chen Chao Yang Peng Li yu-hua huang Zhong Wan Er-Lei Zhi Chen-Cheng Yao Zheng Li Department of Andrology Center for Men’s HealthDepartment of ARTUrologic Medical CenterShanghai General HospitalShanghai Key Lab of Reproductive MedicineShanghai Jiao Tong UniversityShanghai 200080China

We retrospectively reviewed data for 286 patients with varicocele who underwent microsurgical subinguinal varicocelectomy from March 2015 to May 2017 in Shanghai General Hospital(Shanghai,China).In this surgical approach,the testis was delivered,and the gubernacular and external cremasteric veins were *** addition,the spermatic cord was delivered downward with continuous double traction away from the external *** remaining procedure was similar to the conventional *** followed patients for at least 3 months and evaluated postoperative semen parameters,pain symptoms,and *** excluded data for 32 men due to inadequate follow-up(<3 months).Of the remaining 254 patients,73 had oligoasthenospermia,121 had nonobstructive azoospermia,and 60 had symptomatic *** progressive sperm counts increased in the oligoasthenospermic patients from a median preoperative value of 9.15×10^6 ml^?1 to 25.33×10^6 ml^?1(n=34),and 35.6%(26/73)initially oligoasthenospermic men contributed to unassisted *** returned to the ejaculate in 12.4%(15/121)azoospermia *** patients with scrotal pain(n=60),43(71.7%)reported complete resolution of pain,16(26.7%)reported partial resolution,and 1(1.7%)reported no *** patients experienced varicocele *** doubletraction strategy avoids opening the external oblique aponeurosis,and results in less damage and faster *** addition,the stripping strategy eliminates potential damage to the testis caused by the varicose *** results showed that microsurgical subinguinal varicocelectomy using spermatic cord double traction in conjunction with testicular delivery for vein stripping is a safe and effective approach for varicocele repair.

关键词： azoospermia low sperm count sperm motility spermatic cord varicocele

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Modified stepwise mini-incision microdissection testicular sperm extraction:a useful technique for patients with a history of orchidopexy affected by non-obstructive azoospermia

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第1期21卷 87-92页

作者： Peng LI Chen-cheng YAO Er-lei ZHI yuan XU Zhong WAN Ying-chuan JIANG yu-hua huang yue-hua GONG Hui-xing CHEN Ru-hui TIAN Chao YANG Liang-yu ZHAO Zheng LI Department of Andrology Center for Men’s HealthUrologic Medical CenterShanghai General HospitalShanghai Jiao Tong UniversityShanghai 200080China Department of Urology Shanghai General Hospital of Nanjing Medical UniversityShanghai 200080China Reproductive Medicine Center Shanghai General HospitalShanghai Jiao Tong UniversityShanghai 200080China Department of Urology Zhoushan HospitalZhoushan 316021China

Non-obstructive azoospermia(NOA),which is defined as the absence of spermatozoa in the ejaculate secondary to impaired spermatogenesis within the testis,may be caused by a variety of etiologies,including varicocele-induced testicular damage,cryptorchidism,prior testicular torsion,post-pubertal mumps orchitis,gonadotoxic effects from medications,genetic abnormalities,chemotherapy/radiation,and other unknown causes currently classified as idiopathic(Cocuzza et al.,2013).The microdissection testicular sperm extraction(micro-TESE)technique involves a meticulous microsurgical exploration of the testicular parenchyma to identify and selectively extract larger seminiferous tubules that carry a higher probability of complete spermatogenesis(Schlegel,1999).

关键词：非梗阻性无精子症隐睾睾丸显微取精术睾丸下降固定术精子获取

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