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Single-stage anterior debridement and reconstruction with tantalum mesh cage for complicated infectious spondylitis

World Journal of Orthopedics 2017年第9期8卷 710-718页

作者： Shih-Chieh Yang Hung-Shu Chen yu-hsien kao yuan-Kun Tu Department of Orthopedic Surgery E-Da Hospital I-Shou University

AIM To evaluate the clinical and radiographic results of patients with complicated infectious spondylitis treated with single-stage anterior debridement and reconstruction using tantalum mesh cage(TaMC) followed by immediate *** Single-stage radical debridement and subsequent reconstruction with TaMC instead of autograft or allograft were performed to treat 20 patients with spinal deformity or instability due to complicated infectious spondylitis. Clinical outcomes were assessed by careful physical examination and regular serological tests to determine the infection control. In addition, the visual analog score(VAS), neurologic status, length of vertebral body reconstruction, and the correction of sagittal Cobb angle on radiography were recorded and compared before and after surgery. The conditions of the patients were evaluated based on the modified Brodsky's *** The average VAS score significantly decreased after the surgery(from 7.4 ± 0.8 to 3.3 ± 0.8, P < 0.001). The average Cobb angle correction was 14.9 degrees. The neurologic status was significantly improved after the surgery(P = 0.003). One patient experienced refractory infection and underwent additional debridement. Eighteen patients achieved good outcome based on the modified Brodsky's criteria and significant improvement after the surgery(P < 0.001). No implant breakage orTaMC dislodgement was found during at least 24 mo of *** Single-stage anterior debridement and reconstruction with TaMC followed by immediate instrumentation could be an alternative method to manage the patients with spinal deformity or instability due to complicated infectious spondylitis.

关键词： Anterior reconstruction Complicated infectious spondylitis Instrumentation Spinal deformity Tantalum mesh cage

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Review of Computational Approaches to Optimization Problems in Inhomogeneous Rods and Plates

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Communications on Applied Mathematics and Computation 2024年第1期6卷 236-256页

作者： Weitao Chen Chiu-Yen kao Department of Mathematics University of California at Riverside900 University AveRiversideCA92521USA Department of Mathematical Sciences Claremont McKenna College850 Columbia AveClaremontCA91711USA

In this paper,we review computational approaches to optimization problems of inhomogeneous rods and *** consider both the optimization of eigenvalues and the localization of *** problems are motivated by physical problems including the determination of the extremum of the fundamental vibration frequency and the localization of the vibration *** demonstrate how an iterative rearrangement approach and a gradient descent approach with projection can successfully solve these optimization problems under different boundary conditions with different densities given.

关键词： Inhomogeneous rods and plates Bi-Laplacian Optimization of eigenvalues Localization of eigenfunctions Rearrangement

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Antimony oxides-protected ultrathin Ir-Sb nanowires as bifunctional hydrogen electrocatalysts

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Nano Research 2024年第3期17卷 1042-1049页

作者： Bingyan Xu Xuan Huang Shangheng Liu Zhiwei Hu Cheng-Wei kao Ting-Shan Chan Hongbo Geng Ying Zhang Xiaoqing Huang Country State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Max Planck Institute for Chemical Physics of Solids Dresden 01187Germany “National Synchrotron Radiation Research Center” Hsinchu 30076TaiwanChina School of Materials Engineering Changshu Institute of TechnologyChangshu 215500China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China

Developing electrocatalysts with fast kinetics and long-term stability for alkaline hydrogen oxidation reaction(HOR)and hydrogen evolution reaction(HER)is of considerable importance for the industrial production of green and sustainable ***,an ultrathin Ir-Sb nanowires(Ir-Sb NWs)protected by antimony oxides(SbO_(x))was synthesized as an efficient bifunctional catalyst for both HOR and HER under alkaline *** from the much higher mass activities of Ir-Sb nanowires than those of Ir nanowires(Ir NWs)and commercial Pt/C,the SbO_(x) protective layer also contributes to the maintenance of morphology and anti-CO poisoning ability,leading to the long-term cycling performance in the presence of ***,the Ir-Sb NW/SbO_(x) exhibits the highest catalytic activities,which are about 3.5 and 4.8 times to those of Ir NW/C and commercial Pt/C toward HOR,*** work provides that the ultrathin morphology and H_(2)O-occupied Sb sites can exert the intrinsic high activity of Ir and effectively optimize the absorption of OH*both in alkaline HER/HOR electrolysis.

关键词： Ir nanowire amorphous antimony oxides bifunctional mechanism hydrogen evolution reaction hydrogen oxidation reaction

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Variable frequency deep brain stimulation of subthalamic nucleus to improve freezing of gait in Parkinson's disease

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National Science Review 2024年第6期11卷 102-104页

作者： Fumin Jia Aparna Wagle Shukla Wei Hu yu Ma Jianguo Zhang Leonardo Almeida Chris kao Yi Guo Shizhong Zhang Yingqun Tao Zhipei Ling Xin Xu Zhiquan Yang Fan-gang Meng Xinhua Wan Hesheng Liu Peter E.Konard Luming Li National Engineering Laboratory for Neuromodulation Tsinghua University University of Florida Center for Movement Disorders and Neurorestoration Tsinghua University yuquan Hospital Beijing Tiantan Hospital Capital Medical University School of Medicine Vanderbilt University Peking Union Medical College Hospital ZhuJiang Hospital of Southern Medical University The General Hospital of Shenyang Military Chinese PLA General Hospital Xiangya Hospital Central South University Beijing Neurosurgical Institute Capital Medical University Athinoula A. Martinos Center for Biomedical Imaging Harvard Medical School Precision Medicine & Healthcare Research Center Tsinghua-Berkeley Shenzhen Institute Man-Machine-Environment Engineering Institute School of Aerospace EngineeringTsinghua University Center of Epilepsy Beijing Institute for Brain Disorders

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a welle-stablished therapy for patients with Parkinson’s disease (PD) presenting with medication refractory tremors, motor fluctuations and dyskinesias induced by dopaminergic medications [1]. However,traditional high-frequency stimulation(HFS) does not effectively control axial symptoms such as gait dysfunction,postural instability and freezing of gait(FOG)[2,3].

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Symmetric Brownian motor subjected to Lévy noise

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Chinese Physics B 2024年第2期33卷 222-227页

作者：贾考胡兰聂林如 Faculty of Science Kunming University of Science and TechnologyKunming 650500China

In the past few years,attention has mainly been focused on the symmetric Brownian motor(BM)with Gaussian noises,whose current and energy conversion efficiency are very ***,we investigate the operating performance of the symmetric BM subjected to Lévy *** numerical simulations,it is found that the operating performance of the motor can be greatly improved in asymmetric Lévy *** any load,the Lévy noises with smaller stable indexes can let the motor give rise to a much greater *** a load,the energy conversion efficiency of the motor can be enhanced by adjusting the stable indexes of the Lévy noises with symmetry *** results of this research are of great significance for opening up BM’s intrinsic physical mechanism and promoting the development of nanotechnology.

关键词： symmetric Brownian motor average velocity energy conversion efficiency Lévy noise

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Can We Manage Coastal Area? Will We?——The Institutional Change of the Coastal Area Management of Taiwan

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Management Studies 2024年第1期12卷 21-32页

作者： yuh-fen kao National Chengchi University TaipeiTaiwanR.O.C.

The Coastal Zone Management Act was finally promulgated in 2015,while Ministry of the Interior was asked to draft a coastal management act in 1991 by Executive *** was until the government’s lifting of martial law in 1987,vigorous activities started prevailing on coastal *** relevant legal documents were on sea reclamation for development in the 1980’s by Council of *** approval of“Taiwan Coastal Area Natural Environment Protection Plan”showed an era of environmental protection in ***,it was surely not market driven,similar to land development,but some efforts by the administration *** all the years,the efforts were put on drafting plans and these efforts were not quite *** coastal disasters and further climate change caught the attention of relevant NGOs,scholars,politicians,and the *** the critical juncture the government was made to react to outside *** then the Coastal Zone Management Act was passed by Legislative yuan,establishing an integrated coastal management system in *** such,it is proposed to look into this long process of the attempt with the concept of institutional change in order to understand this coastal environmental preservation and protection issue in a broader scope.

关键词： Integrated Coastal Zone Management(ICZM) institutional change new institutionalism coastal area

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The Optimization Design of the Nozzle Section for theWater Jet Propulsion System Applied in Jet Skis

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2277-2304页

作者： Cheng-Yeh Li Jui-Hsiang kao Department of Systems Engineering and Naval Architecture Taiwan Ocean UniversityKeelungTaiwanChina

The performance of a water jet propulsion system is related to the inlet duct,rotor,stator,and ***,the flow inlet design must fit the bottom line of the hull,and the design of the inlet duct is often limited by stern *** entire section,from the rotor to the nozzle through the stator,must be designed based on system integration in that the individual performance of these three components will influence each ***,the section from the rotor to the nozzle significantly impacts the performance of a water jet propulsion *** study focused on nozzle design and established referable analysis results to facilitate subsequent integrated studies on the design parameters regarding nozzle *** existing studies concentrate on discussions on rotor design and the tip leakage flow of rotors or have replaced the existing complex computational domain with a simple flow ***,research has yet to implement an integrated,optimal design of the section from the rotor to the *** the above,our program conducted preliminary research on this system integration design issue,discussed the optimal nozzle for this section in-depth,and proposed design suggestions based on the *** program used an existing model as the design *** study referred to the actual trial data as the design conditions for the proposed *** prior references’simple flow field form,this study added a jet ski geometry and free surface to the computational *** the linear hull shape was considered,the inflow in the inlet duct would be closer to the actual *** on the numerical calculation result,this study recommends that the optimal nozzle outlet area should be 37%of the inlet area and that the nozzle contour should be ***,for the pump head,static pressure had a more significant impact than dynamic pressure.

关键词： Water jet propulsion system rotor nozzle outlet area nozzle contour

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Cornus officinalis with high pressure wine steaming enhanced anti-hepatic fibrosis: Possible through SIRT3-AMPK axis

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Journal of Pharmaceutical Analysis 2024年第5期14卷 758-771页

作者： Xin Han Yan Ning Xinyue Dou Yiwen Wang Qiyuan Shan kao Shi Zeping Wang Chuan Ding Min Hao Kuilong Wang Mengyun Peng Haodan Kuang Qiao Yang Xianan Sang Gang Cao School of Pharmacy Zhejiang Chinese Medical UniversityHangzhou311400China

Cornus officinalis,a medicinal and edible plant known for its liver-nourishing properties,has shown promise in inhibiting the activation of hepatic stellate cells(HSCs),crucial indicators of hepatic fibrosis,especially when processed by high pressure wine steaming(HPWS).Herein,this study aims to investigate the regulatory effects of cornus officinalis,both in its raw and HPWS forms,on inflammation and apoptosis in liver fibrosis and their underlying *** vivo liver fibrosis models were established by subcutaneous injection of CCl4,while in vitro HSCs were exposed to transforming growth factor-b(TGF-b).These findings demonstrated that cornus officinalis with HPWS conspicuously ameliorated histopathological injury,reduced the release of proinflammatory factors,and decreased collagen deposition in CCl4-induced rats compared to its raw *** ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometer(UHPLC-QTOF-MS)combined with network analysis,we identified that the pharmacological effects of the changed components of cornus officinalis before and after HPWS,primarily centered on the adenosine phosphate(AMP)-activated protein kinase(AMPK)*** note,cornus officinalis activated AMPK and sirtuin 3(SIRT3),promoting the apoptosis of activated HSCs through the caspase cascade by regulating caspase3,caspase6 and *** interfering RNA(siRNA)experiments showed that cornus officinalis could regulate AMPK activity and its mediated-apoptosis through *** conclusion,cornus officinalis exhibited the ability to reduce inflammation and apoptosis,with the SIRT3-AMPK signaling pathway identified as a potential mechanism underlying the synergistic effect of cornus officinalis with HPWS on anti-liver fibrosis.

关键词： Liver fibrosis SIRT3 Cornus officinalis AMPK Caspase6

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Manual Order Picking Route Optimization in Distribution Warehouse of Chain Furniture Retail Enterprise

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American Journal of Operations Research 2024年第3期14卷 105-136页

作者： Yongzhen Zeng Junkun Wang Ching-Kuei kao King-Zoo Tang Department of Logistics Management Fujian University of Technology Fuzhou China Key Laboratory of LNG Industry Chain Fujian University of Technology Fuzhou China Department of Information Management National Chung Cheng University Chiayi China

Due to the effects of the COVID-19 pandemic and the rise of online shopping, the offline sales of IKEA Fuzhou have been declining since 2020. Because the cost of distribution warehouse is a major expense for offline chain furniture retailers, and the picking process is a key activity in distribution warehouse operations. To reduce the cost of distribution warehouse and alleviate the survival pressure of the offline chain furniture retailers, this paper focuses on optimizing the picking route of the IKEA Fuzhou distribution warehouse. It starts by creating a two-dimensional coordinate system for the storage location of the distribution warehouse using the traditional S-type picking strategy to calculate the distance and time of the sorting route. Then, the problem of optimizing the picking route is then transformed into the travelling salesman problem (TSP), and picking route optimization model is developed using a genetic algorithm to analyze the sorting efficiency and picking route optimization. Results show that the order-picking route using the genetic algorithm strategy is significantly better than the traditional S-type picking strategy, which can improve overall sorting efficiency and operations, reduce costs, and increase efficiency. Thus, this establishes an implementation process for the order-picking path based on genetic algorithm optimization to improve overall sorting efficiency and operations, reduce costs, increase efficiency, and alleviate the survival pressure of pandemic-affected enterprises.

关键词： S-Shaped Picking Strategy Picking Route Traveling Salesman Problem Genetic Algorithm

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Numerical Approach to Film Cooling Effectiveness Over a Plate Surface with Coolant Impingement

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Journal of Thermal Science 2004年第1期13卷 67-74页

作者： Chang-hsien Tai Jr-Ming Miao A-Fu kao Department of Vehicles Engineering National Pingtung University of Science and TechnologyPingtungTaiwanChinaDepartment of Mechanical EngineeringChung Cheng Institute of TechnologyNational Defense UniversityTaoyuanTaiwanChinaGraduate School of Defense Science StudiesChung Cheng Institute of TechnologyNational Defense UniversityTaoyuanTaiwanChina

The aim of the present study is conducting the numerical approach to a combination of internal jet impingement and external film cooling over a flat plate. A multi-block three-dimensional Navier-Stokes code, CFX 4.4, with k-e turbulence model is used to simulate this complicated thermal-flow structure induced by the interaction of coolant jet and hot cross mainstream. By assuming the adiabatic wall boundary condition on the tested film-cooled plate, both the local and the spanwise-averaged adiabatic film cooling effectiveness are evaluated for comparison of the cooling performance at blowing ratios of Br=0.5, 1.0, and 1.5. Film flow data were obtained from a row of five cylindrical film cooling holes, inclined in angle of 35?and 0?in direction of streamwise and spanwise, respectively. The film cooling hole spacing between adjacent holes is 15 mm for all the holes. Before the coolant flow being injected through individual cooling hole then encountered with the mainstream, an impingement chamber containing an impingement plate with 43 holes is located on the path of coolant flow. Present study also focused on the effect of impingement spacing, 10mm, 20mm, and 30mm. Compare the results, we find the impingement jet has a significant effect on the adiabatic film cooling effectiveness. As the coolant impingement spacing is fixed, results indicated that higher blowing ratio would enhance the local and the spanwise-averaged adiabatic film cooling effectiveness. Moreover, neither uniform nor parabolic distribution of pressure distribution are observed within the coolant hole-pipe.

关键词： film cooling impingement cooling CFD turbulence model.

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