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Fatty acid binding protein 5 is a novel therapeutic target for hepatocellular carcinoma

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World Journal of Clinical Oncology 2024年第1期15卷 130-144页

作者： Yan Li William Lee Zhen-Gang Zhao Yi Liu hao Cui hao-yu wang Department of Gastroenterology Tianjin Third Central HospitalTianjin 300170China Biomedical Engineering Texas A&M UniversityCollege StationTX 77843United States

BACKGROUND Hepatocellular carcinoma(HCC)is an aggressive subtype of liver cancer and is one of the most common cancers with high mortality *** lipid metabolism plays crucial roles in HCC cancer cell survival,growth,and *** evidence suggests the importance of fatty acid binding proteins(FABPs)in contribution to cancer progression and metastasis;however,how these FABPs are dysregulated in cancer cells,especially in HCC,and the roles of FABPs in cancer progression have not been well *** To understand the genetic alterations and expression of FABPs and their associated cancer hallmarks and oncogenes in contributing to cancer *** We used The Cancer Genome Atlas datasets of pan cancer and liver hepatocellular carcinoma(LIHC)as well as patient cohorts with other cancer types in this *** investigated genetic alterations of FABPs in various cancer *** expression was used to determine if FABPs are abnormally expressed in tumor tissues compared to non-tumor controls and to investigate whether their expression correlates with patient clinical outcome,enriched cancer hallmarks and oncogenes previously reported for patients with *** determined the protein levels of FABP5 and its correlated genes in two HCC cell lines and assessed the potential of FABP5 inhibition in treating HCC *** We discovered that a gene cluster including five FABP family members(FABP4,FABP5,FABP8,FABP9 and FABP12)is frequently co-amplified in ***,in fact,is the most common genetic alteration for FABPs,leading to overexpression of ***5 showed the greatest differential mRNA expression comparing tumor with non-tumor *** FABP5 expression correlates well with worse patient outcomes(P<0.05).FABP5 expression highly correlates with enrichment of G2M checkpoint(r=0.33,P=1.1e-10),TP53 signaling pathway(r=0.22,P=1.7e-5)and many genes in the gene sets such as CDK1(r=0.56,P=0),CDK4(r=0.49,P=0),and TP53(r=0

关键词： Hepatocellular carcinoma Fatty acid binding protein Novel target Amplification Correlated expression

Insights into efficient transition metal-nitrogen/carbon oxygen reduction electrocatalysts

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Journal of Energy Chemistry 2021年第5期30卷 470-485页

作者： hao-yu wang Chen-Chen Weng Zhong-Yong yuan National Institute for Advanced Materials School of Materials Science and EngineeringNankai UniversityTianjin 300350China

It is of vital importance to accelerate the sluggish oxygen reduction reaction(ORR)process at the cathode with earth-abundant metal-based catalysts for the commercialization of low-temperature polymer electrolyte membrane fuel *** consideration of high catalytic activity,long-term stability and low cost of potential ORR electrocatalysts,transition metal species have attracted much interest and transition metal-nitrogen-carbon(M-N/C,M=Fe,Co,Ni,Mn,etc.)catalysts have been widely considered as the most promising non-precious metal catalysts for ***,the fundamental understanding of ORR catalytic mechanism and the identification of active centers are briefly introduced,and then different M-N/C catalysts classified by precursors with the strategies for design and optimization are *** challenges and possible opportunity for future development of high-performance ORR catalysts are finally proposed.

关键词： Electrocatalysis Oxygen reduction reaction Metal-nitrogen/carbon Fuel cell

First-principles calculations of structural,elastic and electronic properties of(TaNb)0.67(HfZrTi)0.33 high-entropy alloy under high pressure

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International Journal of Minerals,Metallurgy and Materials 2020年第10期27卷 1405-1414页

作者： Zhi-sheng Nong hao-yu wang Jing-chuan Zhu School of Materials Science and Engineering Shenyang Aerospace UniversityShenyang 110136China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China

To clarify the effect of pressure on a(TaNb)0.67(HfZrTi)0.33 alloy composed of a solid solution with a single body-centered-cubic crystal structure,we used first-principles calculations to theoretically investigate the structural,elastic,and electronic properties of this alloy at different *** results show that the calculated equilibrium lattice parameters are consistent with the experimental results,and that the normalized structural parameters of lattice constants and volume decrease whereas the total enthalpy differenceΔE and elastic constants increase with increasing ***(TaNb)0.67(HfZrTi)0.33 alloy exhibits mechanical stability at high pressures lower than 400 *** high pressure,the bulk modulus B shows larger values than the shear modulus G,and the alloy exhibits an obvious anisotropic feature at pressures ranging from 30 to 70 *** analysis of the electronic structures reveals that the atomic orbitals are occupied by the electrons change due to the compression of the crystal lattices under the effect of high pressure,which results in a decrease in the total density of states and a wider electron energy *** factor is favorable for zero resistance.

关键词： first-principles calculations elastic property electronic structure density of states high-entropy alloys high pressure

Area Efficient Pattern Representation of Binary Neural Networks on RRAM

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Journal of Computer Science & Technology 2021年第5期36卷 1155-1166页

作者： Feng wang Guo-Jie Luo Guang-yu Sun yu-hao wang Di-Min Niu Hong-Zhong Zheng Center for Energy-Efficient Computing and Applications Peking UniversityBeijing 100871China Pingtouge Alibaba GroupHangzhou 310052China

Resistive random access memory(RRAM)has been demonstrated to implement multiply-and-accumulate(MAC)operations using a highly parallel analog fashion,which dramatically accelerates the convolutional neural networks(CNNs).Since CNNs require considerable converters between analog crossbars and digital peripheral circuits,recent studies map the binary neural networks(BNNs)onto RRAM and binarize the weights to{+1,-1}.However,two mainstream representations for BNN weights introduce patterns of redundant 0s and 1s when dealing with negative *** this work,we reduce the area of redundant 0s and 1s by proposing a BNN weight representation framework based on the novel pattern representation and a corresponding ***,we spilt the weight matrix into several small matrices by clustering adjacent columns ***,we extract 1s'patterns,i.e.,the submatrices only containing 1s,from the small weight matrix,such that each final output can be represented by the sum of several ***,we map these patterns onto RRAM crossbars,including pattern computation crossbars(PCCs)and pattern accumulation crossbars(PACs).Finally,we compare the pattern representation with two mainstream representations and adopt the more area efficient *** evaluation results demonstrate that our framework can save over 20%of crossbar area effectively,compared with two mainstream representations.

关键词： binary neural network(BNN) pattern resistive random access memory(RRAM)

Establishment of injury models in studies of biological effects induced by microwave radiation

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Military Medical Research 2021年第2期8卷 253-272页

作者： yun-Fei Lai hao-yu wang Rui-yun Peng Beijing Institute of Radiation Medicine Beijing 100850China

Microwave radiation has been widely used in various fields,such as communication,industry,medical treatment,and military *** radiation may cause injuries to both the structures and functions of various organs,such as the brain,heart,reproductive organs,and endocrine organs,which endanger human ***,it is both theoretically and clinically important to conduct studies on the biological effects induced by microwave *** successful establishment of injury models is of great importance to the reliability and reproducibility of these *** this article,we review the microwave exposure conditions,subjects used to establish injury models,the methods used for the assessment of the injuries,and the indicators implemented to evaluate the success of injury model establishment in studies on biological effects induced by microwave radiation.

关键词： Microwave radiation Injury model Biological effects Methods Biological indicators Review

On Identifying and Explaining Similarities in Android Apps

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Journal of Computer Science & Technology 2019年第2期34卷 437-455页

作者： Li Li Tegawende F.Bissyande hao-yu wang Jacques Klein Faculty of Information Technology Monash University Melbourne 3168 Australia Interdisciplinary Centre for Security Reliability and Trust University of Luxembourg Luxembourg 2721 Luxembourg School of Computer Science Beijing University of Posts and Telecommunications Beijing 100876 China

App updates and repackaging are recurrent in the Android ecosystem,filling markets with similar apps that must be *** the existence of several approaches to improving the scalability of detecting repackaged/cloned apps,researchers and practitioners are eventually faced with the need for a comprehensive pairwise comparison(or simultaneously multiple app comparisons)to understand and validate the similarities among *** this work,we present the design and implementation of our research-based prototype tool called SimiDroid for multi-level similarity comparison of Android *** is built with the aim to support the comprehension of similarities/changes among app versions and among repackaged *** particular,we demonstrate the need and usefulness of such a framework based on different case studies implementing different dissection scenarios for revealing various insights on how repackaged apps are *** further show that the similarity comparison plugins implemented in SimiDroid yield more accurate results than the state of the art.

关键词： Android similarity analysis app clone

A cross-sectional study into the correlation of common household risk factors and allergic rhinitis in Taiwan's tropical environment

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亚太热带医药杂志：英文版 2017年第2期10卷 127-133页

作者： yu-hao wang yu-Chieh wang Pi-Hsiung Wu Lan Hsu Chung-Yang wang Chung-Ren Jan Hsing-hao Su Department of Microbiology and Immunology University of Rochester Department of Biology Wake Forest University Department of Otorhinolaryngology Head and Neck SurgeryKaohsiung Veterans General Hospital Department of Dermatology Kaohsiung Veterans General Hospital Anshing Clinic Department of Medical Education and Research Kaohsiung Veterans General Hospital

Objective:To discuss the effect of lesser-known potential risk factors,such as bedroom showers,on the prevalence of allergic ***:A cross-sectional,population-based study was performed using both survey and fungal culturing in southern *** were 998 participants enrolled in the survey,and 513 sets of fungal culture *** score for allergic rhinitis(SFAR) more than 7,the patient was defined to have allergic *** of allergic rhinitis were calculated as odds ratios for various predicted risk factors by logistic *** between predicted risk factors and fungal level were examined with linear ***:The adjusted odds ratio of frequently using bedroom shower to having allergic rhinitis was 1.572(95% confidence interval:1.090-2.265),and 0.962 for people with older age to have AR(95% confidence interval:0.949-0.976).As to the 24-hour fungal level,the standardized coefficient was 0.254 for frequent use of bedroom shower,and 0.106 for window open ***:Use of bedroom shower is a potential risk factor for allergic rhinitis development.

关键词： Allergic rhinitis Allergens Environment Fungi Indoor air quality

An overview and recent advances in electrocatalysts for direct seawater splitting

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Frontiers of Chemical Science and Engineering 2021年第6期15卷 1408-1426页

作者： hao-yu wang Chen-Chen Weng Jin-Tao Ren Zhong-Yong yuan Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) School of Materials Science and EngineeringNankai UniversityTianjin300350China

In comparison to pure water,seawater is widely accepted as an unlimited *** direct seawater splitting is economical and eco-friendly,but the key challenges in seawater,especially the chlorine-related competing reactions at the anode,seriously hamper its practical *** development of earth-abundant electrocatalysts toward direct seawater splitting has emerged as a promising *** efficient electrocatalysts with improved selectivity and stability are of significance in preventing the interference of side reactions and resisting various *** review first discusses the macroscopic understanding of direct seawater electrolysis and then focuses on the strategies for rational design of electrocatalysts toward direct seawater *** perspectives of improved electrocatalysts to solve emerging challenges and further development of direct seawater splitting are also provided.

关键词： seawater splitting electrocatalysts oxygen evolution reaction hydrogen evolution reaction chlorine chemistry

Application of steam injection in iron ore sintering:fuel combustion efficiency and CO emissions

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Journal of Iron and Steel Research International 2023年第1期30卷 31-39页

作者： Yi-fan wang Tao Yang hao-yu wang Long Ding yun-fei Luo Hong-ming Long School of Metallurgical Engineering Anhui University of TechnologyMa’anshan 243032AnhuiChina Department of Chemical/Biochemical Engineering Western UniversityLondon N6A 5B9OntarioCanada Key Laboratory of Metallurgical Emission Reduction&Resources Recycling(Anhui University of Technology) Ministry of EducationMa’anshan 243002AnhuiChina

Improving the combustion efficiency of fuels is essential to reducing pollutant emissions in the iron ore sintering *** sintering bed surface steam-injection technology has attracted significant research interest for its potential advantages in low-energy consumption and low *** effect of steam injection on fuel combustion efficiency and CO emission was studied by comparing the thermodynamic response from the sintering process before and after steam *** mechanism of improving combustion efficiency was also *** results indicated that the sintering gas medium of H_(2)O-H_(2)-N_(2)-O_(2) with the blown steam improved the heat transfer conditions of fuel combustion and promoted the water gas *** optimum state of steam injection was achieved at 15 min after ignition with 0.02 m^(3) min^(-1).The CO emission reduction is 10.91% compared with the base *** combustion efficiency was 88.83%,6.15% higher than conventional sintering,and the solid fuel consumption was reduced by 1.15 kg t^(-1).It was indicated that steam injection would improve combustion efficiency and reduce solid fuel ***,the steam injection could improve the combustion kinetic conditions in the zone of unburned fuel and low oxygen partial *** was conducive to the reaction of H_(2)O with C and CO to convert the CO of reducing atmosphere to CO_(2),which in turn realized the complete combustion of fuel and CO and improved the efficiency of fuel combustion.

关键词： Sintering Steam injection Fuel Combustion efficiency CO emission