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Genome-wide analysis of Panonychus citrimicro RNAs witha focus on potential insecticidal activity of 4 micro RNAs toeggs and nymphs

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Insect Science 2024年第2期31卷 354-370页

作者： Chuan-Zhen Li yu-hang liu Deng Pan Meng-Hao Xia Qiang Zhang yu-Chuang Li Guo-Rui yuan Jin-Jun Wang Wei Dou Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionAcademy of Agricultural SciencesSouthwestUniversityChongqingChina Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River(Ministry of Education) Academy of Agricultural SciencesSouthwest UniversityChongqingChina

Panonychus citriMcGregor(Acari:Tetranychidae),a destructive citrus pest,causes considerable annual economic losses due to its short lifespan and rapid ***(miRNA)-induced RNA interference is a promising approachfor pest control because of endogenous regulation of pest growth and *** for miRNAs with potential insecticidal activity ***,genome-wide analysis ofmiRNAs at different developmental stages was conducted,resulting in the identificationof 136 miRNAs,including 73 known and 63 novel miRNAs.A total of 17 isomiRNAsand 12 duplicated miRNAs were ***-1 and miR-252-5p were identified asreference miRNAs *** *** on differential expressionanalysis,treatments with miR-let-7a and miR-315 mimics and the miR-let-7a antagomirsignificantly reduced the egg hatch rate and resulted in abnormal egg ***-expression or downregulation of miR-34-5p and miR-305-5p through feeding significantlydecreased the adult eclosion rate and caused molting *** 4 miRNAs,miR-let-7a,miR-315,miR-34-5p,and miR-305-5p,had important regulatory functions and insectici-dal properties in egg hatching and adult *** general,these data advance our un-derstanding of miRNAs in mite biology,which can assist future studies on insect-specificmiRNA-based green pest control technology.

关键词： growth and development microRNAs Panonychus citri referencemiRNAs regulation small RNA libraries

Preparation and Properties of Ultrathin Flexible Expanded Graphite Film via Adding Natural Rubber

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Chinese Journal of Polymer Science 2019年第8期37卷 806-814页

作者： Yan-Ling Mo yu-Xin Tian yu-hang liu Feng Chen Qiang Fu College of Polymer Science and Engineering Sichuan University State Key Laboratory of Polymer Materials Engineering

Expanded graphite(EG) films exhibit potential use in a wide field including thermal management, conductive applications,and electromagnetic interference(EMI) shielding. However, their poor tensile strength and brittleness are crucial deficiencies for commercial applications. To address these defects, in our work, natural rubber(NR) is employed to improve EG films for better mechanical strength and flexibility. The origin of the strengthening effect of EG films by the addition of natural rubber mainly arises from the formation of a simulate shell structure. Compared to the neat EG films, the addition of merely 2 wt% NR can give rise to superior ductility. Further, the loading of 10 wt% NR realizes a significant mechanical enhancement of the EG/NR films, i.e., 2.4 and 11.4 times increase in tensile strength and elongation at break, respectively. Besides, EG/NR films containing 10 wt% NR can still sustain excellent thermal and electric conductivities of 173 W·m^-1·K^-1 and 75 S·cm^-1, respectively. Furthermore, a very high EMI of 41.4 dB is achieved as the film thickness reaches 50 μm. Thus, the lightweight EG/NR films with comprehensive performance as well as their virtue of green and simple large-scale preparation endow them with the possibility of designing next-generation flexible electronics.

关键词： Expanded graphite Natural rubber Composite films Thermal and electric properties

Rapid construction of the tricyclic cores of the abietane- and icetexane-type diterpenoids

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Chinese Chemical Letters 2011年第7期22卷 774-776页

作者： De Lin Chen Xiao yu liu hang Cheng Feng Peng Wang Department of Chemistry of Medicinal Natural Products West China College of Pharmacy Sichuan University Chengdu 610041 China

A short synthesis of the tricyclic 6-6-6 and 6-7-6 ring systems of the abietane- and icetexane-type diterpenoids from a common intermediate is presented, using alkylation and acid-catalyzed cyclization as key steps.

关键词： Abietanes Icetexanes Alkylation Cyclization

IMPULP:A Hardware Approach for In-Process Memory Protection via User-Level Partitioning

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Journal of Computer Science & Technology 2020年第2期35卷 418-432页

作者： Yang-Yang Zhao Ming-yu Chen yu-hang liu Zong-Hao Yang Xiao-Jing Zhu Zong-Hui Hong yun-Ge Guo State Key Laboratory of Computer Architecture Institute of Computing TechnologyChinese Academy of Sciences Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China Peng Cheng Laboratory Shenzhen 518055China

In recent years many security attacks occur when malicious codes abuse in-process memory *** to the increasing complexity,an application program may call third-party code which cannot be controlled by programmers but may contain security *** a result,the users have the risk of suffering information leakage and control flow ***,current solutions like Intel memory protection extensions(MPX)severely degrade performance,while other approaches like Intel memory protection keys(MPK)lack flexibility in dividing security *** this paper,we propose IMPULP,an effective and efficient hardware approach for in-process memory *** rationale of IMPULP is user-level partitioning that user code segments are divided into different security domains according to their instruction addresses,and accessible memory spaces are specified dynamically for each domain via a set of boundary *** instruction related to memory access will be checked according to its security domain and the corresponding boundaries,and illegal in-process memory access of untrusted code segments will be *** can be leveraged to prevent a wide range of in-process memory abuse attacks,such as buffer overflows and memory *** verification,an FPGA prototype based on RISC-V instruction set architecture has been *** present eight tests to verify the effectiveness of IMPULP,including five memory protection function tests,a test to defense typical buffer overflow,a test to defense famous memory leakage attack named Heartbleed,and a test for security *** execute the SPEC CPU2006 benchmark programs to evaluate the efficiency of *** performance overhead of IMPULP is less than 0.2%runtime on average,which is ***,the resource overhead is less than 5.5%for hardware modification of IMPULP.

关键词： in-process isolation memory protection out-of-bounds user-level partitioning

Periprostatic fat thickness measured on MRI correlates with lower urinary tract symptoms,erectile function,and benign prostatic hyperplasia progression

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Asian Journal of Andrology 2021年第1期23卷 80-84页

作者： Bo Zhang Xiang Chen yu-hang liu yu Gan Pei-Hua liu Zhi Chen Wei-Ping Xia Guo-yu Dai Feng Ru Ze-Xiang Jiang Yao He Department of Urology Xiangya HospitalCentral South UniversityChangsha 410008China

This study investigated the correlation between periprostatic fat thickness(PPFT)measured on magnetic resonance imaging and lower urinary tract symptoms,erectile function,and benign prostatic hyperplasia(BPH)progression.A total of 286 treatment-naive men diagnosed with BPH in our department between March 2017 and February 2019 were *** were divided into two groups according to the median value of PPFT:high(PPFT>4.35 mm)PPFT group and low(PPFT<4.35 mm)PPFT *** the initial evaluation,all patients received a combination drug treatment of tamsulosin and finasteride for 12 *** the 286 enrolled patients,244 completed the drug treatment *** with high PPFT had larger prostate volume(PV;P=0.013),higher International Prostate Symptom Score(IPSS;P-0.008),and lower five-item version of the International Index of Erectile Function(IIEF-5)score(P=0.002)than those with low *** high and low PPFT groups showed significant improvements in PV,maximum flow rate,IPSS,and quality of life score and a decrease of IIEF-5 score after the combination drug *** decrease of IIEF-5 score was more obvious in the high PPFT group than that in the low PPFT *** addition,more patients in the high PPFT group underwent prostate surgery than those in the low PPFT ***,Pearson’s correlation coefficient analysis indicated that PPFT was positively correlated with age,PV,and IPSS and negatively correlated with IIEF-5 score;however,body mass index was only negatively correlated with IIEF-5 score.

关键词： benign prostatic hyperplasia clinical progression erectile function lower urinary tract symptoms periprostatic fat thickness

Sustained Ventricular Tachycardia Secondary to Cardiac Metastasis of Lung Cancer

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Chinese Medical Journal 2018年第3期131卷 352-353页

作者： Ying-Ying Li Hua Wang Ya-Dong Cui hang-yu liu Jie-Fu Yang Department of Cardiology Beijing Hospital National Center of Gerontology Beijing 100730 China Department of Radiology Beijing Hospital National Center of Gerontology Beijing 100730 China

Although primary cardiac tumors are rare,cardiac metastasis of malignant tumors is not as infrequent as we might *** pericardium is the most frequently involved site and myocardial involvement is less *** this report,we present the case of a patient with a metastatic tumor on the left ventricular wall secondary to the lung cancer with sustained ventricular tachycardia （VT）.

关键词： MANIFESTATIONS HEART

Development of a novel staging classification for Siewert Ⅱ adenocarcinoma of the esophagogastric junction after neoadjuvant chemotherapy

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2541-2554页

作者： Jian Zhang Hao liu hang yu Wei-Xiang Xu Department of Gastrointestinal Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Stage classification for Siewert Ⅱ adenocarcinoma of the esophagogastric junction(AEG)treated with neoadjuvant chemotherapy(NAC)has not been *** To investigate the optimal stage classification for Siewert Ⅱ AEG with *** A nomogram was established based on Cox regression model that analyzed variables associated with overall survival(OS)and disease-specific survival(DSS).The nomogram performance in terms of discrimination and calibration ability was evaluated using the likelihood-ratio test,Akaike information criterion,Harrell concordance index,time-receiver operating characteristic curve,and decision curve *** Data from 725 patients with Siewert type Ⅱ AEG who underwent neoadjuvant therapy and gastrectomy were obtained from the Surveillance,Epidemiology,and End Results *** and multivariate analyses revealed that sex,marital status,race,ypT stage,and ypN stage were independent prognostic factors of OS,whereas sex,race,ypT stage,and ypN stage were independent prognostic factors for *** factors were incorporated into the OS and DSS *** novel nomogram model performed better in terms of OS and DSS prediction compared to the 8th American Joint Committee of Cancer pathological staging system for esophageal and gastric ***,a user-friendly web application was developed for clinical *** The nomogram established specifically for patients with Siewert type Ⅱ AEG receiving NAC demonstrated good prognostic *** using external data is warranted before its widespread clinical application.

关键词： Stage classification Prognosis Esophagogastric junction cancer Neoadjuvant chemotherapy Siewert type

Highly efficient and stable 2D/3D perovskite solar cells based on surface reconstruction and energy level alignment

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Science China Chemistry 2024年第9期67卷 3083-3090页

作者： Qiaohui Li hang liu Tong Zhou Key Laboratory of Rubber-Plastics Ministry of Education/Shandong Provincial Key Laboratory of Rubber-PlasticsQingdao University of Science and TechnologyQingdao 266042China The Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer Materials Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin 300071China

Realizing simultaneous adjustment of energy levels and work functions in two-dimensional/three-dimensional(2D/3D)perovskite solar cells(PSCs)is a ***,a pseudohalide 3,5-bis(trifluoromethyl)benzylammonium tetrafluoroborate(TFPMABF_(4))was used to react with unreacted Pb I2on the surface of 3D bulky perovskite to form a mixed halide of 2D perovskite denoted(TF-PMA)_(2)FA_(2)Pb_(3)I_(8)(BF_(4))_(2).This novel 2D/3D perovskite enables the simultaneous adjustment of energy levels and work functions on the surface of active *** to the significantly enhanced quality of 2D/3D perovskite film,decreased surface defects and increased charge carrier lifetime,the 2D/3D PSCs exhibit an outstanding power conversion efficiency(PCE)of 25.15%and a high V_(OC)of 1.194 ***,2D/3D PSCs exhibit remarkable enhancements in environmental stability,unencapsulated devices retaining more than 90%of their initial PCE at 50%humidity for 2,280 h.

关键词： 2D/3D perovskite perovskite solar cells organic spacers energy levels alignment

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Patient-derived induced pluripotent stem cells with a MERTK mutation exhibit cell junction abnormalities and aberrant cellular differentiation potential

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World Journal of Stem Cells 2024年第5期16卷 512-524页

作者： hang Zhang Ling-Zi Wu Zhen-yu liu Zi-Bing Jin Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

BACKGROUND Human induced pluripotent stem cell(hiPSC)technology is a valuable tool for generating patient-specific stem cells,facilitating disease modeling,and invest-igating disease ***,iPSCs carrying specific mutations may limit their clinical applications due to certain inherent *** To investigate the impact of MERTK mutations on hiPSCs and determine whether hiPSC-derived extracellular vesicles(EVs)influence anomalous cell junction and differentiation *** We employed a non-integrating reprogramming technique to generate peripheral blood-derived hiPSCs with and hiPSCs without a MERTK ***-somal karyotype analysis,flow cytometry,and immunofluorescent staining were utilized for hiPSC *** and proteomics were employed to elucidate the expression patterns associated with cell junction abnormalities and cellular differentiation ***,EVs were isolated from the supernatant,and their RNA and protein cargos were examined to investigate the involvement of hiPSC-derived EVs in stem cell junction and *** The generated hiPSCs,both with and without a MERTK mutation,exhibited normal karyotype and expressed pluripotency markers;however,hiPSCs with a MERTK mutation demonstrated anomalous adhesion capability and differentiation potential,as confirmed by transcriptomic and proteomic ***,hiPSC-derived EVs were involved in various biological processes,including cell junction and *** HiPSCs with a MERTK mutation displayed altered junction characteristics and aberrant differentiation ***,hiPSC-derived EVs played a regulatory role in various biological processes,including cell junction and differentiation.

关键词： Cell junction Cellular differentiation Extracellular vesicle Human induced pluripotent stem cells Transcriptomics Proteomics