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Carbonic anhydrase-like enzymes in the formation of Lycopodium alkaloid

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Chinese Journal of Natural Medicines 2024年第3期22卷 193-194页

作者： dong Huiwen ge Huiming State key Laboratory of Pharmaceutical Biotechnology Institute of Functional BiomoleculesSchool of Life SciencesNanjing UniversityNanjing 210023China

Plant alkaloids,renowned for their structural diversity and bioactivity,are prominent in both modern and traditional medicine[1].Unraveling the intricacies of plant alkaloid biosynthesis could pave the way for the discovery of new natural products and pathways.It may also shed light on the roles of existing pathways in host biology and provide valuable tools for metabolic engineering in plants and microbes[2].Unlike other major classes of plant natural products,such as terpenoids and polyketides,the formation of alkaloid scaffolds does not conform to a uniform chemical theme or depend on a singular enzyme class[3].A case in point is the Lycopodium alkaloids in the Lycopodiaceae family,where the enzymes responsible for their core scaffold construction remain unidentified[4].

关键词： Lycopodium alkaloid Carbonic anhydrase-like enzymes Biosynthesis

Immune regulation of the gut-brain axis and lung-brain axis involved in ischemic stroke

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Neural Regeneration Research 2024年第3期19卷 519-528页

作者： Xiaodi Xie Lei Wang Shanshan dong ShanChun ge Ting Zhu Institute of Neuroregeneration&Neurorehabilitation Department of PathophysiologySchool of Basic MedicineQingdao UniversityQingdaoShandong ProvinceChina School of Traditional Chinese Pharmacy China Pharmaceutical UniversityNanjingJiangsu ProvinceChina Department of Rehabilitation Medicine The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Local ischemia often causes a series of inflammatory reactions when both brain immune cells and the peripheral immune response are activated.In the human body,the gut and lung are regarded as the key reactional targets that are initiated by brain ischemic attacks.Mucosal microorganisms play an important role in immune regulation and metabolism and affect blood-brain barrier permeability.In addition to the relationship between peripheral organs and central areas and the intestine and lung also interact among each other.Here,we review the molecular and cellular immune mechanisms involved in the pathways of inflammation across the gut-brain axis and lung-brain axis.We found that abnormal intestinal flora,the intestinal microenvironment,lung infection,chronic diseases,and mechanical ventilation can worsen the outcome of ischemic stroke.This review also introduces the influence of the brain on the gut and lungs after stroke,highlighting the bidirectional feedback effect among the gut,lungs,and brain.

关键词： enteric glia cells gut microbiota gut-brain axis immune response inflammation ischemic stroke lung-brain axis microglia

New Exact Travelling Wave Solutions for Zakharov-Kuznetsov Equation

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Communications in Theoretical Physics 2009年第4期51卷 609-612页

作者： MA Hong-Cai yu Yao-dong ge dong-Jie Department of Applied Mathematics College of Science Donghua University Shanghai 201620 China

在这篇论文，非线性的散 Zakharov Kuznetsov 方程被使用概括辅助方程方法解决。作为结果，新独居的模式，独居的波浪和单个独居的波浪，答案被发现。

关键词：辅助方程法精确行波解孤立波解非线性色散方程求解奇异

Quick Hosting Capacity Evaluation Based on Distributed Dispatching for Smart Distribution Network Planning with Distributed generation

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 128-140页

作者： Bing Sun Ruipeng Jing Leijiao ge yuan Zeng Shimeng dong Luyang Hou the School of Electrical and Information Engineering Tianjin UniversityTianjin 300072China State Grid Corporation of China BeijingChina the School of Computer Science(National Pilot Software Engineering School) Beijing University of Posts and TelecommunicationsBeijingChina

The smart distribution network(SDN)is integrat ing increasing distributed generation(DG)and energy storage(ES).Hosting capacity evaluation is important for SDN plan ning with DG.DG and ES are usually invested by users or a third party,and they may form friendly microgrids(MGs)and operate independently.Traditional centralized dispatching meth od no longer suits for hosting capacity evaluation of SDN.A quick hosting capacity evaluation method based on distributed optimal dispatching is proposed.Firstly,a multi-objective DG hosting capacity evaluation model is established,and the host ing capacity for DG is determined by the optimal DG planning schemes.The steady-state security region method is applied to speed up the solving process of the DG hosting capacity evalua tion model.Then,the optimal dispatching models are estab lished for MG and SDN respectively to realize the operating simulation.Under the distributed dispatching strategy,the dual-side optimal operation of SDN-MGs can be realized by several iterations of power exchange requirement.Finally,an SDN with four MGs is conducted considering multiple flexible resources.It shows that the DG hosting capacity of SDN oversteps the sum of the maximum active power demand and the rated branch capacity.Besides,the annual DG electricity oversteps the maximum active power demand value.

关键词： Smart distribution network(SDN) microgrid hosting capacity multi-objective optimization distributed opti mal dispatching flexible resource

Spent graphite regeneration:Exploring diverse repairing manners with impurities-catalyzing effect towards high performance and low energy consumption

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Journal of Energy Chemistry 2024年第4期91卷 656-669页

作者： yu dong Zihao Zeng Zhengqiao yuan Bing Wang Hai Lei Wenqing Zhao Wuyun Ai Lingchao Kong yue Yang Peng ge School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450001HenanChina Shenzhen Xinmao New Energy Technology Co. LTDShenzhen 518100GuangdongChina

Spent battery recycling has received considerable attention because of its economic and environmental potential.A large amount of retired graphite has been produced as the main electrode material,accompanied by a detailed exploration of the repair mechanism.However,they still suffer from unclear repair mechanisms and physicochemical evolution.In this study,spent graphite was repaired employing three methodologies:pickling-sintering,pyrogenic-recovery,and high-temperature sintering.Owing to the catalytic effect of the metal-based impurities and temperature control,the as-obtained samples displayed an ordered transformation,including the interlayer distance,crystalline degree,and grain size.As anodes of lithium ions batteries,the capacity of repaired samples reached up to 310 mA h g^(-1)above after 300loops at 1.0 C,similar to that of commercial graphite.Meanwhile,benefitting from the effective assembly of carbon atoms in internal structure of graphite at>1400℃,their initial coulombic efficiency were>87%.Even at 2.0 C,the capacity of samples remained approximately 244 mA h g^(-1)after 500 cycles.Detailed electrochemical and kinetic analyses revealed that a low temperature enhanced the isotropy,thereby enhancing the rate properties.Further,economic and environmental analyses revealed that the revenue obtained through suitable pyrogenic-recovering manners was approximately the largest value(5500$t^(-1)).Thus,this study is expected to clarify the in-depth effect of different repair methods on the traits of graphite,while offering all-round evaluations of repaired graphite.

关键词： Spent graphite regeneration Repair Temperature treatment

Field-based evidence for the enrichment of intrinsic antibiotic resistome stimulated by plant-derived fertilizer in agricultural soil

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Journal of Environmental Sciences 2024年第1期135卷 728-740页

作者： Shihai Liu Ziming Han dong Zhu Xiao Luan Liujie Deng Liping dong Min Yang yu Zhang State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Environmental Protection Engineering Center for Harmless Treatment and Resource Utilization of Antibiotic Residues Khorgos 835007China University of Chinese Academy of Sciences Beijing 100049China

Animal manures have been demonstrated to enhance antibiotic resistance in agricultural soils.However,little is known about the effects of plant-derived fertilizer on soil antibiotic resistome.Herein,metagenomic sequencing was used to investigate the effects of a plantderived fertilizer processed from sugarcane and beet on soil antibiotic resistance genes(ARGs)in a soybean field along crop growth stages.ARG profiles in the soils amended by plant-derived fertilizer were compared with those in the soils amended by chicken manure.The abundance and diversity of total ARGs in the soils amended by plant-derived fertilizer were significantly(Pge,to a level comparable to that in the manured soils.Whereas,unlike chicken manure mainly introducing manure-borne ARGs to soil,the plant-derived fertilizer was indicated to mainly enrich multidrug resistance genes in soil by nourishing indigenous bacteria.ARGs with abundances in amended soils significantly(Pge of soybean were considered as enriched ARGs.Decrease in the abundance of the enriched ARGs was observed in both the amended soils from the sprout to the harvest.Network analysis further identified Proteobacteria and Bacteroidetes as the primary bacterial taxa involved in the temporal variation of the enriched ARGs in the soils amended by plant-derived fertilizer,while in manured soils were Firmicutes and Actinobacteria.As revealed by multivariate statistical analyses,variation of the enriched ARGs in the soils amended by plant-derived fertilizer was majorly attributed to the response of co-occurred bacteria to depleting nutrients,which was different from the failed establishment of manure-borne bacteria in the manured soils.Our study provided field-based evidence that plant-derived fertilizer stimulated the intrinsic antibiotic resistome,and proposed attention to the un-perceived risk since some clinically relevant ARGs originate and evolve from natural resistome.

关键词： Organic fertilizer Intrinsic antibiotic resistance Indigenous bacteria Metagenomic sequencing

Tumor microenvironment-responsive arsenic-loaded layered double hydroxides film with synergistic anticancer and bactericidal activity

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Rare Metals 2024年第3期43卷 1207-1221页

作者： Shun Xing dong-Hui Wang Hai-Feng Zhang Li-Dan Liu Cheng-Ce Li Chao Wei Jun-yu Liu Nai-Jian ge Xuan-Yong Liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China Intervention Center Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai200438China School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjin300130China

Malignant obstruction makes gallbladder cancer have a high mortality rate.Nickel-titanium alloy(nitinol)stents are commonly used as a local intervention to maximize patient survival time,but the stents lack antitumor and antibacterial capacity and are vulnerable to secondary obstruction.Arsenic-based drugs show good therapeutic promise against gallbladder cancer.To meet clinical needs.the layered double hydroxides(LDHs)film is constructed on the nitinol,whose arsenite loading amounts rose by 60%after simple heat treatment compared with the conventional anion-exchange strategy.In addition,calcination promotes the dissolution of nickel ions from the LDHs lattice,resulting in a powerful synergistic killing effect on tumor cells together with the released arsenic.More importantly,the calcined arsenic-loaded LDHs are sensitive to the acidic microenvironment of tumor tissues,which presents a much lower arsenic and nickel release amount in the normal tissues,guaranteeing its biosafety.Meanwhile,the vertically sharp LDHs nanosheets can synergize with arsenic to achieve effective physical cleavage and chemical killing of adherent and planktonic bacteria.In short,we attempt to use arsenic drugs for local interventions and reasonably avoid their toxic side effects,which provides a new design idea for nitinol stents applied in the treatment of gallbladder cancer.

关键词： Nitinol Layered double hydroxides Arsenic Gallbladder cancer

Investigation on the vortical structures by the Liutex method in turbulent channels at Re_(τ)=180 with scalloped and triangular riblet control

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Journal of Hydrodynamics 2024年第1期36卷 35-52页

作者： Zhang-dan yu Shang Jiang Hai-dong yu Bi-yu Pang Xin dong Yi-qian Wang School of Mathematical Sciences Soochow UniversitySuzhou215006China Beijing Institute of Astronautical System Engineering Beijing100076China

Riblets are a series of small protrusions formed along the flow direction,which have been extensively studied as a passive turbulent drag reduction technique.Experiments and numerical simulations have shown that well-designed riblets can significantly reduce drag in turbulent flows,making them highly promising and valuable for various applications.In this study,we focus on a scalloped riblet,which is designed by smoothly connecting two third-order polynomials,and thus the sharpness of the tip and the curvature of the valley can be well defined.We conduct direct numerical simulations of turbulent channel with smooth plate,scalloped riblet-mounted and triangular riblet-mounted walls.Width in wall units of W^(+)=20 and height-width ratio ofγ=0.5 are selected for both riblet cases.Compared with the smooth plate case,the scalloped riblet case achieves an 8.68%drag reduction,while the triangular riblet case achieves a 4.79%drag reduction.The obtained drag reduction rate of the triangular riblet is consistent with previous experiments and simulations,and the results indicate that the scalloped riblet is more effective in reducing drag and deserves further investigation.We compare turbulent statistics of the scalloped riblet case with those of the triangular riblet case.The mean velocity profiles of riblets are similar,but both the Reynolds shear stress and second-order statistics of velocity fluctuations and Liutex are significantly reduced in the scalloped riblets controlled turbulent channel,indicating that the scalloped riblet can more effectively suppress the spanwise and wall-normal turbulent intensity near the wall.We also compare the pre-multiplied spectra of streamwise velocity and streamwise Liutex component for the three cases to investigate the energy distribution and characteristics of Liutex distribution.The Liutex vortex identification method is also utilized to analyze the instantaneous flow field,which provides insights into the flow field and could be beneficial for the further optimization of riblet.

关键词： Liutex vector riblet drag reduction tip sharpness turbulent channel scalloped

Novel variants in DNAH6 cause male infertility associated with multiple morphological abnormalities of the sperm flagella(MMAF)and ICSI outcomes

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Asian Journal of Andrology 2024年第1期26卷 91-98页

作者： Zhong-Mei Shao yu-Tong Zhu Meng Gu Sen-Chao Guo Hui yu Kuo-Kuo Li dong-dong Tang yu-Ping Xu Ming-Rong Lv Reproductive Medicine Center Department of Obstetrics and Gynecologythe First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Obstetrics and Gynecology Fuyang Hospital of Anhui Medical UniversityFuyang 236112China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract(Anhui Medical University) Hefei 230032China Key Laboratory of Population Health Across Life Cycle(Anhui Medical University) Ministry of Education of the People'sRepublicof ChinaHefei 230032China

Variations in the dynein axonemal heavy chain gene,dynein axonemal heavy chain 6(DNAH6),lead to multiple morphological abnormalities of the flagella.Recent studies have reported that these deficiencies may result in sperm head deformation.However,whether DNAH6 is also involved in human acrosome biogenesis remains unknown.The purpose of this study was to investigate DNAH6 gene variants and their potential functions in the formation of defective sperm heads and flagella.Whole-exome sequencing was performed on a cohort of 375 patients with asthenoteratozoospermia from the First Affiliated Hospital of Anhui Medical University(Hefei,China).Hematoxylin and eosin staining,scanning electron microscopy,and transmission electron microscopy were performed to analyze the sperm morphology and ultrastructure.Immunofluorescence staining and Western blot analysis were conducted to examine the effects of genetic variants.We identified three novel deleterious variants in DNAH6 among three unrelated families.The absence of inner dynein arms and radial spokes was observed in the sperm of patients with DNAH6 variants.Additionally,deficiencies in the acrosome,abnormal chromatin compaction,and vacuole-containing sperm heads were observed in these patients with DNAH6 variants.The decreased levels of the component proteins in these defective structures were further confirmed in sperm from patients with DNAH6 variants using Western blot.After intracytoplasmic sperm injection(ICSl)treatment,the partner of one patient with a DNAH6 variant achieved successful pregnancy.Overall,novel variants in DNAH6 genes that contribute to defects in the sperm head and flagella were identified,and the findings indicated Icsl as an effective clinical treatment for such patients.

关键词： asthenoteratospermia DNAH6 intracytoplasmic sperm injection male infertility