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Heme oxygenase-1 and gut ischemia/reperfusion injury: A short review

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World Journal of Gastroenterology 2013年第23期19卷 3555-3561页

作者： yu-feng liao Wei Zhu Dong-Pei Li Xiao Zhu Department of Laboratory Medicine Ningbo No.2 Hospital Molecular Pathology Platform Key Laboratory of Molecular Diagnosis Guangdong Medical College Institute of Molecular Medicine and Genetics Georgia Health Sciences University

Ischemia/reperfusion (I/R) injury of the gut is a significant problem in a variety of clinical settings and is associated with a high morbidity and mortality. Although the mechanisms involved in the pathogenesis of gut I/R injury have not been fully elucidated, it is generally believed that oxidative stress with subsequent inflammatory injury plays an important role. Heme oxygenase (HO) is the rate-limiting enzyme in the catabolism of heme, followed by production of CO, biliverdin, and free iron. The HO system is believed to confer cytoprotection by inhibiting inflammation, oxidation, and apoptosis, and maintaining microcirculation. HO-1, an inducible form of HO, serves a vital metabolic function as the rate-limiting step in the heme degradation pathway, and affords protection in models of intestinal I/R injury. HO-1 system is an important player in intestinal I/R injury condition, and may offer new targets for the management of this condition.

关键词： Heme oxygenase Ischemia/reperfusion injury Oxidative stress Cytoprotection Gut

Development of a nomogram for overall survival in patients with esophageal carcinoma:A prospective cohort study in China

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 158-168页

作者： Shi-Shi yu Xi Zheng Xiao-Sheng Li Qian-Jie Xu Wei Zhang Zhong-Li liao Hai-Ke Lei Department of Gastroenterology Chongqing University Cancer HospitalChongqing 400030China Chongqing Cancer Multi-omics Big Data Application Engineering Research Center Chongqing University Cancer HospitalChongqing 400030China Department of Health Statistics School of Public HealthChongqing Medical UniversityChongqing 400016China

BACKGROUND Esophageal carcinoma(EC)presents a significant public health issue in China,with its prognosis impacted by myriad *** creation of a reliable prog-nostic model for the overall survival(OS)of EC patients promises to greatly advance the customization of treatment *** To create a more systematic and practical model that incorporates clinically significant indicators to support decision-making in clinical *** This study utilized data from a prospective longitudinal cohort of 3127 EC patients treated at Chongqing University Cancer Hospital between January 1,2018,and December 12,*** the least absolute shrinkage and selection operator regression alongside multivariate Cox regression analyses helped pinpoint pertinent variables for constructing the *** efficacy was assessed by concordance index(C-index),area under the receiver operating characteristic curve(AUC),calibration curves,and decision curve analysis(DCA).RESULTS Nine variables were determined to be significant predictors of OS in EC patients:Body mass index(BMI),Karnofsky performance status,TNM stage,surgery,radiotherapy,chemotherapy,immunotherapy,platelet-to-lymphocyte ratio,and albumin-to-globulin ratio(ALB/GLB).The model demonstrated a C-index of 0.715(95%CI:0.701-0.729)in the training cohort and 0.711(95%CI:0.689-0.732)in the validation *** the training cohort,AUCs for 1-year,3-year,and 5-year OS predictions were 0.773,0.787,and 0.750,respectively;in the validation cohort,they were 0.772,0.768,and 0.723,respectively,illustrating the model's *** curves and DCA verified the model's predictive accuracy and net *** A novel prognostic model for determining the OS of EC patients was successfully developed and validated to help clinicians in devising individualized treatment schemes for EC patients.

关键词： Esophageal carcinoma High-risk factors Prognosis Overall survival Prediction model

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骨科机器人的发展应用及前景

军事医学 2016年第12期40卷 1003-1008页

作者：邵泽宇徐文峰廖晓玲谢文月重庆科技学院冶金与材料工程学院生物材料与活细胞影像技术研究所纳微复合材料与器件重庆市重点实验室重庆401331

骨科机器人是医疗领域的新兴产业,主要用于微创、精确治疗,可提供精确手术导航和规划,是当前骨科临床治疗的重要发展方向。骨科机器人可分为关节外科、整骨科、脊柱外科和创伤骨科几种,该文对其国内外发展与特点进行了介绍,并结合影像... 详细信息

骨科机器人是医疗领域的新兴产业,主要用于微创、精确治疗,可提供精确手术导航和规划,是当前骨科临床治疗的重要发展方向。骨科机器人可分为关节外科、整骨科、脊柱外科和创伤骨科几种,该文对其国内外发展与特点进行了介绍,并结合影像学技术与临床反馈分析骨科机器人在各领域的发展方向,讨论了骨科机器人的未来趋势,并提出了展望。

关键词：外科机器人关节外科脊柱外科整骨疗科创伤骨科

Near-infrared brain functional characteristics of mild cognitive impairment with sleep disorders

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World Journal of Psychiatry 2025年第1期15卷 106-116页

作者： Heng liao Sha liao yu-Jiao Gao Xi Wang Li-Hong Guo Su Zheng Wu Yang Yi-Nan Dai Sleep Psychosomatic Medicine Center Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Integrated Chinese and Western Medicine Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Orthopaedics Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Rehabilitation Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina

BACKGROUND Mild cognitive impairment(MCI)has a high risk of progression to Alzheimer’s *** disease is often accompanied by sleep disorders,and whether sleep disorders have an effect on brain function in patients with MCI is *** To explore the near-infrared brain function characteristics of MCI with sleep *** A total of 120 patients with MCI(MCI group)and 50 healthy subjects(control group)were *** subjects underwent the functional near-infrared spec-troscopy *** baseline data,Mini-Mental State Examination,Montreal Cognitive Assessment scale,fatigue severity scale(FSS)score,sleep parameter,and oxyhemoglobin(Oxy-Hb)concentration and peak time of functional near-infrared spectroscopy test during the task *** relationship between Oxy-RESULTS Compared with the control group,the FSS score of the MCI group was higher(t=11.310),and the scores of Pittsburgh sleep quality index,sleep time,sleep efficiency,nocturnal sleep disturbance,and daytime dysfunction were higher(Z=-10.518,-10.368,-9.035,-10.661,-10.088).Subjective sleep quality and total sleep time scores were lower(Z=-11.592,-9.924).The sleep efficiency of the MCI group was lower,and the awakening frequency,rem sleep latency period,total sleep time,and oxygen desaturation index were higher(t=5.969,5.829,2.887,3.003,5.937).The Oxy-Hb concentration at T0,T1,and T2 in the MCI group was lower(t=14.940,11.280,5.721),and the peak time was higher(t=18.800,13.350,9.827).In MCI patients,the concentration of Oxy-Hb during T0 was negatively correlated with the scores of Pittsburgh sleep quality index,sleep time,total sleep time,and sleep efficiency(r=-0.611,-0.388,-0.563,-0.356).It was positively correlated with sleep efficiency and total sleep time(r=0.754,0.650),and negatively correlated with oxygen desaturation index(r=-0.561)and FSS score(r=-0.526).All comparisons were P<*** Patients with MCI and sleep disorders have lower near-infrared brain function than norm

关键词： Mild Cognitive impairment Sleep disorders Near-infrared Brain functional Characteristics

后2020时期临界贫困群体的识别及影响机理研究——基于重庆市3117份农户样本的实证

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西南大学学报（自然科学版） 2025年第1期47卷 134-146页

作者：蔡进冯朝晖张宇禹洋春廖和平李斌重庆工商大学公共管理学院重庆400067 重庆工商大学工商管理学院重庆400067 西南大学地理科学学院重庆400715

临界贫困群体作为巩固脱贫攻坚时期及乡村振兴中农户返贫的潜在增量,研究其内涵、识别方法和影响机理对构建农村贫困长效治理机制具有重要意义。在阐释临界贫困内涵的基础上,构建了临界贫困群体的识别指标体系,运用全排列多边形综合图... 详细信息

临界贫困群体作为巩固脱贫攻坚时期及乡村振兴中农户返贫的潜在增量,研究其内涵、识别方法和影响机理对构建农村贫困长效治理机制具有重要意义。在阐释临界贫困内涵的基础上,构建了临界贫困群体的识别指标体系,运用全排列多边形综合图示法、中位数比例法和Dagum基尼系数,基于重庆市3117份农户样本,对临界贫困群体的识别及影响机理进行了实证研究。研究结果表明:样本农户的多维临界贫困指数整体较低,且呈现正态分布特征,介于0.257和0.839之间;从3117份一般户样本中识别出330户临界贫困户,临界贫困发生率为10.59%;在15个探测指标因素中,海拔、耕地流转情况、文化程度、劳动力数量、医疗教育负担、到场镇距离、疫情灾情影响、政策满意度、政策期望值9个指标因素与样本农户临界贫困群体在不同水平下具有统计学意义。外部环境因素中区域资源禀赋匮乏、外部机会获取偏少和地方政策支撑薄弱,内部个体因素中农户个体能力较弱、内生动力不足和家庭个体水平较差是造成临界贫困的主要因素。地方政府应规范相对贫困人口识别标准和程序,构建防止返贫致贫的动态监测预警以及农村低收入人口的帮扶机制,建立分类管理、分类帮扶、分类施策机制。

关键词：后2020时期临界贫困影响机理重庆市

单层Cs_(2)PbI_(2)Cl_(2)中点缺陷的形成与稳定性

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原子与分子物理学报 2025年第5期42卷 130-136页

作者：何诗颖赵宇清邹代峰许英廖雨洁禹卓良湖南科技大学物理与电子科学学院湘潭411201 智能传感器与新型传感器材料湖南省重点实验室湘潭411201 湖南理工学院物理与电子科学学院岳阳414006

Cs_(2)PbI_(2)Cl_(2)是卤化铅钙钛矿材料的新成员,由于其高的光吸收系数和长的载流子迁移距离等优异的光电物理性能,在太阳能电池、光电探测器、场效应晶体管以及发光二极管等领域受到广泛的关注.其中光电材料及器件的优良特性由电子结... 详细信息

Cs_(2)PbI_(2)Cl_(2)是卤化铅钙钛矿材料的新成员,由于其高的光吸收系数和长的载流子迁移距离等优异的光电物理性能,在太阳能电池、光电探测器、场效应晶体管以及发光二极管等领域受到广泛的关注.其中光电材料及器件的优良特性由电子结构决定,而钙钛矿的点缺陷对电子结构具有重要的调控,且单层Cs_(2)PbI_(2)Cl_(2)中点缺陷的研究尚且缺乏.本文基于密度泛函理论的第一性原理计算,对单层Cs_(2)PbI_(2)Cl_(2)的铯空位、碘空位、氯空位、铯替代铅、碘替代铯、碘替代铅、碘替代氯、氯替代铯、氯替代铅和氯替代碘的缺陷形成能和稳定性进行了研究.结果表明:在富铅和缺铅条件下,碘替代氯和氯替代碘的缺陷形成能偏低,且氯替代碘能有效降低体系总能,提高体系稳定性.在缺铅条件下铯空位缺陷形成能低于富铅条件,在缺铅条件下更易形成铯空位;富铅和缺铅条件下对碘替代氯和氯替代碘的缺陷形成能基本无影响.上述研究结果有助于理解点缺陷对钙钛矿材料稳定性的影响,同时也为未来实验上设计基于Cs_(2)PbI_(2)Cl_(2)的高效的光电子器件提供理论依据.

关键词：单层Cs_(2)PbI_(2)Cl_(2) 形成能点缺陷稳定性

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体相二硫化铼中点缺陷的形成与稳定性

原子与分子物理学报 2025年第5期42卷 143-150页

二硫化铼是过渡金属二硫族化合物的成员,由于层间的范德华作用、合适的带隙、高的光吸收系数和长的载流子迁移距离在光电子研究领域引起广泛的关注.其中光电材料及器件的优良特性由电子结构决定,而半导体的缺陷能级对电子结构具有重要... 详细信息

二硫化铼是过渡金属二硫族化合物的成员,由于层间的范德华作用、合适的带隙、高的光吸收系数和长的载流子迁移距离在光电子研究领域引起广泛的关注.其中光电材料及器件的优良特性由电子结构决定,而半导体的缺陷能级对电子结构具有重要的调控,且体相二硫化铼的缺陷研究尚且缺乏.本文基于密度泛函理论的第一性原理计算,对体相二硫化铼的铼空位、硫空位、钨掺杂(或替代)铼、钨掺杂硫、锝掺杂铼和锝掺杂硫的缺陷形成能和稳定性进行了研究.结果表明:钨掺杂硫和锝掺杂硫形成深施主能级缺陷,铼空位形成浅施主能级缺陷.在富铼和富硫条件下,钨掺杂铼的缺陷形成能低且能有效降低体系总能,提高体系稳定性.钨掺杂硫的缺陷虽然能降低体系的总能提高二硫化铼的稳定性,但较大的缺陷形成能表明钨掺杂硫缺陷难以形成.上述研究结果有助于理解缺陷能级对半导体深浅能级和稳定性的影响,同时也为未来实验上设计基于二硫化铼的高效的光电子器件提供理论依据.

关键词：体相二硫化铼形成能缺陷能级稳定性

An adaptive switching scheme for iterative computing in the cloud

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Frontiers of Computer Science 2014年第6期8卷 872-884页

作者： yu ZHANG Xiaofei liao Hai JIN Li LIN feng LU Service Computing Technology and System Lab Cluster and Grid Computing Lab School of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074 China

Delta-based accumulative iterative computation （DAIC） model is currently proposed to support iterative algorithms in a synchronous or an asynchronous way. However, both the synchronous DAIC model and the asynchronous DAIC model only satisfy some given conditions, respectively, and perform poorly under other conditions either for high synchronization cost or for many redundant activations. As a result, the whole performance of both DAIC models suffers from the serious network jitter and load jitter caused by multi- tenancy in the cloud. In this paper, we develop a system, namely Hyblter, to guarantee the performance of iterative algorithms under different conditions. Through an adaptive execution model selection scheme, it can efficiently switch between synchronous and asynchronous DAIC model in order to be adapted to different conditions, always getting the best performance in the cloud. Experimental results show that our approach can improve the performance of current solutions up to 39.0%.

关键词： iterative algorithm computational skew communication skew cloud delta-based accumulative iterative computation

Plasmonic-photonic cavity for high-efficiency single-photon blockade

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Science China(Physics,Mechanics & Astronomy) 2021年第7期64卷 98-107页

作者： yu-Wei Lu Jing-feng Liu Zeyang liao Xue-Hua Wang State Key Laboratory of Optoelectronic Materials and Technologies School of PhysicsSun Yat-sen UniversityGuangzhou510275China College of Electronic Engineering South China Agricultural UniversityGuangzhou510642China

The generation and manipulation of single photons are crucial in advanced quantum technologies, such as quantum communication and quantum computation devices. High-purity single photons can be generated from classical light using the single-photon blockade(1 PB). However, the efficiency and purity are exclusive in 1 PB, which hinders its practical applications. Here, we show that the resonantly coupled plasmonic-photonic cavity can boost the efficiency of single-photon generation by more than three orders of magnitude compared with that of all-dielectric microcavity. This significant improvement is attributed to two new mechanisms of atom-microcavity coupling after introducing the plasmonic cavity: the formation of a quasi-bound state and the transition to the nonreciprocal regime, due to the destructive interference between the coupling pathways and the nonzero relative phase of the closed-loop coupling, respectively. The quasi-bound state has a relatively small decaying, while its effective coupling strength is significantly enhanced. Suppressing the dissipative component of the effective atom-microcavity coupling in the nonreciprocal regime can further improve single-photon performance, particularly without temporal oscillations. Our study demonstrates the possibility of enhancing the intrinsically low efficiency of 1 PB in low excitation regime, and unveils the novel light-matter interaction in hybrid cavities.

关键词： single-photon blockade atom-photon quasi-bound state plasmonic-photonic cavity