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Novel subtype of obesity influencing the outcomes of sleeve gastrectomy:Familial aggregation of obesity

World Journal of Gastroenterology 2024年第13期30卷 1887-1898页

作者： Ze-yu Wang yun-fei Qu Tian-Ming yu Zeng-Lin Liu yu-Gang Cheng Ming-Wei Zhong San-yuan Hu Department of General Surgery The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan HospitalJinan 250000Shandong ProvinceChina Department of Postgraduate Shandong First Medical University and Shandong Academy of Medical SciencesJinan 250000Shandong ProvinceChina Department of General Surgery Shandong Provincial Qianfoshan HospitalCheeloo College of Medicine Shandong UniversityJinan 250000Shandong ProvinceChina State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine Lunan Pharmaceutical Group Co.Ltd.Linyi 276005Shandong ProvinceChina

BACKGROUND Differences in the preoperative characteristics and weight loss outcomes after sleeve gastrectomy(SG)between patients with familial aggregation of obesity(FAO)and patients with sporadic obesity(SO)have not been *** To explore the impact of SG on weight loss and the alleviation of obesity-related comorbidities in individuals with *** A total of 193 patients with obesity who underwent SG were *** with FAO/SO were matched 1:1 by propensity score matching and were categorized into 4 groups based on the number of first-degree relatives with obesity(1 SO vs 1FAO,2SO vs 2FAO).The baseline characteristics,weight loss outcomes,prevalence of obesity-related comorbidities and incidence of major surgeryrelated complications were compared between *** We defined FAO as the presence of two or more first-degree relatives with *** with FAO did not initially show significant differences in baseline data,short-term postoperative weight loss,or obesity-related comorbidities when compared to patients with SO ***,distinctions between the two groups became evident at the two-year mark,with statistically significant differences in both percentage of total weight loss(P=0.006)and percentage of excess weight loss(P<0.001).The FAO group exhibited weaker remission of type 2 diabetes mellitus(T2DM)(P=0.031),hyperlipidemia(P=0.012),and non-alcoholic fatty liver disease(NAFLD)(P=0.003)as well as a lower incidence of acid reflux(P=0.038).CONCLUSION FAO patients is associated with decreased mid-to-long-term weight loss outcomes;the alleviation of T2DM,hyperlipidemia and NAFLD;and decreased incidence of acid reflux postoperatively.

关键词： Obesity Bariatric surgery Sleeve gastrectomy Family history Weight loss

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Comparative analysis of thermodynamic and mechanical responses between underground hydrogen storage and compressed air energy storage in lined rock caverns

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International Journal of Mining Science and Technology 2024年第4期34卷 531-543页

作者： Bowen Hu Liyuan yu Xianzhen Mi fei Xu Shuchen Li Wei Li Chao Wei Tao Zhang State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China Key Laboratory of Large Structure Health Monitoring and Control Shijiazhuang Tiedao UniversityShijiazhuang 050043China School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou 221116China

Underground hydrogen storage(UHS)and compressed air energy storage(CAES)are two viable largescale energy storage technologies for mitigating the intermittency of wind and solar ***,it is meaningful to compare the properties of hydrogen and air with typical thermodynamic storage *** study employs a multi-physical coupling model to compare the operations of CAES and UHS,integrating gas thermodynamics within caverns,thermal conduction,and mechanical deformation around rock *** thermodynamic responses are validated using additional simulations and the field test *** and pressure variations of air and hydrogen within rock caverns exhibit similarities under both adiabatic and diabatic simulation *** reaches higher temperature and pressure following gas charging stage compared to air,and the ideal gas assumption may lead to overestimation of gas temperature and *** steel lining of CAES,the sealing layer(fibre-reinforced plastic FRP)in UHS is prone to deformation but can effectively mitigates stress in the sealing *** CAES,the first principal stress on the surface of the sealing layer and concrete lining is tensile stress,whereas UHS exhibits compressive stress in the same *** present research can provide references for the selection of energy storage methods.

关键词： Underground hydrogen storage Compressed air energy storage Mechanical response Thermodynamic response Lined rock caverns

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Rational design of metal selenides nanomaterials for alkali metal ion(Li^(+)/Na^(+)/K^(+))batteries:current status and perspectives

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Rare Metals 2024年第5期43卷 1906-1931页

作者： Rui Sun Feng Xu Cai-Hong Wang Sheng-Jun Lu yu-fei Zhang Hao-Sen Fan College of Materials Science and Metallurgy Engineering Guizhou UniversityGuiyang550025China School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou510006China

Recently,metal selenides have obtained widespread attention as electrode materials for alkali(Li^(+)/Na^(+)/K^(+))batteries due to their promising theoretical capacity and ***,metal selenides,similar to metal oxides and sulfides,also suffer from severe volume explosion during repeated charge/discharge processes,which results in the structure collapse and the following pulverization of electrode ***,it leads to poor cycle stability and influencing their further *** order to solve these issues,some special strategies,including elemental doping,coupling with carbon materials,synthesis of the bimetal selenides with heterostructure,etc.,have been gradually applied to design novel electrode materials with outstanding electrochemical ***,the recent research progress on metal selenides as anodes for alkali ion batteries is summarized,including the regulation of crystal structure,synthesis strategies,modification methods,and electrochemical mechanisms and ***,the challenges of metal selenides and the perspective for future electrode material design are *** is hoped to pave a way for the development of metal selenide electrode materials for the potential applications for alkali metal ion(Li^(+)/Na^(+)/K^(+))batteries.

关键词： Rational design Metal selenides Nanostructure Li^(+) batteries Na^(+) batteries K^(+) batteries

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Intelligent design and construction of novel APN-based theranostic probe driven by advanced computational methods

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Chinese Chemical Letters 2024年第2期35卷 352-357页

作者： Yingli Zhu Jie Qian Kunqian yu Jing Hou Yeshuo Ma fei Chen Jie Dong Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410083China National Engineering Research Center of Rice and Byproduct Deep Processing School of Food Science and EngineeringCentral South University of Forestry and TechnologyChangsha 410004China State Key Laboratory of Drug Research Drug Discovery and Design CenterShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Geriatrics Third Xiangya HospitalCentral South UniversityChangsha 410013China

Multifunctional molecules with both optical signal and pharmacological activity play an important role in drug development,disease diagnosis,and basic theoretical *** N(APN),as a representative tumor biomarker with anti-tumor potential,still lacks a high-precision theranostic probe specifically targeting *** this study,a novel quaternity design strategy for APN theranostic probe was *** proposed strategy utilizes advanced machine learning and molecular dynamics simulations,and cleverly employs the strategy of conformation-induced fluorescence recovery to achieve multi-objective optimization and integration of functional *** this strategy,a unique“Off-On”theranostic probe,ABTP-DPTB,was ingeniously constructed to light up APN through fluorescence restoration,relying on conformation-induced effects and solvent *** from the common diagnostic probes,the intelligent design with non-substrated linkage makes ABTP-DPTB for long-term in-situ *** fabricated probe was used for detecting and inhibiting APN in various environments,with a better in vitro inhibitory than golden-standard drug bestatin.

关键词： Theranostic probe Artificial intelligence Conformational restriction Fluorescence restoration Design strategy

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Vaccinia virus viability under different environmental conditions and different disinfectants treatment

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Biosafety and Health 2024年第1期6卷 21-27页

作者： Shan Mei Liang Wei yu Xie fei Zhao yu Huang Zhangling Fan Yamei Hu Liming Wang Lingwa Wang Ying Wang Fengwen Xu fei Guo NHC Key Laboratory of Systems Biology of Pathogens National Institute of Pathogen Biology and Center for AIDS ResearchChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Otolaryngology Head and Neck Surgery Beijing Tongren HospitalCapital Medical UniversityBejing 100730China Clinical Laboratory Emergency General HospitalBeijing 100028China

Monkeypox(mpox)outbreak in 2022 has caused more than 91,000 cases,has spread to 115 countries,regions,and territories,and has thus attracted much *** stability of poxvirus particles in the environment is recognized as an important factor in determining their ***,few studies have investigated the persistence of poxviruses on material surfaces under various environmental conditions,and their sensitivity to ***,we systematically measured the stability of vaccinia virus(VACV)under different environmental conditions and sensitivity to inactivation methods via plaque assay,quantitative real‐time polymerase chain reaction(qPCR),and Gaussia luciferase(G‐luciferase)reporter *** results show that VACV is stable on the surface of stainless steel,glass,clothing,plastic,towel,A4 paper,and tissue and persists much longer at 4℃ and?20℃,but is effectively inactivated by ultraviolet(UV)irradiation,heat treatment,and chemical *** study raises the awareness of long persistence of poxviruses in the environment and provides a simple solution to inactivate poxviruses using common disinfectants,which is expected to help the control and prevention of mpox virus and future poxvirus outbreaks.

关键词： Poxvirus Mpox virus Vaccinia virus Persistence Disinfectant

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Portable fluorescence instrument for detecting membrane integrity in membrane bioreactor (MBR)

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Frontiers of Environmental Science & Engineering 2024年第2期18卷 121-131页

作者： Yang yu Changchun Xin yuxiang Liu fei Gao Lei Zhang Hui Jia Jie Wang State Key Laboratory of Separation Membranes and Membrane Processes Tiangong UniversityTianjin 300387China School of Environmental Science and Engineering Tiangong UniversityTianjin 300387China School of Environmental Science and Engineering Tianjin UniversityTianjin 300072China Shenyang Academy of Environmental Sciences Shenyang 110167China Cangzhou Institute of Tiangong University Tiangong UniversityCangzhou 061000China

This study proposed the design, fabrication, and assembly of membrane integrity detection instruments in membrane bioreactors (MBR) based on fluorescence spectroscopy. Based on the PARAFAC model, we found that the peak at 280/335 nm strengthened after membrane breakage. The peak at 340/430 nm reflected the sludge concentration in the MBR and reduced the influence of internal filtration effects on detection. Therefore, we determined that the dual-LED light source excitation detection system can detect tryptophan-like substances at 280 nm (T-peak) and humic acid at 340 nm (C-peak). T-peak was identified as the core index indicating membrane integrity. Moreover, the C-peak is the reference indicator factor for a sensitive response to changes in the sludge concentration. The portable fluorescence instrument exhibited high sensitivity and good feedback accuracy compared to particle counting and turbidity detection, where the log reduction value was greater than 3.5. This overcomes the disadvantage of false alarms in particle counters and is not affected by the position of the pump system. This portable instrument provides a flexible and highly sensitive method for the assessment of industrial membrane integrity.

关键词： Membrane integrity Fluorescence spectrum Portable instrument Membrane bioreactor

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Nanocomposite: Keggin-type Co_(4)-polyoxometalate@cobaltporphyrin linked graphdiyne for hydrogen evolution in seawater

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Nano Research 2024年第3期17卷 1281-1287页

作者： Jiejie Ping Danyang He fei Wang Nan Wang Yi-cheng Fu Zihao Xing Zhiyu Jia Guo-yu Yang Key Laboratory of Cluster Science Ministry of EducationSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Facluty of Chmeistry Northeast Normal UniversityChangchun 130024China Peking University Third Hospital Beijing 100190China

Polyoxometalate-based nanocomposites with electrocatalytic activity have been applied in hydrogen evolution reactions(HER).Seawater as the main water resource on the earth should be developed as the water electrolysis to prepare high-purity *** this paper,we used two synthesis strategies to prepare the nanocomposite Co_(4)-POM@Co-PGDY(Co_(4)-POM:the Kegging-type microcrystals of K_(10)[Co_(4)(PW_(9)O_(3)4)2]and Co-PGDY:cobalt-porphyrin linked graphdiyne)with excellent activity for ***-PGDY as the porous material is applied not only as the protection of microcrystals towards the metal ion in seawater but also as the co-electrocatalyst of Co_(4)-***_(4)-POM@Co-PGDY exhibits excellent HER performance in seawater electrolytes with low overpotential and high stability at high ***,we have observed a key H_(3)O+intermediate emergence on the surface of nanocomposite during hydrogen evolution process in seawater by Raman synchrotron radiation-based Fourier transform infrared(SR-FTIR).The results in this paper provide an effective strategy for preparing polyoxometalate-based electrocatalysts with high-performance toward hydrogen evolution reaction.

关键词： polyoxometalate graphdiyne seawater hydrogen evolution reaction

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MACS-W:A modified optical clearing agent for imaging 3D cell cultures

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Journal of Innovative Optical Health Sciences 2024年第2期17卷 24-34页

作者： Xiang Zhong Chao Gao Hui Li yuening He Peng fei Zaozao Chen Zhongze Gu Dan Zhu Tingting yu Britton Chance Center for Biomedical Photonics-MoE Key Laboratory for Biomedical Photonics Huazhong University of Science and Technology Wuhan Hubei 430074P.R.China Wuhan National Laboratory for Optoelectronics-Advanced Biomedical Imaging Facility Huazhong University of Science and Technology Wuhan Hubei 430074P.R.China School of Optical and Electronic Infrmation Huazhong University of Science and Technology Wuhan Hubei 430074P.R.China State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University NanjingJiangsu 210096P.R.China Institute of Biomaterials and Medical Devices Southeast University Suzhou Jiangsu 215163P.R.China

Three-dimensional(3D)cell cultures have contributed to a variety of biological research fields by filling the gap between monolayers and animal *** modern optical sectioning microscopic methods make it possible to probe the complexity of 3D cell cultures but are limited by the inherent *** tissue optical clearing methods have emerged as powerful tools for investigating whole-mount tissues in 3D,they often have limitations,such as being too harsh for fragile 3D cell cultures,requiring complex handling protocols,or inducing tissue deformation with shrinkage or *** address this issue,we proposed a modified optical clearing method for 3D cell cultures,called MACS-W,which is simple,highly efficient,and *** our evaluation of MACS-W,we found that it exhibits excellent clearing capability in just 10 min,with minimal deformation,and helps drug evaluation on tumor *** summary,MACS-W is a fast,minimally-deformative and fluorescence compatible clearing method that has the potential to be widely used in the studies of 3D cell cultures.

关键词： Tissue optical clearing 3D cell cultures imaging

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Rapid lithium-ion insertion/extraction and migration behavior of Na_(2)WO_(4)-encapsulated lithium-rich layered oxide cathode

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Rare Metals 2024年第8期43卷 3647-3660页

作者： yu-Shen Zhao Fan-Fan Wang Jian-Cang Wang Peng-fei Wang Ting-Feng Yi Jun-Hong Zhang School of Materials Science and Engineering Northeastern UniversityShenyangShenyang 110819China Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province School of Resources and MaterialsNortheastern University at QinhuangdaoQinhuangdao 066004China Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology College of Chemistry and Chemical EngineeringLiaocheng UniversityLiaocheng 252059China

Due to the low cost,high working voltage and high storage capacity,Li-rich Mn-based layered compounds show promise as the cathode materials for lithiumion batteries(LIBs).However,the side reactions at the solid-liquid interface of the cathode will lead to rapid capacity decay and inferior rate ***,this article proposes a liquid-phase dispersion strategy to introduce a Na_(2)WO_(4)layer on the Li_(1.2)Ni_(0.13)-Co_(0.13)Mn_(0.54)O_(2) cathode,which can reduce the side effects between raw materials and electrolyte and promote the insertion/extraction rate of Li^(+),thus enhancing the material stability and rate *** a result,the capacity retention rate is 96.9%after 200 cycles under ***,the capacities are 177.5,149.5,111.1 and58.3 mAh·g^(-1)at 1C,2C,5C and 10C,implying a superior fast charging *** exceptional performance can be ascribed to both the increased conductivity and enhanced structural stability of the cathode ***'s more,based on the investigation of ion insertion/extraction behavior in electrode materials and the ion migration kinetics in the electrolyte,this study suggests that coating Li-rich Mn-based materials with Na_(2)WO_(4)can be a promising strategy to improve their performance in LIBs.

关键词： Li-ion battery Coating Rate performance Li_(1.2)Ni_(0.13)Co_(0.13)Mn_(0.54)O_(2) Reaction kinetics

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Synergy between CSST galaxy survey and gravitational-wave observation: Inferring the Hubble constant from dark standard sirens

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 7-19页

作者： Ji-yu Song Ling-Feng Wang Yichao Li Ze-Wei Zhao Jing-fei Zhang Wen Zhao Xin Zhang Key Laboratory of Cosmology and Astrophysics(Liaoning)&College of Sciences Northeastern UniversityShenyang 110819China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of ChinaChinese Academy of SciencesHefei 230026China School of Astronomy and Space Sciences University of Science and Technology of ChinaHefei 230026China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Northeastern UniversityShenyang 110819China Key Laboratory of Data Analytics and Optimization for Smart Industry(Ministry of Education) Northeastern Universty Shenyang 110819China

Gravitational waves(GWs) from compact binary coalescences encode the absolute luminosity distances of GW sources. Once the redshifts of GW sources are known, one can use the distance-redshift relation to constrain cosmological parameters. One way to obtain the redshifts is to localize GW sources by GW observations and then use galaxy catalogs to determine redshifts from a statistical analysis of redshift information of the potential host galaxies, commonly referred to as the dark siren method. The third-generation(3G) GW detectors are planned to work in the 2030s and will observe numerous compact binary *** these GW events as dark sirens requires high-quality galaxy catalogs from future sky survey projects. The China Space Station Telescope(CSST) will be launched in 2024 and will observe billions of galaxies within a 17500 deg^(2) survey area with redshift up to z ~ 4, providing photometric and spectroscopic galaxy catalogs. In this work, we simulate the CSST galaxy catalogs and the 5-year GW data from the 3G GW detectors and combine them to infer the Hubble constant(H_(0)). Our results show that the measurement precision of H0could reach the sub-percent level, meeting the standard of precision cosmology. We conclude that the synergy between CSST and the 3G GW detectors is of great significance in measuring the Hubble constant.

关键词： CSST galaxy survey galaxy catalogs gravitational waves dark sirens the Hubble constant

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