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Expression of MMIF, HIF-1α and VEGF in Serum and Endometrial Tissues of Patients with Endometriosis

Current Medical Science 2018年第3期38卷 499-504页

作者： Fan ZHANG xiao-ling LIU Wan WANG Hong-ling DONG yu-fang xia Li-ping RUAN Li-ping LIU Department of Obstetrics and Gynecology Wuhan 6th Hospital Affiliated to Jianghan University Wuhan 430000 China Department of Obstetrics and Gynecology Wuhan Children's Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430000 China

The aim of this study was to investigate the expression of macrophage migration inhibitory factor （MMIF）, hypoxia-inducible factor- 1 α（HIF- 1α ）and vascular endothelial growth factor （VEGF） in the serum and endometrial tissues of patients with endometriosis （EM） and the clinical significance. Eighty EM patients [American Reproductive Association stage Ⅰ （n=20）, stage Ⅱ （n=22）, stage Ⅲ （n=21） and stage Ⅳ （n=17）] were enrolled and divided into mild （10- 14 points, n=28）, moderate （16-24 points, n=27） and severe （26-30 points, n=25） dysmenorrhea groups. The control group included 40 healthy women of childbearing age who underwent routine healthcare examinations in the enrolment period. The expression of MMIF, HIF- 1α and VEGF in the serum and endometrial tissues was measured by enzyme-linked immunosorbent assay and Western blotting, respectively. Meanwhile, the sensitivity and specificity of serum MMIF, HIF-1α, and VEGF when separately used as single indexes or jointly used as one index were examined as well. The results showed that serum concentrations of MMIF, HIF-1α, and VEGF were significantly higher in EM patients than in controls （P〈0.05）. The expression of all three proteins in both serum and endometrial tissues increased significantly with the R-AFS stage （P〈0.05） and with dysmenorrheal severity （P〈0.05）. The sensitivity and specificity of the combined detection of serum MMIF, HIF-1α, and VEGF levels were significantly higher than those of single index detection （P〈0.05）. In conclusion, the expression of MMIF, HIF-1α, and VEGF in the serum and endometrial tissues may be used to assess the stage of EM and the severity of dysmenorrhea. Combined evaluation of MMIF, HIF-1α, and VEGF significantly improves the diagnostic sensitivity and specificity.

关键词： macrophage migration inhibitory factor hypoxia-inducible factor-1α vascular endothelial growth factor endometriosis diagnosis

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Inexact proximal gradient algorithm with random reshuffling for nonsmooth optimization

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Science China(Information Sciences) 2025年第1期68卷 219-237页

作者： xia JIANG Yanyan fang xianlin ZENG Jian SUN Jie CHEN National Key Lab of Autonomous Intelligent Unmanned Systems School of AutomationBeijing Institute of Technology Beijing Institute of Technology Chongqing Innovation Center School of Electronic and Information Engineering Tongji University

Proximal gradient algorithms are popularly implemented to achieve convex optimization with nonsmooth regularization. Obtaining the exact solution of the proximal operator for nonsmooth regularization is challenging because errors exist in the computation of the gradient; consequently, the design and application of inexact proximal gradient algorithms have attracted considerable attention from researchers. This paper proposes computationally efficient basic and inexact proximal gradient descent algorithms with random reshuffling. The proposed stochastic algorithms take randomly reshuffled data to perform successive gradient descents and implement only one proximal operator after all data pass through. We prove the convergence results of the proposed proximal gradient algorithms under the sampling-without-replacement reshuffling *** computational errors exist in gradients and proximal operations, the proposed inexact proximal gradient algorithms can converge to an optimal solution neighborhood. Finally, we apply the proposed algorithms to compressed sensing and compare their efficiency with some popular algorithms.

关键词： proximal operator random reshuffling inexact computation compressed sensing nonsmooth optimization

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中国农产品进口种类增长的消费者福利测算——基于混合法的Armington微观替代弹性估计

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国际经贸探索 2019年第12期35卷 4-22页

作者：许统生方玉霞江西财经大学国际经贸学院

文章将国家统计局发布的19种农产品的商品名称同CEPII-BACI数据库的HS6位码进行匹配,采用Soderbery(2015)的混合估计法估计19种统计用农产品的Armington微观替代弹性,从总体和结构视角上分别测算进口农产品质量不变与变化两种情况下进... 详细信息

文章将国家统计局发布的19种农产品的商品名称同CEPII-BACI数据库的HS6位码进行匹配,采用Soderbery(2015)的混合估计法估计19种统计用农产品的Armington微观替代弹性,从总体和结构视角上分别测算进口农产品质量不变与变化两种情况下进口农产品种类的福利。结果表明:农产品Armington微观替代弹性平均值不到工业品平均值的一半;总体而言,在产品质量不变与变化两种情况下,农产品进口种类增加都使得我国进口福利增加,但是在质量变化情况下的进口福利增加幅度小于质量不变情况下的进口福利增加幅度。因此,我国进口市场应多元化,充分利用进口来源地农产品之间的替代弹性,降低市场风险;努力增加进口农产品种类的同时,应注重进口农产品的质量。

关键词：统计用农产品进口种类 Armington微观替代弹性混合估计法福利

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宏观替代弹性、国内生产率与进口种类利得纠偏

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当代财经 2021年第8期 102-114页

作者：许统生方玉霞江西财经大学国际经贸学院江西南昌330013 江西师范大学财政金融学院江西南昌330022

基于2006—2016年中国与124个进口来源国(地区)数据,证实了中国国内产品种类与进口产品种类的替代性,考察了阿明顿(Armington)宏观替代弹性、国内生产率对进口产品种类利得的影响,测算了中国工业品贸易利得的偏误。结果发现:在中国国内... 详细信息

基于2006—2016年中国与124个进口来源国(地区)数据,证实了中国国内产品种类与进口产品种类的替代性,考察了阿明顿(Armington)宏观替代弹性、国内生产率对进口产品种类利得的影响,测算了中国工业品贸易利得的偏误。结果发现:在中国国内产品种类与进口产品种类具有替代性的条件下,中国国内生产率会放大贸易成本对进口产品种类的影响;Armington宏观替代弹性越高,贸易成本对进口产品种类的影响越大;中国工业平均贸易利得被高估12%,国内生产率导致的平均贸易利得被高估9%;从行业结构看,有12个行业的进口利得被低估或高估,其中"煤炭"贸易利得被高估3~5倍。因此,应科学判断进口产品种类利得,不断提高国内生产率。

关键词： Armington宏观替代弹性国内生产率贸易成本进口种类利得

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进口产品种类提高了企业成本加成吗

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当代财经 2020年第3期 114-125页

作者：许统生方玉霞江西财经大学国际经贸学院江西南昌330013

将2000—2007年中国工业企业数据库和海关统计数据库进行匹配,使用双重差分法及工具变量法研究进口产品种类对企业成本加成的影响。研究结果表明:从总体上看,进口产品种类与企业成本加成呈U型关系,即进口产品种类增加,企业成本加成下降... 详细信息

将2000—2007年中国工业企业数据库和海关统计数据库进行匹配,使用双重差分法及工具变量法研究进口产品种类对企业成本加成的影响。研究结果表明:从总体上看,进口产品种类与企业成本加成呈U型关系,即进口产品种类增加,企业成本加成下降,当企业进口产品种类增加到一定门槛值之后,企业成本加成上升;从分样本来看,进口产品种类对企业成本加成的影响具有明显异质性,其依赖于企业进口贸易方式、企业技术水平、企业进口产品类型以及企业所在地区;机制检验表明,进口产品种类通过竞争效应和技术溢出效应影响企业成本加成。因此,为提高企业成本加成,企业应不断提高进口产品种类,政府应针对不同技术类型、不同地区、不同贸易方式、不同产品类型采取差异化的进口发展战略。

关键词：进口产品种类企业成本加成企业异质性

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Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第1期68卷 201-208页

作者： Hui-Feng Wang Wen-Jie Shi yu-Xin Yang Bao-xia Dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

关键词： metal-organic frameworks dinuclear metal centers synergistic catalysis CO2 reduction photocatalysis

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Actively tunable electromagnetically induced transparency in hybrid Dirac-VO2 metamaterials

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Optoelectronics Letters 2025年第1期21卷 13-20页

作者： DI Ke XIE Meng xia Huarong CHENG Anyu LIU yu DU Jiajia Department of Optoelectronic Engineering Chongqing University of Post and Telecommunications Chongqing Key Laboratory of Autonomous Navigation and Microsystem Chongqing University of Posts and Telecommunications Department of Automation Chongqing University of Post and Telecommunications

In this paper, we present a metamaterial structure of Dirac and vanadium dioxide（VO2） and investigate its optical properties using the finite-difference time-domain（FDTD） technique. Using the phase transition feature of VO2, the design can realize active tuning of the plasmon induced transparency（PIT） effect at terahertz frequency, thereby converting from a single PIT to a double-PIT. When VO2is in the insulating state, the structure is symmetric to obtain a single-band PIT effect. When VO2is in the metallic state, the structure turns asymmetric to realize a dual-band PIT effect. This design provides a reference direction for the design of actively tunable metamaterials. Additionally, it is discovered that the transparent window's resonant frequency and the Fermi level in this structure have a somewhat linear relationship. In addition, the structure achieves superior refractive index sensitivity in the terahertz band, surpassing 1 THz/RIU. Consequently, the design exhibits encouraging potential for application in refractive index sensors and optical switches.

关键词： Transparency

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Advances in the Development of Gradient Scaffolds Made of Nano‑Micromaterials for Musculoskeletal Tissue Regeneration

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Nano-Micro Letters 2025年第3期17卷 455-500页

作者： Lei fang xiaoqi Lin Ruian Xu Lu Liu yu Zhang Feng Tian Jiao Jiao Li Jiajia Xue Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China School of Biomedical Engineering Faculty of Engineering and ITUniversity of Technology SydneySydneyNSW 2007Australia

The intricate hierarchical structure of musculoskeletal tissues,including bone and interface tissues,necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered *** has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic *** on the anatomical characteristics of bone and interfacial tissues,this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues,specifically focusing on methods used to construct compositional and structural gradients within the *** latest applications of gradient scaffolds for the regeneration of bone,osteochondral,and tendon-to-bone interfaces are ***,the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed,as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

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Double [5]carbohelicene: facile synthesis, chiroptical properties,isomerization study, and lasing application

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Science China Chemistry 2025年第1期68卷 233-240页

作者： Peipei Liu Yantong Li Meng-xiang Wu Hao Kang xiao-Li Zhao Lin Xu Linlin Liu xiaodong Li Junfeng fang Zhiwei fang Ya Cheng Hai-Bo Yang Huakang yu Xueliang Shi State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polymer Optoelectronic Materials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isomerization process and lasing application is presented. 1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key intermediate. It is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM, which were successfully isolated and unambiguously confirmed by Xray crystallography. The optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography（HPLC）, and 1-PP and 1-MM were characterized by circular dichroism. Interestingly, it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating, and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated. 1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously, which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm-2. We believe that our studies, including the facile synthesis methodology, detailed isomerization studies, and lasing application, will shed some light on the design and synthesis of novel carbohelical systems with more functions.

关键词： double carbohelicene optical resolution organic laser isomerization X-ray diffraction

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Cross-subcarrier precoder design for massive MIMO-OFDM downlink with symplectic optimization

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Science China(Information Sciences) 2025年

作者： yu-Xuan ZHANG An-An LU xiang-Gen xia Xi-Qi GAO National Mobile Communications Research Laboratory Southeast University Purple Mountain Laboratories Department of Electrical and Computer Engineering University of Delaware

We propose a cross-subcarrier precoder design(CSPD) for massive multiple-input multiple-output(MIMO) orthogonal frequency division multiplexing(OFDM) downlink. This work aims to significantly improve the channel estimation and signal detection performance by enhancing the smoothness of the frequency domain effective channel. This is accomplished by designing a few vectors known as the transform domain precoding vectors(TDPVs), which are then transformed into the frequency domain to generate the precoders for a set of subcarriers. To combat the effect of channel aging, the TDPVs are optimized under imperfect channel state information(CSI). The optimal precoder structure is derived by maximizing an upper bound of the ergodic weighted sum-rate(WSR) and utilizing the a posteriori beam-based statistical channel model(BSCM). To avoid the large-dimensional matrix inversion, we propose an algorithm with symplectic optimization. Simulation results indicate that the proposed cross-subcarrier precoder design significantly outperforms conventional methods.

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