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柳州市大气污染物一氧化碳对缺血性心脏病发病风险的前瞻性队列研究

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环境与健康杂志 2024年第8期41卷 675-680页

作者：钟志诚周丽芳裴培孙点剑一苏莉蓝剑广西医科大学公共卫生学院广西南宁530021 柳州市疾病预防控制中心办公室北京大学公众健康与重大疫情防控战略研究中心北京大学公共卫生学院流行病与卫生统计学系重大疾病流行病学教育部重点实验室(北京大学) 柳州市疾病预防控制中心慢病防制与健康促进所

目的探讨柳州市环境大气污染物一氧化碳(CO)暴露与缺血性心脏病发病风险的关系。方法基于中国慢性病前瞻性研究队列(CKB)的柳州子队列,构建时间序列的分布滞后非线性模型,分析大气污染物与缺血性心脏病发病风险之间的关联。结果CO暴露... 详细信息

目的探讨柳州市环境大气污染物一氧化碳(CO)暴露与缺血性心脏病发病风险的关系。方法基于中国慢性病前瞻性研究队列(CKB)的柳州子队列,构建时间序列的分布滞后非线性模型,分析大气污染物与缺血性心脏病发病风险之间的关联。结果CO暴露与缺血性心脏病发病风险的关联有统计学意义,CO每升高1 mg/m^(3),单日滞后(lag1)效应最大,缺血性心脏病发病风险增加1.102%(95%CI:1.010%~1.202%);累积滞后(lag03)效应最大,缺血性心脏病发病风险增加1.375%(95%CI:1.038%~1.821%)。CO、SO_(2)和NO_(2)对缺血性心脏病发病风险的影响在冷季时更为明显,≥60岁、体育锻炼≥3次/周和退休人群更易受到CO的影响。结论大气污染物CO暴露可能增加缺血性心脏病的发病风险。有必要采取措施降低大气CO的浓度,从而降低缺血性心脏病的发生风险。

关键词：大气污染缺血性心脏病时间序列

Difference of Phytic Acid Content and its Relation to Four Protein Composition Contents in Grains of Twenty-nine japonica Rice Varieties from Jiangsu and Zhejiang Provinces,China

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Rice science 2007年第4期14卷 311-314页

作者： WU Wei CHENG fang-min LIU Zheng-hui WEI Ke-su Seed Management Station of Zhejiang Province Hangzhou 310020 China Institute of Crop Sciences Zhejiang University Hangzhou 310029 China Department of Agronomy Nanjing Agricultural University Nanjing 210095 China

Twenty-nine japonica rice varieties collected from Jiangsu and Zhejiang Provinces, China were planted in Hangzhou, China, to investigate the phytic acid content in brown rice and its frequency distribution as well as the correlation among the contents of phytic acid, total protein and four protein compositions in brown rice. The phytic acid content in brown rice ranged from 0.699% to 1.034%, with a mean of 0.868% for the 29 tested rice varieties. Xiushui series rice varieties generally exhibited lower phytic acid level than Wuyujing and Huai series rice varieties. A rough normal distribution, with a mean of 8.722%, was observed for the total protein contents in the tested varieties. Of the four protein compositions, the glutelin, globulin and albumin contents had larger coefficient of variation than the prolamin content, although the difference in prolamin content was genotype-dependent. No significant correlation was found between the phytic acid and four protein composition contents, whereas the total protein content was significantly and positively related to the glutelin content in brown rice.

关键词： rice phytic acid content protein content protein compositions nutritional quality relationship analysis

Isolated metachronous splenic multiple metastases after colon cancer surgery: A case report and literature review

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World Journal of Clinical Cases 2020年第15期8卷 3320-3328页

作者： Li Hu Ji-yun Zhu Lei fang Xiu-Chong yu Zhi-Long Yan Department of Gastrointestinal surgery Ningbo First HospitalNingbo 315000Zhejiang ProvinceChina

BACKGROUND Isolated splenic metastasis is a rare clinical *** metastases in the spleen after radical colon resection in a patient who subsequently underwent a second local resection for isolated metachronous splenic metastasis are exceedingly *** suMMARY We report a colon cancer patient who underwent laparoscopic radical colon resection 14 mo previously,and subsequently underwent a second local resection due to local recurrence detected by elevated serum carcinoembryonic antigen(CEA)and positron emission tomography(PET).However,multiple metastases in the spleen were found 7 mo later by elevated serum CEA and PET-magnetic resonance *** the patient underwent total laparoscopic *** tumor recurrence and splenic metastasis from colorectal cancer(CRC)were found by postoperative *** analysis of these recurrent and metastatic tissues showed KRAS exon2,APC exon16 and TP53 exon6 missense mutations,but no mutations of NRAS,KRAF,EGFR,ERBB2,MET,MLH1,MSH2 and MSH6 were *** and target therapy were administered after multiple disciplinary team(MDT)consultation,and no tumor recurrence has been observed to *** also reviewed the literature by conducting a search of the PubMed database using the following key words:CRC,splenic metastasis,isolated,and *** identified 34 relevant papers,which included 28 cases of metachronous metastasis and 6 cases of simultaneous *** Close monitoring of serum CEA levels is crucial for the detection of isolated splenic metastases after colon *** terms of overall survival and progression-free survival,MDT plays an important role in the entire process of disease management.

关键词： Colon cancer Isolated Metachronous Splenic metastasis Literature review Case report

Two new C_(21) steroidal glycosides isolated from Cynanchum komarovii

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Chinese Journal of Natural Medicines 2018年第8期16卷 610-614页

作者： ZHAO Dan su Shan-Shan CHEN Shao-Fei LU Xiao-Jie CHEN Gang WANG yu-Bo su Guang-yue PEI yue-Hu Key Laboratory of Structure-Based Drug Design & Discovery Ministry of EducationShenyang Pharmaceutical University School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Testing Laboratory Qinghai Entry Exit Inspection and Quarantine Bureau School of Pharmacy Jinzhou Medical University

The present study was designed to further investigate the C_(21) steroidal glycosides in Cynanchum *** new steroidal glycosides based on a 13,14:14,15-disecopregnane-type aglycone,komaroside P(1) and komaroside Q(2),together with three known compounds(3-5) were isolated from the whole herbs of Cynanchum *** aglycones of compounds 1 and 2 were two new *** structures were elucidated on the basis of 1 D,2 D NMR spectroscopic data and acid *** the compounds(1-5) showed potent inhibitory activities against human leukemia cell lines(HL-60) with IC50 values ranging from 16.6 to 26.3 μmol·L^(-1),compared to the positive control 5-fluorouracil(6.4 μmol·L^(-1)).

关键词： Cynanchum komarovii C21 steroidal glycosides Cytotoxic activity

类风湿关节炎患者血清镍纹蛋白和疾病活动度及血脂谱的相关性

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贵州医科大学学报 2024年第8期49卷 1176-1182页

作者：李星一黄颖苏航赵芳申婷婷李龙刘俊贵州医科大学附属医院风湿免疫科贵州贵阳550004 贵州医科大学临床医学院贵州贵阳550004 贵州中医药大学第二附属医院风湿免疫科贵州贵阳550003 贵州省人民医院超声科贵州贵阳550499 贵州医科大学

目的探讨类风湿关节炎(RA)患者血清镍纹蛋白(Metrnl)和疾病活动度及部分脂质指标的相关性。方法66例RA患者根据28个关节炎疾病活动性评分(DSA28)分为低中度组(n=33)和重度组(n=33),比较2组RA患者的一般资料、实验室指标[类风湿因子(RF)... 详细信息

目的探讨类风湿关节炎(RA)患者血清镍纹蛋白(Metrnl)和疾病活动度及部分脂质指标的相关性。方法66例RA患者根据28个关节炎疾病活动性评分(DSA28)分为低中度组(n=33)和重度组(n=33),比较2组RA患者的一般资料、实验室指标[类风湿因子(RF)、抗环瓜氨酸多肽抗体(anti-CCP)、白细胞介素-6(IL-6)、C反应蛋白(CRP)、血细胞沉降率(ESR)、甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)]及血清Metrnl水平,采用Spearman分析不同疾病活动度RA患者IL-6、ESR、CRP、DSA28评分、RF及anti-CCP与血清Metrnl的相关性;根据是否合并高脂血症将RA患者分为单纯RA组(n=41)和RA合并高脂血症组(n=25),比较2组RA患者血清TG、TC、HDL-C、LDL-C及Metrnl水平,采用Spearman分析2组RA患者脂质指标与血清Metrnl的相关性。结果与低中度组RA患者比较,重度组RA患者的DSA28评分、IL-6、CRP、ESR及Metrnl水平升高(P<0.05),Spearman相关性分析表明不同疾病活动度RA患者的ESR、CRP、DSA28评分及RF与血清Metrnl呈正相关(r=0.3717、0.3009、0.8203、0.6650,P<0.05);与单纯RA组比较,RA合并高脂血症组患者的TG及血清Metrnl水平升高(P<0.05),TC与血清Metrnl呈负相关(r=-0.2453,P<0.05)。结论Metrnl与RA患者疾病活动度及血脂谱脂质指标变化有一定的相关性。

关键词：类风湿关节炎脂质指标镍纹蛋白心血管事件脂质悖论动脉粥样硬化

MOF-Transformed In_(2)O_(3-x)@C Nanocorn Electrocatalyst for Efficient CO_(2)Reduction to HCOOH

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Nano-Micro Letters 2022年第10期14卷 219-234页

作者： Chen Qiu Kun Qian Jun yu Mingzi sun Shoufu Cao Jinqiang Gao Rongxing yu Lingzhe fang Youwei Yao Xiaoqing Lu Tao Li Bolong Huang Shihe Yang Guangdong Key Lab of Nano-Micro Material Research School of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhen 518055People’s Republic of China Department of Chemistry and Biochemistry Northern Illinois UniversityDeKalbIL 60115USA Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China School of Materials Science and Engineering China University of PetroleumQingdaoShandong 266580People’s Republic of China Shenzhen International Graduate School Tsinghua UniversityShenzhenPeople’s Republic of China X-Ray Science Division and Joint Center for Energy Storage Research Argonne National LaboratoryLemontIL 60439USA Institute of Biomedical Engineering Shenzhen Bay LaboratoryShenzhen 518107People’s Republic of China

For electrochemical CO_(2) reduction to HCOOH,an ongoing challenge is to design energy efficient electrocatalysts that can deliver a high HCOOH current density(JHCOOH)at a low *** oxide is good HCOOH production catalyst but with low *** this work,we report a unique corn design of In_(2)O_(3-x)@C nanocatalyst,wherein In_(2)O_(3-x)nanocube as the fine grains dispersed uniformly on the carbon nanorod cob,resulting in the enhanced *** performance is achieved with 84%Faradaic efficiency(FE)and 11 mA cm^(−2)JHCOOH at a low potential of−0.4 V versus *** the current density of 100 mA cm^(−2),the applied potential remained stable for more than 120 h with the FE above 90%.Density functional theory calculations reveal that the abundant oxygen vacancy in In_(2)O_(3-x) has exposed more In^(3+) sites with activated electroactivity,which facilitates the formation of HCOO**** X-ray absorp-tion spectroscopy also confirms In^(3+) as the active site and the key intermediate of HCOO*during the process of CO_(2) reduction to HCOOH.

关键词： CO_(2)reduction Indium oxide Formate Corn design Active sites

Feasibility and utility of intraoperative optical coherence tomography during vitreoretinal surgery:A 4-year report in Chinese population

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Journal of Innovative Optical Health Sciences 2021年第1期4卷 46-55页

作者： Jiwei Tao Huan Chen Jiafeng yu Dan Cheng Yiqi Chen Jianbo Mao Jia fang Lijun Shen Department of Retina Center Affiliated Eye Hospital of Wenzhou Medical University HangzhouZhejiang ProvinceP.R.China

The objective is to introduce the application of intraoperative optical coherence tomography(iOCT)in pars plana vitrectomy(PPV)for various vitreoretinal diseases,and to report the 4-year assessment of feasibility and utility in Chinese *** reported a retrospective case series of patients who underwent PPV and iOCT scan at Eye Hospital of Wenzhou Medical University from January 2016 to January *** characteristics were documented before operation,and we intraoperatively recorded the time and results of iOCT scanning,specific surgical maneuvers performed,the consistency with the planned strategies before surgery,the type of OCT images obtained,and adverse events(AEs).The surgeon feedback was collected to evaluate the utility of iOCT during *** total 339 eyes successfully completed iOCT scan,with an average scanning time of 3.54±2.3 min,including 59 cases of idiopathic macular hole(iMH),134 cases of idiopathic epiretinal membrane(iERM),33 cases of lamellar macular hole(LMH),40 cases of high myopic maculopathy,13 cases of vitreous macular traction(VMT),60 cases of dense vitreous hemorrhage(VH).The iOCT findings were not consistent with exami-nation under the operating microscope in 49 cases(14.5%),including 29 cases(8.6%)which changed the operation strategies during *** Hole-door phenomenon arose in 20 cases(33.9%)of iMH and 3 cases(25%)of high myopic MH after ILMs ***,the residue ERM was observed in nine cases(6.7%)of iERM and two cases(14.3%)in high myopic ERM after ILMs *** new surgical methods could also be confirmed using *** ap-plication of iOCT has a significant clinical functionality in vitreoretinal surgery,providing the surgeon with a new surgical understanding,guiding the selection of a more reasonable operative procedure during surgery,predicting postoperative recovery and improving postoperative outcomes.

关键词： Intraoperative optical coherence tomography vitreoretinal diseases pars plana vit-rectomy surgical guidance

Activation of medial septum cholinergic neurons restores cognitive function in temporal lobe epilepsy

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Neural Regeneration Research 2023年第11期18卷 2459-2465页

作者： Junzi Chen yu Wang Cong Chen Qingyang Zhang Shuang Wang Yi Wang Jiajia fang Ying Wang Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical ScienceThe First Affiliated HospitalZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Epilepsy Center The Second Affiliated HospitalZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Neurology The Fourth Affiliated HospitalZhejiang UniversityYiwuZhejiang ProvinceChina Institute of Neuropsychiatric Diseases Qingdao UniversityQingdaoShandong ProvinceChina

Cognitive impairment is the most common complication in patients with temporal lobe epilepsy with hippocampal scle *** is no effective treatment for cognitive *** septum cholinergic neurons have been reported to be a potential target for controlling epileptic seizures in tempo ral lobe epile ***,their role in the cognitive impairment of temporal lobe epilepsy remains *** this study,we found that patients with temporal lobe epile psy with hippocampal sclerosis had a low memory quotient and severe impairment in verbal memory,but had no impairment in nonverbal *** cognitive impairment was slightly correlated with reduced medial septum volume and medial septum-hippocampus tra cts measured by diffusion tensor *** a mouse model of chronic temporal lobe epilepsy induced by kainic acid,the number of medial septum choline rgic neurons was reduced and acetylcholine release was reduced in the ***,selective apoptosis of medial septum cholinergic neurons mimicked the cognitive deficits in epileptic mice,and activation of medial septum cholinergic neurons enhanced hippocampal acetylcholine release and restored cognitive function in both kainic acid-and kindling-induced epile psy *** res ults suggest that activation of medial septum cholinergic neurons reduces cognitive deficits in temporal lobe epilepsy by increasing acetylcholine release via projections to the hippocampus.

关键词： acetylcholine cholinergic neuron cognitive deficit diffusion tensor imaging hippocampal sclerosis hippocampus medial septum microdialysis optogenetics temporal lobe epilepsy

Whole-exome sequencing reveals genetic underpinnings of salivary adenoid cystic carcinoma in the Chinese population

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Journal of Genetics and Genomics 2020年第7期47卷 397-401页

作者： Shuhang Wang yue yu yuan fang Huiyao Huang Dawei Wu Hong fang Ying Bai Chao sun Anqi yu Qi Fan Zicheng yu Chao Zhang Changxi Wang Zaixian Tai Yi Huang Ning Li Departmenr of Clinical Trial Center National Cancer Ceniter/National Clinical Research Center for Cancer/Cancer HospitalChinese Acadermy of Medical Sciences and Peking Union Medical CollegeBeijing100O21China Geneplus-Shenzhen Shenzhen.518000China Department of Clinical Trial Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academyof Medical Sciences and Peking Union Medical CollegeBeijing100021China

Salivary gland carcinomas(SGCs)are rare malignancies that remain poorly understood owing to their low incidence(Matsuba et al.,1986b;Liu et al.,2012).As per GLOBOCAN 2018.52.800 new cancers arising from salivary glands were estimated to be diag-nosed across the world that *** of their high propensity to invade local and perineural structures.

关键词： salivary al. Whole