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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping yu Emily Choi Michael QJiang Ling wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

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AI-Enhanced Secure Data Aggregation for Smart Grids with Privacy Preservation

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Computers, Materials & Continua 2025年第1期82卷 799-816页

作者： Congcong Wang chen Wang Wenying Zheng wei Gu School of Software Nanjing University of Information Science and TechnologyNanjing210044China School of Information Science and Engineering Zhejiang Sci-Tech UniversityHangzhou310018China State Key Laboratory of Public Big Data Guizhou UniversityGuiyang550025China School of Computer Science and Technology(School of Artificial Intelligence) Zhejiang Sci-Tech UniversityHangzhou310018China School of Computer Science(School of Cyber Science and Engineering) Nanjing University of Information Science and TechnologyNanjing210044China

As smart grid technology rapidly advances,the vast amount of user data collected by smart meter presents significant challenges in data security and privacy *** research emphasizes data security and user privacy concerns within smart ***,existing methods struggle with efficiency and security when processing large-scale *** efficient data processing with stringent privacy protection during data aggregation in smart grids remains an urgent *** paper proposes an AI-based multi-type data aggregation method designed to enhance aggregation efficiency and security by standardizing and normalizing various data *** approach optimizes data preprocessing,integrates Long Short-Term Memory(LSTM)networks for handling time-series data,and employs homomorphic encryption to safeguard user *** also explores the application of Boneh Lynn Shacham(BLS)signatures for user *** proposed scheme’s efficiency,security,and privacy protection capabilities are validated through rigorous security proofs and experimental analysis.

关键词： Smart grid data security privacy protection artificial intelligence data aggregation

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Resistance of Cement-based Grouting Materials with Nano- SiO_(2) Emulsion to Chloride Ion Penetration

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 114-119页

作者： LI Shuiping chenG Jian wei Chao yuAN Bin yu chengxiao College of Architectural Science and Engineering Yangzhou UniversityYangzhou 225127China

The chloride penetration resistance of cement-based grout materials was improved by nano-silica *** of mixtures containing different nano-silica particles or emulsions were exposed in sodium chloride solutions of specific concentrations with different test *** properties of the mixes were assessed in terms of weight loss and compressive strength.X-ray diffraction(XRD)and scanning electron microscopy(SEM)of mixes were performed to analysis the phase evolution and *** results demonstrated that the introduction of nano-SiO_(2) emulsion significantly decreased the compressive strength loss and calcium hydroxide(CH)crystal content of hydration production,and then enhanced the resistance of cement-based grouting materials to chloride ion *** improvement derives from the filling and pozzolanic effects of nano-SiO_(2) particles,which were incorporated via an emulsion and attributed to a well dispersion in grouting matrix.

关键词： grouting materials nano-SiO_(2)emulsion chloride ion penetration,weight loss strength loss

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Precise gradient separation of nanoparticles using reduced graphene oxide-polyoxomolybdate membranes

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Science China Chemistry 2025年第01期 209-216页

作者： Yixin Yang Wanlei Zhao Ruoxuan Zheng Hongqiang Li wei chen yu-Fei Song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Quzhou Institute for Innovation in Resource Chemical Engineering

The purification and size sieving of nanoparticles （NPs） represents a significant scientific ***,the r GO-polyoxometalates (POMs=PMo12,Mo132and Mo368) membranes were fabricated successfully via a simple and scalable POMsassisted in-situ photoreduction *** the mass ratio of r GO to PMo12was 1:30,the resultant r GO-PMo12membranes with highly ordered and uniform nanochannels of 1.0 nm can be obtained,which showed an accurate carbon quantum dots（CQDs） separation with a cut-off size approximately 1.0 *** increase of the size of the interlayered POMs from PMo12（1.0 nm）,{Mo132}（2.9 nm） to{Mo368}（3.8 nm）,the resultant r GO-PMo12,r GO-Mo132and r GO-Mo368exhibited precise gradient separation of CQDs and Au nanoparticles by size exclusion *** results pave a promising way to construct new twodimensional （2D） membranes for highly efficient size-selective separation.

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固溶时效工艺对2297铝锂合金微观组织和力学性能的影响

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中国有色金属学报 2017年第11期27卷 2187-2194页

作者：李红英王小雨余玮琛中南大学材料科学与工程学院长沙410083 中南大学有色金属材料科学与工程教育部重点实验室长沙410083 中南大学有色金属先进结构材料与制造协同创新中心长沙410083 轻质高强结构材料重点实验室长沙410083

通过扫描电镜(SEM)、透射电镜(TEM)和拉伸性能测试等方法系统研究固溶和时效工艺对2297铝锂合金组织和性能的影响。结果表明:实验合金较为适宜的固溶制度为((535±5)℃,1.5 h),基体中的第二相得到比较充分的溶解,同时抑制再结晶晶粒长大... 详细信息

通过扫描电镜(SEM)、透射电镜(TEM)和拉伸性能测试等方法系统研究固溶和时效工艺对2297铝锂合金组织和性能的影响。结果表明:实验合金较为适宜的固溶制度为((535±5)℃,1.5 h),基体中的第二相得到比较充分的溶解,同时抑制再结晶晶粒长大。T6态的主要强化相为T_1相和θ′相,T8态的主要强化相为T_1相,时效前的预变形可以促进T1相的形成,提高合金的强度峰值,缩短合金达到峰值的时间,160℃时效后,未经预变形的合金的强度峰值为392 MPa,到峰时间为48 h,变形量为7%时,合金的强度峰值最高,达到482 MPa,到峰时间为23 h。

关键词： 2297铝锂合金固溶时效微观组织力学性能

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时效制度对2050铝锂合金微观组织和力学性能的影响

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中国有色金属学报 2018年第12期28卷 2433-2440页

通过金相显微分析(OM)、扫描电镜观察(SEM)、透射电镜观察(TEM)、X射线衍射(XRD)、显微硬度测试、拉伸性能测试和断裂韧性测试,研究不同时效制度对2050铝锂合金组织及性能的影响。结果表明:2050铝锂合金的最佳时效制度为(145℃,80 h)。T... 详细信息

通过金相显微分析(OM)、扫描电镜观察(SEM)、透射电镜观察(TEM)、X射线衍射(XRD)、显微硬度测试、拉伸性能测试和断裂韧性测试,研究不同时效制度对2050铝锂合金组织及性能的影响。结果表明:2050铝锂合金的最佳时效制度为(145℃,80 h)。T8态合金峰时效的主要析出相为T_1相和S相,其中主要强化相为尺寸细小弥散分布的T_1相,合金强化效果较好。实验合金经时效处理后存在明显的各向异性,合金沿轧制方向的屈服强度和抗拉强度最高。随着时效温度升高,合金断裂韧性下降。

关键词： 2050铝锂合金时效 T1相各向异性

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Tubal Pregnancy Treated with Trichosanthin and Followed up by Hysterosalpingography

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Chinese Journal of Integrative Medicine 1995年第4期1卷 265-267页

作者： Zhong Hui-ping (钟慧萍) Lu Pei-xin (陆培新) Jin yu-cui(金毓翠) and chen wei-zhen (陈伟珍)(Department of Obsretrics and Gynecology, Rui Jin Hospital,Shaanghai Second Medical University, Shanghai 200025) Department of Obstetrics and Gynecology Rui Jin Hospital Shaanghai Second Medical University Shanghai

Twenty cases of unruptured tubal pregnancy were treated with trichosanthin *** two cases were eventoally operated, so the effective rate was 90% . Hysterosalpingography was takenin 14 of 18 cases who was willing to accept the procedure at 0. 5- 1.5 year after the conservative *** tubes were patent in 10 of 14 cases, the rate of patency was 71.4% .

关键词： Tubal pregnancy Trichosanthin hysterosalpingography

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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng wei Tan Xingxing chen Shuyuan Bai Qiong Wu yushan chen Zhen wei yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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Adaptive-basis decomposition-based low-rank network for efficient non-uniform motion deblurring

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Optoelectronics Letters 2025年第1期21卷 43-50页

作者： chen Lei XIONG Qingbo ZHANG wei LI Runde School of Software Henan University School of Applied Technology China University of Labor Relations

In this study, we present a unified sparsity-driven framework that significantly enhances motion deblurring performance by integrating two key components: a custom-designed dataset and a low-rank module(LRM). This framework leverages the inherent sparsity of per-pixel blur kernels to bolster both deblurring accuracy and model interpretability. Firstly, we propose an adaptive-basis decomposition-based deblurring(ADD) approach, which constructs a tailored training dataset to enhance the generalization capacity of the deblurring network. The ADD framework adaptively decomposes motion blur into sparse basis elements, effectively addressing the intricacies associated with non-uniform blurs. Secondly, an LRM is proposed to improve the interpretability of deblurring models as a plug-and-play module, primarily designed to identify and harness the intrinsic sparse features in sharp images. A series of ablation studies have been conducted to substantiate the synergistic advantages of combining the proposed ADD with the LRM for overall improvement in deblurring efficacy. Subsequently, we empirically demonstrate through rigorous experimentation that incorporating the LRM into an existing Uformer network leads to substantial enhancement in reconstruction performance. This integration yields a sparsity-guided low-rank network(SGLRN). Operating under the overarching principle of sparsity, SGLRN consistently outperforms state-of-the-art methods across multiple standard deblurring benchmarks. Comprehensive experimental results, assessed through quantitative metrics and qualitative visual evaluations, provide compelling evidence of its effectiveness. The overall deblurring results are available at Google Drive.

关键词： Image enhancement

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波长扫描法测量光纤偏振模色散研究

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红外与毫米波学报 2006年第1期25卷 64-66页

作者：吴玉年黄志明陈育伟褚君浩中国科学院上海技术物理研究所红外物理国家重点实验室上海200083

利用基于波长扫描法而改进的测试装置对一段很短长度(2m)保偏光纤进行了测量,采用极值密度法计算光纤的偏振模色散.在计算过程中采用了一种有效的信号提取方法,大大降低了噪声的影响,提高了测量的准确度.

关键词：光纤偏振模色散噪声波长扫描法

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