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Insulin-like growth factor 2 targets IGF1R signaling transduction to facilitate metastasis and imatinib resistance in gastrointestinal stromal tumors

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3585-3599页

作者： De-Gang li Jia-Peng Jiang Fan-Ye Chen Wei Wu Jun Fu Gong-He Wang yu-bo li Department of Gastrointestinal and Anorectal Surgery The First Affiliated Hospital of Guangxi University of Chinese MedicineNanning 530023Guangxi Zhuang Autonomous RegionChina

BACKGROUND Gastrointestinal stromal tumors(GISTs)are typical gastrointestinal tract *** is the first-line therapy for GIST *** resistance limits the long-term effectiveness of *** regulatory effect of insulin-like growth factor 2(IGF2)has been confirmed in various cancers and is related to resistance to chemotherapy and a worse *** To further investigate the mechanism of IGF2 specific to *** IGF2 was screened and analyzed using Gene Expression Omnibus(GEO:GSE225819)*** IGF2 knockdown or overexpression by transfection,the phenotypes(proliferation,migration,invasion,apoptosis)of GIST cells were characterized by cell counting kit 8,Transwell,and flow cytometry *** used western blotting to evaluate pathway-associated and epithelial-mesenchymal transition(EMT)-associated *** injected transfected cells into nude mice to establish a tumor xenograft model and observed the occurrence and metastasis of *** Data from the GEO indicated that IGF2 expression is high in GISTs,associated with liver metastasis,and closely related to drug *** cells with high expression of IGF2 had increased proliferation and migration,invasiveness and *** of IGF2 significantly inhibited those *** addition,OEIGF2 promoted GIST metastasis in vivo in nude ***2 activated IGF1R signaling in GIST cells,and IGF2/IGF1R-mediated glycolysis was required for GIST with liver *** cells with IGF2 knockdown were sensitive to imatinib treatment when IGF2 overexpression significantly raised imatinib ***,2-deoxy-D-glucose(a glycolysis inhibitor)treatment reversed IGF2 overexpressionmediated imatinib resistance in *** IGF2 targeting of IGF1R signaling inhibited metastasis and decreased imatinib resistance by driving glycolysis in GISTs.

关键词： Insulin-like growth factor 2 Gastrointestinal stromal tumors IGF1R Glycolysis Imatinib resistance

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劳务外包的法律性质及其与劳务派遣的分辨

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哈尔滨学院学报 2024年第6期45卷 84-89页

作者：于浬博弭维天津大学法学院天津300072

劳务外包是一种人力资源服务经营活动,兼具劳务派遣和业务外包的法律特征,其正当价值在于为组织降本增效,兼顾灵活用工的实际需求,不应被用作逃避雇主责任的工具。劳务外包与劳务派遣在外观上具有一定的相似性,对二者进行分辨的主要目... 详细信息

劳务外包是一种人力资源服务经营活动,兼具劳务派遣和业务外包的法律特征,其正当价值在于为组织降本增效,兼顾灵活用工的实际需求,不应被用作逃避雇主责任的工具。劳务外包与劳务派遣在外观上具有一定的相似性,对二者进行分辨的主要目的在于确定劳动关系的真实归属以及法律适用。应当审视个案中的具体法律关系,以人格从属性为关键因素进行实质判定。

关键词：劳务外包法律性质劳务派遣人格从属性

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Sensitivity study of searching for τ^-→γμ^- at HIEPA

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Science Bulletin 2016年第4期61卷 307-312页

作者： yu-bo li Cheng-Ping Shen Chang-Zheng yuan School of Physics and Nuclear Energy Engineering Beihang University Institute of High Energy Physics Chinese Academy of Sciences

The charged lepton flavor violation process is a clean and sensitive probe of new physics beyond the Standard Model. A sensitivity study is performed to the process τ^-→γμ^- based on a 3 fb^(-1) inclusive Monte Carlo sample of e^+e^- collisions at a center-of-mass energy of4.26 or 4.6 Ge V, in the framework of the BESIII software system. The 90 % confidence level upper limits on B(τ^-→γμ^-) are estimated assuming no signal is produced. We also obtain the sensitivity on B(τ^-→γμ^-) as a function of the integrated luminosity, to serve as a reference for the HIEPA being proposed in China. It is found that 6.34 ab^(-1) are needed to reach the current best upper limit of 4:4 10^(-8) and about 2510 ab^(-1) are needed to reach a sensitivity of 10^(-9) if the detector design is similar to that of BESIII.

关键词： Charged lepton flavor violation Branching fraction New physics

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Solvent effects on gold nanoparticle formation from photochemical reduction of Au(Ⅲ)by UV irradiation

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Nuclear Science and Techniques 2018年第11期29卷 201-204页

作者： Ming yuan yu-bo li Jun Guo Rui-bo Zhong li-Ping Wang Feng Zhang School of life Science Inner Mongolia Agricultural University306 Zhaowuda RoadHohhot 010018China Department of Biomedical Engineering School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhou 511436China School of Biomedical Engineering Shanghai Jiaotong UniversityShanghai 200241China Affiliated Stomatological Hospital of Guangzhou Medical University Guangzhou 510150China

Colloidal gold nanoparticles(AuNPs) have attracted more and more attention in areas of materials science, biotechnology and organic chemistry due to their unique functions as molecular markers and their applications in diagnostic imaging and catalysis. The AuNP synthesis approaches have been well developed; however, the solvent effects have not been systematically studied *** we analyzed and compared solvent effects on AuNP formation using UV irradiation of Au(Ⅲ) without adding any other ligands. By monitoring the surface plasmonresonance absorption of Au(Ⅲ)-containing solutions,results showed that both ketone and alcohol solvents can induce Au(Ⅲ) to form gold nanospheres; on the other hand, solvents like ACN and THF can induce Au(Ⅲ) to form nanostructures with longer dimensions. The possible mechanism was discussed, which could facilitate efficient photochemical synthesis of AuNPs and might apply to other metal NP synthesis.

关键词： Solvent effect Gold nanoparticle UV irradiation Photochemical reduction

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Morphological structures of poly(vinylidene fluoride)/montmorillonite nanocomposites

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Science China Chemistry 2007年第6期50卷 790-796页

作者： SONG yuMing ZHAO ZhuDi yu WenXue li bo CHEN XinFang College of Materials Science and Engineering Jilin University Changchun 130012 China College of Materials Science and Engineering Jilin University Changchun 130012 China College of Materials Science and Engineering Jilin University Changchun 130012 China College of Materials Science and Engineering Jilin University Changchun 130012 China College of Materials Science and Engineering Jilin University Changchun 130012 China

Poly(vinylidene fluoride)(PVDF)/montmorillonite(MMT)nanocomposites were prepared by melt blending a kind of organically modified montmorillonite with *** morphological structures of the nanocomposites were studied using X-ray diffraction(XRD),transmission electron microscopy(TEM),Fourier transform infrared(FTIR)spectroscopy,and differential scanning calorimetry(DSC).The results indicate that organically modified montmorillonites are in the form of intercalation,exfoliation,and fragments in the PVDF *** the composites,the(001)peak position of MMT was found to shift to a lower angle in XRD patterns,and some MMT fragments could be observed under *** loading was favorable to producing the piezoelectric beta phase in the PVDF matrix and caused internal stress in a *** the same time,the crystallinity and spherulite size of PVDF decreased with the MMT *** induced beta phase is stable even at high temperatures(160℃).For these changes in morphological structures,some possible explanations were proposed based on the experimental results.

关键词： organically modified montmorillonite, nanocomposite, crystalline structure

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Giant and controllable Goos—Hänchen shift of a reflective beam off a hyperbolic metasurface of polar crystals

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Chinese Physics B 2024年第1期33卷 428-435页

作者：薛天李宇博宋浩元王相光张强付淑芳周胜王选章 Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of Educationand School of Physics and Electronic EngineeringHarbin Normal UniversityHarbin 150025China Department of Basic Courses Guangzhou Maritime UniversityGuangzhou 510725China

We conduct a theoretical analysis of the massive and tunable Goos–Hänchen(GH) shift on a polar crystal covered with periodical black phosphorus(BP)-patches in the THz range. The surface plasmon phonon polaritons(SPPPs), which are coupled by the surface phonon polaritons(SPh Ps) and surface plasmon polaritons(SPPs), can greatly increase GH *** on the in-plane anisotropy of BP, two typical metasurface models are designed and investigated. An enormous GH shift of about-7565.58 λ_(0) is achieved by adjusting the physical parameters of the BP-patches. In the designed metasurface structure, the maximum sensitivity accompanying large GH shifts can reach about 6.43 × 10^(8) λ_(0)/RIU, which is extremely sensitive to the size, carrier density, and layer number of BP. Compared with a traditional surface plasmon resonance sensor, the sensitivity is increased by at least two orders of magnitude. We believe that investigating metasurface-based SPPPs sensors could lead to high-sensitivity biochemical detection applications.

关键词： Goos–H?nchen shift black phosphorus surface plasmon phonon polaritons sensitivity metasurfaces

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Effect of coronary artery revascularization on in-hospital outcomes and long-term prognoses in acute myocardial infarction patients with prior ischemic stroke

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Journal of Geriatric Cardiology 2016年第2期13卷 145-151页

作者： bo-yu li Xiao-Ming li Yan ZHANG Zhan-yun WEI Jing li Qi HUA Department of Cardiology Xuanwu Hospital Capital Medical University Beijing China School of Nursing Capital Medical University Beijing China Department of Geriatrics Xuanwu Hospital Capital Medical University Beijing China

Objective To investigate whether coronary artery revascularization therapies （CART）, including percutaneous coronary intervention （PCI） and coronary artery bypass grafting （CABG）, can improve the in-hospital and long-term outcomes for acute myocardial infarction （AMI） patients with prior ischemic stroke （IS）. Methods A total of 387 AMI patients with prior IS were enrolled consecutively from January 15, 2005 to December 24, 2011 in this cohort study. All patients were categorized into the CART group （n = 204） or the conservative medications （CM） group （n = 183）. In-hospital cardiocerebral events and long-term mortality of the two groups after an average follow-up of 36 months were recorded by Kaplan-Meier survival curves and compared by Logistic regression and the Cox regression model. Results The CART patients were younger （66.5 ± 9.7 years vs. 71.7 ± 9.7 years, P 〈 0.01）, had less non-ST segment elevation myocardial infarction （11.8% vs. 20.8%, P = 0.016） and more multiple-vascular coronary lesions （50% vs. 69.4%, P = 0.031）. The hospitalization incidence of cardiocerebral events in the CART group was 9.3% while 26.2% in the CM group （P 〈 0.01）. CART significantly reduced the risk of in-hospital cardiocerebral events by 65% [adjusted odds ratio （OR） = 0.35, 95% CI： 0.13-0.92]. By the end of follow-up, 57 cases （41.6%） died in CM group （n = 137） and 24 cases （12.2%） died in CART group （n = 197）. Cox regression indicated that CART decreased the long-term mortality by 72% [adjusted hazard ratio （HR） = 0.28, 95% CI： 0.064）.46], while categorical analysis indicated no s{gnificant dif- ference between PCI and CABG. Conclusions CART has a significant effect on improving the in-hospital and long-term prognoses for AMI patients with prior IS.

关键词： Acute myocardial infarction Conservative medications Coronary artery bypass grafting Coronary artery revascularization Ischemic stroke Percutaneous coronary intervention

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Evolution of MnO–SiO2–Al_(2)O_(3)–MgO inclusions during heat treatment at 1100℃

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Journal of Iron and Steel Research International 2024年第5期31卷 1221-1231页

作者： Xu-bo Lei Jian-li li Qiang Zeng Hang-yu Zhu yue yu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan430081HubeiChina

To investigate the evolutionary behavior of the MnO–SiO_(2)–Al_(2)O_(3)–MgO inclusions during heat treatment,water quenched samples were isothermally held at 1100°C for 120 min in Ar and air atmosphere,and the obtaining samples were analyzed by X-ray diffraction,scanning electron microscopy and energy dispersive *** showed that 3MnO·Al_(2)O_(3)·3SiO_(2)and MnO·SiO_(2)were detected in the 5 wt.%MgO system after isothermal holding in Ar atmosphere,while MgO·Al_(2)O_(3),MnO·SiO_(2)and Mn7O8·SiO4 were detected in air *** evolutionary behavior of the 10,15 and 20 wt.%MgO systems after isothermal holding in different atmosphere were *** affected the solid phase transformation of the low MgO content *** calculation results of FactSage 8.1 showed that MgO·Al_(2)O_(3)was formed in the 5 wt.%MgO system with air *** solid phase transformation was accompanied by grain coarsening during the isothermal holding *** differences in the solid phase transformation in different atmosphere of the 5 wt.%MgO system indicated that it was a gas-phase transport grain coarsening *** enrichment of Al element in the liquid phase region at the grain edges,the homogeneous distribution of Mg element and the disappearance of the liquid phase within the crystal revealed that other MgO content systems were liquid–solid transport grain coarsening mechanism.

关键词： Evolution Glassy phase Inclusion Heat treatment MgO·Al_(2)O_(3)

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Changes in percentage of lymphocyte subsets after ^(131)I treatment in patients with differentiated thyroid cancer

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Nuclear Science and Techniques 2005年第4期16卷 214-216页

作者： LUO Quan-Yong CHEN li-bo yu Yong-li LU Han-Kui ZHU Rui-Sen Department of Nuclear Medicine Shanghai Sixth People＇s Hospital. Shanghai Jiaotong University Shanghai 200233

To monitor the extent and the duration of lymphocyte subset changes in patients with thyroid carcinoma undergoing therapeutic 131I administration, the percentage of lymphocyte subsets were serially analyzed before and after 131I treatment. In patients who received 1850 MBq of 131I for ablation of thyroid remnants, only for NK cells and B cells showed a significant reduction. In patients received 3700 MBq of 131I for treatment of local lymph node me-tastases, NK cells, B cells and CD4+ were found decreased. In patients received 7400 MBq of 131I for treatment of distant metastases, NK cells, B cells and CD4+ and CD8+ were all affected. However, there is no significant reduc-tion compared to the baseline in the percentage of all lymphocyte subsets three months after 131I treatment. The re-sults show that the sensitivity of lymphocytes to 131I internal radiation depends upon lymphocyte phenotype and 131I activity. The immunosuppression effects are temporary and reversible.

关键词：淋巴细胞 ^131I 甲状腺癌症放射性疗法抑制免抑反应

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Strong and tough chitin hydrogel constructed by dehydration and rehydration strategy

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Nano Research 2024年第9期17卷 8192-8199页

作者： Rui-Rui liu li-bo Mao Shu-Hong yu Division of Nanomaterials and Chemistry Hefei National Research Center for Physical Sciences at the MicroscaleDepartment of ChemistryInstitute of Biomimetic Materials and ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsUniversity of Science and Technology of ChinaHefei 230026China Institute of Innovative Materials Department of Materials Science and EngineeringDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China

As a renewable,biocompatible,biodegradable soft material,chitin hydrogels have better advantages in stability,antibacterial activity,antifouling,cost,immunogenicity,and so on than most polymer ***,compared with other widely used polymer hydrogels with high strength and toughness,the practical applications of chitin-based hydrogels have been limited by their weak mechanical properties,such as cartilage repair and meniscus ***,we present the design and fabrication of chitin hydrogels with excellent mechanical strength and toughness by a dehydration and rehydration *** sequential dehydration and rehydration processes,the crystalline domains in the chitin hydrogels can be properly *** optimized crystallinity,the elastic modulus of the chitin hydrogels exceeds all previously reported values,and the fracture toughness is even comparable to some synthetic polymer hydrogels,while maintaining a high-water-content of about 80 wt.%.At the same water content,the mechanical properties of the chitin hydrogels are positively correlated with the hydrogel crystallinity,which proves that the change of mechanical properties of hydrogels is not simply dependent on weight *** hydrogels can be further strengthened by incorporating other biopolymers that are intrinsically weak,which makes the hydrogels promising for applications in fields such as cartilage repair and meniscus ***,the hydrogels enable loading and release of water-soluble and poorly water-soluble *** highly extendable strengthening and toughening strategy of chitin and chitin-based biopolymer hydrogels paves the way for their widely applications.

关键词： chitin hydrogel crystallinity rehydration chemical transformation strong and tough

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