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ASARA,a prediction model based on Child-Pugh class in hepatocellular carcinoma patients undergoing transarterial chemoembolization

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国际肝胆胰疾病杂志:英文版 2023年第5期22卷 490-497页

作者： ke-Feng Jia Hao Wang Chang-Lu yu Wei-Li Yin Xiao-Dong Zhang Fang Wang Cheng Sun Wen Shen Department of Radiology First Central Clinical CollegeTianjin Medical UniversityTianjin 300192China Department of Radiology Tianjin Third Central HospitalTianjin 300170China Department of Radiology Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjin 300192China Department of Gastroenterology and Hepatology Tianjin Third Central HospitalTianjin 300170China

Background:Due to the high heterogeneity among hepatocellular carcinoma(HCC)patients receiving transarterial chemoembolization(TACE),the prognosis of patients varies *** decisionmaking on the initiation and/or repetition of TACE under different liver functions is a matter of concern in clinical ***,we aimed to develop a prediction model for TACE candidates using risk stratification based on varied liver ***:A total of 222 unresectable HCC patients who underwent TACE as their only treatment were included in this *** proportional hazards regression was performed to select the independent risk factors and establish a predictive model for the overall survival(OS).The model was validated in patients with different Child-Pugh class and compared to previous TACE scoring ***:The five independent risk factors,including alpha-fetoprotein(AFP)level,maximal tumor size,the increase of albumin-bilirubin(ALBI)grade score,tumor response,and the increase of aspartate aminotransferase(AST),were used to build a prognostic model(ASARA).In the training and validation cohorts,the OS of patients with ASARA score≤2 was significantly higher than that of patients with ASARA score>2(P<0.001,P=0.006,respectively).The ASARA model and its modified version“AS(ARA)”can effectively distinguish the OS(P<0.001,P=0.004)between patients with Child-Pugh class A and B,and the C-index was 0.687 and 0.706,*** repeated TACE,the ASARA model was superior to Assessment for Retreatment with TACE(ART)and ALBI grade,maximal tumor size,AFP,and tumor response(ASAR)among Child-Pugh class A *** the first TACE,the performance of AS(ARA)was better than that of modified hepatoma arterial-embolization prognostic(mHAP),mHAP3,and ASA(R)models among Child-Pugh class B ***:The ASARA scoring system is valuable in the decision-making of TACE repetition for HCC patients,especially Child-Pugh class A *** modified AS(ARA)can be

关键词： Hepatocellular carcinoma Transarterial chemoembolization Scoring system Prognostic model Child-Pugh class Survival prediction

Covalent modification of multiwalled carbon nanotubes with a low molecular weight chitosan

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Chinese Chemical Letters 2007年第3期18卷 361-364页

作者： Gang ke Wen Chao Guan Chang yu Tang Zhen Hu Wen Jie Guan Dan Lin Zeng Feng Deng Department of Chemistry Huazhong University of Science and Technology Wuhan 430074 China key Laboratory of Cellulose and Lignocellulosics Chemistry Guangzhou Institute of Chemistry Chinese Academy of Sciences Guangzhou 510650 China Department of Physics Wuhan University Wuhan 430072 China State key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences Wuhan 430071 China

Covalent modification of shortened multiwalled carbon nanombes （MWNTs） with a natural low molecular weight chitosan （LMCS） was accomplished by the nucleophilic substitution reaction. The LMCS modified MWNTs （MWNT-LMCS） were characterized by FTIR, solid-state ^13C NMR, and XPS spectroscopies, thermogravimetric analysis, and transmission electron microscopy. The results revealed that amino and primary hydroxyl groups of the LMCS participated mainly in the formation of the MWNT-LMCS conjugates. The MWNT-LMCS consists of 58 wt.% LMCS, and about four molecular chains of the LMCS were attached to 1000 carbon atoms of the nanotube sidewalls. As a novel derivative of the MWNTs, the MWNT-LMCS not only solved in DMF, DMAc and DMSO, but also in aqueous acetic acid solution.

关键词： Carbon nanotubes Chitosan Renewable resources Modification

南黄海强屏蔽层下富低频强能量气枪震源设计及应用

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物探与化探 2024年第5期48卷 1294-1301页

作者：黄福强陈建文李斌张异彪杨佳佳李珂青岛海洋科技中心海洋矿产资源评价与探测技术功能实验室山东青岛266237 中石化海洋石油工程有限公司上海物探分公司上海201208 中国地质调查局青岛海洋地质研究所山东青岛266237

南黄海盆地新近系和中—古生界地层之间存在一个强屏蔽层,阻碍地震波能量向下传播,导致深部地层地震反射波能量低、波组特征差,严重制约了中—古生界油气勘探的突破。为了进一步改善南黄海强屏蔽下中—古生界地层的成像质量,从震源激发... 详细信息

南黄海盆地新近系和中—古生界地层之间存在一个强屏蔽层,阻碍地震波能量向下传播,导致深部地层地震反射波能量低、波组特征差,严重制约了中—古生界油气勘探的突破。为了进一步改善南黄海强屏蔽下中—古生界地层的成像质量,从震源激发端进行大量的模拟分析研究,提出了富低频、强能量震源设计方法,优化设计了6 050 in~3富低频、强能量震源。在崂山隆起西部极浅水区开展了拖缆地震采集,新采集的资料在强屏蔽层下深层的信噪比更高,同相轴更连续,构造特征更清晰,强屏蔽层下的地震资料品质改善明显。

关键词：南黄海强屏蔽层大容量富低频震源设计

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盐胁迫对水稻籽粒灌浆特性及产量形成的影响

作物学报 2024年第3期50卷 734-746页

作者：韦还和张翔朱旺耿孝宇马唯一左博源孟天瑶高平磊陈英龙许轲戴其根江苏省作物遗传生理重点实验室/江苏省作物栽培生理重点实验室/江苏省粮食作物现代产业技术协同创新中心/扬州大学水稻产业工程技术研究院/农业农村部盐碱土改良与利用(滨海盐碱地)重点实验室/国家耐盐碱水稻技术创新中心华东中心扬州大学江苏扬州225009 扬州大学教育部农业与农产品安全国际合作联合实验室/扬州大学农业科技发展研究院扬州大学225009

以江苏沿海滩涂主栽常规粳稻南粳9108和淮稻5号为试材,研究不同盐胁迫处理包括对照(CK,盐浓度0)、中盐(medium-salinity stress,MS,盐浓度0.15%)和高盐(high-salinity stress,HS,盐浓度0.3%)对水稻籽粒灌浆及产量形成生理特性的影响。... 详细信息

以江苏沿海滩涂主栽常规粳稻南粳9108和淮稻5号为试材,研究不同盐胁迫处理包括对照(CK,盐浓度0)、中盐(medium-salinity stress,MS,盐浓度0.15%)和高盐(high-salinity stress,HS,盐浓度0.3%)对水稻籽粒灌浆及产量形成生理特性的影响。结果表明:(1)与对照相比,中盐和高盐胁迫均显著降低水稻产量,降幅分别为26.3%和57.7%(两品种平均);盐胁迫处理下,穗数、每穗粒数、结实率和千粒重均显著下降。(2)盐胁迫显著降低穗长、每穗强势粒和弱势粒籽粒数、结实率和千粒重,其中强势粒结实率和千粒重的降幅均低于弱势粒。(3)盐胁迫下,水稻植株抽穗期和成熟期干物重以及抽穗期至成熟期干物质积累量显著下降,但收获指数明显增加。此外,抽穗后15 d和30 d盐胁迫处理的叶片净光合速率和SPAD值均显著低于对照。(4)盐胁迫降低籽粒最大灌浆速率和平均灌浆速率,但达最大灌浆速率时间和有效灌浆天数有所增加;盐胁迫提高了强势粒和弱势粒有效灌浆天数,但平均灌浆速率显著下降,其中强势粒灌浆量的降幅低于弱势粒。(5)盐胁迫下,籽粒腺苷二磷酸焦磷酸化酶(AGPase)、淀粉合成酶(SSS)、颗粒型淀粉合成酶(GBSS)和淀粉分支酶(SBE)活性显著下降,其中弱势粒的降幅高于强势粒。综上所述,盐胁迫下水稻强势粒和弱势粒灌浆天数有所增加,但籽粒灌浆速率及其淀粉合成关键酶活性显著下降,致使籽粒充实度、粒重和产量显著下降,其中盐胁迫对弱势粒抑制作用大于强势粒。

关键词：盐胁迫水稻籽粒灌浆产量

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罗汉果甜苷Ⅲ延缓猪卵母细胞体外老化的作用机制

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南方农业学报 2024年第7期55卷 1949-1960页

作者：赵磊曾筱乔高祖维吴诗瑶彭珂严煜钧万润田梁兴伟广西大学动物科学技术学院/广西畜禽繁育与疾病防控重点实验室广西南宁530004

【目的】验证罗汉果甜苷Ⅲ是否具有延缓猪卵母细胞体外老化进程的功效,为采用植物提取物延缓卵母细胞体外老化提供参考依据。【方法】以体外培养44 h获得的猪卵母细胞为研究对象,通过孤雌激活筛选出罗汉果甜苷Ⅲ对猪卵母细胞的有效作用... 详细信息

【目的】验证罗汉果甜苷Ⅲ是否具有延缓猪卵母细胞体外老化进程的功效,为采用植物提取物延缓卵母细胞体外老化提供参考依据。【方法】以体外培养44 h获得的猪卵母细胞为研究对象,通过孤雌激活筛选出罗汉果甜苷Ⅲ对猪卵母细胞的有效作用浓度;然后设新鲜卵母细胞(Fresh)、老化卵母细胞(Aging)及老化卵母细胞添加罗汉果甜苷Ⅲ(MogⅢ)3个处理组,采用免疫荧光染色和实时荧光定量PCR等分别检测猪卵母细胞的线粒体数量和分布、腺嘌呤核苷三磷酸(ATP)含量、线粒体膜电位、活性氧(ROS)水平、DNA损伤、抗氧化相关基因表达及早期凋亡水平等指标。【结果】老化导致猪卵母细胞孤雌激活后的胚胎分裂率及囊胚发育率极显著下降(P<0.01,下同),而添加罗汉果甜苷Ⅲ能有效提高老化卵母细胞孤雌激活后的胚胎分裂率和囊胚发育率,尤其以添加25.0µmol/L罗汉果甜苷Ⅲ的效果最优,故确定25.0µmol/L为罗汉果甜苷Ⅲ的有效作用浓度。与Fresh组猪卵母细胞相比,Aging组猪卵母细胞线粒体荧光强度显著下降(P<0.05,下同)、ATP含量极显著下降、线粒体膜电位显著下降、抗氧化相关基因相对表达量极显著下降,而ROS水平、γ-H2AX荧光强度和Annexin-V阳性率均极显著上升;但添加25.0µmol/L罗汉果甜苷Ⅲ后上述问题均得到有效改善,即罗汉果甜苷Ⅲ能有效缓解猪卵母细胞的老化进程。【结论】罗汉果甜苷Ⅲ通过改善老化猪卵母细胞线粒体数量和ATP含量的异常、恢复ROS平衡、上调抗氧化相关基因表达,以及缓解猪卵母细胞老化引起的DNA损伤和早期凋亡,而有效延缓猪卵母细胞的老化进程,进而提高猪卵母细胞的体外发育能力。

关键词：猪卵母细胞老化罗汉果甜苷Ⅲ 氧化应激

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Optimization for data de-duplication algorithm based on file content

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Frontiers of Optoelectronics 2010年第3期3卷 308-316页

作者： Xuejun NIE Leihua QIN Jingli ZHOU ke LIU Jianfeng ZHU yu WANG School of Computer Science and Technology Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology

Content defined chunking(CDC) is a prevalent data de-duplication algorithm for removing redundant data segments in archival storage systems. Current researches on CDC do not consider the unique content characteristic of different file types, and they determine chunk boundaries in a random way and apply a single strategy for all file types. It has been proven that such method cannot achieve optimal performance for compound archival data. We analyze the content characteristic of different file types and propose candidate anchor histogram(CAH) to capture it. We propose an improved strategy for determining chunk boundaries based on CAH and tune some key parameters of CDC based on the data layout of underlying data de-duplication file system(TriDFS), which can efficiently store variable-sized chunks on fixed-sized physical blocks. These strategies are evaluated with representative archival data, and the result indicates that they can increase on average the compression ratio by 16.3% and write throughput by 13.7%, while only decrease the read throughput by 2.5%.

关键词： data de-duplication content defined chunking (CDC) file content candidate anchor histogram (CAH)

Co-processing petroleum catalytic slurry with coal

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Journal of Coal Science & Engineering(China) 2013年第4期19卷 554-559页

作者： Yong-bing XUE Zhi-yu WANG bing-Zheng LI ke-Qiong ZHANG School of Chemical & Biological Technology Taiyuan University of Science & Technology Taiyuan 030021 China Institute of Coal Chemistry Chinese Academy of Sciences Taiyuan 030001 China

It is studied that reactivity of petroleum catalytic slurry （PCS） and coal with Fe catalyst in 1 L autoclave, the fol- lowing is mainly discussed, coal conversion and asphalt properties, especially related with petroleum cracking slurry （PCS） properties. The results show that co-processing conversion and asphalt yield increase with the increase of PCS ratio. PCS prop- erties have important effect on coal conversion and asphalt properties. One kind of PCS shows negative effect on coal conver- sion. High aromatic PCS can lead to high ductility asphalt with good colloid properties. Coal and the PCS can lead to a strong matching effect.

关键词： petroleum cracking slurry coal co-processing asphalt colloid

Reconsideration on Homogeneous Quadratic Riemann Boundary Value Problem

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Wuhan University Journal of Natural Sciences 2004年第1期9卷 1-5页

作者： LuJian-ke SchoolofMathematicsandStatistics WuhanUniversityWuhan430072HubeiChina

The homogeneous quadratic riemann boundary value problem (1) with H?lder continuous coefficients for the normal case was considered by the author in 1997. But the solutions obtained there are incomplete. Here its general method of solution is obtained. key words homogeneous quadratic Riemann boundary value problem - ordinary and special nodes - index - sectionally holomorphic function CLC number O 175.5 Foundation item: Supported by the National Natural Science Foundation of China (19871064)Biography: Lu Jian-ke (1922-), male, Professor, research direction: complex analysis and its applications.

关键词： homogeneous quadratic Riemann boundary value problem ordinary and special nodes index sectionally holomorphic function

黄连及其炮制品对实热型口腔溃疡大鼠干预作用的代谢组学研究

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中国中药杂志 2024年第2期49卷 389-402页

作者：张振凯郑亚娟张冰贤王永祥张金英曹玉敏冯卫生郑晓珂周宁河南中医药大学河南郑州450046 河南省中药开发工程技术研究中心河南郑州450046 河南中医药大学呼吸疾病中医药防治省部共建协同创新中心河南郑州450046 豫药全产业链研发河南省协同创新中心河南郑州450046

采用UPLC-Q/TOF-MS技术,探究黄连及其3种炮制品对实热型口腔溃疡大鼠体内代谢的干预作用,揭示黄连3种炮制品的药效差异。将雄性SD大鼠随机分为假手术组、实热型口腔溃疡模型组、生黄连组、酒/姜/萸/黄连组、阳性药黄连上清片组。除假手... 详细信息

采用UPLC-Q/TOF-MS技术,探究黄连及其3种炮制品对实热型口腔溃疡大鼠体内代谢的干预作用,揭示黄连3种炮制品的药效差异。将雄性SD大鼠随机分为假手术组、实热型口腔溃疡模型组、生黄连组、酒/姜/萸/黄连组、阳性药黄连上清片组。除假手术组外,其他组连续灌胃2周党参-黄芪水煎液,实热造模期间记录大鼠肛温和饮水量,实热造模完成后结合乙酸进行口腔溃疡造模。苏木精-伊红(HE)观察口腔溃疡黏膜病理学变化;比色法检测血清中谷胱甘肽过氧化物酶(GSH-Px)的水平;ELISA检测大鼠血清中肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)、超氧化物歧化酶(SOD)和丙二醛(MDA)的含量;收集血清样本,利用UPLC-Q/TOF-MS技术进行非靶向代谢组学分析,通过主成分分析(PCA)和正交偏最小二乘判别分析(OPLS-DA)构建代谢轮廓并筛选潜在生物标志物,应用Mev软件对标志物相对定量结果进行热图绘制和聚类分析,最后结合MBRole、keGG和MetaboAnalyst等在线数据库进行通路富集分析和代谢网络构建。实验结果显示,造模后大鼠口腔黏膜病理损伤严重,血清中TNF-α、IL-6、IL-1β、MDA水平显著升高,SOD、GSH-Px水平显著降低;给药后各指标均有回调趋势,以酒黄连的改善效果最佳。非靶向代谢组学最终鉴定出48个差异代谢物,包括正源模式下27个、负源模式下21个,富集得到甘油磷脂代谢、亚油酸代谢、酪氨酸代谢等5条共有通路。综上,黄连及其3种炮制品均可通过干预脂质代谢、氨基酸代谢等途径,改善实热型口腔溃疡大鼠机体的炎症反应和氧化应激损伤,其中酒黄连的治疗效果最显著。

关键词：黄连实热型口腔溃疡代谢组学 UPLC-Q/TOF-MS