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Chinese Journal of Polymer Science 2021年第7期39卷 925-933页

作者： bin zhao Mei-Jiao Liu Chao Wang Ying-Cai Chen yu-Ci Xu Department of Physics Taizhou UniversityTaizhou 318000China Key Laboratory of Computational Physical Science Fudan UniversityShanghai 200433China Department of Chemistry Zhejiang Sci-Tech UniversityHangzhou 310018China Faculty of Materials Science and Chemical Engineering Ningbo UniversityNingbo315211China

Hybrid nanostructures possess a great potential for application in advanced nanotechnologies due to the anisotropic properties from different *** previous work demonstrated that a linear A_(1)B_(1)A_(2)B_(2)tetrablock copolymer of symmetric overall volume fraction can self-assemble into a hybrid lamella-sphere(LS)structure by tuning the relative length of the two A-blocks through self-consistent field theory(SCFT),where the spherical and the lamellar domains are mainly composed of the long Ar and short A2-blocks,***,the phase region of LS is *** order to expand the stable region of LS,we change the linear A2B2 copolymer to a branched A_(1)B_(1)A_(2)B_(2)copolymer resulting in an increase of the local spontaneous curvature between A2-and *** examine the impact of the branching number m of 62-block on the stable region of LS in the phase diagram with respect to f_(A1)and for fixed f_(B)=0.5 and f_(B1)=0.26,and find that m=2 expands the LS region significantly in contrast to the linear *** the other hand,the stability window of LS does not change notably when m=2 is increased to 3 in our calculated parameter space.

关键词： Block copolymer Self-assembly Self-consistent field theory Hybrid structure

An in situ infrared study of dimethyl carbonate synthesis from carbon dioxide and methanol over well-shaped CeO2

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Chinese Chemical Letters 2017年第1期28卷 65-69页

作者： shu-yang zhao sheng-ping wang yu-jun zhao xin-bin ma key laboratory for green chemical technology school of chemical engineering and technologytianjin universitycollaborative innovation center of chemical science and engineeringTianjin 300072China

The mechanism of dimethyl carbonate（DMC） formation from CO2 and methanol is investigated using three well-shaped CeO2 catalysts, nanorod, nanocube and octahedron, which are packed with different crystal planes. In situ Fourier Transform Infrared Spectroscopy（FTIR） is employed to probe each reaction step in the DMC synthesis. The number of –OH groups and the species of CO2 adsorptions on ceria surface have significant influence on the activity of ceria with different morphologies. Rod-ceria has favorable catalytic activity because of the large amount of –OH groups and the formation of bidentate carbonate species.

关键词： Dimethyl carbonate CeO2 -OH Bidentate carbonate Crystal planes

A direct electrochemical biosensor for rapid glucose detection based on nitrogen-doped carbon nanocages

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Rare Metals 2024年第5期43卷 2184-2192页

作者： Lan-Lan Li yu zhao Li-Jia Pan Jian-bin Xu Yi Shi College of Mechanical and Electrical Engineering Henan Agricultural UniversityZhengzhou 450002China School of Electronic Science and Engineering Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing210093China Department of Electronic Engineering The Chinese University of HongKongHongkong 999077China

Given the increasing number of diabetic patients,rapid and accurate detection of glucose in body fluids is *** study developed a direct electrochemical biosensor for glucose based on nitrogen-doped carbon nanocages(NCNCs).NCNCs possess a large specific surface area of 1395 m^(2)·g^(-1),a high N atomic content of 9.37%and good biocompatibility,which is favorable for enzyme loading and electron *** surface average concentration of electroactive glucose oxidase on NCNCs was 2.82×10^(-10)mol·cm^(-2).The NCNC-based direct electrochemical biosensor exhibited a high sensitivity of 13.7μA·(mmol·L^(-1))^(-1)·cm^(-2),rapid response time of 5 s and an impressive electron-transferrate constant(ks)of 1.87 s^(-1).Furthermore,we investigated an NCNC-based direct electron transfer(DET)biosensor for sweat glucose detection,which demonstrated tremendous promise for non-invasive wearable diabetes diagnosis.

关键词： Direct electron transfer(DET) Nitrogen-doped carbon nanocages(NCNCs) Glucose oxidase Biosensor

A multifunctional cross-validation high-throughput screening protocol enabling the discovery of new SHP2 inhibitors

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Acta Pharmaceutica Sinica B 2021年第3期11卷 750-762页

作者： Yihui Song Min zhao Yahong Wu bin yu Hong-Min Liu School of Pharmaceutical Sciences&Key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationZhengzhou UniversityZhengzhou 450001China School of Life Sciences Zhengzhou UniversityZhengzhou 450001China

The protein tyrosine phosphatase Src homology phosphotyrosyl phosphatase 2(SHP2) is implicated in various cancers, and targeting SHP2 has become a promising therapeutic approach. We herein described a robust cross-validation high-throughput screening protocol that combined the fluorescence-based enzyme assay and the conformation-dependent thermal shift assay for the discovery of SHP2 inhibitors. The established method can effectively exclude the false positive SHP2 inhibitors with fluorescence interference and was also successfully employed to identify new protein tyrosine phosphatase domain of SHP2(SHP2-PTP) and allosteric inhibitors. Of note, this protocol showed potential for identifying SHP2 inhibitors against cancer-associated SHP2 mutation SHP2-E76 A. After initial screening of our in-house compound library(w2300 compounds), we identified 4 new SHP2-PTP inhibitors(0.17%hit rate) and 28 novel allosteric SHP2 inhibitors(1.22% hit rate), of which SYK-85 and WS-635 effectively inhibited SHP2-PTP(SYK-85: IC_(50) Z 0.32 mmol/L;WS-635: IC_(50) Z 4.13 mmol/L) and thus represent novel scaffolds for designing new SHP2-PTP inhibitors. TK-147, an allosteric inhibitor, inhibited SHP2 potently(IC_(50) Z 0.25 mmol/L). In structure, TK-147 could be regarded as a bioisostere of the well characterized SHP2 inhibitor SHP-099, highlighting the essential structural elements for allosteric inhibition of SHP2. The principle underlying the cross-validation protocol is potentially feasible to identify allosteric inhibitors or those inactivating mutants of other proteins.

关键词： SHP2 High-throughput screening Enzyme assay Thermal shift assay Allosteric inhibitors

Multi-loop adaptive internal model control based on a dynamic partial least squares model

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第3期12卷 190-200页

作者： zhao zhao bin HU Jun LIANG State Key Lab of Industrial Control Technology Department of Control Seienee & Engineering Zhejiang University Hangzhou 310027 China

A multi-loop adaptive internal model control (IMC) strategy based on a dynamic partial least squares (PLS) frame-work is proposed to account for plant model errors caused by slow aging,drift in operational conditions,or environmental *** PLS decomposition structure enables multi-loop controller design within latent spaces,a multivariable adaptive control scheme can be converted easily into several independent univariable control loops in the PLS *** each latent subspace,once the model error exceeds a specific threshold,online adaptation rules are implemented separately to correct the plant model mismatch via a recursive least squares (RLS) *** the IMC extracts the inverse of the minimum part of the internal model as its structure,the IMC controller is self-tuned by explicitly updating the parameters,which are parts of the internal *** parameter convergence and system stability are briefly analyzed,and proved to be ***,the proposed control scheme is tested and evaluated using a widely-used benchmark of a multi-input multi-output (MIMO) system with pure delay.

关键词： Partial least squares (PLS) Adaptive internal model control (IMC) Recursive least squares (RLS)

Spectral-spatial classification for hyperspectral imagery: a novel combination method based on affinity scoring

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Science China(Information Sciences) 2016年第10期59卷 181-193页

作者： zhao CHEN bin WANG State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal University Key Laboratory for Information Science of Electromagnetic Waves (Ministry of Education) Fudan University Research Center of Smart Networks and Systems School of Information Science and Technology Fudan University

Recently, a general framework for spectral-spatial classification has caught the attention of the hyperspectral imagery(HSI) society. It consists of three parts: classification, segmentation and combination of the former results to make a refined labeled map. Seeing the potentials of the last part, we derive a novel combination rule based on affinity scoring(CRAS). The core of the system is affinity score(AS), which is derived from fuzzy logic. Every AS measures the degree, i.e., the affinity, by which a pixel belongs to a class. The score is essentially decided by three factors: local spatial consistency, spectral similarity, and prior knowledge. The method is compatible with basic classification and segmentation tools, thus saving the trouble of designing complex techniques for the other parts in the framework. Experimental results show that CRAS excels several basic techniques as well as various state-of-the-art methods in the area of spectral-spatial classification.

关键词： hyperspectral imagery spectral-spatial classification affinity score local spatial consistency fuzzy superpixel

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L-quantum spaces

Science China(Information Sciences) 2016年第3期59卷 153-161页

作者： bin zhao Nana MA College of Mathematics and Information Science Shaanxi Normal University

In this paper, based on a complete residuated lattice L, we introduce the definitions of L-quantum spaces and continuous mappings. Then we establish an adjunction between the category of stratified L-quantum spaces and the opposite category of two-sided L-quantales. We also prove that the category of sober L-quantum spaces is dually equivalent to the category of spatial two-sided L-quantales.

关键词： L-quantum space L-quantale adjunction stratified L-quantum space spatial two-sided L quantale

X-ray irradiation-induced degradation in Hf_(0.5)Zr_(0.5)O_(2) fully depleted silicon-on-insulator n-type metal oxide semiconductor field-effect transistors

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Rare Metals 2021年第11期40卷 3299-3307页

作者： yu-Dong Li Qing-Zhu Zhang Fan-yu Liu zhao-Hao Zhang Feng-yuan Zhang Hong-bin zhao Bo Li Jiang Yan Key Laboratory of Microelectronics Devices and Integrated Technology Integrated Circuit Advanced Process Center(ICAC)Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Advanced Materials for Smart Sensing GRINM Group Co.LtdBeijing 100088China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China School of Information Science and Technology North China University of TechnologyBeijing 100144China

The n-type ultrathin fully depleted silicon-on-insulator(FDSOI) metal-oxide-semiconductor field-effect transistors(MOSFETs),with a Hf_(0.5)Zr_(0.5)O_(2) high dielectric permittivity(high-k) dielectric as gate insulator,were *** total ionizing dose effects were investigated,and an X-ray radiation dose up to 1500 krad(Si) was applied for both long-and short-channel *** short-channel devices(0.025-0.100 μm) exhibited less irradiation sensitivity compared with the long-channel devices(0.35-16 μm),leading to a 71% reduction in the irradiation-induced drain current growth and a 26% decrease in the shift of the threshold *** was experimentally demonstrated that the OFF mode is the worst case among the three working conditions(OFF,ON and A110) for short-channel ***,the determined effective electron mobility was enhanced by 38% after X-ray irradiation,attributed to the different compensations for charges triggered by radiation between the highk dielectric and buried *** extracting the carrier mobility,gate length modulation,and source/drain(S/D)parasitic resistance,the degradation mechanism on X-ray irradiation was ***,the split capacitance-voltage measurements were used to validate the analysis.

关键词： Total ionizing dose Fully depleted silicon-on-insulator(FDSOI) Metal–oxide–semiconductor field-effect transistor(MOSFET) High-k Hf_(0.5)Zr_(0.5)O_(2)

Test system of the front-end readout for an application-specific integrated circuit for the water Cherenkov detector array at the large high-altitude air shower observatory

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Nuclear Science and Techniques 2017年第6期28卷 140-149页

作者： Er-Lei Chen Lei zhao Li yu Jia-Jun Qin yu Liang Shu-bin Liu Qi An State Key Laboratory of Particle Detection and Electronics University of Science and Technology of China Department of Modern Physics University of Science and Technology of China

The water Cherenkov detector array(WCDA) is an important part of the large high-altitude air shower observatory(LHAASO),which is in a research and development *** central scientific goal of LHAASO is to explore the origin of high-energy cosmic rays of the universe and to push forward the frontier of new *** simplify the WCDA's readout electronics,a prototype of a front-end readout for an application-specific integrated circuit(ASIC) is designed based on the timeover-threshold method to achieve charge-to-time ***-precision time measurement and charge measurement are necessary over a full dynamic range[1-4000photoelectrons(P.E.)].To evaluate the performance of this ASIC,a test system is designed that includes the front-end ASIC test module,digitization module,and test *** first module needs to be customized for different ASIC versions,whereas the digitization module and test software are tested for general-purpose *** the digitization module,a field programmable gate array-based time-todigital converter is designed with a bin size of 333 ps,which also integrates an inter-integrated circuit to configure the ASIC test module,and a universal serial bus interface is designed to transfer data to the remote *** results indicate that the time resolution is better than 0.5 ns,and the charge resolution is better than 30%root mean square(RMS) at 1 *** 3%RMS at 4000 P.E.,which are beyond the application requirements.

关键词： Time and charge measurement Photomultiplier tube (PMT) Water Cherenkov detector array Inter-integrated circuit Application-specific integrated circuit Test system

Self-assembly Behavior of Copolymers with Super Segregated Structure Containing Fluorinated Segments

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Chinese Journal of Polymer Science 2014年第7期32卷 817-817,818-822页

作者： Jin-ni Deng Wen-bin Wang zhao-hui Zheng 丁小斌 yu-xing Peng Chengdu Institute of Organic Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences

Copolymers with super segregated structure of hydrophilic methoxy poly（ethylene glycol）（mPEG） and fluorophilic poly（1H,1H,2H,2H-perfluorodecyl acrylate）（PFA） were prepared. And just because of this super segregated structure which was resulted from the extremely strong incompatibility between the two blocks, several interesting self- assembly behaviors of the copolymers were displayed and studied under different conditions. Transmission electron microscope （TEM） showed that with the increase of PFA in the polymerization system, the incompatibility in this super segregated structure became stronger, and the self-assembly behavior changed from ball-like or rod-like to vesicles, and finally collapsed to sheet-like. The self-assembly behavior changed likewise when the initial concentration increased. And the interesting formation of these barrel-like and spindle-like vesicles was finally studied with different cooling speeds. It＇s finally found that with this super segregation structure, these new self-assembly morphology might be formed due to the extremely strong incompatibility between mPEG and PFA segments.

关键词： Super segregated structure Self-assembly behavior Barrel-like and spindle-like vesicles.