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Expression of kallikrein-related peptidase 7 is decreased in prostate cancer

Asian Journal of Andrology 2015年第1期17卷 106-110,I0010页

作者： Chong-yu Zhang yu Zhu wen-bin Rui Jun Dai Zhou-Jun Shen Department of Urology Ruijin Hospital School of Medicine Shanghai Jiaotong University Shanghai China.

Recent evidence suggests that the human kallikrein 7 （KLK7） is differentially regulated in a variety of tumors. The aim of this study was to determine the expression of kallikrein-related peptidase 7 and KLK7 in our large collection of prostate samples. Between August 2000 and December 2012, 116 patients with histologically confirmed prostate cancer （PCa） and 92 with benign prostate hyperplasia （BPH） were recruited into the study. Using immunohistochemistry, quantitative reverse transcription polymerase chain reaction （RT-PCR） and western blot, kallikrein-related peptidase 7 expression in BPH and PCa tissues was determined at the mRNA and protein levels. The relationships between kallikrein-related peptidase 7 mRNA expression and clinicopathological features were analyzed. A total of 64 of 92 （69.57%） benign cases showed positive staining for KLK7 and 23 of 116 （19.83%） malignant cases showed positive, the difference of KLK7 expression between PCa and BPH was statistically significant （P〈 0.001）. The expression level of kallikrein-related peptidase 7 mRNA was significantly decreased in PCa tissues compared with that in BPH tissues and normal prostate tissue. Kallikrein-related peptidase 7 mRNA exhibited different expression patterns in terms of localization depending on pathological category of PCa. Similarly, our western immunoblot analyses demonstrated that the protein expression levels of KLK7 was lower in PCa than in BPH tissues and normal prostate tissue. Kallikrein-related peptidase 7 and KLK7 expression are down-regulated in PCa and lower expression of kallikrein-related peptidase 7 closely correlates with higher Gleason score and higher prostate-specific antigen level.

关键词： human kallikrein 7 kallikrein-related peptidase 7 prostate cancer prostate-specific antigen

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Clinicopathological Analysis of 155 Patients with Persistent Isolated Hematuria

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Chinese Medical Sciences Journal 2014年第3期29卷 148-155页

作者： Rong-rong Li Hang Li yu-bin wen Qing-yuan Huang Lin Duan Yan Li Department of Clinical Nutrition Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Department of Nephrology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College

Objectives To reveal etiologies of persistent isolated hematuria （PIH） through ultrastructural pathological examination, to disclose clinicopathological correlation in cases with PIH, and to summarize appropriate management of patients with PIH. Methods we retrospectively studied 155 P1H patients receiving renal biopsy between January, 2003 and December, 2008 in Peking Union Medical College Hospital. All the clinical data and follow-up result were analyzed. Results All subjects included 38 children and 117 adults, with mean age of 11.38±3.25 years for children and 35.17±8.44 years for adults. Thin basement membrane nephropathy （TBMN） was the most common pathology （55.3% of children and 49.6% of adults）, followed by IgA nephropathy （18.4% of children and 32.5% of adults, mainly grade 2-3） and mesangial proliferative glomerulonephritis （MsPGN） without IgA deposition （13.2% of children and 12.8% of adults）. Besides, A1port syndrome （2.6% of children） and membrane nephropathy （2.6% of children and 0.9% of adults） were demonstrated as other causes of PIH. Elevated mean arteral pressure or protein excretion rate, as well as episodic macrohematuria, indicated higher risk for MsPGN rather than TBMN. On the other hand, severity of microhematuria was irrelevant to pathological types of PIH. Totally, 86 patients were followed up and 37 cases therein stayed on track for long term （mean duration 41.11±28.92 months, range 8-113 months）. Most cases had benign clinical course except 3 cases with TBMN, 5 cases with IgA nephropathy, 1 case with MsPGN （without IgA deposition）, and 1 case with Alport syndrome, who developed hypertension or proteinuria. All of them were administered timely intervention. Conclusions Close follow-up should be required as the primary management for PIH. Equally important is careful monitoring for early identification of undesirable predictors; while renal biopsy and other timely intervention are warranted if there is hypertension, significant proteinuri

关键词： isolated hematuria renal biopsy pathology IgA nephropathy thin basement membrane nephropathy

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Effect of the regimen of Gaoshan Hongjingtian on the mechanism of poly（ADP-ribose） polymerase regulation of nuclear factor kappa B in the experimental diabetic retinopathy

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Chinese Medical Journal 2013年第9期126卷 1693-1699页

作者： ZHAO Hong-shu SHI Xiang-yu WEI wen-bin WANG Ning-li Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology & Visual Sciences Key Laboratory Beijing 100730 China

Background Poly（ADP-ribose） polymerase （PARP） plays an important role in the death of retinal capillary cells in diabetic retinopathy （DR） partly via its regulation of nuclear factor kappa B （NF-κB）. The current study investigated the effect of the regimen of Gaoshan Hongjingtian （RG） on the mechanism of PARP regulation of NF-κB, and demonstrated the possible impact of the RG and Gaoshan Hongjingtian （Rhodiola sachalinensis, RS） on diabetic retinopathy. Methods Wistar rats were made diabetic by administering streptozotocin. They were then assigned to three groups at random. After 2 months, the three groups of these diabetic rats were treated with RS or RG, or untreated. Analyses of expression levels of PARP, NF-κB, and intercellular adhesion molecule-1 （ICAM-1） in the retinas of rats in different groups were performed by Western blotting and immunohistochemical assays, and mRNA levels of NF-κB and ICAM-1 were determined by real-time polymerase chain reaction （PCR）. In addition, the basement membranes of capillaries in the rats＇ retinas were observed using electron microscopy, and diabetes-induced capillary degeneration （ghost pericytes and acellular capillaries） were quantitated. Results From the third month after the injection of streptozotocin, the diabetic rats were given daily RG, RS or tap water separately. The diabetic rats failed to gain weight compared with normal age-matched rats, whereas their glycated hemoglobin levels were significantly increased. After 5 months, the mRNA levels of NF-KB and ICAM-1 and the protein expression of PARP, NF-κB, and ICAM-1 were significantly increased in the retinas of diabetic rats in the untreated group compared with the nondiabetic controls. After 8 months, the number of degenerated retinal capillaries （ghost pericytes and acellular capillaries） was significantly increased in the diabetic rats in the untreated group compared with normal age-matched rats. RG and RS inhibited diabetes-induced over-expression of PARP, NF-KB,

关键词： Rhodiola sachalinensis Gaoshan Hongjingtian diabetic retinopathy poly(ADP-ribose) polymerase nuclear factor kappa B

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反对称角铺设复合材料层合板热后屈曲和模态跃迁分析

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振动与冲击 2011年第8期30卷 169-174页

作者：钟轶峰余文斌重庆大学土木工程学院重庆400045 山地城镇建设与新技术教育部重点实验室(重庆大学) 重庆400045 犹他州立大学机械与航空工程系美国843224130

为有效分析反对称角铺设复合材料层压板热后屈曲性能,由渐近修正几何非线性理论推导双耦合四阶偏微分方程(即协调方程和动态控制方程),通过双Fourier级数将耦合非线性控制偏微分方程转换为系列非线性常微分方程,从而获得相对简单的求解... 详细信息

为有效分析反对称角铺设复合材料层压板热后屈曲性能,由渐近修正几何非线性理论推导双耦合四阶偏微分方程(即协调方程和动态控制方程),通过双Fourier级数将耦合非线性控制偏微分方程转换为系列非线性常微分方程,从而获得相对简单的求解方法。使用广义Galerkin方法求解与角交铺设复合层合板相关的边界值问题,研究了模态跃迁前后不同复杂程度的后屈曲模式。通过四边简支、面内不可移边界下复合层合板的数值计算表明:该解析法与有限元方法在主后屈曲区域的计算结果有很好的吻合性;有限元方法在解靠近二次分岔点时失去收敛性,而解析法仍具有深入探索后屈曲区域和准确捕捉模态跃迁现象的能力。

关键词：复合材料力学层合板热后屈曲模态跃迁

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用渐近变分法对复合材料层合板简化数值建模及仿真

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重庆大学学报（自然科学版） 2011年第2期34卷 130-135页

作者：钟轶峰余文斌重庆大学土木工程学院重庆400045 重庆大学山地城镇建设与新技术教育部重点实验室重庆400045 美国犹他州立大学机械与航空工程系美国843224130

为有效分析三维复合材料层合板非线性、单向耦合弹性问题,基于渐近变分方法构建单斜对称的复合材料层合板的简化模型。推导了基于旋转张量分解概念的复合材料层合板能量表达式;利用渐近变分法将三维层合板严格拆分为二维板分析和沿法线... 详细信息

为有效分析三维复合材料层合板非线性、单向耦合弹性问题,基于渐近变分方法构建单斜对称的复合材料层合板的简化模型。推导了基于旋转张量分解概念的复合材料层合板能量表达式;利用渐近变分法将三维层合板严格拆分为二维板分析和沿法线方向的一维非线性分析;进行了降维后近似能量推导及reissner形式转换;提供了三维场重构关系以得到沿厚度方向的准确应力分布。通过对一具有四层复合层合板的柱形弯曲算例表明:基于该理论和重构过程开发的渐近变分程序VAPAS重构生成的三维应力场精确性较古典层合理论更好,与三维有限元精确解相一致。

关键词：渐近变分法层合板三维重构 reissner模型

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Lenalidomide regulates the CCL21/CCR7/ERK1/2 axis to inhibit migration and proliferation in diffuse large B-cell lymphoma

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Oncology Research 2025年第1期33卷 199-212页

作者： wen YANG bin TANG DAN XU wenXIU YANG Department of Pathology Guizhou Medical UniversityThe Affiliated Hospital of Guizhou Medical UniversityGuiyang550004China

Background:The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma(DLBCL)has been reported ***,the detailed mechanisms of CCR7 in DLBCL,particularly regarding its interaction with lenalidomide treatment,are not fully ***:Our study utilized bioinformatics approaches to identify hub genes in SU-DHL-2 cell lines treated with lenalidomide compared to control *** data and clinical information from 122 patients with DLBCL were analyzed to assess the correlation of CCR7 and p-ERK1/2 expression with the prognosis of ***,in vitro and in vivo experiments were conducted to clarify the role of CCR7 in the response of DLBCL to lenalidomide ***:Our bioinformatics analysis pinpointed CCR7 as a hub gene in the context of lenalidomide treatment in ***,31.14%and 36.0%(44/122)of DLBCL cases showed positive expression for CCR7 and ERK1/2 respectively,establishing them as independent prognostic factors for adverse outcomes in DLBCL via multivariate Cox regression ***,our studies demonstrated that the external application of the protein CCL21 promoted proliferation,migration,invasion,and activation of the ERK1/2 pathway in SU-DHL-2 and OCI-LY3 cell lines with high levels of CCR7 *** effect was mitigated by CCR7 silencing through siRNA,application of ERK inhibitors,or lenalidomide *** vivo experiments reinforced the efficacy of lenalidomide,significantly reducing tumor growth rate,tumor mass,serum total LDH levels,and expression of CCR7 and p-ERK1/2 in a SUDHL-2 xenograft model in nude mice(p<0.05).Conclusion:Our study clarifies the potential role of the CCL21/CCR7/ERK1/2 axis in the therapeutic effects of lenalidomide in DLBCL treatment.

关键词： CCR7 CCL21 ERK1/2 Lenalidomide Diffuse large B-cell lymphoma(DLBCL)

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基于飞行保护头盔的主动消声研究

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航天医学与医学工程 2005年第4期18卷 306-307页

作者：余文斌武哲北京航空航天大学航空科学与工程学院北京100084

目的研制一种闭环反馈式头盔有源消声系统.方法在系统频率特性函数的基础上,从自动控制理论的角度建立了有源消声耳罩的数学模型,提出了有源消声耳罩对电声器件特性的要求,并把优化设计方法引入到反馈式控制器的设计中来.结果有源消声... 详细信息

目的研制一种闭环反馈式头盔有源消声系统.方法在系统频率特性函数的基础上,从自动控制理论的角度建立了有源消声耳罩的数学模型,提出了有源消声耳罩对电声器件特性的要求,并把优化设计方法引入到反馈式控制器的设计中来.结果有源消声耳罩将声学元件和模拟电路相匹配,在不改变头盔其他性能的基础上,取得了良好的消声效果.该系统样机在50～1 000 Hz频率范围内的有源消声量大于15 dB,最高可达19 dB.结论飞行头盔的有源消声耳罩的消声结果已达到国际先进水平并可批量生产.

关键词：主动消声系统耳罩头盔飞行员

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Wave effect of gravitational waves intersected with a microlens field Ⅱ:An adaptive hierarchical tree algorithm and population study

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 241-254页

作者： Xikai Shan Guoliang Li Xuechun Chen wen Zhao bin Hu Shude Mao Department of Astronomy Tsinghua University Purple Mountain Observatory Chinese Academy of Sciences Institute for Frontier in Astronomy and Astrophysics Beijing Normal University School of Physics and Astronomy Beijing Normal University School of Astronomy and Space Science University of Science and Technology of China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of Astronomy University of Science and Technology of ChinaChinese Academy of Sciences

The gravitational lensing wave effect generated by a microlensing field embedded in a lens galaxy is an inevitable phenomenon in strong lensed gravitational waves （SLGWs）.This effect presents both challenges and opportunities for the detection and application of ***,investigating this wave effect requires computing a complete diffraction integral over each microlens in the *** is extremely time-consuming due to the large number of microlenses （10～3-10～6）.Therefore,simply adding all the microlenses is ***,the complexity of the time delay surface makes the lens plane resolution a crucial factor in controlling numerical *** this paper,we propose a trapezoid approximation-based adaptive hierarchical tree algorithm to meet the challenges of calculation speed and *** find that this algorithm accelerates the calculation by four orders of magnitude compared to the simple adding method and is one order of magnitude faster than the fixed hierarchical tree algorithm proposed for electromagnetic *** importantly,our algorithm ensures controllable numerical errors,increasing confidence in the *** with our previous work （***.66,239511,2023）,this paper addresses all numerical issues,including integral convergence,precision,and computational time1).Finally,we conducted a population study on the microlensing wave effect of SLGWs using this algorithm and found that the microlensing wave effect cannot be ignored,especially for Type II SLGWs （from saddle position of the time delay surface） due to their intrinsic geometric structures and their typical intersection with a denser microlensing ***,more than 33%（11%） of SLGWs have a mismatch larger than 1%（3%） compared to the unlensed ***,we found that the mismatch between signal pairs in a doubly imaged GW is generally larger than 10-3,and 61%（25%） of signal pairs have a mismatch larger than 1%（3%）.Therefo

关键词： gravitational lensing diffractional integral algorithm gravitational wave

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Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang yu-wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

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深井动压影响沿空掘巷锚梁网支护技术

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煤矿开采 2010年第5期15卷 55-58页

作者：余文彬中国矿业大学矿业工程学院江苏徐州221116 淮南矿业集团潘集第三煤矿安徽淮南232096

介绍了深部煤层沿空掘进巷道在受本煤层及上覆煤层双重采动影响下的支护方案和围岩变形情况,分析了采动压力对掘进巷道的影响范围和加固方法。

关键词：深井动压影响沿空掘巷锚梁网支护参数

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