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Mass screening of prostate cancer in a Chinese population:the relationship between pathological features of prostate cancer and serum prostate specific antigen

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Asian Journal of Andrology 2005年第2期7卷 159-163页

作者： Hong-WenGao yu-LinLi ShanWu Yi-ShuWang Hai-FengZhang yu-zhuopan LingZhang HirooTateno IkuroSato MasaakiKuwahara Xue-JianZhao DepartmentofPathology JilinUniversitySecondHospitalChangchun130041China／／ProstateDiseasesPreventionandTreatmentResearchCenterJilinUniversityChangchun130021China DepartmentofPathology BasicMedicalCollegeJilinUniversityChangchun130021China ProstateDiseasesPreventionandTreatmentResearchCenter JilinUniversityChangchun130021China DepartmentofPathology MiyagiCancerCenterMiyagiPrefectureJapan DepartmentofUrology MiyagiCancerCenterMiyagiPrefectureJapan

Aim:To investigate the pathological features of the prostate biopsy through mass screening for prostate cancer in a Chinese cohort and their association with serum prostate specific antigen (PSA).Methods:A total of 12 027 Chinese men in Changchun were screened for prostate cancer by means of the serum total prostate specific antigen (tPSA) test (by Elisa assay).Transrectal ultrasound-guided systematic six-sextant biopsies were performed on those whose serum tPSA value was >4.0 ng/mL and those who had obstructive symptoms (despite their tPSA value) and were subject to subse- quent pathological analysis with the aid of the statistic software SPSS 10.0 (SPSS.Inc.,Chicago.USA).Results:Of the 12 027 cases,158 (including 137 patients whose serum tPSA values were >4.0 ng/mL and 21 patients [serum tPSA <4. 0 ng/mL] who had obstructive symptoms) undertook prostate biopsy.Of the 158 biopsies,41 cases of prostatic carci- noma were found (25.9 %,41/158).The moderately differentiated carcinoma and poorly differentiated carcinoma ac- counted for 61% and 34 %,respectively.A significant linear positive correlation between the serum tPSA and the Gleason scores in the 41 cases of prostatic carcinoma (r=0.312,P<0.01) was established.A significant linear positive correlation between the serum tPSA value of the 41 prostatic carcinoma and the positive counts of carcinoma in sextant biopsies was established (r=0.406,P<0.01),indicating a significant linear relationship between serum tPSA and the size of tumor. Condusion:This study was the first to conduct mass screening for prostate cancer by testing for serum tPSA values and the first to investigate the pathological features of prostate cancer in a cohort of Chinese men.Our results reveal that the moderately differentiated carcinoma is the most common type of prostate cancer.This study also has shown that the serum tPSA value in prostate cancer is associated with the Gleason score and the size of tumor.

关键词： prostate cancer mass screening prostate specific antigen pathomorphology

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Early diagnosis of prostate cancer using free/total prostate specific antigen ratio: a population based screening data

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Asian Journal of Andrology 2004年第4期6卷 342-342页

作者： LingZhang Guo-YIJi Xiao-MengLi Wei-HuaWang Hong-WenGao yu-zhuopan Hong-JunWang KuwaharaMasaaki Xue-JianZhao ResearchCenterforProstateDiseasePreventionandTreatment JilinUniversityChangchun130021China ResearchInstituteofMilitaryMedicine ShenyangCommandShenyang110000China DivisionofUrology MiyagiCancerCenterNatori981Japan

Aim: To evaluate the use of free/total prostate specific antigen ratio (fPSA/tPSA ratio) in improving the early diagnosis of prostate cancer. Methods: The fPSA/tPSA ratio in the serum was analyzed in 187 men with tPSA ranging between 4.0 and 20.0 μg/L. All of them underwent ultrasound guided sextant prostatic biopsy. The results were calculated by SPSS 10.0 software. Results: (1) When the tPSA was within the ranges of 4.0 - 10.0 and 10.0 -20.0 μg/L, the prostate cancer detection rate was 18.1 % and 22.5 %, respectively; (2) The area under the curve (AUC) was bigger in fPSA/tPSA than in tPSA (P<0.05) in all the men; (3) When the cut off value of fPSA/tPSA ratio was set at 0.25 and the tPSA at 4.0 - 10.0 μg/L and 10.0 - 20.0 μg/L, the diagnostic sensitivity of tPSA was 90.5 % and 87.5 %, respectively. Thus at the tPSA ranges of 4.0 - 10.0 and 10.0 - 20.0 μg/L, 26.7 % and 11.3 % of biopsies could be avoided, respectively. Conclusion: The use of fPSA/tPSA ratio can improve the prostate cancer detection rate and reduce unnecessary biopsies when tPSA is within the range of 4.0 - 20.0 μg/L.

关键词： prostate cancer prostate specific antigen free/total PSA ratio

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云南永平卓潘新生代碱性杂岩体的元素地球化学和Nd-Sr-Pb同位素特征及地质意义

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岩石学报 2007年第5期23卷 986-994页

作者：董方浏莫宣学喻学惠侯增谦王勇中国地质调查局发展研究中心北京100037 中国地质大学地球科学与资源学院北京100083 中国地质科学院地质研究所北京100037 东华理工学院地球科学系抚州344000

云南永平卓潘碱性杂岩体是金沙江-哀牢山富碱斑岩带中的重要岩体,位于兰坪走滑拉分盆地西部。该岩体的主要岩石类型为辉石正长岩、正长岩和霞石正长岩等。岩石地球化学显示高碱、高K_2O/Na_2O比值、低TiO_2、高Al_2O_3的超钾质钾玄岩系... 详细信息

云南永平卓潘碱性杂岩体是金沙江-哀牢山富碱斑岩带中的重要岩体,位于兰坪走滑拉分盆地西部。该岩体的主要岩石类型为辉石正长岩、正长岩和霞石正长岩等。岩石地球化学显示高碱、高K_2O/Na_2O比值、低TiO_2、高Al_2O_3的超钾质钾玄岩系列岩石。微量元素表现为富集K、Rb、Sr、Ba等大离子亲石元素(LILE),亏损Ta、Nb、Ti、P、Zr等高场强元素(HFSE),表现为明显的"Ta-Nb-Ti"负异常,同时富集过渡性元素Cr、Ni、Co等。稀土元素为稀土总量高,富集LREE、(La/Yb)_N比值高、Eu异常不明显为特征。(^(87)Sr/^(86)Sr)_i比值为0.707611～0.709167、ε_(Nd)(t)值为-4.89～-6.57,^(206)Pb/^(204)Pb变化于18.6886～18.7022、^(207)Pb/^(204)Pb变化于15.6169～15.63493、^(208)Pb/^(204)Pb变化于38.7972～38.8927,显示岩浆源区具有富集地幔(EMⅡ)与下地壳共同作用的壳幔过渡带特征,构造环境判别为大陆弧(CAP)环境。岩体是在碰撞造山过程中大陆板片俯冲,使曾经遭受古洋壳板片流体强烈交代的壳幔过渡带在上升的软流圈熔体的注入而发生部分熔融,在走滑拉分盆地的核心部位沿构造断裂上升侵位而形成。

关键词：碱性杂岩体元素地球化学 Nd-Sr-Pb同位素云南永平卓潘

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滇西卓潘-六合碱性岩的辉石成分及其岩石化学特征

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矿物岩石 2005年第2期25卷 15-19页

作者：韦栋梁夏斌张玉泉王冉万哨凯中国科学院边缘海地质重点实验室中国科学院广州地球化学研究所中国科学院研究生院

　卓潘、六合碱性岩体地属哀牢山-金沙江碱性岩带,由碱性辉长岩、正长岩和正长斑岩组成,岩石学分析表明,二者均属钾质碱性系列的岩石,具有富碱、高钾、高Ca及高K2O/Na2O的特征。岩石中赋存的辉石是透辉石和钙铁辉石,属钙质辉石,为非碱... 详细信息

　卓潘、六合碱性岩体地属哀牢山-金沙江碱性岩带,由碱性辉长岩、正长岩和正长斑岩组成,岩石学分析表明,二者均属钾质碱性系列的岩石,具有富碱、高钾、高Ca及高K2O/Na2O的特征。岩石中赋存的辉石是透辉石和钙铁辉石,属钙质辉石,为非碱性暗色矿物。钙质辉石的出现与碱性岩的化学成分密切相关,正是由于岩石中高含量Ca的存在,导致了钙质辉石的产生。

关键词：辉石成分岩石化学钾质碱性岩卓潘和六合云南

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