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Risk factors of interstitial lung diseases in clinically amyopathic dermatomyositis

Chinese Medical Journal 2020年第6期133卷 644-649页

作者： yu-zhou gan Li-Hua Zhang Lin Ma Feng Sun yu-Hui Li yuan An Zhan-Guo Li Hua Ye Department of Rheumatology Immunology and Beijing Key Laboratory for Rheumatism and Immune Diagnosis(BZ0135) Peking University People's HospitalBeijing 100044China Center of Clinical Immunology Peking UniversityBeijing 100044China Department of Rheumatology Hulunbeier People's HospitalHulunbeierInner Mongolia 021008China Department of Rheumatology Hebei Hospital of Traditional Chinese MedicineShijiazhuangHebei 050200China

Background:Clinically amyopathic dermatomyositis(CADM)is a unique sub-type of idiopathic inflammatory myopathies with a high prevalence of interstitial lung disease(ILD).Poor prognosis of the patients was strongly associated with rapid progressive *** aim of this study was to identify risk factors for prediction of different types of ILD in ***:In this study,data of 108 inpatients with CADM were collected,including 87 with *** baseline clinical data and laboratory parameters,including myositis-specific and associated antibodies and tumor-associated antigens were analyzed to identify risk factors for acute or subacute interstitial pneumonitis(A/SIP)and chronic interstitial pneumonitis(CIP).Results:In 87 patients with CADM-ILD,39(36.1%)were A/SIP,and 48(44.4%)were *** were 22(20.4%)patients with asymptomatic ILD who were detected by routine high resolution computed ***-19 fragment(CYFRA21-1)was significantly higher in CADM-ILD than that in CADM patients without ILD;carcinoembryonic antigen and neuron-specific enolase were significantly elevated in A/SIP than that in *** with A/SIP had a higher positive rate of anti-melanoma differentiation-associated gene 5(MDA5),while patients with CIP had a higher positive rate of anti PL-12 and *** regression analysis indicated that elevation of CYFRA21-1 was a risk factor for ILD,higher titer of anti-MDA5 indicated increased likelihood for A/SIP,and higher titer of anti-Ro-52 was also clearly associated with ***:This study indicated that the prevalence of ILD was high in *** ILD has been previously ***-MDA5 was a risk factor for the presence of A/SIP,and CYFRA21-1 was a risk factor for ILD.

关键词： Clinically amyopathic dermatomyositis Interstitial lung diseases Myositis autoantibodies Tumor-associated antigen

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Numerical Simulation of the Mass Movement Process of the 2018 Sedongpu Glacial Debris Flow by Using the Fluid-Solid Coupling Method

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Journal of Earth Science 2024年第2期35卷 583-596页

作者： Xing-yu Long yu-Xiang Hu Bin-Rui gan Jia-Wen zhou State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu610065China College of Water Resource and Hydropower Sichuan UniversityChengdu610065China

In the context of global warming and intensified human activities,glacier instability in plateau regions has increased,and glacier debris flows have become active,which poses a significant threat to the lives and property of people and socioeconomic *** mass movement process of glacier debris flows is extremely complex,so this paper uses the 2018 Sedongpu glacier debris flow event on the Qinghai-Tibet Plateau as an example and applies a numerical simulation method to invert the whole process of mass *** view of the interaction between phases in the process of motion,we use the fluid-solid coupling method to describe the mass *** granular-flow model and drift-flux model are employed in FLOW3D software to study the mass movement process of glacier debris flows and explore their dynamic *** results indicate that the glacier debris flow lasted for 700 s,and the movement process was roughly divided into four stages,including initiation,scraping,surging and deposition;the depositional characteristics calculated by the fluid-solid coupling model are consistent with the actual survey results and have good reliability;strong erosion occurs during the mass movement,the clear volume amplification effect,and the first wave climbs 17.8 m across the *** fluid-solid coupling method can better simulate glacier debris flows in plateau regions,which is helpful for the study of the mechanism and dynamic characteristics of such disasters.

关键词： glacial debris flow Qinghai-Tibet Plateau fluid-solid coupling FLOW3D mass movement depositional characteristics disasters engineering geology

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Elevated serum Dickkopf-1 is a biomarker for bone erosion in patients with psoriatic arthritis

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Chinese Medical Journal 2021年第21期134卷 2583-2588页

作者： yukchiu Chung Zhi-Chang Li Xiao-Lin Sun Yan-Ying Liu Miao Shao yu-zhou gan Yi-Min Li yu-Hui Li Xue-Wu Zhang Department of Rheumatology and Immunology Beijing Key Laboratory for Rheumatism and Immune Diagnosis(BZ0135)Peking University People’s HospitalBeijing 100044China Arthritis Clinic and Research Center Peking University People’s HospitalBeijing 100044China

Background:Psoriatic arthritis(PsA)is an inflammatory arthropathy characterized by psoriasis and bone erosion on ***-1(Dkk-1)is considered to be the main inhibitor of the Wnt signaling pathway and results in reduced osteoblast *** aim of this study was to investigate the serum level of Dkk-1 and its association with bone erosion in PsA ***:Serum Dkk-1 levels were measured by enzyme-linked immunosorbent assay(ELISA)in 69 patients with PsA and 60 controls,including 39 rheumatoid arthritis(RA)patients,and 21 healthy controls(HCs).Rheumatoid factor and anti-cyclic citrullinated peptide levels were also determined by *** association of Dkk-1 level with clinical and laboratory features of PsA was *** regression analysis was used to analyze the risk factors for bone erosion in ***:Dkk-1 was elevated in 68.1%(47/69)of the patients with PsA,46.2%(18/39)of RA patients,and 9.5%(2/21)of *** Dkk-1 concentration was significantly higher in PsA patients compared with that in *** level of serum Dkk-1 was correlated with a swollen joint count,and levels of complement components 3 and *** Dkk-1 level(odds ratio=4.440,95%confidence interval:1.246-15.817,P=0.021)was identified as the risk factor for bone erosion in ***:The serum level of Dkk-1 is abnormally elevated in PsA *** elevation of Dkk-1 might be involved in the mechanism of bone erosion in patients with PsA.

关键词： Dickkopf-1 Psoriatic arthritis Bone erosion

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A Sustainable Dual Cross‑Linked Cellulose Hydrogel Electrolyte for High‑Performance Zinc‑Metal Batteries

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Nano-Micro Letters 2024年第6期16卷 63-75页

作者： Haodong Zhang Xiaotang gan yuyang Yan Jinping zhou Hubei Engineering Center of Natural Polymers‑Based Medical Materials Key Laboratory of Biomedical Polymers of Ministry of EducationCollege of Chemistry and Molecular SciencesWuhan UniversityWuhan 430072People’s Republic of China Zhongnan Hospital of Wuhan University Institute of Hepatobiliary Diseases of Wuhan UniversityTransplant Center of Wuhan UniversityWuhan 430072People’s Republic of China

Aqueous rechargeable Zn-metal batteries(ARZBs)are considered one of the most promising candidates for grid-scale energy ***,their widespread commercial application is largely plagued by three major challenges:The uncontrollable Zn dendrites,notorious parasitic side reactions,and sluggish Zn^(2+) ion *** address these issues,we design a sustainable dual crosslinked cellulose hydrogel electrolyte,which has excellent mechanical strength to inhibit dendrite formation,high Zn^(2+) ions binding capacity to suppress side reaction,and abundant porous structure to facilitate Zn^(2+) ions ***,the Zn||Zn cell with the hydrogel electrolyte can cycle stably for more than 400 h under a high current density of 10 mA cm^(−2).Moreover,the hydrogel electrolyte also enables the Zn||polyaniline cell to achieve high-rate and long-term cycling performance(>2000 cycles at 2000 mA g^(−1)).Remarkably,the hydrogel electrolyte is easily accessible and biodegradable,making the ARZBs attractive in terms of scalability and sustainability.

关键词： Cellulose Dual cross-linked Aqueous rechargeable Zn-metal batteries Hydrogel electrolyte

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Bismuth clusters pinned on TiO_(2) porous nanowires boosting charge transfer for CO_(2) photoreduction to CH_(4)

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Nano Research 2024年第3期17卷 1190-1198页

作者： Jiazhi Meng Kaiwen Wang Yang Wang Jiangping Ma Chaogang Ban Yajie Feng Bin Zhang Kai zhou Liyong gan Guang Han Danmei yu Xiaoyuan zhou College of Physics and Institute of Advanced Interdisciplinary Studies Chongqing UniversityChongqing 401331China School of Chemistry and Chemical Engineering Chongqing UniversityChongqing 401331China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Beijing Key Lab of Microstructure and Properties of Advanced Materials Beijing University of TechnologyBeijing 100124China Analytical and Testing Center Chongqing UniversityChongqing 401331China

Artificial photosynthesis in carbon dioxide(CO_(2))conversion into value-added chemicals attracts considerable attention but suffers from the low activity induced by sluggish separation of photogenerated carriers and the kinetic bottleneck-induced unsatisfied ***,we prepare a new-style Bi/TiO_(2) catalyst formed by pinning bismuth clusters on TiO_(2) nanowires through being confined by pores,which exhibits high activity and selectivity towards photocatalytic production of CH_(4) from CO_(2).Boosted charge transfer from TiO_(2) through Bi to the reactants is revealed via in situ X-ray photon spectroscopy and time-resolved photoluminescence(PL).Further,in situ Fourier transform infrared results confirm that Bi/TiO_(2) not only overcomes the multi-electron kinetics challenge of CO_(2) to CH_(4) via boosting charge transfer,but also facilitates proton production and transfer as well as the intermediates*CHO and*CH_(3)O generation,ultimately achieving the tandem catalysis towards *** calculation also underlies that the more favorable reaction step from*CO to*CHO on Bi/TiO_(2) results in CH_(4) production with higher *** work brings new insights into rational design of photocatalysts with high performance and the formation mechanism of CO_(2) to CH_(4) for solar energy storage in future.

关键词： carbon dioxide(CO_(2))photoreduction charge transfer tandem catalysis methanation

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Quantum Spin Exchange Interactions to Accelerate the Redox Kinetics in Li–S Batteries

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Nano-Micro Letters 2024年第5期16卷 370-383页

作者： yu Du Weijie Chen yu Wang yue yu Kai Guo gan Qu Jianan Zhang Key Laboratory of Advanced Energy Catalytic and Functional Materials Preparation of Zhengzhou City College of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001People’s Republic of China

Spin-engineering with electrocatalysts have been exploited to suppress the“shuttle effect”in Li–S *** selec-tion,spin-dependent electron mobility and spin potentials in activation barriers can be optimized as quantum spin exchange interactions lead-ing to a significant reduction of the electronic repulsions in the orbitals of ***,we anchor the MgPc molecules on fluorinated carbon nanotubes(MgPc@FCNT),which exhibits the single active Mg sites with axial *** to the density functional theory calculations,the electronic spin polarization in MgPc@FCNT not only increases the adsorption energy toward LiPSs intermediates but also facilitates the tunneling process of electron in Li–S *** a result,the MgPc@FCNT provides an initial capacity of 6.1 mAh cm^(-2) even when the high sulfur loading is 4.5 mg cm^(-2),and still maintains 5.1 mAh cm^(-2) after 100 *** work provides a new perspective to extend the main group single-atom catalysts enabling high-performance Li–S batteries.

关键词： Metal phthalocyanines Spin polarization Electrocatalysis Li–S batteries

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High-performance,stable CoNi LDH@Ni foam composite membrane with innovative peroxymonosulfate activation for 2,4-dichlorophenol destruction

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Journal of Environmental Sciences 2024年第7期141卷 235-248页

作者： yu Liu Weibao Liu Xinrui gan Jiangwei Shang Xiuwen Cheng College of Chemistry and Environmental Science Xinjiang Laboratory of Phase Transitions and Microstructures of Condensed Matter PhysicsYili Normal UniversityYining 835000China Key Laboratory for Environmental Pollution Prediction and Control Gansu ProvinceCollege of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China

In this study,the cobalt-nickel layered double hydroxides(CoNi LDH)were synthesized with a variety of Co/Ni mass ratio,as *** comparison,Co1Ni3LDH presented the best peroxymonosulfate(PMS)activation efficiency for 2,4-dichlorophenol ***,CoNi LDH@Nickel foam(CoNi LDH@NF)composite membrane was constructed for enhancing the stability of catalytic ***,CoNi LDH@NF-PMS system exerted high degradation efficiency of 99.22%within 90 min for 2,4-DCP when[PMS]_(0)=0.4 g/L,Co^(1)Ni^(3)LDH@NF=2 cm×2 cm(0.2 g/L),reaction temperature=298 *** the surface morphology and structure of the catalyst,it was demonstrated that the CoNi LDH@NF composite membrane possessed abundant cavity structure,good specific surface area and sufficient active ***,·OH,SO_(4)·^(-)and^(1)O_(2)played the primary role in the CoNi LDH@NF-PMS system for 2,4-DCP decomposition,which revealed the PMS activation mechanism in CoNi LDH@NF-PMS ***,this study eliminated the stability and adaptability of CoNi LDH@NF composite membrane,proposing a new theoretical basis of PMS heterogeneous catalysts selection.

关键词： CoNi LDH@NF composite membrane Peroxymonosulfate 2,4-dichlorophenol Reactive radicals

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Research progress on intelligent operation and maintenance of bridges

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第2期11卷 173-187页

作者： Wanshui Han gan Yang Shizhi Chen Kai zhou Xin Xu School of Highway Chang'an UniversityXi'an 710064China

In the context of the increasing scale of bridges and the increasing service life of bridges,it is very important to carry out efficient,accurate and intelligent bridge operation and *** recent years,advanced equipment,technology and intelligent algorithms have developed *** is necessary to apply advanced equipment and algorithms to bridge operation and maintenance business to facilitate the digitalization and intelligence of bridge operation and *** grasp the research progress on the bridge intelligent operation and maintenance,this paper summarizes the research progress in recent years from the aspects of intelligent detection equipment and technology,intelligent monitoring equipment and technology,intelligent data analysis,intelligent evaluation and early warning,and intelligent repair and *** to the review,more and more smart devices have been used to replace human beings to detect dangerous and hidden bridge *** the same time,image processing,radar and other technologies have been used to analyze component damage more objectively and *** solve the shortcomings of traditional sensors such as short life and low robustness,more non-contact measurement methods have been *** have proposed various intelligent algorithms to process the massive amount of bridge health monitoring data to improve the quality of the *** achieve the rapid perception of bridge status and timely early warning of structural abnormalities,different from traditional theoretical calculations,scholars have tried to use data-driven methods to intelligently evaluate and early warning of bridge structural *** terms of intelligent repair and maintenance,more intelligent algorithms have been used to optimize structural maintenance strategies and determine the best maintenance time by integrating multisource heterogeneous *** these provide strong support for the automation,digitization and intelligence o

关键词： Bridge engineering Bridge intelligent operation and maintenance Intelligent equipment Technology and algorithms

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Capturing and visualizing the phase transition mediated thermal stress of thermal barrier coating materials via a cross-scale integrated computational approach

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Journal of Advanced Ceramics 2024年第4期13卷 413-428页

作者： Mengdi gan Tianlong Lu Wei yu Jing Feng Xiaoyu Chong Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China

The generation and evaluation of severely high thermal stress(σ)is known to be responsible for failure of thermal barrier coatings(TBCs)during thermal *** is crucial and challenging to capture fluctuations inσcaused by the phase transition,which has motivated us to develop a high-throughput multiscale evaluation method forσin TBCs that considers the phase transition of the top ceramic materials by coupling first-principles calculations with finite element *** method quantitatively evaluates and visualizesσof the real TBC structure under thermal cycling by multifield ***,the thermophysical properties calculated by the first-principles calculations consider the effects of temperature and phase transition,which not only reduces the cost of obtaining data but also has a more physical *** this work,rare earth tantalites(RETaO_(4))are introduced as ceramic layers,and the results demonstrate thatσundergoes a rapid escalation near the phase transition temperature(T_(t)),particularly in the TBCs_GdTaO_(4) system,where it rises from 224 to 435 *** discontinuity inσmay originate from the significant alterations in Young’s modulus(increase by 27%–78%)and thermal conductivity(increase by 53%–146%)near T_(t).The TBCs_NdTaO_(4) and TBCs_SmTaO_(4) systems exhibit noteworthy temperature drop gradients and minimalσfluctuations,which are beneficial for extending service lifetime of *** approach facilitates the prediction of failure mechanisms and provides theoretical guidance for the reverse design of TBC materials to obtain low thermal stress systems.

关键词： thermal conductivity first-principles calculations thermodynamics thermal stress thermophysical properties

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Elaborating strengthen mechanism of Pt-Ir solid solution superalloy at finite temperature

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Rare Metals 2024年第3期43卷 1243-1256页

作者： Wei yu Xiao-yu Chong yun-Xuan zhou Meng-Di gan Ying-Xue Liang Yan Wei Ai-Min Zhang Chang-Yi Hu Xing-yu Gao Li Chen Hai-Feng Song Jing Feng Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming650093China yunnan Precious Metals Laboratory Co.LTD Kunming650106China Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing100088China

Pt-Ir alloy is potential superalloys used above 1300℃because of their high strength and creep ***,the ductility of Pt-Ir alloy has rapidly deteriorated with the increase of Ir,resulting in poor *** work quantitatively evaluated the solid solution strengthening(SSS)and grain refinement strengthening(GRS)of Pt-Ir alloy using first-principles calculations combined with experimental ***,the stretching force constants in the second nearest neighbor region(SFC^(2nd))of pure Ir(193.7 eV·nm^(-2))are 3.40 times that of pure Pt(57.0 eV·nm^(-2)),i.e.,the interatomic interaction is greatly enhanced with the increase of Ir content,which leads to the decrease of ductility,and modulus misfit plays a dominant role in ***,the physical mechanisms responsible for the hardness(H_(V))of Pt-Ir alloy,using the power-law-scaled function of electron work function coupled SSS and GRS,are attributed to the electron redistribution caused by different Ir ***,a thorough assessment of the thermodynamic characteristics of Pt-Ir binary alloy was conducted,culminating in development of a mapping model that effectively relates enmposition,temperature and *** results revealed that the compressive strength incrcases with the Ir content,and the highest strength was observed in Pt_(0.25)Ir_(0.75).This study provides valuable insights into the Pt-Ir alloy system.

关键词： Elastic properties Phonon Solid solution strengthen Force constants CALPHAD

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